Latest news with #Cabenuva
Medscape
17-07-2025
- Health
- Medscape
What Comes Next After Failure of Injectable HIV Medication?
While the injectable HIV treatment regimen cabotegravir/rilpivirine (Cabenuva) is an increasingly important option, including for people who have struggled with adherence to daily tablets, it comes with a caution that must be discussed with each patient. Around 1.5% of people who switch to the injections experience virologic failure, often despite perfect adherence to the injection schedule. While this rate is not higher than for daily oral HIV regimens, failures are frequently accompanied by resistance-associated mutations. Since cabotegravir is an integrase inhibitor — as are dolutegravir and bictegravir, the most frequently used anchor drugs in modern HIV treatment — the development of resistance to integrase inhibitors risks significantly limiting future HIV treatment options. Virologic failure on cabotegravir/rilpivirine is therefore considered 'a low incidence, but high consequence event' (a phrase shared by Saye Khoo at the Conference on Retroviruses and Opportunistic Infections earlier this year). But there is limited data and a lack of guidance on the most effective regimens to use following failure associated with resistance. 'In reality, what people do in case of failures with cabotegravir/rilpivirine is that they base their therapy on genotypic results,' explained Pierre Giguère, MSc, clinical pharmacy specialist at the Ottawa Hospital, Ottawa, Ontario, Canada. 'We like to go with agents for which there are no mutations that could predict treatment failure. And in situations with cabotegravir/rilpivirine, when you have dual-class resistance mutations, like in our cases, what's left are the protease inhibitors.' The protease inhibitor darunavir — typically boosted with cobicistat or ritonavir — has become 'the pillar of therapy' in these situations, he said in an interview. However, he and his colleagues reported an unusual case series of six patients at the International AIDS Society Conference on HIV Science this week. Each one was successfully treated with bictegravir/emtricitabine/tenofovir alafenamide (Biktarvy), a single-tablet daily regimen based on an integrase inhibitor. All patients had major mutations associated with both integrase inhibitors and non-nucleoside reverse transcriptase inhibitors. Despite this, all achieved viral suppression to below 20 copies/mL after switching to the bictegravir-based regimen and have maintained this for between 6 and 18 months. This approach emerged unexpectedly during clinical practice. The first patient was a woman who initially chose to switch to the bictegravir-based regimen because she could not tolerate the pain she experienced at the injection site. However, samples taken at the time of her switch subsequently revealed that she had a virologic breakthrough with resistance to integrase inhibitors (148R) and reverse transcriptase (101E). Given that this regimen would not normally be recommended in these circumstances, her clinicians considered taking her off the bictegravir she had already started but decided against it as she was now virally suppressed. 'What would be the motivation to change therapy in a patient who is currently on a simple regimen that is working?' asked Giguère. 'So, the decision was to keep following this patient closely, making sure that she remains suppressed. And that was our patient zero.' The next five patients to go on the regimen were the next five patients to experience virologic failure on cabotegravir/rilpivirine at the hospital. 'We decided just to keep going with the Biktarvy, based on that n of one experience, which ended up being an n of two, and now is an n of six,' Giguère said. Three of the subsequent patients had mutations at both positions 138 and 148. While cabotegravir frequently selects for these mutations, and they rapidly confer a significant loss of susceptibility to cabotegravir, that is not the case for bictegravir. 'From an in vitro perspective, you would not suspect that these mutations would much impact bictegravir susceptibility,' Giguère said. 'But what has been lacking has been clinical data.' Laura Waters, MD, consultant physician in sexual health and HIV medicine at Central and North West London NHS Foundation Trust, London, England, described the approach as 'brave.' She noted that while other cases of patients switching to integrase inhibitors after failure of cabotegravir/rilpivirine have been reported, they did not generally involve people who had integrase inhibitor resistance mutations. 'But as we're learning more and more, resistance isn't absolute, and both our second-generation integrase inhibitors have high inhibitory quotients, and so we would expect that virologic suppression would be possible for many individuals,' she told Medscape Medical News. She said she would be worried about the durability of the response. For three of the five cases reported, follow-up was for less than 1 year, while the patient observed the longest had 20 months of follow-up. 'The concern is around forgiveness: What happens if somebody misses a dose? What happens if somebody takes a cation-containing treatment or supplement that reduces integrase concentrations further?' For his part, Giguère stresses the importance of defining a safe approach that can be implemented when virologic failure on cabotegravir/rilpivirine occurs. 'I think we have to be able to come up with a simple, well-tolerated backup regimen in the case of failure,' he said. For the moment, it's not clear that the bictegravir-based regimen is the right one, but he hopes other clinicians will try to replicate the experience. 'Time will tell if the effect is long-lasting, and we need more people to confirm it.' The study received no funding. Giguère reported having no relevant financial relationships. Waters had received speaker and advisory fees from Merck Sharp & Dohme (MSD), ViiV Healthcare, Janssen Pharmaceuticals, and AbbVie. She is also an investigator on trials funded by Gilead Sciences, MSD, and ViiV Healthcare with funding provided to her institution.
