Latest news with #BetterLife
Yahoo
22-05-2025
- Business
- Yahoo
BetterLife Provides Comments on CEO's Share Position Ownership and Recent BCSC Press Release
VANCOUVER, British Columbia, May 22, 2025 (GLOBE NEWSWIRE) -- BetterLife Pharma Inc. ('BetterLife' or the 'Company') (CSE: BETR / OTCQB : BETRF / FRA: NPAU), an emerging biotech company focused on the development of BETR-001, a non-hallucinogenic neuroplastogen in the treatment of psychiatric and neurological disorders, is issuing the following press release in response to British Columbia Securities Commission's ('BCSC') May 21, 2025 news release. BetterLife announced on July 16, 2024, that it had amended its past Management Information Circulars ('MIC') to correct disclosures of beneficial ownership by its Chief Executive Officer, Dr. Ahmad Doroudian. The July 16, 2024, press release corrected Mr. Doroudian's beneficial ownership as follows: Dates of MIC andRelated RecordDates Section in MIC Amount of BeneficialOwnership andPercentage of Class (ifapplicable) asDisclosed in MIC Amended Amount ofBeneficial Ownershipand Percentage ofClass (if applicable) February 28 andFebruary 10, 2023 Proposal No. 2 – Election ofDirectors 5,506,367 common 5,863,786 common November 23 andNovember 5, 2021 Proposal No. 2 – Election ofDirectors 5,155,162 common 5,529,887 common November 20 andNovember 9, 2020 Voting Securities andPrincipal Holders of VotingSecurities 5,155,162 common13.9% 5,251,637 common14.2% February 15 andFebruary 13, 2019 Principal Stockholders andSecurity Ownership ofManagement 9,161,929 common9.455% 21,330,518 common22.01% Since early 2023, through direct investment of $675,000 and settlement of his annual salary with BetterLife shares, Dr. Doroudian has increased his ownership from approximately 5.8 million shares to 16 million shares. 'I am disappointed by the recent BCSC penalty, but extremely proud of my contributions to BetterLife and the Company's achievements thus far. I am truly excited about the prospects of BetterLife and its lead asset BETR-001,' said Dr. Doroudian. About BetterLife Pharma BetterLife Pharma Inc. is an emerging biotechnology company primarily focused on developing and commercializing two compounds, BETR-001 and BETR-002, to treat neuro-psychiatric and neurological disorders. BETR-001, which is in preclinical and IND-enabling studies, is a non-hallucinogenic neuroplastogen. BETR-001 is a non-controlled substance. BETR-001 will be developed for the treatment of various psychiatric and neurological disorders. BETR-001 pending patent, for composition and method of use, covers treatment of major depressive disorder, anxiety disorder and neuropathic pain and other neuro-psychiatric and neurological disorders. BETR-002, which is in preclinical and IND-enabling studies, is based on honokiol, the active anxiolytic ingredient of magnolia bark. BetterLife's pending method of use and formulations patent covers treatment of anxiety-related disorders including benzodiazepine dependency. BetterLife also owns a drug candidate for the treatment of viral infections and is in the process of seeking strategic alternatives for further development. For further information, please visit BetterLife Pharma. ContactDavid Melles, Investor Relations Manager Email: 1-778-887-1928 Cautionary Note Regarding Forward-Looking Statements No securities exchange has reviewed nor accepts responsibility for the adequacy or accuracy of the content of this news release. This news release contains forward-looking statements relating to product development, licensing, commercialization and regulatory compliance issues and other statements that are not historical facts. Forward-looking statements are often identified by terms such as 'will', 'may', 'should', 'anticipate', 'expects' and similar expressions. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company's expectations include the failure to satisfy the conditions of the relevant securities exchange(s) and other risks detailed from time to time in the filings made by the Company with securities regulations. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements as expressly required by applicable in to access your portfolio
Ottawa Citizen
14-05-2025
- Health
- Ottawa Citizen
BetterLife Pharma Provides Scientific Update of Mechanism of Action of BETR-001 in Treatment of Psychiatric Disorders
Article content VANCOUVER, British Columbia, May 14, 2025 (GLOBE NEWSWIRE) — BetterLife Pharma Inc. ('BetterLife' or the 'Company') (CSE: BETR / OTCQB : BETRF / FRA: NPAU), an emerging biotech company focused on the development of BETR-001, a non-hallucinogenic neuroplastogen in the treatment of psychiatric and neurological disorders, recently presented a scientific update at Bloom Burton Conference on May 5, 2025 in Toronto, Canada. Article content Article content Article content BetterLife reported that its proprietary compound, BETR-001, is showing very promising preclinical data of its breakthrough ability to provide therapeutic effect in depression/anxiety animal models. Current methods of treating depression/anxiety primarily focus on increasing the level of one of the three neurotransmitters: serotonin, norepinephrine and/or dopamine in the brain. Each neurotransmitter has different receptor targets, and each receptor performs different functions. Current treatments are usually reuptake inhibitors such as SSRIs (selective serotonin reuptake inhibitors) and by increasing the amount of