Latest news with #DariushMozaffarian
Yahoo
18-07-2025
- Health
- Yahoo
A Cardiologist Says This Is the One Vegetable Everyone Should Eat for Better Heart Health
Key Takeaways Rich in monounsaturated fats, fiber, potassium, and antioxidants, avocado supports heart health by lowering LDL cholesterol, reducing blood pressure, and fighting inflammation. Avocado's soluble fiber binds to cholesterol in the digestive tract, helping the body remove it naturally and further reducing heart disease risk. Versatile and mild in flavor, avocado can be easily added to salads, sandwiches, smoothies, and dressings to boost your daily intake of heart-friendly a diet rich in fruits and vegetables is one of the best things you can do for your heart. That's because these foods are high in heart-healthy nutrients, including fiber, minerals, and antioxidants. They're also naturally low in saturated ('bad') fats and sodium, which can have negative effects on the heart. However, there's one vegetable that's particularly beneficial for cardiac health, and it's more impressive than you may think. Read on to learn a cardiologist's pick for the best vegetable for heart health, along with ways to eat it at home. Best Vegetable for Heart Health According to Dariush Mozaffarian, MD, DrPH, cardiologist and director of Food is Medicine Institute at the Friedman School at Tufts University, one vegetable wins in the realm of cardiac health: avocado. Though technically a fruit, avocado is commonly eaten and prepared like a vegetable, and it's highly beneficial for your Our Expert Dariush Mozaffarian, MD, DrPH, cardiologist and director of Food is Medicine Institute at the Friedman School at Tufts UniversityThis is partly due to its rich content of unsaturated fatty acids, or 'good' fats. 'Unsaturated fats come in two major classes, monounsaturated and polyunsaturated,' explains Dr. Mozaffarian. Both types can help manage blood cholesterol levels, a key component of healthy heart function. According to Dr. Mozaffarian avocados contain mostly monounsaturated fatty acids, which help decrease LDL ('bad') cholesterol. This is a noteworthy effect, as high LDL cholesterol levels can increase the risk of heart disease and stroke, per the experts at the Centers for Disease Control and Prevention. Avocado also provides fiber; just half an avocado satisfies 20 percent of your daily fiber needs. This includes soluble fiber, which binds to cholesterol in the intestine and removes it from the body via stool. This reduces cholesterol absorption in the body, thereby supporting healthy blood cholesterol levels and lowering the risk of heart disease. Plus, avocado contains potassium, an essential mineral for heart health. 'Potassium lowers blood pressure and helps offset the harms of sodium,' shares Dr. Mozaffarian. (ICYDK, excess sodium can increase blood pressure, or the force of blood flow against your artery walls.) This can help manage or prevent high blood pressure, or hypertension, another risk factor of cardiovascular disease. To top it off, avocado is teeming with antioxidants. These beneficial compounds fight oxidative stress and inflammation, two factors that also contribute to heart disease. Antioxidants also prevent LDL cholesterol from oxidizing, a process that would otherwise promote plaque buildup in arteries, causing atherosclerosis. If such buildup occurs, it can prevent proper blood flow and lead to heart issues like heart attack and stroke—but antioxidants, like those in avocado, may help reduce the risk. How to Eat More Avocado Equal parts creamy and mild, avocado can be used in many ways. Do your heart a favor and try these delicious avocado recipes, below. Mash It Into Guacamole You can't go wrong with a batch of homemade guacamole. Serve it with tortilla chips, burritos, or sliced vegetables for a boost of fiber and healthy fats. Make a Dressing Make a creamy dressing sans dairy with avocado. Simply toss it in a blender or food processor with spices, lemon juice, and heart-healthy oil (such as olive oil), then blitz until smooth. Pair it with a simple salad, like this Grilled Romaine Salad with Avocado Dressing. Toss In Salads No time to make dressing from scratch? Add chunks, slices, or even half an avocado to your next salad or grain bowl. Try our Grilled Chicken and Corn Salad with Avocado or our Avocado Grain Bowl with Ginger Dressing. Use It In Smoothies Thanks to its rich and creamy texture, avocado can help thicken fruit smoothies. Plus, it has a relatively mild flavor, so it can pair well with a variety of ingredients. Layer In Burgers or Sandwiches For a heart-healthy sandwich upgrade, add a layer of sliced avocado. It's especially tasty in turkey burgers and our Fancy Tomato Sandwiches. Read the original article on Real Simple
