Latest news with #Accent
New York Post
09-05-2025
- Entertainment
- New York Post
Our 41 best Father's Day gift ideas for every kind of dad in 2025
New York Post may be compensated and/or receive an affiliate commission if you click or buy through our links. Featured pricing is subject to change. Want to see your dad's jaw drop to the floor on Father's Day? Silly socks and or a last-minute mug might be your usual M.O., but this Father's Day brings a new opportunity to tap your gifting skills for the guy that got you through life — you know he deserves it. We've spent hours penning elaborate gift guides for every person in your life, and understand that Father's Day gifting can be particularly tricky, especially if you're dad is the type to insist he doesn't need anything. Advertisement We've scored the internet, sifting through thousands of popular gifts, and enlisted help from dads on the Post Wanted team, to put together a Father's Day 2025 gift guide that has the perfect present to appease any kind of man — whether his favorite activity is snoring, he never stops talking about his favorite sports team, or he can't get enough of his grill this summer. This year, we've got gifts across every budget, from comfy walking shoes to luxe watches, smartwatches, and more surprises that are guaranteed to make him smile (plus, let you flex your fine taste). Best for An Active Dad: HOKA Clifton 9 New York Post Dubbed a 'dad shoe' for a reason, Hoka Clifton 9s offer the cushioned, cloud-like support that he needs to stay on his feet all day. Our Live Events Reporter, Matt Levy, raves about his pair, 'The last thing you'll be worrying about is foot pain or insoles. They're everything you need.' Between the impressive 3mm stack and improved outsole design, you really can't go wrong with Hokas. Best for The Chef: HENCKELS Forged Accent Razor-Sharp Steak Knife Set of 4 If he watched every episode of 'The Bear,' takes any chance to pull out a recipe book, and slices and dices faster than you've ever seen, he probably would love nothing more than a new knife set. This ravor-shar, ergonomically designed by HENCKELS, boasts exceptional durability and performance. Best for a Man Who Never Shops: Calvin Klein Men's Cotton Classics 3-Pack Boxer Brief Amazon If his underwear drawer could use a restock (it probably does), Calvin Klein has you covered. The classic cotton boxers are a best-seller for good reason. They're soft, breathable, stretchy, and feature a flexible waistband for all-day comfort. Grab them in a three-pack, available in an assortment of his favorite colors. For the Bookworm: Amazon Kindle Paperwhite Amazon The Kindle Paperwhite is just what the bookworm-dad needs in his life. Light, bright, and slim enough to throw in his carry-on, this e-reader has one the hearts of thousands of Amazon reviewers and is an exceptionally thoughtful gift. You could even step up the gift a notch and pre-load it with his favorite books, so he doesn't have to do any of the heavy lifting. Best for Any Dad: YETI Rambler 30-Ounce Tumbler Yeti Dads never let go of a good YETI, and this may be our favorite one yet. Why? It keeps liquid hot or cold for hours, has a stunning stainless-steel outer shell, and offers a generous 30-ounce capacity, so he should have no problem staying hydrated all day long. Best for The Music-Loving Dad: Sony WH-1000XM5 Wireless Noise-Canceling Headphones Amazon If dad is the type to plug in his headphones and tune out the rest of the world, the Sony WH-1000XM5 noise-cancelling muffs will serve him well. These deliver industry-leading noise cancellation for an immersive listening experience that he will love. Plus, they boast 30 hours of battery life, so he can take them on a work trip, no problem. Best Personalized Father's Day Gift: Custom Coffee Mug Amazon We may have made fun of mugs earlier, but a cheesy gift is kind of perfect for the right guy who needs a smile. This customizable option from Amazon is made from high-quality ceramic and is safe in the dishwasher (new parents always appreciate things that are easy to clean). Best for the dad Who Loves Burgers: Firstgrill Burger Press Amazon Since summer is just around the corner, we had to throw a simple grilling gift on this list. Once called the 'most indestructible cooking tool you use,' the cast-iron Burger Press is sure to leave your patties sizzling with perfect marks. It's also under $30 on Amazon, which makes it a great budget-friendly choice, even as a last-minute buy. Best for the Stylish Dad: Wrangler Authentics Men's Long Sleeve Shirt Amazon If you're dad actually has some style, a handsome flannel never disappoints. This lightweight long-sleeve is built with comfort and function first, with brushed polyester, collar lining, and cuff closures. It's available in an array of colors, so you can find one that suits his vibe. Best First Father's Day Gift: LEGO Speed Champions Oracle Red Bull Racing RB20 F1 Race Car Model Kits LEGO Commerce Partnership Manager and new dad of one, Frank Massaro, explained that a LEGO set is a great choice for a new dad who could use some stress relief. 