a neurotransmitter, all its receptors are activated. What is needed are new treatments that activate the neuroreceptors themselves, and more importantly, only selective subsets of these receptors. Article content The therapeutic effects of BETR-001 seen in preclinical models are primarily driven by its activation (agonism) of serotonin's 5HT2A receptor. Not only does BETR-001 activate the 5HT2A receptor, which plays a key role in depression/anxiety, this activation is via a mechanism that allows for a highly efficacious therapeutic effect without hallucinogenic side effects. This stands in contrast to other potent 5HT2A activators, such as LSD, psilocybin and other psychedelics. BetterLife has reported on the details of BETR-001 activation of the 5HT2A receptor previously (Lewis et al., Cell Reports, 2023). Recently studies have shown that the activation of the 5HT2A receptor above 70% leads to hallucination (Wallach et al., Nature Communications, 2023). Ideally, a therapeutic agent should activate 5HT2A but stay below the 70% threshold. BETR-001 fulfills this parameter perfectly: activating 5HT2A maximally to 60%, unlike LSD, which activates 5HT2A to near 90%. This is shown in our 5HT2A receptor activation data below, where the X-axis is an increasing amount of the drug, and the Y axis is the percentage activation of the 5HT2A receptor. The drugs tested are 5-HT (the parent serotonin), LSD and BETR-001. Article content Article content BetterLife believes that BETR-001's novel mechanism of action provides a new paradigm for treatment of psychiatric disorders such as depression, anxiety and PTSD. It activates the 5HT2A receptor partially but stays below the hallucination threshold. In addition, unlike LSD, psilocybin, MDMA and other such agents BETR-001 is not an activator of the 5HT2B receptor. Activation of 5HT2B has been linked to cardiac safety. The neuroreceptor selectivity of BETR-001 in this regard is another of its key advantages over other competitor agents. An additional benefit of BETR-001 is that repeated dosing does not induce tolerance, unlike classic agents like LSD. This allows daily administration if needed. Furthermore, the lack of hallucinations with BETR-001 means it is a non-controlled substance and patient self-administration at home is possible. Finally, an overarching property of BETR-001 is that it is a very potent neuroplastogen.
Buzz Feed
11-05-2025
- General
- Buzz Feed
27 Shark Tank Products That Actually Work
A self-sealing, airtight, and leakproof reusable silicone bag designed to help keep food fresh while reducing your reliance on single-use plastics. You can put it in the microwave, dishwasher, oven, or freezer, and even use it for sous vide! A car seat gap filler so you can stop struggling to dig for your phone, keys, or anything else that tends to fall into the dreaded black hole between the seats. Some scratch-free, odor-resistant Scrub Daddy sponges – they just wanna smile and make your life easier. They're firm in cold water for tough scrubbing, soft in warm water for light cleaning — and that charming smiley face isn't just for looks! The eyes make this sponge easier to grip so you can reach tight corners or deep into cups, and the mouth is ideal for cleaning both sides of utensils. :) A pair of DrainWigs so the situation in your drain doesn't get too ~hairy.~ Simply leave it in your drain until it's full of hair, then toss and replace as needed. A doctor-recommended Squatty Potty to help you have an easier #2 when nature calls. And if your feet are currently resting on one while you're reading this, you already know what I'm talkin' about! Some seriously strong, plant-based Better Life tile and tub cleaner — it'll leave your tub, tile, grout, fixtures, sinks, toilet seats, and even shower walls, doors, and curtains sparkling like new. Just spray, let it sit for 15 minutes, and when you come back, the soap scum, mold, mildew, rust, and hard-water stains will easily wipe right off! A Spatty Daddy set because now you can easily get to every last bit of food and makeup stuck in virtually any bottle's hard-to-reach nooks and crannies. After all, you paid for those remnants! Why let them go to waste? These are FDA- and USDA-approved, and BPA-free. Plus, they're made of sturdy, resilient, and flexible material, and they're dishwasher-safe! Wanna learn more? Check out one BuzzFeeder's full review of the Spatty Daddy (#1)!Promising review: "So worth it! I'm so happy with it. You will definitely save money using this. I think about how much I could have saved if this was invented 30 years ago. I mostly use it for small makeup jars. I tested out the Spatty Daddy on an 18-ounce lotion and it worked fine. You get so much more makeup than you would without it. I give it 5 stars." —LizGet a pack of two from Amazon for $9.99. A Souper Cube so you can store soup or sauce in convenient single-serving portions that make it easy to defrost *only* the amount you need! Each tray has four spaces that fit one cup of liquid each. A set of Wad-Free pads brilliantly designed to help prevent your sheets from getting all tangled, twisted, and balled up every time you wash them. It'll also help them dry faster with fewer wrinkles so you can stop paying for extra cycles. A super fluffy bean bag chair that easily converts into a surprisingly comfy full-size bed! It's the perfect solution for sleepovers, so you can leave the hassle of busting out the air mattress in the past