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Wordle Hints August 10: Sunday's puzzle #1,513 keeps players guessing with fresh clues and answers
Wordle Hints August 10: Sunday's puzzle #1,513 keeps players guessing with fresh clues and answers

Time of India

time10-08-2025

  • Entertainment
  • Time of India

Wordle Hints August 10: Sunday's puzzle #1,513 keeps players guessing with fresh clues and answers

A Brief Look Back at Wordle's Rise Wordle: How the Game Works Live Events Wordle: Beyond the Daily Challenge Recent Wordle Answers Aug 9: NASAL Aug 8: IMBUE Aug 7: CORAL Aug 6: GROAN Aug 5: STORK Wordle Hints for August 10 Meaning clue: Something you might describe about your breath after brushing your teeth, using mouthwash, or chewing gum. Something you might describe about your breath after brushing your teeth, using mouthwash, or chewing gum. Letter clue: The word contains no repeated letters. The word contains no repeated letters. First-letter clue: It begins with the letter M. Wordle Today's Answer Revealed FAQs Who created Wordle and when? Who owns Wordle now? (You can now subscribe to our (You can now subscribe to our Economic Times WhatsApp channel Word game enthusiasts across the globe woke up to a new challenge this Sunday as The New York Times released puzzle #1,513 of its widely popular daily game, Wordle. With its familiar mix of strategy and deduction, the latest edition kept both long-time players and curious newcomers its humble beginnings in 2021, Wordle has become a daily ritual for millions, a cultural touchpoint in the online puzzle community. The concept remains unchanged: uncover a hidden five-letter word within six tries, using feedback from each guess to guide the developed by Josh Wardle, the game shot to prominence in late 2021 thanks to its shareable emoji grids that allowed players to compare results without spoiling answers. This viral feature, coupled with its simple design, turned it into an overnight New York Times acquired Wordle in early 2022, integrating it into its growing games portfolio. By 2024, the publisher reported an astounding 5.3 billion plays in a single year, cementing its place among the most played online puzzles rules of Wordle are straightforward yet deceptively challenging. Players type in a five-letter word as their opening guess. Letters in the correct position appear in green, while correct letters in the wrong spot turn yellow. Incorrect letters are marked grey on the in-game only six attempts allowed, each guess becomes a careful balance of logic, vocabulary, and intuition. Letters may appear more than once, and there's no penalty for using greyed-out letters again in later guesses, sometimes a necessity when narrowing down those who find a single puzzle insufficient, a New York Times Games subscription opens the door to an archive of more than 1,500 past Wordle games. Subscribers also gain access to the Wordle Bot, an analysis tool that reviews each move and offers statistical tracking patterns often look at previous solutions to anticipate upcoming ones. In the past week, the game has served up:As part of our daily guide, here are today's Wordle hints without immediately giving away the solution, as mentioned in a report by Yahoo Tech:These hints are designed to narrow the field without removing the element of discovery, ideal for players who want a nudge but not a readers who have exhausted their guesses or are simply curious, here is the solution to Wordle #1,513 for Sunday, August 10:The refreshing term fits neatly with today's clue and adds a sensory twist to the game's usual wordplay. With another puzzle wrapped up, players can look forward to Monday's fresh challenge, and perhaps a new set of strategic guesses to keep their win streak game was created by Josh Wardle in 2021 and gained massive popularity later that New York Times acquired Wordle in early 2022 and integrated it into its games portfolio.

Celebrate Ocean Conservation with SEKKISEI's SAVE THE BLUE 2025 Limited Edition Launch Supporting Coral Reefs Around the World, One Bottle at a Time
Celebrate Ocean Conservation with SEKKISEI's SAVE THE BLUE 2025 Limited Edition Launch Supporting Coral Reefs Around the World, One Bottle at a Time

Associated Press

time03-07-2025

  • Business
  • Associated Press

Celebrate Ocean Conservation with SEKKISEI's SAVE THE BLUE 2025 Limited Edition Launch Supporting Coral Reefs Around the World, One Bottle at a Time