'Taking care of a baby requires immense focus and problem-solving skills,' he shared. 'In my free time, it is nice to just look at instructions, turn the majority of my brain off, and build a really cool LEGO set.' Best for The Coffee Addict: Breville Barista Express Espresso Machine Amazon If you're dad wants to become a seasoned barista, he needs the Breville Barista Express. Between the temperature control and manual steam wand, you know his coffees will taste top-notch. Yes, it's a splurge, but according to reviewers, well worth it. I mean, who doesn't want an all-in-one espresso machine that grinds, doses, and brews in one seamless flow? Best Last-Minute Father's Day Gift: Concert tickets Vivid Seats Naturally, our Live Events Reporter would love nothing more than some concert tickets as a last-minute Father's Day gift. 'There are so many shows coming to NYC this year and I want to go to all of them,' shared Levy. 'The only problem is that Levy doesn't have time to see everything.' Make their problem a little easier by snagging tickets for one of their favorite shows far in advance. You can iron out the details later. Best for The Hip Dad: Apple AirPods (2nd Generation) Amazon Happy Father's Day to all! Over 600,000 satisfied listeners have given these AirPods their stamp of approval, and your dad will be the next. They're a phenomenal choice for any dad, but especially the ones who try and keep up with the trends. If he's always on the go, even better. Best Gift for The Home Security Guy: Ring Video Doorbell We all know that dad. The one who always wants to see when the delivery guy shows up, or has to watch the front door when his kids are due back by curfew. The Ring Video Doorbell is the single gift he needs to feel safe, offering motion-detection, real-time alerts, and two-way voice, so he can stay ahead of home security. Best Gift for Dad From Kids: Rawlings Baseball Glove Amazon A baseball glove is a classic gift for a dad, and it's even sweeter when it comes right from his kiddo. Our Live Events reporter seems to agree. According to Levy, there's nothing better than taking your kid to the ballpark: 'I like to bring a mitt to the park in case a foul ball flies my way. There's no better pop than one that casually grabs a ball from the sky and hands it to their kid. And that can easily be you.' Best Father's Day gift for Grandpa: AncestryDNA Genetic Test Kit As the sign synonymous with lineage, sea goats get down with DNA testing. Amazon Something fun for the whole family, but especially for pops — The AncestryDNA Genetic Test Kit offers a comprehensive way to explore your heritage and family history. All it takes is a simple cheek swab, and Ancestry's advanced DNA technology opens all the doors to uncovering your unique ancestral story. You might just find a new relative by gifting this grandpa Father's Day gift! Best for The Fit Dad: Apple Watch SE 2nd Generation (GPS) 40mm Have a fitness-focused father with lofty goals? Whether he's training for his next marathon or just trying to shed a few pounds, the coveted 2nd-generation Apple Watch is a wonderful gift. This tiny, wearable device tracks your workout performance, heartbeat, and sleep cycles to deliver the most accurate health metrics possible. Unique Father's Day Gift: Ooni Karu 12 Multi-Fuel Outdoor Pizza Oven Amazon Here's something different — the esteemed Ooni Karu 12 Multi-Fuel Outdoor Pizza Oven. With this handy machine, he can whip out wood-fired and stone-baked pies (and save money on weekly pizza delivery). It delivers a powerful blast of searing flame that cooks your pizzas to perfection, so really, it's a gift for the entire family. Kiehl's Believe it or not, maintaining a beard is a lot of work. But, Keihl's has him covered. This popular grooming kit comes with everything he needs to look and feel his best, from face wash and shave cream to after-shave gel and face moisturizer. His smooth, refreshed skin will thank you. Best for The Dad Who Likes Bling: Fossil Nate Men's Watch Amazon There's no need to dish out thousands of dollars for a Rolex. This stunning design from Fossil will easily impress him, and won't wallow your bank account, either. The luxe