Latest news with #Bevacizumab
Time of India
04-08-2025
- Health
- Time of India
What types of cancers are most responsive to immunotherapy in patients
Immunotherapy is proving to be one of the most revolutionary steps in contemporary cancer treatment. In contrast to the conventional methods like chemotherapy and radiation, immunotherapy utilizes the immunity of the human body to mark and eliminate cancer cells. It brings hope, particularly for those patients who have failed to respond to the conventional approach. How immunotherapy works Immunotherapy strengthens the immune system to better see and destroy cancer. This is done either by augmenting the body's own defenses or by arming it with man-made proteins and antibodies that enable it to better attack cancer cells. Not a cure for every type of cancer, immunotherapy has been truly successful in a broad spectrum of cancers and continues to evolve. Important forms of immunotherapy 1. Immune Checkpoint Inhibitors Checkpoint inhibitors act by inhibiting the proteins that shield cancer from immune cells. The most common checkpoint inhibitors are: PD-1 Inhibitors: Pembrolizumab Nivolumab PD-L1 Inhibitors: Atezolizumab Avelumab Durvalumab 2. Monoclonal Antibodies (MAbs) These laboratory-made molecules function as replacement antibodies that can replace, stimulate, or copy the immune system's attack against cancer cells. Brentuximab Trastuzumab Bevacizumab Cetuximab 3. CAR T-Cell Therapy It is an individualized treatment that alters the T cells of a patient to identify and destroy cancer cells more effectively. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like The Best Method for a Flat Stomach After 50 (It's Genius!) Lulutox Undo It has been exceptionally effective in cancers affecting the blood, such as lymphoma and leukemia. Immunomodulators They are drugs that manage the immune response in certain types of cancer. Some of them are: BCG (for cancer of the bladder) Imiquimod cream (for skin cancer) 5. Cancer Vaccines Vaccines against viruses such as HPV have demonstrated a clear advantage in the prevention of cervical and other cancers due to HPV. Cancers responding well to immunotherapy Immunotherapy has made notable strides in treating various cancers, either alone or in combination with other treatments: 1) Brain Cancer - Medications such as Dostarlimab, Pembrolizumab, and Bevacizumab have enhanced treatment outcomes. 2) Breast and Cervical Cancer - The same medications have also demonstrated additional success in increasing survival rates. 3)Colorectal Cancer - Treatments consist of Bevacizumab, Cetuximab, Panitumumab, and Ramucirumab. 4) Lung Cancer – Amivantamab and other checkpoint inhibitors and monoclonal antibodies, have become routine in most cases. 5)Lymphoma - Treatments such as Retuximab, Brentuximab, and CAR T-cell therapy are making a huge difference. 6) Melanoma - One of the most malignant skin cancers, melanoma is highly sensitive to immunotherapy, so it's often the treatment of choice. 7)Other common cancers - Head and neck, cervical, intestinal, oesophageal, pancreato-biliary, kidney, and genito-urinary cancers also yield good results with immunotherapy. As continuing research hones and individualizes these treatments, immunotherapy is a potent weapon in the oncologist's arsenal. Its capacity to treat where other means fail already has altered the lives of countless patients and it holds still greater promise for the future. Immunotherapy is not only a therapy - it's a revolution in the war against cancer.