NEW YORK, July 3, 2025 /PRNewswire/ -- Since 2009, SEKKISEI has championed ocean conservation through its global SAVE THE BLUE initiative. In 2025, the brand continues this mission with the launch of a Limited Edition SAVE THE BLUE Lotion, designed to raise awareness and funds for the protection of marine ecosystems and the preservation of coral reefs. For the seventh consecutive year, SEKKISEI is proudly partnering with the Coral Reef Alliance (CORAL)–a global nonprofit organization dedicated to safeguarding coral reefs and the ocean life that depends on them. CORAL's science-based, holistic approach addresses water quality issues, unsustainable fisheries, and the impacts of climate change to help coral reefs not just survive–but thrive. In honor of this year's campaign, from July 1 - July 31, SEKKISEI will donate $1 for every Limited Edition SAVE THE BLUE Lotion ($88, 16.9 fl oz / 500 mL) sold through its U.S. e-commerce site, supporting CORAL's work across the United States and the Caribbean. This ultra-hydrating liquid lotion is a cult-favorite J-Beauty essential. Lightweight and nutrient-rich, it preps skin to better absorb treatments and enhances radiance with every use. Perfect for morning and night, this lotion can be used as a traditional liquid moisturizer or a hydrating mask for an instant refresh. Since launching SAVE THE BLUE, SEKKISEI has planted more than 20,000 coral polyps globally and expanded its conservation efforts to eight countries. The initiative has restored over 122 million cm² of reef habitat, helping build a more resilient ocean for future generations. For more information on SAVE THE BLUE and the products, go to About SEKKISEI: SEKKISEI, a Japanese skincare brand trusted since 1985, has been setting new standards in hydration, clarity, and even skin tone. SEKKISEI blends ancient Asian herbal remedies with cutting-edge Japanese scientific research to deliver highly effective skincare solutions that are accessible to all, without gender boundaries or age limits. Infused with carefully selected botanicals from hundreds of herbs, their formulas deeply hydrate, brighten, and refine skin tone, unlocking radiant, healthy skin. Media Contact: PURPLE PR Email: [email protected] Learn more at View original content to download multimedia: SOURCE Kose America

Avextra Cannabis extract can potentially reduce symptom burden for late palliative patients
Avextra Cannabis extract can potentially reduce symptom burden for late palliative patients

Yahoo

time13-06-2025

  • Health
  • Yahoo

Avextra Cannabis extract can potentially reduce symptom burden for late palliative patients

Prof. Dr. med. Sven Gottschling, Principal Investigator for the CORAL study. New Study Demonstrates Significant Symptom Relief for Late-Stage Palliative Patients Treated with Cannabis-based Medicines Bensheim, Germany – 13th June 2025 – According to the World Health Organization, an estimated 56.8 million palliative care patients worldwide suffer from significant symptom burden every year. In palliative care — particularly for oncology patients — effective symptom management is essential to maintaining dignity, comfort, and quality of life in the final stages of illness. Despite advances in conventional therapies, many patients continue to suffer from uncontrolled pain, anxiety, and other distressing symptoms. The CORAL study offers promising evidence that cannabinoid-based medicines may play a critical role in addressing this unmet need. The CORAL study (CannabinOid-TheRapie in der PALliativmedizin or Cannabinoid Therapy in Palliative Care) is a non-interventional, parallel group study designed to examine the reduction of symptom burden in patients receiving end-of-life care. Led by Prof. Dr. med. Sven Gottschling from Universitätsklinikum des Saarlandes in Homburg, 150 patients in advanced palliative stages were enrolled in the study, with over 80% being oncology patients. 