Yahoo
15-07-2025
- Health
- Yahoo
ViiV's HIV shot preferred, as activists spotlight funding crisis at IAS 2025
ViiV Healthcare's combination injectable human immunodeficiency virus (HIV) medication was preferred over a daily tablet in treatment-naïve patients in a Phase IIIb trial. A global specialist in HIV that is majority owned by GSK, with Pfizer and Shionogi as shareholders, ViiV announced data from the Phase IIIb VOLITION study (NCT05917509) at the International AIDS Society (IAS) conference 2025, taking place from 13 to 15 July in Kigali, Rwanda. In the study, 89% of treatment-naïve HIV patients switched to Cabenuva (a combination treatment of cabotegravir and rilpivirine) following rapid viral suppression with daily Dovato (dolutegravir/lamivudine). Cabenuva is dosed once every two months by a healthcare professional. Patients were initially treated with daily Dovato until they achieved viral suppression. At this point, they were offered the opportunity to change to Cabenuva. The most common reasons cited for choosing Cabenuva were not having to worry about missing a dose each day (80%) and not having to carry medication (68%). ViiV CMO Jean van Wyk said: 'Long-acting injectables provide options that can offer high effectiveness and tolerability, improved adherence, and a preferred dosing schedule compared with daily oral pills. We believe they are a key part of HIV treatment and prevention and will play a critical role in achieving our ambition of ending HIV and AIDS.' Patients were initially treated with daily Dovato until they achieved viral suppression. At this point, they were offered the opportunity to change to Cabenuva. Effectiveness was also sustained with Cabenuva in the real world, with data from several observational studies. In these studies, Cabenuva was shown to address challenges associated with daily oral pills, offering improved treatment satisfaction, high effectiveness and a patient-preferred treatment option that supports long-term virologic control. It also provides better adherence to treatment, something which is a real issue with daily PrEP options due to stigma concerns. GlobalData, the parent company of Clinical Trials Arena, predicts sales of Cabenuva to reach $2.83bn in 2030. ViiV is also investigating an HIV therapy that can be dosed once every four months. In a Phase IIb trial, the therapy was able to suppress viral load below 50 copies per millimetre in blood. Long-acting pre-exposure prophylaxis (PrEP) for HIV has been prominent on the agenda at the IAS 2025 meeting. MSD has initiated two Phase III studies of its monthly oral PrEP candidate, and Gilead is set to report more positive data from its two-Phase III studies of twice-yearly Yeztugo (lenacapavir). On 14 July, the World Health Organization (WHO) endorsed the use of Yeztugo, saying that without a vaccine, it is the 'next best thing'. GlobalData analysts highlighted that the approval of Yeztugo is a 'momentous step in improving PrEP options available for people vulnerable to contracting HIV'. The main topic of conversation at the IAS 2025 conference, however, is the loss of various funding schemes which helped to provide treatment and research into HIV. Funding cuts by Trump's administration are already impacting low-income and middle-income countries, with cases of HIV already rising just six months after the reductions were made. During IAS's opening session, a group of activists took to the stage to vocalise their anger at the loss of funding, as well as some companies removing their diversity policies that recognised patients from LGBTQ+ communities, many of whom are more susceptible to transmitting HIV. The activists chanted 'we will not be erased' as they took to the stage, with several members of the group sharing their views and experiences as HIV patients from the LGBTQ+ community. The conference states it is welcoming of protests and that it 'endorses freedom of speech as an essential principle to end the HIV pandemic as a threat to public health'. "ViiV's HIV shot preferred, as activists spotlight funding crisis at IAS 2025" was originally created and published by Clinical Trials Arena, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site.
