Latest news with #Bei
Hans India
23-05-2025
- Health
- Hans India
New gene therapy to target airway and lungs via nasal spray
US researchers have engineered a novel gene therapy to target the airway and lungs via a nasal spray. For gene therapy to work well, therapeutic molecules need to be efficiently delivered to the correct locations in the body. It is commonly done by using adeno-associated viruses (AAV) gene therapy. To improve the AAV's ability to deliver therapeutics specifically to the lungs and airway, researchers at the Mass General Brigham engineered a new version, called which can be administered with a nasal spray. In preclinical models, outperformed previous versions by more effectively targeting the airway and lungs and showing promise for respiratory and lung gene therapy, said the researchers in the paper published in the journal Cell Reports Medicine. "We noticed that which we initially engineered to enter the central nervous system, also efficiently targeted lung cells," said senior author FengFeng Bei, from the Department of Neurosurgery at Brigham and Women's Hospital. "This prompted us to further investigate for intranasal gene delivery to the respiratory airways," Bei added. In the study, outperformed previous versions (AAV6 and AAV9) in cell culture, mouse models, and non-human primate models. 'Our findings highlight as a promising vector for respiratory and lung gene therapy,' the team said. They then used the more efficient tool to deliver scar-preventing gene therapy for pulmonary fibrosis, using a mouse model of the respiratory disease. They also used the tool to deliver gene therapy for a viral infection, where the therapy prevented the replication of the SARS-CoV-2 virus in a mouse model of Covid-19. "Although further research is needed, our findings suggest that intranasal has strong translational potential as a promising delivery tool for targeting the airway and lung," said Bei.
New York Post
20-05-2025
- Entertainment
- New York Post
Harvey Weinstein lashes out at celebrity accusers in new jailhouse interview: ‘Complete fabrication'
Harvey Weinstein has turned on his celebrity accusers during a prison interview airing Tuesday – while admitting to making a creep 'pass' at Gwyneth Paltrow and paying off Rose McGowan to keep his secrets. The disgraced movie mogul, who is currently in the middle of a high-profile rape retrial in Manhattan, gave his first on-camera interview to conservative podcaster Candace Owens since his initial arrest seven years ago to cry about his conviction. The ailing 73-year-old took aim at a handful of his A-lister accusers, including Ashley Judd as well as Paltrow and McGowan. Advertisement 3 Convicted rapist Harvey Weinstein lashed out at his accusers in a new jailhouse interview with Candace Owens. YouTube / Candace Owens In a one-minute teaser clip from the interview that's set to air in full Tuesday, Weinstein claims he did not 'commit these crimes' and swears 'it before God and on the people watching now and on my family.' He denied ever touching Paltrow — but copped that he 'definitely made a pass' at her. Advertisement 'It's a complete fabrication about my relationship with Gwyneth. I didn't put my hands on her. I didn't touch her,' he said. 3 Gwyneth Paltrow and Harvey Weinstein in 1999 at a Miramax post-Oscar party. Bei/Shutterstock At the height of the #MeToo movement, Paltrow came forward to accuse Weinstein of preying on her on the set of several of his films. She accused him of inviting her to his hotel room, putting his hands on her and even suggesting a massage after she was cast in the 1996 film 'Emma.' Advertisement He also took aim at McGowan, who alleged the Hollywood bigwig orally raped her after she was cast in 'Scream' back in 1997. 'I settled with Rose McGowan,' he admitted. 'I gave her $100,000, don't tell my wife, don't get me into trouble. It's all conflated, and it's all led to the idea that I'm going to be the one they persecute.' Weinstein married fashion designer Georgina Chapman in 2003 but they divorced in 2021 when he was hit with the barrage of sex abuse and rape allegations. Advertisement Meanwhile, Weinstein bluntly dismissed Judd's claims as 'ridiculous.' 3 Weinstein also took aim at Rose McGowan, who accused him of assaulting her in 1997. WireImage Once a Hollywood heavy-hitter, Weinstein became a symbol of sexual misconduct in 2017 after scores of women started accusing him of sex pest behavior — fueling the #MeToo movement. He was later convicted of various sex crimes in both New York and California. Weinstein is on trial again in the Big Apple after an appeals court found last year that his New York trial was tainted by prejudicial testimony and overturned that conviction. He has pleaded not guilty and faces up to 25 years behind bars if re-convicted.