100 of them were additionally treated with the cannabis extract Avextra 10:10 (THC/CBD), the other 50 with a non-cannabinoid treatment. Key Findings from the CORAL Study Significant Symptom Reduction: Patients treated with Avextra's extract showed statistically and clinically significant improvement in MIDOS scores (a palliative symptom assessment tool), while the control group's symptoms worsened. 68% of patients treated with Avextra showed clinically relevant improvement (≥20%). Mental Health Improvements: Stress, anxiety, and depression levels (measured by DASS-21) improved in the Avextra group, but worsened in the control group. All were statistically and clinically superior to the control group ; 50% were stress responders, and over 20% improved in all three DASS categories. Quality of Life Gains: Patients reported better outcomes across multiple domains in the EORTC QLQ-C15-PAL questionnaire, a quality-of-life tool validated for palliative care. Nearly 25% of patients in the Avextra group showed clinically relevant quality of life improvement. Lower Co-medication Burden: Avextra-treated patients require significantly less use of sedatives, sleep aids, benzodiazepines, and muscle relaxants. High Tolerability: The extract was well tolerated, with fewer than 15% of patients reporting any adverse reactions and only three dropouts due to side effects. Principal investigator Prof. Dr. Sven Gottschling, Head Physician of the Center for All-Age Palliative Medicine and Paediatric Pain Therapy at the UKS in Homburg, presents the study results during the 6th Medicinal Cannabis Congress in Berlin. He stated: "The CORAL study is another significant contribution to improving the treatment of those with serious, terminal diseases. We would like to thank our study partner Avextra: Together, we are committed to improving symptom burden reduction of those affected and further optimizing palliative care treatment options for patients and caregivers." Enhanced quality of life towards the end of lifeThere is a significant need for interdisciplinary studies, particularly in palliative care. This was highlighted in February by representatives of the Leopoldina (German National Academy of Sciences) and other scientific experts in Berlin. "Avextra's goal is to further improve symptom relief for palliative care patients. We are happy that our products appear to be helping to achieve that, and this motivates us to develop even better, innovative dosage forms for this patient group," said Dr. Bernhard Babel, CEO of Avextra. About Avextra AG Avextra is one of Europe's leading vertically integrated medical cannabis operators focused on the development and production of regulator-approved medicines. Founded in 2019 and based in Germany, the company works in close collaboration with doctors, pharmacists and researchers to develop and produce innovative Cannabis-based Medicines. Avextra controls the entire value chain – from cultivation to EU-GMP certified extraction and manufacturing in Germany. Avextra´s products are distributed in federally regulated cannabis access programmes across Europe. Going forward, Avextra will keep conducting studies focusing on the clinical outcomes of cannabis-based medicines on patients' overall reduction of symptom burden. Clinical trials represent a key element of the German biotech company's strategic focus towards getting a registered medicine. Learn more at and stay up to date at LinkedIn: Avextra Media Enquiries: For media enquiries or to set up an interview please contact: Email: press@ Phone: +49 30 408174037 Attachment Prof. Dr. med. Sven Gottschling, Principal Investigator for the CORAL in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