Globe and Mail
09-07-2025
- Business
- Globe and Mail
GSK's Specialty Medicines Unit on a Strong Footing: Here's Why
GSK plc 's GSK Specialty Medicines segment includes medicines that prevent and treat diseases like HIV, cancer, asthma and immune-inflammation diseases like lupus. Specialty Medicines now represents close to 40% of GSK's sales. The company is witnessing increased sales growth of its Specialty Medicines unit, particularly reflecting successful new launches in Oncology and long-acting HIV medicines. Sales are rising in all areas, HIV, Immunology/Respiratory as well as Oncology. Sales of the Specialty Medicines unit rose 17% in the first quarter of 2025. In the segment, while products like Nucala and Dovato are key top-line drivers, new long-acting HIV medicines, Cabenuva and Apretude, as well as new oncology drugs Jemperli and Ojjaara, are also witnessing strong patient demand and contributing to top-line growth. GSK is also increasing R&D investment in promising new long-acting and specialty medicines in Respiratory, Immunology & Inflammation, Oncology and HIV areas. Blujepa/gepotidacin for treating uncomplicated urinary tract infection ('UTI') was approved in the United States in the first quarter of 2025. Its blockbuster drug Nucala was approved for treating chronic obstructive pulmonary disease or COPD, its fifth indication, in May 2025. Regulatory applications seeking approval of the Blenrep combination for relapsed/refractory multiple myeloma and depemokimab for two indications (chronic rhinosinusitis with nasal polyps or CRSwNP and asthma with type II inflammation) are under review in the United States and some other countries. FDA decisions on all these filings are expected in 2025. Blenrep combinations were approved in the United Kingdom and Japan in April/May 2025. Backed by its existing portfolio of medicines as well as new drugs, GSK expects sales in the Specialty Medicines segment to rise in a low double-digit percentage at CER in 2025, despite the impact from the Inflation Reduction Act or IRA. Specialty Medicines, which now accounts for around 40% of GSK's sales, is expected to be more than 50% of GSK's total revenues by 2031. Competition for GSK's Specialty Medicines In the Specialty Medicines segment, most of GSK's products are up against significant competition from small as well as large pharmaceutical companies like AstraZeneca AZN, Merck MRK, Sanofi SNY, Gilead, Pfizer, J&J and Novartis, among others. In the respiratory market, Advair is facing stiff competition in the COPD and asthma markets from AstraZeneca and Merck's respiratory disease drugs. The launch of AstraZeneca's Fasenra and Sanofi's Dupixent has raised competitive pressure for Nucala. Continued competitive and pricing pressure is hurting sales of GSK's ICS/LABA class of medicines. In HIV, GSK's medicines face competition from Gilead and MRK's drugs. AstraZeneca, Pfizer, Merck and Lilly are GSK's key competitors in the oncology space. GSK's Price Performance, Valuation and Estimates GSK stock has risen 16.3% year to date compared with an increase of 0.3% for the industry. GSK's stock is trading at an attractive valuation relative to the industry. Going by the price/earnings ratio, the company's shares currently trade at 8.34 on a forward 12-month basis, lower than 14.93 for the industry. The stock also trades below its 5-year mean of 10.21. The Zacks Consensus Estimate for earnings has risen from $4.38 to $4.41 per share for 2025 but declined from $4.82 to $4.81 per share for 2026 over the past 60 days. GSK has a Zacks Rank #3 (Hold). You can see the complete list of today's Zacks #1 Rank (Strong Buy) stocks here. 5 Stocks Set to Double Each was handpicked by a Zacks expert as the #1 favorite stock to gain +100% or more in the coming year. While not all picks can be winners, previous recommendations have soared +112%, +171%, +209% and +232%. Most of the stocks in this report are flying under Wall Street radar, which provides a great opportunity to get in on the ground floor. Today, See These 5 Potential Home Runs >> Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Sanofi (SNY): Free Stock Analysis Report AstraZeneca PLC (AZN): Free Stock Analysis Report GSK PLC Sponsored ADR (GSK): Free Stock Analysis Report Merck & Co., Inc. (MRK): Free Stock Analysis Report
Yahoo
18-06-2025
- Business
- Yahoo
GSK Stock Rises Almost 22% in 6 Months: Time to Buy, Sell or Hold?