matte black finish is timeless, yet modern, and the classic face has impressed over 20,000 Amazon shoppers. Best for The Working Dad: Carhartt Lunch Cooler Bag Amazon Carhartt is a favorite brand for hard-working guys, dads included. They're lunch cooler selection happens to be top-notch, and this simple tote could seriously transform his lunch breaks. The roomy, insulated main compartment is made with heavy-duty, waterproof fabric to keep his food cool and dry. Not to mention, it's also large enough for a six-pack. Best for a Dad Who Needs to Relax: Cozy Earth Luxe Bath Robe Cozy Earth Multiple Post Wanted members rave about their Cozy Earth bedding and pajamas, but the robes can go unnoticed, too. These make a superb gift for the dad who loves to lounge in style. A blend of cotton and bamboo viscose envelopes the body in immediate warmth, but still makes way for airflow, so he can jump out of the shower feeling relaxed and rejuvenated. Best Cool Father's Day Gift: Lululemon ABC Classic-Fit Trouser Warpstreme lululemon Another Post Wanted pick is lululemon's coveted ABC trousers, which feature four-way stretch, quick-drying fabric, and hidden snaps to ensure back pockets stay closed and lay flat. 'I've heard nothing but good things about these pants,' Murphy insisted. They are easy to style and wash well, which always makes dad-life a bit easier. Best for The Stressed Dad: Theragun Mini Amazon Take his stress and tension away with a handy tool that thousands of reviewers swear by. Don't let its size fool you, the Theragun Mini massage gun is super-powered, portable, and comes with three high-quality, scientifically designed attachments to target aches and pains. We've reviewed it here and understand the difference it can make. Best for The Conservative Dad: VIWIS Funny President Trump Mug Amazon Your dad? A great dad. Other dads? Losers! If your dad leans to the right, then he might want to sip his morning brew from something that will make him laugh, and hopefully, these presidential puns do the trick. Politics aside, it's made with double-wall insulation to help keep his coffee piping hot or ice-cold, either way he likes it. Best for The Practical Dad: Courant Catch:3 Belgian Linen Wireless Charging Station and Valet Tray Amazon You can't beat a practical gift, and the Courant Catch:3 is just that. This wireless pad offers up to 10W of charging for all his technology — phones, laptops, smartwatches, and more. No cords necessary. It's a brilliant way to keep everything organized, and you'll never have to worry about stealing his charger again. Best for a Gamer Dad: PlayStation DualSense Wireless Controller Amazon New father and Commerce Partnership Manager Frank Massaro highly recommends a PlayStation controller for a gamer dad who needs to take down the mental load from time to time. 'There are times when I find myself couch-trapped, because my son has fallen asleep on me. That is usually when I grab the nearest game controller and hop into the latest video game,' he shared. Best for The Beach Dad: Huckberry Performance Lined Swim Trunks Huckberry There's nothing like catching some sun on the beach or taking a swim in the pool on a hot summer day. For a dad who loves to do both, a pair of swim trunks is a wonderful option. Our Commerce Partnerships Manager, Ryan Murphy, loves his pair of ultra-soft, moisture-wicking swim trunks by Huckberry: 'Hybrid shorts for the gym, beach, or just for running errands. Versatility is unmatched!' he exclaimed. Best for the Tech Dad: Samsung Galaxy Watch5 Pro Bespoke Edition Another quality smartwatch to consider, the Samsung Galaxy Watch5 Pro Bespoke Edition offers a range of personalization options so your dad can enjoy a custom experience. The full suite of features doesn't disappoint either; from a sleep tracker and body composition analyses to advanced coaching for forming better habits. Best Amazon Father's Day Gift: COOFANDY Linen Shirt Amazon It's a common conundrum. Dad has no clue what to pack for his upcoming vacation. If he needs a little extra help when it comes to finding the perfect fit for your upcoming trip, we suggest adding this lightweight linen shirt to your cart ASAP. It's available in more colors and prints than we can count, so you should have no problem finding something that suits him. Best for The Hungry Dad: California Reserve Ribeye Goldbelly Golbelly is our go-to store for decadent treats and delicious bites from our favorite cities, and they're steak selection is no exception. This California Reserve Ribeye gift box from Goldbelly would make a splendid gift for the carnivores. Its dry-aged ribeyes are marbled, boneless, and