Medscape
08-07-2025
- Health
- Medscape
New Advisory Offers First Consensus in Prescribing GLP-1s
Anywhere from 6% to 12% of the US population has taken a GLP-1 agonist. But until now there hasn't been a cohesive message among physicians for how to care for this growing patient population. Last month the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society released a joint advisory that included a list of nutritional and lifestyle priorities to help physicians guide patients on their weight-loss journey. Published in late May in the journal Obesity, the priorities included a baseline nutritional assessment, an understanding of patient goals, management of the most common medication side effects, reduced dependence on ultra-processed foods, prevention of nutrient deficiencies, strength training to prevent muscle loss, and other lifestyle factors that might influence weight loss. 'GLP-1s are reshaping the landscape of obesity treatment, but it's clear that medication alone is not a complete solution,' John E. Courtney, PhD, CEO of the American Society for Nutrition, said in a statement. While the medications can powerfully reduce hunger in patients who take them, they work best in conjunction with lifestyle changes, the most important of which is proper nutrition. An Emphasis on Diet Primary care physicians need to work with patients to better understand their diet before prescribing these medications, said lead study author and Advisory Chair Dariush Mozaffarian, MD, PhD, director of the Food is Medicine Institute of Tufts University, Boston. 'These medications are approved as an adjunct to nutrition and lifestyle therapy and right now they're being used as a first line in most cases,' said Mozaffarian. Asking a simple set of questions about what patients eat in a day, whether they snack, and whether they eat out at restaurants can provide physicians with a good idea of a patient's diet pitfalls. Dariush Mozaffarian, MD, PhD Other barriers to healthy eating can include cost but also knowledge of how to prepare healthy meals, proper cooking equipment, culture, and food traditions around healthy eating. Additionally, some patients might not live near grocery stores. A study published last year in the journal Obesity Pillars found that physicians and dietitians can help patients maximize long-term weight loss results by providing them with personalized guidance. For example, apps that can help patients track nutrition and daily caloric intake as well as personalized advice that can help highlight their dietary sticking points. Additionally, about half of all patients have significant gastrointestinal issues on these medications and eating a healthy, well-balanced diet can help them to stave off some of the most common side effects, including constipation, nausea, and vomiting, said Mozaffarian. This includes tricks of the trade like drinking ample water, eating small meals, getting enough fiber, and avoiding fatty foods. Ramping up dosages of the medications more slowly can also help patients to avoid these symptoms. Reducing Dependence on Ultra-Processed Foods 'Many patients not only eat less but their preferences for foods change and one of the most common themes is that they no longer crave ultra-processed foods that are very sweet or contain artificial ingredients,' said Mozaffarian. These are the foods that can be high in fat and contain chemicals that make people want to keep eating them. There's also research to show that ultra-processed foods are increasing some of the comorbidities that go along with weight gain like diabetes and nonalcoholic fatty liver disease. Some of the chemicals in these foods might also be driving effects on the gut microbiome and intestinal health, said Carolynn Francavilla, MD, a nationally recognized obesity physician who owns and operates Green Mountain Partners for Health and Colorado Weight Care, both in Denver. Staving Off Nutrient Deficiencies What's more, some research has shown that many patients aren't getting ample nutrition because their appetite is so suppressed. One study released in April in Frontiers in Nutrition found that patients on GLP-1s were not getting sufficient amounts of fiber, calcium, iron, magnesium, potassium, and choline as well as vitamins A, C, D, and E. Carolynn Francavilla, MD Focusing on minimally processed foods can help patients to avoid deficiencies that come with the medications. When a patient's diet is drastically reduced, it can make it difficult to get enough protein as well as essential micronutrients. Carefully planning meals to fit in enough protein as well as fruits, vegetables, and whole grains is a great way to ensure that patients avoid deficiencies. However, some processed foods, for example, meal replacement shakes and bars might help patients get enough nutrients when they don't have the appetite they once did. 