Globe and Mail
18-07-2025
- Business
- Globe and Mail
EGFR + NSCLC Pipeline Appears Robust With 25+ Key Pharma Companies Actively Working in the Therapeutics Segment
DelveInsight's, 'EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC) Pipeline Insight, 2025' report provides comprehensive insights about 25+ companies and 30+ pipeline drugs in EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC) pipeline landscape. It covers the EGFR + NSCLC pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. Explore our latest breakthroughs in EGFR + NSCLC research. Learn more about our innovative pipeline today! @ EGFR + NSCLC Pipeline Outlook Key Takeaways from the EGFR + NSCLC Pipeline Report In July 2025, ETOP IBCSG Partners Foundation announced a primary objective of the trial is to assess the efficacy of amivantamab and bevacizumab added to continued treatment with the third-generation EGFR-TKI lazertinib, in patients with EGFR-mutant advanced NSCLC, who have been previously treated with a third-generation EGFR-TKI in order to provide data on treatment effect and sample size required for a future phase III trial. In June 2025, BlossomHill Therapeutics conducted a study in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) and/or human epidermal growth factor receptor (HER2) mutations. The study drug, BH-30643 capsules, will be self-administered by mouth twice daily in 21-day cycles. In June 2025, Merck Sharp & Dohme LLC organized a study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs). DelveInsight's EGFR + NSCLC pipeline report depicts a robust space with 25+ active players working to develop 30+ pipeline therapies for EGFR + NSCLC treatment. The leading EGFR + NSCLC Companies such as Cullinan Oncology, Betta Pharmaceuticals, G1 Therapeutics, Janux Therapeutics, Daiichi Sankyo Company, Suzhou Puhe Pharmaceutical Technology, Genor Biopharma, J Ints Bio, Avistone Pharmaceuticals, Mythic Therapeutics and others. Promising EGFR+NSCLC Pipeline Therapies such as IN10018, Furmonertinib, Oral S-1 + Oral Osimertinib, YH25448, JS111 capsules (AP-L1898), Osimertinib, Gefitinib, RC108, Sunvozertinib, and others. Stay informed about the cutting-edge advancements in EGFR + NSCLC treatments. Download for updates and be a part of the revolution in cancer care @ EGFR + NSCLC Clinical Trials Assessment EGFR + NSCLC Emerging Drugs Profile CLN-081 is a novel irreversible Epidermal Growth Factor Receptor (EFGR) inhibitor. It is administered through oral route, and is developed by Cullinan Oncology. The drug is being developed in association with Taiho Pharmaceuticals. The drug is currently being investigated in the Phase III stage of development for the treatment of EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC). BPI-361175: Betta Pharmaceuticals BPI-361175 is a novel, oral, highly potent and selective 4th generation EGFR inhibitor developed by Betta Pharmaceutical Co., Ltd. The new chemical entity targets EGFR C797S mutation and other EGFR related mutations that are resistant to 3rd generation EGFR TKI in non-small cell lung cancer (NSCLC) and other solid tumors. It shows excellent inhibitory effect and selectivity in vitro assay and exhibits significant anti-tumor activity in a variety of xenograft models harboring EGFR C797S or other related mutations. The IND application of BPI-361175 has been approved by NMPA. Currently, the drug is the Phase I/II stage of its development for the treatment of Non-small Cell Lung Cancer. G1T38: G1 Therapeutics G1T38 is an investigational, oral CDK4/6 inhibitor designed to be used along with other targeted therapies for various oncology indications. G1 Therapeutics has entered a clinical trial collaboration to assess its G1T38 in combination with AstraZeneca's Tagrisso (osimertinib) in a Phase Ib/II clinical trial to treat patients suffering from EGFR mutation-positive non-small cell lung cancer (NSCLC). Currently, the drug is being evaluated in the Phase I/II stage in combination with osimertinib in patients with EGFR mutation-positive metastatic non-small cell lung cancer. JANX008: Janux Therapeutics JANX008, is a TRACTr that targets Epidermal Growth Factor Receptor (EGFR), and is