hand-cut, and sourced exclusively from small California producers — perfect even for the pickiest dads. Best for The Dad Who Loves To Grill: Weber Spirit II E-210 2-Burner Liquid Propane Grill Amazon A two-burner propane grill is a no-brainer for the guy who's always standing behind the barbecue. This Weber design offers a compact surface, foldable side table, and porcelain-enameled, cast iron cooking grates. He'll be smitten, and your summer dinners will taste that much better. Best Space-Saving Fitness Gift: Bowflex SelectTech 552 Adjustable Dumbbells Amazon Setting up a home gym isn't always easy, especially if you're working with a tight space. The Bowflex SelectTech 552 Adjustable Dumbbells are a genius hack, offering an adjustable weight range from 5 to 52.5 pounds, so you're dad can get his lifting sessions in without tripping over a bunch of equipment. Best for The Dad Who Needs Deodorant: Nécessaire The Body Essentials Mini Necassaire There's no reason to sweat over the perfect gift. Deodorant is among the more underrated options on this list, but for a certain guy, it's exactly what they need. Our editors rave about Nécessaire's long-lasting deodorant sticks, and the santal scent is supposedly a cult-favorite. With help from the body lotion and wash, this little kit should help him curb unwanted odors and feel like a million bucks. Best for The Dad Who Travels: trtl Travel Pillow Amazon We know catching flights can be exhausting, but with a little help from the trtl Travel Pillow, your dad could be catching some great ZZZ's too. This cushioned, thermal pillow combines bio-blended fabrics, which are cool, comfortable, breathable, and provide excellent thermoregulation. He'll arrive at his destination feeling ready to go! Best Cheap Father's Day Gift: Hu Keto Friendly Vegan Hunks Amazon If he's a total hunk, he's going to love these (and you, for gifting them). Hu's chocolate-covered hunks are editor-tested and absolutely decadent. Sweet, salty, and made without refined sugar, these keto-friendly almond bites are a much healthier take on a traditional sweet treat, so he can also keep his dad bod in check. And, under $20 for a two-pack? Done deal. Best gift for athletic dad: The Cold Pod Ice Bath Tub for Athletes Amazon Dads who prioritize their health will understand the value of a good cold plunge. These were designed for athletes, and the benefits of cold therapy (like reduced inflammation and faster recovery) far outweigh the temporary discomfort of sitting in fridge temps. Plunges can go for well over $1000, but you can snag this one for just over $100 on Amazon Amazon Dad, husband, grandfather, or friend — if there's any guy in your life that you care about, he needs one of these. The MANSCAPED Lawn Mower 5.0 Ultra is the grooming tool for the man who appreciates the perfect cut. It's designed for groin and body hair, and features skin-safe technology for a smooth, gentle shave. It's also waterproof, so he can you it in the shower when he's in a rush, Best Gift for The Handyman: DeWalt Max Cordless Drill Combo Kit Perhaps it's not the sexiest gift on this list, but it doesn't make it any less desirable. The DeWALT Cordless Drill Combo kit is trusted by professionals and ordinary DIY home makeover dads alike. It's easy to use, powerful, durable, and comes with a handy carry bag so he can bring it with him on all his projects. Best for The Whiskey-Loving Dad: Whiskey Peaks Mountain Whiskey Decanter and Glasses Does Dad need a drink? If we're placing bets, a whiskey decanter and glass is going to impress almost any kind of guy. But, for the whiskey-loving dad, this charming decanter and set of four whiskey glasses add a touch of adventure to the evening dram. Best gift under $50: TOLOCO Massage Gun Amazon It's not often that we spot a massage tool for under $50 on Amazon. When such a deal does arise, we suggest jumping on it ASAP (perhaps for dad and you). The TOLOCO deep tissue massage gun fits the mark. It's small but mighty, providing a powerful penetration force of 12 mm and speeds up to 3,200 RPM. Looking for a headline-worthy haul? Keep shopping Post Wanted. This article was written by Miska Salemann, New York Post Commerce Journalist. As a Gen Z first-time mother of one, Miska tests baby, maternity and postpartum products ranging from stylish new kids clothes to long-trusted diaper brands with her daughter. She evaluates baby- and mom-approved products for practicality and quality, and consults medical and parenting experts to weigh in on safe ingredients, usage and more. Before arriving at the Post, she covered the lifestyle and consumer verticals for the U.S. Sun.
