Latest news with #BMP-2
Time of India
a day ago
- Health
- Time of India
NIT Rourkela decodes sugar molecules, protein complex to boost bone regeneration tech
New Delhi: Researchers at the National Institute of Technology (NIT), Rourkela have uncovered how natural sugar-like molecules in the human body can alter the behaviour of Bone Morphogenetic Protein-2 (BMP-2), a protein responsible for bone formation and repair, according to officials. Published in the prestigious journal Biochemistry, the findings of this research can be used for advanced treatments in bone and cartilage regeneration, improved implants and more effective protein-based medicines. According to Harekrushna Sahoo, Associate Professor, NIT, Rourkela, proteins carry out various functions in the human body -- from building tissues and supporting chemical reactions to acting as signals between cells. However, for the best productivity, they need to be folded or unfolded into precise three-dimensional shapes. Understanding why and how proteins unfold is a major goal in biology, with implications for medicine, biotechnology and drug delivery. "In this context, BMP-2 plays a crucial role in forming bones and cartilage, healing injuries and guiding stem cells to become bone-forming cells. However, in the human body, this protein interacts with different Glycosaminoglycans (GAGs), special sugar-like molecules found in connective tissues and joint fluids," Sahoo said. The team observed that BMP-2 unfolded faster in the presence of Sulfated Hyaluronic Acid (SHA), a type of GAG, compared to regular Hyaluronic Acid or without additives. The researchers found that SHA binds directly to BMP-2 protein, gently altering its structure and making it unfold in a more controlled manner. "BMP-2 is a critical protein in humans that plays a fundamental role in osteogenesis and bone regeneration . Our study reveals how specific GAG-BMP-2 interactions influence unfolding dynamics and structural stability. These insights allow scaffold designs to actively preserve BMP-2's functional conformation, prolong bioactivity, lower dosage needs and reduce side effects. "Furthermore, the work offers a mechanistic basis for tailoring GAG functional group modifications to modulate protein structure and activity, guiding next-generation pharmaceutical formulation," he said.
India Today
4 days ago
- Health
- India Today
NIT Rourkela study cracks protein puzzle for stronger bone repair
Researchers at the National Institute of Technology (NIT) Rourkela have found how certain natural sugar-like molecules in human body can change the way a key bone protein behaves. The work, published in the journal Biochemistry, offers clues for improving bone and cartilage repair treatments, designing better medical implants, and developing more effective protein-based are workhorses in the human body, building tissues, carrying signals, and supporting chemical reactions. For these roles, proteins must fold into specific three-dimensional in their structure can affect how well they work. Understanding how and why a protein unfolds is a long-standing challenge in biology, with applications ranging from drug delivery to tissue ROURKELA MAPS SUGAR-PROTEIN LINK FOR BETTER BONE REPAIR METHODS The study focused on Bone Morphogenetic Protein-2 (BMP-2), a molecule central to bone and cartilage formation. BMP-2 also helps stem cells turn into bone-forming cells and supports healing after the body, BMP-2 operates in an environment rich in glycosaminoglycans (GAGs), sugar-like molecules found in connective tissue and joint fluids. The NIT Rourkela team, led by Professor Harekrushna Sahoo from the Department of Chemistry, examined how different GAGs affect BMP-2 under chemical scholars Devi Prasanna Behera and Suchismita Subadini worked alongside him in the study. The team used urea to induce unfolding and compared the behaviour of BMP-2 with and without results showed that in the presence of Sulfated Hyaluronic Acid (SHA), a type of GAG, BMP-2 unfolded faster than it did with regular hyaluronic acid or without any study suggests that SHA binds directly to BMP-2, altering its structure in a way that makes the unfolding process more Sahoo explained that BMP-2 functions within a GAG-rich environment in bone tissue, and these molecular interactions shape its structure and understanding these interactions, it may be possible to design scaffolds that keep BMP-2 in its active form for longer, reduce the dosage needed in treatments, and limit side research also points to a broader idea, modifying the functional groups of GAGs, such as through targeted sulfation, could help stabilise proteins like BMP-2 under stress without losing their could guide the creation of new drug formulations, extend protein shelf life, and make therapeutic delivery more mapping these detailed molecular relationships, the NIT Rourkela study provides a framework for future work in regenerative medicine, where fine-tuning the environment around proteins can be as important as the proteins themselves.- Ends
Yahoo
02-06-2025
- Politics
- Yahoo
Mykolaiv marines show how they wipe out Russian forces on Pokrovsk front
Soldiers from the 36th Separate Marine Brigade named after Rear Admiral Mykhailo Bilynskyi have shown footage of Russian military equipment being destroyed and personnel being killed on the Pokrovsk front in Donetsk Oblast. Source: 36th Separate Marine Brigade; an Ukrainska Pravda source in the military Details: A source told Ukrainska Pravda that the video shows the most effective strikes of the past week. A mechanised assault by Russian troops using a BMP-2 infantry fighting vehicle was stopped by attack drones and Russian armoured vehicles were completely destroyed using a Javelin anti-tank system. Mykolaiv marines also wiped out an assault unit of four Russian soldiers on motorcycles using FPV drones. Three more Russian soldiers hiding in shelters were also killed with FPV drones. Support Ukrainska Pravda on Patreon!