being developed by Janux Therapeutics for the treatment of various solid tumors including non-small cell lung cancer. According to preclinical studies, JANX008 showed potent cleavage dependent anti-tumor activity, with limited toxicities in healthy tissues or CRS. JANX008, is currently being evaluated in phase I clinical trial for the treatment of various solid tumors. The EGFR + NSCLC Pipeline report provides insights into The report provides detailed insights about companies that are developing therapies for the treatment of EGFR + NSCLC with aggregate therapies developed by each company for the same. It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for EGFR + NSCLC Treatment. EGFR + NSCLC Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects. EGFR + NSCLC Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type. Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the EGFR + NSCLC market. Learn more about EGFR + NSCLC Drugs opportunities in our groundbreaking EGFR + NSCLC research and development projects @ EGFR + NSCLC Unmet Needs EGFR + NSCLC Companies Cullinan Oncology, Betta Pharmaceuticals, G1 Therapeutics, Janux Therapeutics, Daiichi Sankyo Company, Suzhou Puhe Pharmaceutical Technology, Genor Biopharma, J Ints Bio, Avistone Pharmaceuticals, Mythic Therapeutics and others. EGFR Non-Small Cell Lung Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as Intravenous Subcutaneous Oral Intramuscular EGFR + NSCLC Products have been categorized under various Molecule types such as Monoclonal antibody Small molecule Peptide Discover the latest advancements in EGFR + NSCLC treatment by visiting our website. Stay informed about how we're transforming the future of oncology @ EGFR + NSCLC Market Drivers and Barriers, and Future Perspectives Scope of the EGFR + NSCLC Pipeline Report Coverage- Global EGFR + NSCLC Companies- Cullinan Oncology, Betta Pharmaceuticals, G1 Therapeutics, Janux Therapeutics, Daiichi Sankyo Company, Suzhou Puhe Pharmaceutical Technology, Genor Biopharma, J Ints Bio, Avistone Pharmaceuticals, Mythic Therapeutics and others. EGFR+NSCLC Pipeline Therapies- IN10018, Furmonertinib, Oral S-1 + Oral Osimertinib, YH25448, JS111 capsules (AP-L1898), Osimertinib, Gefitinib, RC108, Sunvozertinib, and others. EGFR + NSCLC Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination EGFR + NSCLC Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III For a detailed overview of our latest research findings and future plans, read the full details of EGFR + NSCLC Pipeline on our website @ EGFR + NSCLC Emerging Drugs and Companies Table of Contents Introduction Executive Summary EGFR Non-Small Cell Lung Cancer: Overview Pipeline Therapeutics Therapeutic Assessment EGFR Non-Small Cell Lung Cancer – DelveInsight's Analytical Perspective Late Stage Products (Phase III) CLN-081: Cullinan Oncology Drug profiles in the detailed report….. Mid Stage Products (Phase II) Drug Name: Company Name Drug profiles in the detailed report….. Early Stage Products (Phase I/II) BPI-361175: Betta Pharmaceuticals Drug profiles in the detailed report….. Preclinical and Discovery Stage Products Drug Name: Company Name Drug profiles in the detailed report….. Inactive Products EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC) Key Companies EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC) Key Products EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC)- Unmet Needs EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC)- Market Drivers and Barriers EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC)- Future Perspectives and Conclusion EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC) Analyst Views EGFR Non-Small Cell Lung Cancer (EGFR + NSCLC) Key Companies Appendix About Us DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve. Media Contact Company Name: DelveInsight Business Research LLP Contact Person: Yash Bhardwaj Email: Send Email Phone: 09650213330 Address: 304 S. Jones Blvd #2432 City: Las Vegas State: NV Country: United States Website:
Business Wire
24-06-2025
- Business
- Business Wire
Trially AI Taps Serial Entrepreneur Christian Smith as CRO to Expand AI Clinical Trial Enrollment Across U.S.