Daily Mail
07-05-2025
- Entertainment
- Daily Mail
Prince Harry's 'Cali cool' accent baffles fans as he becomes increasingly 'Americanised'
Prince Harry 's no-holds-barred interview with the BBC made headlines after he opened up about the years-long tension with the Royal Family - but staunch royal observers noticed a subtle difference in the prince. He spoke to the BBC about losing a legal challenge over his UK security provision, saying it is 'impossible' to bring Meghan Markle and his children back to the UK. Quick-eared listeners pointed out an American twang in Harry's accent, as he mirrored his interviewer with some words. Although he was taught to speak the King's English, after five years of living in Montecito with Meghan, it appears Harry's prim and proper Eton accent is disappearing in favour of a California drawl. In the BBC interview he drops many of his 'Ts' such as in words like 'citizen', 'repeat', 'putting', 'whatever' and 'security'. Linguistically this is known as a 'Quick T' used between vowels, which sounds like a 'D'. At one point the American interviewer asked: 'A change in your status - did you not accept that from the court?' Harry replied by saying 'My status' in a British accent and then repeating the word with a Quick T and smiling. This line had now been removed from the BBC iPlayer version of the video. Harry's no-holds-barred interview with the BBC made headlines after he opened up about the years-long tension with the Royal Family Although he was taught to speak the King's English, after five years of living in Montecito with Meghan, it appears Harry's prim and proper Eton accent is disappearing in favour of a California drawl When it comes to saying dates, he pronounces 2016 the American way of 'twenty sixteen' - as well as dropping the final 'T'. He even uses the word 'dad' rather than 'papa', which Royal Family members have preferred for centuries. This comes after a language expert said that Harry might have picked up a few Americanisms since moving to the States with his wife Meghan and son Archie in 2020. Former King's College language specialist Tony Thorne said shades of an American accent could be heard in the Duke's voice in a previous interview with US broadcaster NBC. He said Prince Harry could be heard dropping his 'Ts' in some instances - including when talking about his home in Santa Barbara, California. In November during a two-minute skit with musician Jelly Roll, filmed at New York tattoo parlour East Side Ink, people pointed out that he has now gone Cali cool. One person wrote on X: 'He totally has an American accent now,' while another said: 'Prince Harry's British accent sounds more diluted to make way for the American accent.' Another said: 'It sounds like Prince Harry is losing his British accent.' In the clip, which was filmed to promote The Invictus Games, the Duke says the American term 'Screw it, let's do it,' to American rapper and singer Jelly Roll. He then used several American colloquialisms, calling the tattoo artist 'dude' and saying: 'That [tattoo] feels big man.' The royal then exclaimed: 'You put your name on my neck,' raising his voice at the end of the sentence, as US speakers tend to do. He also appeared to say that the ink could be put on his 'a**', rather than using the English term 'a***'. Anthony Shuster, a communication coach and accent specialist, told The Telegraph: 'You notice that there's a huge difference between the way the King speaks and the way these guys speak.' Speaking of Harry's accent in the clip, he said: 'It's not exactly the stiff upper lip... There's very little articulation at all.' Mr Shuster also looked at another video of Prince Harry from 2004, during his gap year, where he spent eight weeks in Lesotho. Harry can be heard saying: 'Yeah it's learning about the culture, isn't it. Different country – not everybody knows about it.' The language expert said that there is much research about children from affluent backgrounds dropping their t's in order to sound 'less posh'. But it was in 2019 when the real change shifted after he met Meghan Markle, says Mr Shuster. When he first introduced baby Archie into the word, Harry said: 'Wow, he's already got a little bit of facial hair as well.' Except his t's became d's, which made the world 'little' sound like 'liddle'. Mr Shuster told the outlet: 'That's something that's quite distinctly American, is to let your final 't' sort of soften to a 'd'.' Jennifer Dorman, a linguistics expert, said that his vocabulary has become more Americanised since his big move in 2020. In podcast recordings with his wife in 2021, Harry started peppering his speech with phrases including 'awesome' and 'you guys', she noted. 'It could be that Prince Harry has started to borrow American phrases and words in order to fit in and be understood better by the American press,' she told Cosmopolitan in 2021. 'This could become so habitual that he uses these words when speaking to Brits and Americans alike. 'Or he may just be mimicking his wife: interacting at a close level with someone all the time can cause us to pick up their speaking habits.' Commenting on his tattoo video, one fan said: 'He's picking up American words. That's good.' Another chimed in and said: 'American slang, a bit of the accent, love it!' In 2021 behaviour expert Judi James said Harry had adopted elements of an American accent, with a rising inflection and 'blending of words' and that his accent was likely to change more in the future. 'Harry, like many of us, has a tendency to adapt to his surroundings by mirroring and it was a trait that his mother Diana was good at too. 'It can help create rapport as long as it's not too obvious.' Harry and Meghan's children are growing up stateside, so it is no surprise they have their mother's accent. Videos shared on Meghan's social media revealed three-year-old Princess Lilibet's American twang. Last month the Duchess of Sussex posted a video on Instagram in which she can be heard asking Lilibet what she thinks of her strawberry jam while preparing a fresh batch. 'It's beautiful,' the toddler gushed, as her Californian accent shone through. The first time royal fans heard Lilibet's voice was in January 2025 when the Duchess posted an emotional tribute in memory of the Sussexes' late beagle, Guy, on social media. Meghan's video included a tender moment in which the royal children sang to the beloved pooch, as well as a clip of Prince Archie and Guy that was taken during a car journey. It appears that both Lilibet and Archie, five, have developed strong American accents since moving stateside; at one point, viewers can hear Archie say 'he might fall' with a pronounced twang while referring to the family's beloved dog. While it is unclear whether Harry's new Cali twang is a natural change or a deliberate effort to fit in, it is certainly causing a stir.
