Latest news with #AssemblyBiosciences
Business Insider
27-07-2025
- Business
- Business Insider
Assembly Biosciences presents Phase 1a data for ABI-5366, ABI-1179
Assembly Biosciences (ASMB) announced Phase 1a clinical and preclinical data for its herpes simplex virus, HSV, helicase-primase inhibitor candidates ABI-5366 and ABI-1179 are featured in multiple poster presentations, including one late-breaker, during the STI & HIV 2025 World Congress, taking place July 26-30, 2025, in Montreal, Canada, as well as in oral and poster presentations at the 49th Annual International Herpesvirus Workshop, taking place July 26-30, 2025, in Berlin, Germany. At the STI & HIV 2025 World Congress, two posters highlight the safety and pharmacokinetic profiles of ABI-5366 and ABI-1179 as observed in healthy participants in Phase 1a studies, supporting their progression to Phase 1b evaluation. The late-breaking poster for ABI-1179, the first scientific presentation of Phase 1a clinical data for this candidate, includes additional new interim data showing that, as was also the case in the ABI-5366 Phase 1a study, no clinically significant food effect was observed. Unblinded safety data for ABI-1179 are also included in this presentation. Elevate Your Investing Strategy:
Yahoo
26-07-2025
- Business
- Yahoo
Assembly Bio's (ASMB) HBV Drug Shows Strong Efficacy in Phase 1b Trial
Assembly Biosciences, Inc. (NASDAQ:ASMB) is one of the growth stocks that could double by 2027. On June 25, the company announced positive topline results from its Phase 1b trial of ABI-4334, a capsid assembly modulator for the treatment of chronic hepatitis B. A scientist in a white lab coat working at a bench with biopharmaceutical equipment. The 28-day study showed HBV DNA reductions of 2.9 log10 IU/mL at 150 mg and 3.2 log10 IU/mL at 400 mg, with additional declines in HBV RNA. The lower dose achieved saturated inhibition of viral replication, while the higher dose may enhance suppression of cccDNA formation, a key viral reservoir. The drug was well-tolerated, with no serious adverse events and pharmacokinetics supporting once-daily oral dosing. These results activate a licensing decision for Gilead Sciences, which holds rights to further develop ABI-4334. Assembly Biosciences, Inc. (NASDAQ:ASMB) is a clinical-stage biotech focused on small-molecule therapies for serious viral infections. Its pipeline includes candidates for hepatitis B, hepatitis delta, herpesviruses, and transplant-related infections. The company collaborates with Gilead Sciences to advance next-generation antiviral treatments. While we acknowledge the potential of ASMB as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. READ NEXT: and . Disclosure: None. This article is originally published at Insider Monkey. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
03-07-2025
- Business
- Yahoo
Assembly Biosciences, Inc. (ASMB) Announces Key Leadership and Plan Changes
Assembly Biosciences, Inc. (NASDAQ:ASMB) is among the best growth stocks to invest in for the next 5 years. In the wake of its recent Annual Meeting of Stockholders, Assembly Biosciences, Inc. (NASDAQ:ASMB) has unleashed a wave of major approvals and shifts. While accepting two amendments to the company's Amended and Restated 2018 Stock Incentive Plan (the '2018 Plan'), the stockholders elected Jeanette M. Bjorkquist as the chief financial officer. As mentioned earlier, the 2018 Plan has been amended in two distinct ways: Amendment 1 raises the number of common stock shares for issuance to 1,478,333 from 1,103,333, whereas Amendment 2 reserves an additional 225,000 shares for issuance contingent upon performance-based vesting to strengthen an extensive supplemental retention grant program. A scientist in a lab coat laboring over petri dishes and microscope in a biotechnology laboratory. During the meeting, all director nominees were appointed to serve until the 2026 annual meeting of stockholders, and in the management change, Jeanette M. Bjorkquist, the principal executive officer of Assembly Biosciences, Inc. (NASDAQ:ASMB), will also serve as the CFO. These adjustments are a testament to the company's efforts to incentivize performance and retain talent, positioning ASMB to perform well in the times ahead. Assembly Biosciences, Inc. (NASDAQ:ASMB) is a California-based biotechnology company that develops therapeutic products for treating viral diseases. Incorporated in 2005, the company collaborates with Gilead Sciences, Inc. for the research and development of virology therapies. The giant is dedicated to delivering high-quality treatments. While we acknowledge the potential of ASMB as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. READ NEXT: The Best and Worst Dow Stocks for the Next 12 Months and 10 Unstoppable Stocks That Could Double Your Money. Disclosure: None. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
02-05-2025
- Business
- Yahoo
Assembly Biosciences (NASDAQ:ASMB) Is In A Good Position To Deliver On Growth Plans
Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the right price. For example, although software-as-a-service business lost money for years while it grew recurring revenue, if you held shares since 2005, you'd have done very well indeed. Having said that, unprofitable companies are risky because they could potentially burn through all their cash and become distressed. So should Assembly Biosciences (NASDAQ:ASMB) shareholders be worried about its cash burn? In this report, we will consider the company's annual negative free cash flow, henceforth referring to it as the 'cash burn'. We'll start by comparing its cash burn with its cash reserves in order to calculate its cash runway. Our free stock report includes 4 warning signs investors should be aware of before investing in Assembly Biosciences. Read for free now. You can calculate a company's cash runway by dividing the amount of cash it has by the rate at which it is spending that cash. As at December 2024, Assembly Biosciences had cash of US$112m and no debt. Importantly, its cash burn was US$51m over the trailing twelve months. That means it had a cash runway of about 2.2 years as of December 2024. Importantly, analysts think that Assembly Biosciences will reach cashflow breakeven in 3 years. That means it doesn't have a great deal of breathing room, but it shouldn't really need more cash, considering that cash burn should be continually reducing. The image below shows how its cash balance has been changing over the last few years. See our latest analysis for Assembly Biosciences We're hesitant to extrapolate on the recent trend to assess its cash burn, because Assembly Biosciences actually had positive free cash flow last year, so operating revenue growth is probably our best bet to measure, right now. Happily for shareholders, the revenue is up a stonking 298% over the last year. While the past is always worth studying, it is the future that matters most of all. So you might want to take a peek at how much the company is expected to grow in the next few years. There's no doubt Assembly Biosciences' revenue growth is impressive but even if it's only hypothetical, it's always worth asking how easily it could raise more money to fund further growth. Generally speaking, a listed business can raise new cash through issuing shares or taking on debt. Commonly, a business will sell new shares in itself to raise cash and drive growth. By comparing a company's annual cash burn to its total market capitalisation, we can estimate roughly how many shares it would have to issue in order to run the company for another year (at the same burn rate). Assembly Biosciences' cash burn of US$51m is about 60% of its US$85m market capitalisation. That's high expenditure relative to the value of the entire company, so if it does have to issue shares to fund more growth, that could end up really hurting shareholders returns (through significant dilution). On this analysis of Assembly Biosciences' cash burn, we think its revenue growth was reassuring, while its cash burn relative to its market cap has us a bit worried. Shareholders can take heart from the fact that analysts are forecasting it will reach breakeven. While we're the kind of investors who are always a bit concerned about the risks involved with cash burning companies, the metrics we have discussed in this article leave us relatively comfortable about Assembly Biosciences' situation. On another note, Assembly Biosciences has 4 warning signs (and 2 which are significant) we think you should know about. Of course Assembly Biosciences may not be the best stock to buy. So you may wish to see this free collection of companies boasting high return on equity, or this list of stocks with high insider ownership. Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team (at) article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned. Sign in to access your portfolio