Avextra Cannabis extract can potentially reduce symptom burden for late palliative patients
Avextra Cannabis extract can potentially reduce symptom burden for late palliative patients

Yahoo

time13-06-2025

  • Health
  • Yahoo

Avextra Cannabis extract can potentially reduce symptom burden for late palliative patients

Prof. Dr. med. Sven Gottschling, Principal Investigator for the CORAL study. New Study Demonstrates Significant Symptom Relief for Late-Stage Palliative Patients Treated with Cannabis-based Medicines Bensheim, Germany – 13th June 2025 – According to the World Health Organization, an estimated 56.8 million palliative care patients worldwide suffer from significant symptom burden every year. In palliative care — particularly for oncology patients — effective symptom management is essential to maintaining dignity, comfort, and quality of life in the final stages of illness. Despite advances in conventional therapies, many patients continue to suffer from uncontrolled pain, anxiety, and other distressing symptoms. The CORAL study offers promising evidence that cannabinoid-based medicines may play a critical role in addressing this unmet need. The CORAL study (CannabinOid-TheRapie in der PALliativmedizin or Cannabinoid Therapy in Palliative Care) is a non-interventional, parallel group study designed to examine the reduction of symptom burden in patients receiving end-of-life care. Led by Prof. Dr. med. Sven Gottschling from Universitätsklinikum des Saarlandes in Homburg, 150 patients in advanced palliative stages were enrolled in the study, with over 80% being oncology patients. 100 of them were additionally treated with the cannabis extract Avextra 10:10 (THC/CBD), the other 50 with a non-cannabinoid treatment. Key Findings from the CORAL Study Significant Symptom Reduction: Patients treated with Avextra's extract showed statistically and clinically significant improvement in MIDOS scores (a palliative symptom assessment tool), while the control group's symptoms worsened. 68% of patients treated with Avextra showed clinically relevant improvement (≥20%). Mental Health Improvements: Stress, anxiety, and depression levels (measured by DASS-21) improved in the Avextra group, but worsened in the control group. All were statistically and clinically superior to the control group ; 50% were stress responders, and over 20% improved in all three DASS categories. Quality of Life Gains: Patients reported better outcomes across multiple domains in the EORTC QLQ-C15-PAL questionnaire, a quality-of-life tool validated for palliative care. Nearly 25% of patients in the Avextra group showed clinically relevant quality of life improvement. Lower Co-medication Burden: Avextra-treated patients require significantly less use of sedatives, sleep aids, benzodiazepines, and muscle relaxants. High Tolerability: The extract was well tolerated, with fewer than 15% of patients reporting any adverse reactions and only three dropouts due to side effects. Principal investigator Prof. Dr. Sven Gottschling, Head Physician of the Center for All-Age Palliative Medicine and Paediatric Pain Therapy at the UKS in Homburg, presents the study results during the 6th Medicinal Cannabis Congress in Berlin. He stated: "The CORAL study is another significant contribution to improving the treatment of those with serious, terminal diseases. We would like to thank our study partner Avextra: Together, we are committed to improving symptom burden reduction of those affected and further optimizing palliative care treatment options for patients and caregivers." Enhanced quality of life towards the end of lifeThere is a significant need for interdisciplinary studies, particularly in palliative care. This was highlighted in February by representatives of the Leopoldina (German National Academy of Sciences) and other scientific experts in Berlin. "Avextra's goal is to further improve symptom relief for palliative care patients. We are happy that our products appear to be helping to achieve that, and this motivates us to develop even better, innovative dosage forms for this patient group," said Dr. Bernhard Babel, CEO of Avextra. About Avextra AG Avextra is one of Europe's leading vertically integrated medical cannabis operators focused on the development and production of regulator-approved medicines. Founded in 2019 and based in Germany, the company works in close collaboration with doctors, pharmacists and researchers to develop and produce innovative Cannabis-based Medicines. Avextra controls the entire value chain – from cultivation to EU-GMP certified extraction and manufacturing in Germany. Avextra´s products are distributed in federally regulated cannabis access programmes across Europe. Going forward, Avextra will keep conducting studies focusing on the clinical outcomes of cannabis-based medicines on patients' overall reduction of symptom burden. Clinical trials represent a key element of the German biotech company's strategic focus towards getting a registered medicine. Learn more at and stay up to date at LinkedIn: Avextra Media Enquiries: For media enquiries or to set up an interview please contact: Email: press@ Phone: +49 30 408174037 Attachment Prof. Dr. med. Sven Gottschling, Principal Investigator for the CORAL in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

Trevi Therapeutics Announces Positive Topline Results from the Phase 2b CORAL Trial of Haduvio in Patients with Idiopathic Pulmonary Fibrosis Chronic Cough
Trevi Therapeutics Announces Positive Topline Results from the Phase 2b CORAL Trial of Haduvio in Patients with Idiopathic Pulmonary Fibrosis Chronic Cough

Yahoo

time02-06-2025

  • Business
  • Yahoo

Trevi Therapeutics Announces Positive Topline Results from the Phase 2b CORAL Trial of Haduvio in Patients with Idiopathic Pulmonary Fibrosis Chronic Cough