Malaysian Reserve
28-04-2025
- Business
- Malaysian Reserve
Accent Therapeutics Presents Data Supporting Therapeutic Potential of First-in-Class DHX9 Inhibitor, ATX-559, and Novel KIF18A Inhibitor, ATX-295, at the AACR Annual Meeting 2025
ATX-559, a first-in-class oral DHX9 inhibitor, shown to induce potent and selective tumor growth inhibition in preclinical models of cancers with high genomic instability and replication stress Oral presentation showcases robust, selective activity of potentially best-in-class KIF18A inhibitor, ATX-295, in KIF18A-dependent ovarian cancer models exhibiting whole genome doubling LEXINGTON, Mass., April 28, 2025 /PRNewswire/ — Accent Therapeutics, a clinical-stage biopharmaceutical company pioneering novel, targeted, small molecule cancer therapeutics, today announced new preclinical data on its first-in-class oral DHX9 inhibitor, ATX-559, and its potentially best-in-class KIF18A inhibitor, ATX-295, in poster and oral presentations, respectively, at the AACR Annual Meeting 2025 taking place April 25-30 in Chicago, Illinois. ATX-559 and ATX-295 are currently under investigation in Phase 1/2 clinical trials. 'Our presentations at the AACR annual meeting showcase the outputs of Accent's precision oncology approach to drug development, with strong foundational data that inform our current and future clinical development plans for our lead programs, ATX-559 and ATX-295,' said Serena Silver, Ph.D., Chief Scientific Officer of Accent Therapeutics. 'These preclinical data reinforce our assets' therapeutic potential across several cancer indications with high unmet need.' The company's poster presentation includes preclinical data supporting continued clinical evaluation of ATX-559, a first-in-class potent, selective, and orally bioavailable small-molecule inhibitor of DHX9. Results within characterize the compound's activity in cancer cell lines with genomic instability and elevated replication stress spanning several indications, including dMMR/MSI-H colorectal cancer and BRCA-altered triple negative breast cancer, and in subtypes of lung, gastric, ovarian, and prostate cancers. ATX-559 was shown to be well tolerated in vivo, leading to robust and dose dependent tumor growth inhibition and regression in BRCA deficient breast cancer and dMMR/MSI-H cell- and patient-derived xenograft models. ATX-559 is currently under investigation in a first-in-human, Phase 1/2, open-label, dose-escalation and expansion study, with a focus on advanced or metastatic patients with BRCA-1 and/or BRCA-2-deficient breast cancer or MSI-H and/or dMMR solid tumors (NCT06625515). Additional undisclosed solid tumor indications undergoing replicative stress and representing significant patient populations may be explored either in parallel or in subsequent studies. For Accent's second lead program, preclinical data included in the company's oral presentation demonstrates sensitivity to KIF18A inhibition across several solid tumor indications with high chromosomal instability, signaling significant opportunity for patient impact by leveraging KIF18A as a selective oncology target. Results further characterize ATX-295 as a potent and selective KIF18A inhibitor capable of inducing mitotic arrest, cell death, and anti-tumor activity in cancer models with high chromosomal instability. Studies in relevant cellular and xenograft models exhibiting whole genome doubling confirm selective anti-cancer activity, providing rationale for whole genome doubling as a predictive biomarker of ATX-295 sensitivity in ovarian and triple negative breast cancer. Accent recently initiated clinical evaluation of ATX-295 in a first-in-human Phase 1/2 open-label, dose-escalation and expansion study designed to evaluate the molecule's safety, tolerability, and preliminary efficacy in patients with locally advanced or metastatic solid tumors, including high-grade serious ovarian cancer (NCT06799065). Details for the presentations are as follows: Presentation Title: Activity of the Novel KIF18A Inhibitor, ATX-295, is Enriched in Whole Genome Doubled Ovarian Cancer Pre-Clinical Models Abstract Number: 3784 Session Type: Minisymposium Session Title: Novel Antitumor Agents Session Date and Time: Monday, April 28, 2:30 pm – 4:30 pm CT Location: Room S103 – McCormick Place South (Level 1) Presenter: Maureen Lynes, Ph.D. Poster Title: ATX-559, a First in Class DHX9 Inhibitor, and Targeted Therapeutic for Molecularly Defined Tumors with Genomic Instability and Replicative Stress Abstract Number: 1758 Session Title: Novel Antitumor Agents 1 Session Date and Time: Monday, April 28, 9:00 am – 12:00 pm CT Location: Poster Section 22 Poster Board Number: 10 Presenter: Jennifer Castro About ATX-559ATX-559 is a first-in-class potent and selective inhibitor of DHX9, a novel and previously undrugged RNA