GSK GSK stock has risen 21.5% in the past six months. The consistently strong performance of the Specialty Medicines unit, regulatory and pipeline successes and an optimistic outlook for the long term are the key factors driving the increase amid several headwinds like slowing sales in the Vaccines unit, generic competition for some drugs and broader economic pressure. Let's discuss these factors in detail to understand how to play GSK's stock amid the recent price increase. GSK is witnessing increased sales growth of its Specialty Medicines unit, particularly reflecting successful new launches in Oncology and long-acting HIV medicines. Sales are rising in all areas, HIV, Immunology/Respiratory as well as Oncology. Sales of the Specialty Medicines unit rose 19% in 2024, driven by double-digit growth in all therapy areas. The positive trend continues in 2025 with sales rising 17% in the first quarter of 2025. In the segment, while products like Nucala and Dovato are key top-line drivers, new long-acting HIV medicines, Cabenuva and Apretude, as well as new oncology drugs Jemperli and Ojjaara, are also witnessing strong patient demand and contributing to top-line growth. In 2025, the company expects sales in the Specialty Medicines segment to rise in a low double-digit percentage at CER, despite the impact from the Inflation Reduction Act or IRA. Specialty Medicines, which now accounts for around 40% of GSK's sales, is expected to be more than 50% of GSK's total revenue by 2031. GSK is increasing R&D investment in promising new long-acting and specialty medicines in Respiratory, Immunology & Inflammation, Oncology and HIV areas. GSK's pentavalent MenABCWY meningococcal vaccine and Blujepa/gepotidacin for treating uncomplicated urinary tract infection ('UTI') were approved in the United States in the first quarter of 2025. Its blockbuster drug Nucala was approved for treating chronic obstructive pulmonary disease or COPD, its fifth indication, in May 2025. Regulatory applications seeking approval of the Blenrep combination for relapsed/refractory multiple myeloma and depemokimab for two indications (chronic rhinosinusitis with nasal polyps or CRSwNP and asthma with type II inflammation) are under review in the United States and some other countries. FDA decisions on all these filings are expected in 2025. Blenrep combinations were approved in the United Kingdom and Japan in April/May 2025. In 2025, GSK expects to launch five new products/line extensions, including Blenrep, depemokimab (severe asthma and CRSwNP), Nucala for COPD, Penmenvy and Blujepa. Of these, Penmenvy, Blujepa and Nucala for COPD are already approved in the United States. GSK's first-quarter Vaccine sales declined 6% due to lower sales of its RSV vaccine, Arexvy, and shingles vaccine, Shingrix. U.S. sales of Shingrix declined 21% in the first quarter of 2025 due to lower demand as a result of challenges in activating harder-to-reach consumers. Arexvy's global sales declined 57% in the first quarter. Revised recommendations for RSV vaccinations issued in June 2024 by the U.S. Advisory Committee on Immunization Practices (ACIP) have been hurting sales of Arexvy from the second half of 2024 in the United States. In June, the ACIP recommended the use of Arexvy for all adults aged 75 and above. However, for adults aged 60-74, the ACIP recommended the vaccine only for those who are at increased risk of severe RSV disease. A challenging macro environment in China and potential for changes in vaccination policies in the United States are expected to hurt Vaccine sales in the near term. In 2025, the company expects sales in the Vaccines segment to decline by a low single-digit percentage at CER. GSK stock has risen 20.1% year to date compared with an increase of 4.0% for the industry. The stock has also outperformed the sector and the S&P 500 index, as seen in the chart below. The stock has also been trading above 200 and 50-day moving averages since May. Image Source: Zacks Investment Research GSK's stock is trading at an attractive valuation relative to the industry. Going by the price/earnings ratio, the company's shares currently trade at 8.63 on a forward 12-month basis, lower than 15.63 for the industry. The stock also trades below its 5-year mean of 10.25. The stock is much cheaper than several other large drugmakers like Eli Lilly LLY, Novo Nordisk NVO, AbbVie ABBV and AstraZeneca. Image Source: Zacks Investment Research The Zacks Consensus Estimate for earnings has risen from $4.26 to $4.42 per share for 2025 and from $4.71 to $4.82 per share for 2026 over the past 60 days. Image Source: Zacks Investment Research GSK has its share of problems. Competitive