Haduvio met the primary endpoint with statistically-significant reductions in 24-hour cough frequency across all dose groups (108 and 54 mg BID p<0.0001; 27 mg BID p<0.01); a -43.3% placebo-adjusted change from Baseline was achieved at the 108 mg BID dose group Patients saw a rapid reduction in 24-hour cough frequency at Week 2, the first time point measured Haduvio was generally well-tolerated at all doses; discontinuation rates due to adverse events were similar in the Haduvio and placebo groups, 5.6% and 5.0%, respectively Trevi plans to request an End-of-Phase 2 meeting with the FDA later this year and is planning to initiate the Phase 3 program in the first half of 2026 Company to host a conference call and webcast today at 8:30 a.m. ET and will be joined by the study's UK Lead Investigator, Professor Philip Molyneaux NEW HAVEN, Conn., June 2, 2025 /PRNewswire/ -- Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine ER) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and in patients with refractory chronic cough (RCC), is pleased to announce today positive topline results from its Phase 2b CORAL trial of Haduvio for the treatment of chronic cough in patients with IPF (N=165). The primary endpoint in the CORAL trial was achieved, demonstrating statistically significant reductions in 24-hour cough frequency across all dose groups at Week 6. The 108 mg BID, 54 mg BID and 27 mg BID dose groups achieved reductions from Baseline of 60.2% (p<0.0001), 53.4% (p<0.0001), and 47.9% (p<0.01), respectively, compared to a placebo reduction from Baseline of 16.9%1. Statistically significant improvements were observed across secondary endpoints at Week 6 in the 108 mg BID and 54 mg BID dose groups. "The CORAL trial is the first positive Phase 2b parallel group study for the treatment of chronic cough in patients with IPF, a significant milestone for patients and Trevi," said Jennifer Good, President and CEO of Trevi Therapeutics. "Chronic cough is one of the most debilitating comorbidities for patients with IPF, impacting an estimated 85% of these patients. There are no approved therapies for chronic cough in this population and with these data, Trevi is one step closer to addressing this unmet need." "In my patients with IPF, chronic cough is one of the most challenging comorbidities I face clinically," said Philip Molyneaux, MD, Professor of Pulmonary Medicine at the Royal Brompton Hospital, London. "IPF treatments focus on slowing disease progression but have not shown benefit on chronic cough, which can lead to poor health outcomes and quality of life. I am excited about the CORAL data and the potential continued development of nalbuphine ER for this significant unmet need among IPF patients." Primary Endpoint – Relative Change from Baseline in 24-hour Cough Frequency (coughs per hour) at Week 6Placebo1 (N=39) Haduvio 27 mg BID (N=42) Haduvio 54 mg BID (N=43) Haduvio 108 mg BID (N=40) Baseline 24-hour Cough Frequency (coughs/hour) 29.4 24.6 28.0 31.5 Relative Change from Baseline in 24-hour Cough Frequency at Week 6 -16.9 % -47.9% (p<0.01) -53.4% (p<0.0001) -60.2% (p<0.0001) Placebo-adjusted difference - -30.9 % -36.5 % -43.3 %1One placebo patient with an extreme outlier value at Week 6 was excluded from the modified intent-to-treat (mITT) population. Inclusion of the patient in the placebo group would have resulted in an increased cough frequency from Baseline in the placebo group and much greater placebo-adjusted differences. The primary efficacy endpoint was the relative change in objective 24-hour cough frequency (coughs per hour) for the mITT population at the end of Week 6 versus Baseline for Haduvio compared to placebo. The mITT population consists of all randomized patients who received at least one dose of study drug or placebo. Additional Trial Results A rapid reduction was seen in 24-hour cough frequency at Week 2 with Haduvio, the first time point measured. A 50% reduction in 24-hour cough frequency at Week 6 vs Baseline was seen in 65% of patients on 108 mg BID Haduvio (p<0.001), 63% of patients on 54 mg BID Haduvio (p<0.001) and 60% of patients on 27 mg BID Haduvio (p<0.001) dose groups, compared to 19% of placebo patients. A statistically-significant response was observed on the cough-severity numerical rating scale (CS-NRS), a secondary endpoint, at Week 6 on Haduvio in both the 108 mg BID and 54 mg BID dose groups. There was a mean reduction on a 0 – 10 scale of 3.0 points on the 108 mg BID (p<0.05), 3.2 points on the 54 mg BID (p<0.01) and 2.0 points on the 27 mg BID (p=0.46) dose groups compared to a 1.5-point reduction on placebo at Week 6. The 108 mg BID and 54 mg BID dose groups were statistically-significant (p<0.01) on the patient-reported outcome E-RS®: IPF Cough Subscale, a secondary endpoint, with mean relative change from Baseline of -42.4% and -43.1%, respectively at Week 6, compared to -23% for those on placebo at Week 6. The 27 mg BID dose group was not statistically-significant with a mean relative change from Baseline of –31.6%. Discontinuation rates due to adverse events were similar in the combined Haduvio groups (5.6%) and placebo group (5.0%). The safety profile observed in the trial was generally consistent with the known safety profile of Haduvio from previous trials. The most common adverse events experienced included: nausea, vomiting, constipation, dizziness, headache, fatigue, somnolence, and dry mouth. Serious adverse events (all non-fatal) were reported for four patients (10.0%) in the placebo group and for two patients (1.6%) across all Haduvio doses combined. James Cassella, Ph.D., Chief Development Officer of Trevi Therapeutics added, "We are very pleased with the findings from the CORAL trial, which continue to demonstrate