'These should be an exception because for some patients they can help fill in the gaps,' said Francavilla. Other Lifestyle Factors That Help Optimize Weight Loss Patents not only lose fat on GLP-1s but also lose bone and muscle if they don't participate in strength training at least twice weekly. And as mentioned above, protein, calcium, and vitamin D are also very important for reducing the bone and muscle loss that can lead to frailty later in life. The advisory also names other lifestyle factors like sleep, mental stress, substance use, and social connections as important priorities that can help patients maximize long-term success on these medications. 'GLP-1s help more than all the prior generations of obesity drugs, but that doesn't obviate the need for good physical activity and managing all the other stressors in one's life,' said Ziyad Al-Aly, MD, an assistant professor in the Division of General Medicine & Geriatrics at Washington University School of Medicine in St. Louis. Ziyad Al-Aly, MD Sleep is especially important and can often be overlooked. A wide breadth of research shows that sleep deprivation plays a role in weight loss. A study published in the April 2022 issue of the journal Nutrients found that individuals who slept for 5.5 hours per night lost less fat than those who slept for 8.5 hours per night. Al-Aly noted that one of the lesser known side effects of these medications is that they can cause sleep disturbance. This means that sleep hygiene, for example, going to bed at the same time nightly, avoiding screen time before bed, and avoiding caffeine later in the day are particularly important for those taking these medications. Substance use can also be problematic because while some research has shown that these medications impact the brain reward center, thereby reducing addictive behavior like alcohol abuse, patients who still drink too much are at a much greater risk for dangerous nutrient deficiencies. Physicians need to ensure that their patients are aware of these risks. This advisory is tremendously helpful for physicians in providing a unified message, said Al-Aly. 'This is exactly what prescribers and doctors in patient communities really need, not only to help patients reach dramatic weight loss but to take into account their long-term risk factors and health.'
BBC News
08-06-2025
- Health
- BBC News
Seed oils dey bad for your health?
E don dey fly upandan recently say seed oils like canola and sunflower oil get harmful effects. Dis na true? You fit get bottle of sunflower oil or canola (rapeseed) oil inside your kitchen cupboard. You fit use am cook, spray ontop salad, seed oils dey popular across di world. But dis seed oils don become centre of debate online. For recent years, seed oils don dey collect plenty attack from social media wia some pipo dey claim say e dey "toxic", "poisonous" and dey damage pipo health. Some critics don give some seed oils nickname as 'di hateful eight' - dis dey refer to di eight popular seed oils canola, corn, cottonseed, grapeseed, soy, rice bran, sunflower and safflower - and dey blame dem say na dem dey cause heart diseases and type 2 diabetes. Question be weda na true true say seed oils be di enemy, abi pipo just dey fight dem for no reason? Seed oils dey connected to heart issue? Some pipo wey dey tok against seed oil dey focus on di high omega 6 fatty acid wey dey inside am. Omega 6 fatty acid na essential fatty acid, wey mean say we need dem, but we no fit produce dem oursefs. For recent years, some scientists don argue say omega 6 fit cause chronic inflammation (e fit increase risk of developing diseases wey include heart disease and cancer). But trials wey dem do show say omega 6 fatty acid no dey increase inflammation, na so Dariush Mozaffarian tok. Im be professor and doctor for di Food is Medicine Institute for Tufts University for Massachusetts, US. "New research show say omega 6 fatty acids dey give rise to unique natural molecules like lipoxins, wey get powerful anti-inflammatory effects for body, na so Mozaffarian tok. For recent research wey cover over 200,000 pipo for US wey dey around age 30, di researchers find out say pipo wey dey chop more of plant oil (including seed oils) dey less likely to die from cardiovascular diseases or cancer. On di oda hand, pipo wey dey take in more of butter dey likely to die during di same period. Plenti observational studies about how omega 6 dey affect our hearts dey. Dem dey look into data of diet and health and find out say di two get relationship. But