and DNA/RNA helicase, shown to play a critical role in tumors with high levels of replication stress (including breast, ovarian, colorectal, endometrial, gastric, and others), representing large patient populations with significant unmet medical need. DHX9 has been reported to play important roles in replication, transcription, translation, RNA splicing, RNA processing, and maintenance of genomic stability, making it a compelling novel oncology target. In addition to exploiting key tumor vulnerabilities in DNA repair deficient backgrounds (e.g., BRCA) and hyper-mutated states (e.g., MSI-H/dMMR), Accent is exploring the sensitivity of other tumor types to DHX9 inhibition, and the potential to combine DHX9 inhibitors with other cancer treatments to maximize its full potential for helping patients. Accent retains full worldwide rights to ATX-559, currently being evaluated in a Phase 1/2 clinical trial (NCT06625515), and the DHX9 program. About ATX-295Accent's second lead program is a potential best-in-class inhibitor for KIF18A which may address a large patient population across several cancer indications, including ovarian and triple negative breast cancer (TNBC). KIF18A is a mitotic kinesin motor protein critical for cell division in select tumors with chromosomal instability, but not in healthy cells. KIF18A inhibitor treatment results in rapid cell death for cancers with an abnormal number of chromosomes (aneuploid) in vitro and in vivo, while cells with normal numbers of chromosomes (euploid) are unaffected. Accent retains full worldwide rights to ATX-295, which is currently being evaluated in a Phase 1/2 clinical trial (NCT06799065), and the KIF18A program. About Accent TherapeuticsAccent Therapeutics is pioneering a new class of small molecule precision cancer therapies targeting critical intracellular dependencies that span multiple types of cancer. Building upon industry-leading expertise in RNA-modifying proteins (RMPs) and the systematic mapping of both the RMP space and adjacent high-value areas for drug discovery, the company employs a flexible model that allows for a diversity of approaches to developing potentially transformative biomarker-driven cancer medicines. Accent's therapies are designed for both novel and known, but suboptimally addressed, high-impact oncology targets with the potential to benefit large patient populations with significant unmet need. For more information on Accent's mission to translate extraordinary science into life-changing therapeutics for patients living with cancer, visit or follow us on LinkedIn. Media ContactAmanda Sellers, Deerfield
Daily Record
23-04-2025
- Business
- Daily Record
Dunelm's 'perfect' swivel accent chair that shoppers 'love' gets £50 price slash
Crafted in three beautiful colours, this 'sleek' swivel chair would make a great addition to your home. Now that we are fully in the midst of spring, many people have decided to give their homes a revamp to reflect the more vibrant world outside. While there are many ways to change up your space - from adding new cushions and rugs to changing your curtains and towels - adding an accent chair can be a practical yet stylish option. If you have been looking for a statement chair to add to your home, then we suggest having a look at the Dunelm website where one "elegant" accent chair has received an also perfect rating from delighted shoppers. There is also the added bonus that the retailer has slashed 20 per cent off its price tag. The Tulip Chenille Curved Swivel Accent Chair, which has been praised by shoppers for its "outstanding" quality, has received a huge £50 price cut by Dunelm. Usually retailing for £249, home decor lovers can now snatch it up for only £199.20. Dunelm's Swivel Accent Chair is available in three colours - natural, olive and orange - so you can buy the chair that will perfectly match the vibe of your house. Wrapped in a textured chenille fabric, the statement chair is described as having a "sleek, curved silhouette" which will add a refined and cozy touch to your room. This Chenille Chair is also built to last as it features a sturdy rubberwood frame that is said to provide "long-lasting support", reports Liverpool Echo. Additionally, this beautiful seat was crafted to be both "stylish and highly functional" as the swivel base offers a smooth 360 degree rotation. Dunelm's top rated swivel chair is also perfect for filling empty corners or tight spaces in your house. And with it being just 71cm tall, 67cm wide, and 68cm deep, it won't take up too much room but is still big enough to be the perfect addition to a reading nook. The Tulip Swivel Chair currently has an amazing 4.9 star rating on Dunelm, and shoppers have left reviews gushing over its quality, style and colour. One happy shopper wrote: "Great product, perfect size