pressure on HIV and respiratory drugs has risen. The dolutegravir HIV franchise patent expires in the 2028-2029 period, and U.S. vaccine sales are slowing down. In 2025, GSK also expects a negative sales impact of £400-500 million due to the impact of the IRA Medicare Part D redesign. However, the company is consistently growing its sales and profits, mainly driven by its Specialty Medicines segment. For the five-year period till 2026, GSK expects to record more than 7% sales growth while core operating profit is expected to increase more than 11% on a CAGR basis. In this period, Specialty Medicines is expected to rise in the low-to-mid teens percentage while General Medicines is expected to rise by a low single-digit percentage. The growth in Specialty Medicines and improvement in General Medicines are making up for a slowdown in the Vaccines unit. The company also resolved the vast majority of Zantac litigations in 2024, which had long been an overhang on the stock. GSK believes it is well-positioned to navigate and mitigate the potential financial impact of tariffs on pharmaceutical imports through supply chain and increased productivity initiatives We suggest investors who own this Zacks Rank #3 (Hold) stock stay invested for now, considering steady sales and profit improvement in the coming years. Consistently rising estimates also reflect analysts' optimistic outlook for future growth in profits. Buying the stock at its present cheap valuation can prove prudent for long-term investors who are interested in buying blue-chip companies. You can see the complete list of today's Zacks #1 Rank (Strong Buy) stocks here. Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report GSK PLC Sponsored ADR (GSK) : Free Stock Analysis Report Novo Nordisk A/S (NVO) : Free Stock Analysis Report Eli Lilly and Company (LLY) : Free Stock Analysis Report AbbVie Inc. (ABBV) : Free Stock Analysis Report This article originally published on Zacks Investment Research ( Zacks Investment Research Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Globe and Mail
18-06-2025
- Business
- Globe and Mail
GSK Stock Rises Almost 22% in 6 Months: Time to Buy, Sell or Hold?
GSK GSK stock has risen 21.5% in the past six months. The consistently strong performance of the Specialty Medicines unit, regulatory and pipeline successes and an optimistic outlook for the long term are the key factors driving the increase amid several headwinds like slowing sales in the Vaccines unit, generic competition for some drugs and broader economic pressure. Let's discuss these factors in detail to understand how to play GSK's stock amid the recent price increase. GSK Specialty Medicines Unit on a Strong Footing GSK is witnessing increased sales growth of its Specialty Medicines unit, particularly reflecting successful new launches in Oncology and long-acting HIV medicines. Sales are rising in all areas, HIV, Immunology/Respiratory as well as Oncology. Sales of the Specialty Medicines unit rose 19% in 2024, driven by double-digit growth in all therapy areas. The positive trend continues in 2025 with sales rising 17% in the first quarter of 2025. In the segment, while products like Nucala and Dovato are key top-line drivers, new long-acting HIV medicines, Cabenuva and Apretude, as well as new oncology drugs Jemperli and Ojjaara, are also witnessing strong patient demand and contributing to top-line growth. In 2025, the company expects sales in the Specialty Medicines segment to rise in a low double-digit percentage at CER, despite the impact from the Inflation Reduction Act or IRA. Specialty Medicines, which now accounts for around 40% of GSK's sales, is expected to be more than 50% of GSK's total revenue by 2031. GSK's Promising Pipeline GSK is increasing R&D investment in promising new long-acting and specialty medicines in Respiratory, Immunology & Inflammation, Oncology and HIV areas. GSK's pentavalent MenABCWY meningococcal vaccine and Blujepa/gepotidacin for treating uncomplicated urinary tract infection ('UTI') were approved in the United States in the first quarter of 2025. Its blockbuster drug Nucala was approved for treating chronic obstructive pulmonary disease or COPD, its fifth indication, in May 2025. Regulatory applications seeking approval of the Blenrep combination for relapsed/refractory multiple myeloma and depemokimab for two indications (chronic rhinosinusitis with nasal polyps or CRSwNP and asthma with type II inflammation) are under review in the United States and some other countries. FDA decisions on all these filings are expected in 2025. Blenrep combinations were approved in the United Kingdom and Japan in April/May 2025. In 2025, GSK