18-03-2025
NCAA Tournament - Creighton vs Louisville Prediction: Odds, Expert Picks, Betting Trends and Stats
No. 9 Creighton (24-10) takes the court Thursday against No. 8 Louisville (27-7) in the first of four games in the First Round in the South Region. It is a matchup of teams who lost in their respective conference title games.
Prior to Saturday night's loss to the Johnnies in the Big East Final, the Bluejays had won three in a row. Ryan Kalkbrenner leads the team nightly in scoring (19.4) and rebounding (8.8). Steven Ashworth directs the offense from the point averaging 6.8 assists per game.
The Cardinals had won 11 straight prior to their loss to Duke in the ACC Title Game. Terrence Edwards Jr. leads Louisville in scoring averaging 16.6 points per game. Former Wisconsin Badger Chucky Hepburn runs the show for the Cardinals averaging 5.8 assists per game.
The winner earns the right to more than likely face the No. 1 seed in the region, the Auburn Tigers on Saturday.
Lets dive into the matchup and offer some information and possibly a sweat or two.
We've got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch the opening tip, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
Game details & how to watch Creighton vs. Louisville
Date: Thursday, March 20, 2025
Time: 12:15PM EST
Site: Rupp Arena
City: Lexington, KY
Network/Streaming: CBS
Never miss a second of the action and stay up to date with all the latest scores and player news. Check out our day-by-day NCAA Basketball Schedule Page that includes live game updates.
Game odds for Creighton vs. Louisville
The latest odds as of Tuesday courtesy of BetMGM:
Odds: Creighton Bluejays (+120), Louisville Cardinals (-145)
Spread: Cardinals -2.5
Total: 145.5 points
Expert picks & predictions for Creighton at Louisville
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NCAA calendar based on data points like past performance, player matchups, injuries, and the schedule.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for today's Bluejays & Cardinals game:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on Creighton +2.5.
Total: NBC Sports Bet is leaning towards a play on the Game Total OVER 145.5.
Creighton vs. Louisville: Top betting trends and recent stats
Creighton is 4-6 against the spread in their last 10 games
The Game Totals in Creighton's last 10 games are 6-4 to the OVER
Louisville is 6-4 against the spread in their last 10 games
These schools last met March 11, 1999 with Creighton defeating Louisville 62-58
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our NCAA Basketball Top Trends Tool on
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
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· Jay Croucher (@croucherJD)
· Drew Dinsick (@whale_capper)
· Vaughn Dalzell (@VmoneySports)
· Brad Thomas (@MrBradThomas)