the robust cough suppressant activity of nalbuphine ER. The study has provided critical dose-ranging data to inform the planning of our Phase 3 program. We intend to request an End-of-Phase 2 meeting with the FDA to discuss our plans for initiating the Phase 3 program for the treatment of chronic cough in patients with IPF. I would like to take the opportunity to thank the patients, investigators and site staff for moving research forward for these patients. We look forward to advancing development of this program." Conference Call/Webcast The Company will host a conference call and webcast to review the topline results today, June 2nd, at 8:30 a.m. ET. The live webcast, including audio and presentation slides, will be accessible at the time of the meeting and can be accessed here. To participate in the live conference call by phone, please dial (877) 870 4263 (domestic) or (412) 317 0790 (international) and ask to join the Trevi Therapeutics call. No code is necessary for access. An archived replay of the webcast will also be available for 30 days on the Company's website following the event. About the CORAL TrialThe Phase 2b Cough Reduction in IPF with Nalbuphine ER (CORAL) trial was a double-blind, randomized, placebo-controlled, parallel-arm trial evaluating three doses of Haduvio (27 mg, 54 mg, and 108 mg twice daily) compared to placebo for the treatment of chronic cough in patients with IPF over a 6-week treatment period. 165 patients with IPF chronic cough were randomized 1:1:1:1 to one of three Haduvio doses or placebo with an initial 2-week titration period to the target dose followed by 4 weeks of fixed dosing. The primary efficacy endpoint for the trial was the relative change in 24-hour cough frequency (coughs per hour), as determined by an objective cough monitor, for the modified intent-to-treat (mITT) population at the end of Week 6 versus Baseline for Haduvio compared to placebo. The mITT population consisted of all patients who were randomized and received at least one dose of study drug or placebo. About Idiopathic Pulmonary Fibrosis (IPF) Chronic CoughChronic cough is a highly prevalent condition in patients with IPF, impacting up to 85% of the IPF population. There are ~140,000 patients in the U.S. with IPF. The impact of chronic cough is significant with patients coughing up to 1,500 times per day. This consistent cough and any associated damage may lead to worsening disease, a higher risk of progression, death, or need for lung transplant. Chronic cough also often leads to a decline in patients' social, physical, and psychological quality of life. There are no approved therapies for the treatment of chronic cough in patients with IPF and current off-label treatment options provide minimal benefit to patients. About Trevi Therapeutics, Inc. Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine extended-release) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and in patients with refractory chronic cough (RCC). Haduvio is the first and only investigational therapy to show a statistically-significant reduction in cough frequency in clinical trials of patients with IPF chronic cough and in patients with RCC. Haduvio acts on the cough reflex arc both centrally and peripherally as a kappa agonist and a mu antagonist (KAMA), targeting opioid receptors that play a key role in controlling chronic cough. Nalbuphine is not currently scheduled by the U.S. Drug Enforcement Agency. Trevi intends to propose Haduvio as the trade name for oral nalbuphine ER. Its safety and efficacy have not been evaluated by any regulatory authority. For more information, visit and follow Trevi on X (formerly Twitter) and LinkedIn. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements are subject to risks and uncertainties and actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding Trevi's business plans and objectives, including future plans or expectations for Haduvio and plans and timing with respect to clinical trials and clinical data and other statements containing the words "believes," "anticipates," "plans," "expects," and similar expressions. Risks that contribute to the uncertain nature of the forward-looking statements include: uncertainties regarding the success, cost and timing of Trevi's product candidate development activities and clinical trials; the risk that positive data from a clinical trial may not necessarily be predictive of the results of later clinical trials in the same or a different indication; uncertainties regarding Trevi's ability to execute on its strategy; uncertainties with respect to regulatory authorities' views as to the data from Trevi's clinical trials and next steps in the development path for Haduvio in the United States and foreign countries; uncertainties inherent in estimating Trevi's cash runway, future expenses and other financial results, including Trevi's ability to fund future operations, including clinical trials, as well as other risks and uncertainties set forth in the quarterly report on Form 10-Q for the quarter ended March 31, 2025 filed with the Securities and Exchange Commission and in subsequent filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Trevi undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. Investor Contact Jonathan CarlsonTrevi Therapeutics, Inc.(203) 654 3286carlsonj@ Media Contact Rosalia Scampoli914-815-1465rscampoli@ 2Evaluating Respiratory Symptoms in Idiopathic Pulmonary Fibrosis as collected in the EXACT® (EXAcerbation of Chronic pulmonary disease Tool). EXACT© 2013, Evidera, Inc. All rights reserved. View original content to download multimedia: SOURCE Trevi Therapeutics, Inc. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

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