where it belongs. Plus you can put it in the washer and dryer for easy cleaning! Some haircutting clips — they'll help make DIY haircuts look like they were done by a pro! You'll have a much easier time getting salon-worthy results at home *and* you'll save money in the long run! A portable, microwaveable Rapid Ramen Cooker for anyone who wants the flavor and texture of stovetop-cooked noods without the hassle and wait time that stands between you and a delicious meal. A set of nonslip silicone mats that'll do... a lot! Here's the rundown: *clears throat* these mats will 1) help you safely grab hot plates without burning your hands, 2) protect surfaces from heat and scratches, 3) cover dishes in the microwave to avoid splatters, 4) help you open stubborn jars without the struggle, and 5) act as a utensil rest or curling iron mat. They're also BPA-free, and can be put in the top rack of the dishwasher! A pack of Bottle Bright tablets to make your gunky, stained tumbler look and smell brand new, no scrubbing required! A Rocketbook smart reusable notebook — it'll blast your handwritten notes and doodles straight to your preferred cloud service so you can save them forever. Then you can simply wipe the pages blank using the included cloth and start fresh without constantly having to buy a new notebook! A tube of all-natural Nerdwax here to help keep your glasses in place on your nose, instead of partaking in their favorite activity — constantly slipping down your face no matter how many times you push them back up. A tube of Grip Clean perfect for anyone who works with their hands all day long and needs something a little more heavy-duty than regular soap. It's tough on grease, oil, ink, odors, and more — all without relying on harsh chemicals. This stuff is made from only natural ingredients like coconut and olive oils, so even those with sensitive skin can use it regularly without winding up with dry, cracked, or irritated review: "I work for the railroad and I am always getting my hands dirty! I could never seem to find anything that worked. Also, I live in Utah so when it starts getting cold my hands dry out. Well, with Grip Clean that doesn't happen! I have my coworkers coming to my locker asking to get some soap since the soap we have at doesn't work as well as Grip Clean!" —NickGet it from Amazon for $9.97+ (available in three styles and refills). Some gift wrap cutters that'll take the struggle out of achieving perfectly straight lines. Just slide it over one end of the roll, pull the paper through the opening, and gently push it along as its sharp blade makes a precise cut much faster and easier than with scissors. You can even leave it on the roll to keep things neat and tidy for storage! The Safety Nailer to make you feel a lil' less nervous about accidentally slamming your fingers when doing some hammering. A splatter guard so you don't have to give your entire stove a deep clean whenever you fry up some dinner. Plus, it'll help protect you from sizzling oil splashes that would just love to hop out of the pan and land on your bare skin. A wearable blanket for anyone who wants to take the whole "never coming out from under my blankie" thing to a whole new level. It even has sleeves so you can work on your devices without exposing your arms to the cold, unforgiving air! A handy Dip Clip — it fits on horizontal or vertical air vents *and* can hold sauce packs from popular fast food chains to make eating in the parking lot wayyyy easier! A beard trimmings catcher so you can stop dreading the cleanup that inevitably comes with shaving your face over the sink. Tired of thousands of tiny hairs scattered all over the counter every time you wanna give yourself a trim? This brilliant invention is here to save the day. A waterproof and crushproof SubSafe sandwich container ingeniously designed to keep your sammies fresh, dry, and intact instead of soggy and smooshed. You can also use it as a cup, wine bottle protector, cocktail shaker, or even as dry storage for your phone or other valuables! A wash-and-go kit that'll streamline your routine, and replace various styling products — leaving you with moisturized, bouncy, and defined curls that'll last for three to seven days, regardless of your hair type! A magnetic eyeglass holder so you can stop worrying about your glasses falling out of your shirt pocket *and* put an end to having to call in a search party every time you forget where you left them. These'll hold them much more securely and keep 'em nearby at all times! Readerest is a US-based small business specializing in glasses accessories. Promising review: "I can't tell you how many reading glasses I've killed in the past few years, largely from jettisoning them from my breast pocket or hooking them awkwardly in my shirt collar. These clips are amazing. They're discreet enough that I don't look like a goon wearing one on my shirt all day, and when I hang my glasses from them, I can tie my shoes without spilling them lens-first on the ground. What else can a fellow ask for?" —Asha EmberGet a pack of two from Amazon for $5.49+ (available in thre colors/styles and a combo pack). And finally, a pair of discreet, form-fitting acoustic filter earplugs to help reduce decibel levels at loud concerts without messing up the sound quality. Hate bulky earplugs that never fit comfortably, look clunky, and make shows sound like they're happening underwater? Then you need to give these a shot.