expects to launch five new products/line extensions, including Blenrep, depemokimab (severe asthma and CRSwNP), Nucala for COPD, Penmenvy and Blujepa. Of these, Penmenvy, Blujepa and Nucala for COPD are already approved in the United States. GSK's Vaccine Sales Slowing Down GSK's first-quarter Vaccine sales declined 6% due to lower sales of its RSV vaccine, Arexvy, and shingles vaccine, Shingrix. U.S. sales of Shingrix declined 21% in the first quarter of 2025 due to lower demand as a result of challenges in activating harder-to-reach consumers. Arexvy's global sales declined 57% in the first quarter. Revised recommendations for RSV vaccinations issued in June 2024 by the U.S. Advisory Committee on Immunization Practices (ACIP) have been hurting sales of Arexvy from the second half of 2024 in the United States. In June, the ACIP recommended the use of Arexvy for all adults aged 75 and above. However, for adults aged 60-74, the ACIP recommended the vaccine only for those who are at increased risk of severe RSV disease. A challenging macro environment in China and potential for changes in vaccination policies in the United States are expected to hurt Vaccine sales in the near term. In 2025, the company expects sales in the Vaccines segment to decline by a low single-digit percentage at CER. GSK's Price Performance, Valuation & Estimate Movement GSK stock has risen 20.1% year to date compared with an increase of 4.0% for the industry. The stock has also outperformed the sector and the S&P 500 index, as seen in the chart below. The stock has also been trading above 200 and 50-day moving averages since May. GSK Stock Outperforms Industry, Sector and S&P GSK's stock is trading at an attractive valuation relative to the industry. Going by the price/earnings ratio, the company's shares currently trade at 8.63 on a forward 12-month basis, lower than 15.63 for the industry. The stock also trades below its 5-year mean of 10.25. The stock is much cheaper than several other large drugmakers like Eli Lilly LLY, Novo Nordisk NVO, AbbVie ABBV and AstraZeneca. GSK Stock Valuation Image Source: Zacks Investment Research The Zacks Consensus Estimate for earnings has risen from $4.26 to $4.42 per share for 2025 and from $4.71 to $4.82 per share for 2026 over the past 60 days. GSK's Estimates Stay Invested in GSK Stock GSK has its share of problems. Competitive pressure on HIV and respiratory drugs has risen. The dolutegravir HIV franchise patent expires in the 2028-2029 period, and U.S. vaccine sales are slowing down. In 2025, GSK also expects a negative sales impact of £400-500 million due to the impact of the IRA Medicare Part D redesign. However, the company is consistently growing its sales and profits, mainly driven by its Specialty Medicines segment. For the five-year period till 2026, GSK expects to record more than 7% sales growth while core operating profit is expected to increase more than 11% on a CAGR basis. In this period, Specialty Medicines is expected to rise in the low-to-mid teens percentage while General Medicines is expected to rise by a low single-digit percentage. The growth in Specialty Medicines and improvement in General Medicines are making up for a slowdown in the Vaccines unit. The company also resolved the vast majority of Zantac litigations in 2024, which had long been an overhang on the stock. GSK believes it is well-positioned to navigate and mitigate the potential financial impact of tariffs on pharmaceutical imports through supply chain and increased productivity initiatives We suggest investors who own this Zacks Rank #3 (Hold) stock stay invested for now, considering steady sales and profit improvement in the coming years. Consistently rising estimates also reflect analysts' optimistic outlook for future growth in profits. Buying the stock at its present cheap valuation can prove prudent for long-term investors who are interested in buying blue-chip companies. You can see the complete list of today's Zacks #1 Rank (Strong Buy) stocks here. 5 Stocks Set to Double Each was handpicked by a Zacks expert as the #1 favorite stock to gain +100% or more in the coming year. While not all picks can be winners, previous recommendations have soared +112%, +171%, +209% and +232%. Most of the stocks in this report are flying under Wall Street radar, which provides a great opportunity to get in on the ground floor. Today, See These 5 Potential Home Runs >> Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report GSK PLC Sponsored ADR (GSK): Free Stock Analysis Report Novo Nordisk A/S (NVO): Free Stock Analysis Report Eli Lilly and Company (LLY): Free Stock Analysis Report AbbVie Inc. (ABBV): Free Stock Analysis Report