KANSAS CITY, Mo.--(BUSINESS WIRE)-- Trially®, a breakthrough AI clinical trial recruitment technology to unlock faster qualified patient enrollment, today announced the appointment of as Chief Revenue Officer. A serial entrepreneur and proven operator, Smith brings a track record of scaling quality service for healthcare organizations and will lead efforts to accelerate trial enrollment for U.S. site networks, healthcare systems, and sponsors with Trially's AI tools. When my mom passed away of breast cancer in 2005, we had no clue there were 28 studies running within driving distance, including studies for Trastuzumab and Bevacizumab which represent some of the top treatments on the market today. Smith joins Trially at a pivotal moment. As clinical research sites face mounting enrollment pressure and shrinking pipelines, Trially has emerged as a category-defining technology. In a landscape where 68% of sites miss enrollment targets and screen failure rates continue to rise, Trially AI is enabling sites to predictably prescreen and qualify patients for trials — with or without an EHR integration — helping teams multiply enrollment for even the most complex protocols in record time. 'In my late teens, I found how difficult it is to navigate medical care when standard treatment paths do not yield results,' said Smith. 'When my mom passed away of breast cancer in 2005, we had no clue there were 28 studies running within driving distance, including studies for Trastuzumab and Bevacizumab which represent some of the top treatments on the market today. It is an honor to join Trially to serve the physician networks and sites by matching patients with novel drug therapies to improve health outcomes and the standard of care.' Prior to Trially, Smith co-founded TrackR, where he helped create the Bluetooth tracking category and grew revenue to over $50 million. During the COVID-19 pandemic, he led direct-to-consumer operations at Dascena, opening 44 testing sites across 26 cities. Most recently, he co-founded Forta, where he pioneered a family centric autism therapy model powered by AI. His expertise in direct-to-patient recruitment, AI-driven care models, and scaling operational quality — are critical to best support Trially partners. 'Christian brings the exact mindset we value at Trially: efficiency, transparency, empathy,' said Trevor Welch, Co-founder and Chief Product Officer of Trially. "He understands what it means to scale with purpose, and he's passionate about empowering research teams to help patients get access to life-saving therapies. His arrival marks a new chapter in our mission to unlock faster qualified patient enrollment across the industry.' About Trially Trially® is shaping the future of clinical trial recruitment with its proprietary AI matching technology that safely unlocks rich clinical data to enroll qualified patients faster. Proven to multiply enrollment rates by 200%, dramatically reduce screen failures and improve site efficiency, Trially's site-based software rapidly integrates with any EHR or CTMS system while maintaining full compliance with HIPAA, SOC 2, FDA 21 CFR Part 11 and ISO 27001 regulations. Designed to meet the needs of physicians, research sites and pharmaceutical sponsors, Trially empowers you to achieve outstanding results in clinical research. For more information visit
Business Standard
24-06-2025
- Health
- Business Standard
Biocon Biologics partners with National Cancer Society of Malaysia
To launch a Patient Assistance Program (PAP) in Malaysia Biocon Biologics has partnered with the National Cancer Society of Malaysia (NCSM), a prominent not-for-profit cancer organization, to launch a Patient Assistance Program (PAP) in Malaysia aimed at improving access to affordable, high-quality biosimilars for underserved cancer patients in Malaysia. Biocon Biologics will provide quality-assured biosimilars from its oncology portfolio, including Trastuzumab, Pegfilgrastim and Bevacizumab, to NCSM, which will manage patient enrolment and medicine supply as part of its healthcare services. This collaboration combines Biocon's expertise in biosimilars with NCSM's community outreach to enhance cancer care accessibility and affordability in Malaysia. The program will start with providing bTrastuzumab to cancer patients facing treatment delays due to budget constraints. The MoU was signed during the National Cancer Congress Malaysia 2025 event, emphasizing a commitment to improving patient-centric healthcare.
BusinessToday
24-06-2025
- Health
- BusinessToday
National Cancer Malaysia Partners Biocon In Offering Affordable Cancer Care For The Underserved
Biocon Biologics Limited, has partnered with the National Cancer Society of Malaysia to launch a Patient Assistance Program (PAP) in Malaysia aimed at improving access to affordable, high-quality biosimilars for underserved cancer patients in Malaysia. The partnership will see Biocon Biologics providing quality-assured biosimilars from its oncology portfolio, including Trastuzumab, Pegfilgrastim and Bevacizumab, to NCSM, which will manage patient enrolment and medicine supply as part of its healthcare services. This collaboration combines Biocon's expertise in biosimilars with NCSM's community outreach to enhance cancer care accessibility and affordability in Malaysia. The program will start with providing Trastuzumab to cancer patients facing treatment delays due to budget constraints. Ratish Trehan, Head of Commercial – Emerging Markets, Biocon Biologics, said, 'Together, we hope to positively impact thousands of lives and strengthen Malaysia's efforts to deliver inclusive, patient-centric healthcare.' Biocon Biologics aims to build on its previous success in expanding access to diabetes care in Malaysia, having served over 345,000 patients, and is now focusing on oncology through strategic partnerships like this. Related