and perfect for needs. Great value and best delivery service. Overall, outstanding. Thank you." While another added: "Great statement piece. Really easy to put together. Love the retro colour and style. Smaller than I thought, which I was ok with." A third reviewer also gushed: "Lovely little chair looks good and fits just right in our lounge. A beautiful colour, it was delivered with care by a pleasant, friendly delivery person who kindly put it in our lounge and checked inside the packaging." While a fourth customer remarked: "Brilliant. The chair was perfect and so was the colour. It was easy to put together. I love it." However, despite giving a four star rating, one shopper gave a suggestion on how to improve the much-loved chair. They wrote: "Lovely colour and design however the stitching is a little crooked in some parts. Overall decent for the price paid." Another highly rated chair available on Dunelm is the Elsie Multi Chenille Cocktail Chair. This chair retails for £99 and currently has a perfect five-star rating. Alternatively, you can get the Yaheetech Tub Chair from Amazon for £82.99. This chair is currently one of Amazon's top choices and has been given a 13 per cent price slash from its usual price of £94.99. Join the Daily Record WhatsApp community! Get the latest news sent straight to your messages by joining our WhatsApp community today. You'll receive daily updates on breaking news as well as the top headlines across Scotland. No one will be able to see who is signed up and no one can send messages except the Daily Record team. All you have to do is click here if you're on mobile, select 'Join Community' and you're in! If you're on a desktop, simply scan the QR code above with your phone and click 'Join Community'. We also treat our community members to special offers, promotions, and adverts from us and our partners. If you don't like our community, you can check out any time you like. To leave our community click on the name at the top of your screen and choose 'exit group'.
Yahoo
17-04-2025
- Business
- Yahoo
Frasers links with Accent to drive Sports Direct expansion in ANZ
British sportswear and fashion retailer Frasers Group has entered a multi-year retail partnership with Accent Group to introduce and manage its Sports Direct brand in Australia and New Zealand (ANZ). The agreement supports Frasers' broader international expansion strategy and represents its latest move to extend the reach of its retail portfolio into new markets. Accent, which operates more than 900 stores and 12 brand distributions, intends to establish at least 50 Sports Direct stores along with an online presence by 2031. The group is optimistic about the potential for opening up to 100 Sports Direct outlets across Australia and New Zealand. Accent Group CEO Daniel Agostinelli stated: "After extensive discussions, we are very pleased to announce a long-term strategic relationship with Frasers to open Sports Direct in Australia and New Zealand. Sports Direct is one of the leading sporting goods retailing businesses globally. Frasers and Accent see a significant opportunity to bring a new and exciting global sports business to the Australian and New Zealand markets.' The collaboration will see Frasers, as the primary shareholder of Accent Group, intensify efforts to bolster their sports retail footprint in ANZ. Accent gains from the alliance by accessing Frasers' portfolio of proprietary brands such as Everlast and Slazenger. The partnership will also capitalise on Frasers' established relationships with internationally recognised sports brands such as Nike and adidas, offering Accent a significant avenue for growth. Frasers has decided to increase its stake in the company to 19.57%. The capital raised through the share subscription, totalling £29m ($38m), will be allocated to support the initial phase of establishing the Sports Direct brand in the region. The deal also includes Accent's acquisition of Frasers' MySale platform, which consolidates Frasers' Australian operations under Accent's umbrella and expands its online market presence. Frasers Group CEO Michael Murray stated: 'We're looking forward to expanding our partnership to launch Sports Direct in Australia and New Zealand, working towards our bold plan of opening 100 stores. This re-affirms our commitment to drive growth of the Sports Direct brand internationally and marks a significant step forward in our ambition to becoming the leading global sporting goods retailer." In March 2025, Frasers unveiled plans to expand the global footprint of its Sports Direct brand with 350 stores across India and Southeast Asia. "Frasers links with Accent to drive Sports Direct expansion in ANZ" was originally created and published by Retail Insight Network, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site.