Indian Express
21-05-2025
- Politics
- Indian Express
As India struck terror targets inside Pakistan and PoK, T-72 tanks, BMP-2 armoured vehicles moved up to LoC
After 'effectively neutralising' six of the nine terror locations falling opposite Poonch, Rajouri and Akhnoor in Jammu on the night of May 6-7, Indian troops prepared to respond to Pakistani aggression, said the Commander of an Army Brigade at Poonch on Tuesday. Referring to the Poonch Brigade's engagement in the 'intense and continous operations during Operation Sindoor to blunt and respond to the unprovoked aggression by Pakistan across the Line of Control', Commander Poonch Brigade, Brig Mudit Mahajan, said, 'To that extent, Poonch Brigade was not a part but the heart of Operation Sindoor. We did not wait to react; we prepared to respond.' Official sources said that while targeting terror infrastructure in Pakistan and PoK, the Indian Army also moved its T-72 tanks and BMP-2 armoured personnel carriers up to the Line of Control as a preemptive move. Sources said the tanks targeted Pakistani posts that were facilitating the infiltration of terrorists into J&K. The Pahalgam terror attack was met with a 'calibrated response' from the Indian Army, initially focusing solely on terrorist infrastructure, Brig Mahajan said, adding, 'The Army struck with unmatched precision and purpose – six of nine critical terrorist targets struck were opposite Poonch, Rajouri and Akhnoor and these were neutralised effectively that night.' 'Only when the Pakistan Army escalated by indiscriminately targeting civilian areas did the Indian Army decisively shift to hitting their military assets,' he said. 'As the enemy unleashed a new threat of drone swarms, it was the Indian Army's air defence that truly emerged as the shining shield — demonstrating exceptional skill, resilience, and cutting-edge coordination to intercept every aerial menace,' he said. 'The Pakistani Army losses were not just in numbers but in morale and initiative,' he said. 'So far, we have inputs of imposing heavy numbers in fatal and non-fatal casualties upon the enemy.' Pointing out that Operation Sindoor is not over but only remains suspended for the time being, he said that the Indian Army 'remains alert and ready, and if challenged again, we will respond yet again not with words but fire and resolve of the nation.'
NDTV
19-05-2025
- Politics
- NDTV
Indian Tanks Operated From LoC During Op Sindoor, Took Out Pak Posts
Jammu: T-72 tanks had rolled up to the Line of Control and took part in the May 7 Operation Sindoor that had destroyed terror bases in 9 locations in Pakistan and Pakistan-Occupied Kashmir, an officer of the Indian army has told NDTV in an exclusive interview. The tanks - and the BMP-2 armoured personnel carriers - still deployed along the LoC -- indicate the high prepared status of the army despite the ongoing ceasefire with Pakistan. Speaking to NDTV, a Colonel, whose name is not being revealed due to security concerns, said they were put in position ahead of Operation Sindoor to take on specific targets marked out by the army. In the operation, their key role was to destroy the routes through which terrorists could infiltrate into India - as a pre-emptive measure. "We also hit enemy posts which were facilitating infiltration. We know which posts are used as bases for infiltration by the enemy. An informed call was taken -- and the targets were hit," he told NDTV. Given their deadly accuracy, the tanks, he said, were used sparingly to prevent escalation. The T-72s are fitted with 125 mm guns "and we also have missiles that have a range of 4000 meters," he said. "Only a fraction of the equipment was used for to combat ceasefire violation... 300-mm guns and 4000-metre missiles can have devastating effect on the enemy," he said, pointing to India's measured response. He also indicated that the men and equipment were ready to roll whenever orders came. Operation Sindoor was launched on May 7 - a retaliation against the horrific terror attack on tourists in Jammu and Kashmir's Pahalgam, in which 25 Indians and one Nepali tourist had died on April 22. The Indian reprisal had taken out the headquarters of Lashkar e-Taiba - a proxy of which had claimed responsibility for the Pahalgam attack - and Jaish-e Mohammad. More than 100 terrorists were killed, a handful of them wanted for various attacks in India including the 1999 hijack of an Indian Airlines plane to Kandahar in Afghanistan. While the role of the Air Force,and the infantry division of the army was known and applauded, very little was known about the part played by the armoured division. India had said its action was "focused, measured and non-escalatory". Pakistan attempted to hit back immediately with missiles and drones but was trounced. A ceasefire was worked out on May 10. The Centre is now sending a team of 51 political leaders, parliamentarians and former ministers, cutting across party lines, who would travel to key nations to put across India's resolve to tackle terrorism against the backdrop of Operation Sindoor.