some observational studies dey rely on account of wetin di pipo tok say dem eat, na so Matti Marklund tok. Im be professor of human nutrition for Johns Hopkins Bloomberg School of Public Health for US. E add say dis fit be problem as pipo fit no remember wetin dem eat or dem fit no dey honest about dia diet. Anoda way to measure omega 6 intake na to measure how much di amount of omega 6 individual components and ingredients dey inside pesin diet. However Marklund add say e dey difficult to translate how much of food pesin chop into quantities. Plenty studies wey dey investigate di effects of omega 6 fatty acids on our health dey focus on linoleic acid. Dis na omega 6 fatty acid wey dey in high amounts inside seed oil. Dem don find out say e dey lower bad LDL cholesterol inside blood. For study wey dem do for 2019, Marklund focus on levels of fatty acid for blood of participants from 30 observational studies - wey some role for upto 30 years. E look at how many of dem develop cardiovascular disease and die from am. E find out say di ones wey get di highest levels of linoleic acid for blood, na dem get di lowest risk of developing cardiovascular disease. Anoda allegation dem sama seed oils be say e dey harmful to pipo wey dey eat plenty of omega 6 if you compare am wit pipo wey dey take plenti omega 3. Some confusion dey between omega 6 and health of di heart, na wetin Christopher Gardener tok, I'm be Director of nutrition studies for Stamford Prevention Research Centre for US. Dis na sake of role wey omega 6 dey play wen blood clots happun, Gradner say pipo dey relate am only to stroke and heart attack. E say Omega 3 dey do more of blood thinning. "If you get wound for your hand and you want make e clot, you gas need balance." Meanwhile, scientists conclude for analysis of 30 studies wey dem conduct for 2019 say pipo wey get higher amounts of linoleic acid for dia blood dey 7% less likely to develop heart disease. Linoleic (acid) fit improve cholesterol to reduce di risk of cardiovascular disease, and improve glucose metabolism wey dey reduces di risk of type 2 diabetes, na so Marklund tok. Seed oils and 3.6 ratio Anoda common accuse wey dem sama on seed oils be say to eat plenty omega 6 compared to eating omega 3 dey harmful. For western world, omega 6 fatty acid dey account for around 15% of our total energy intake. Average person ratio of omega 3 to omega 6 fit be upto 50:1. However e suppose be like 4:1 to reduce our risk of cardiovascular disease, according to one study like dat. Review and meta analysis wey World Health Organization do for 2022 report say higher omega 6:3 ratio dey associated wit greater risk of cognitive decline and ulcerative colitis, wey be chronic inflammatory bowel disease. For di oda side, dem link higher omega 3:6 ratio to reduced risk of depression. Di scientists wey conduct di WHO study conclude say higher omega intake of omega 6 fatty acid from sees oils dey unlikely to increase your risk of death and disease - but add say dem need more quality research. But while some scientists dey argue say you no suppose get too much omega 6 for your system pass omega 3, Marklund say e better to take more omega 3, dan to reduce your omega 6, as both get health benefits. How dem dey process seed oils Unlike oda oils, na from plant dem dey from extract seed oils. Some dey concerned say dem dey extract seed oils wit hexane - wey be chemical wey dem make from crude oil - but little evidence dey wey suggest say di process fit cause issue. Researchers don recently find out say omega 6 fit cause growth of one specific type of breast cancer. While some evidence suggest say hexane fit dey linked to plenty health conditions, after dem extract am, dem dey deodorise and bleach am to remove and additives. Scientists fit tok say hexane extract dey normal for food processing, and say di process of deodorizing and bleaching it Dey help remove potential harmful compounds," na so Gardener tok. Seed oils wey dem use cold-press method dey avoid di process completely, as di process involve to squeeze di seeds to extract di oil - but dis result dey more expensive. Seed oils for cause growth of tumours? Upon say plenty research dey wey show di potential benefits of omega 6 on our health, Researcher don recently find out say dis fatty acid fit fuel di growth of specific type of breast cancer. Di findings fit also get implications say di impact of omega 6 consumption on oda diseases. Cancer cells dey use nutrients as fuel to grow and multiply but till now, dem bin get limited research wey dey look at di role wey omega 6 fatty acid dey play. But study wey dem publish for March dis year find mechanism wey linoleic acid, wey be omega 6 fatty acid dey use grow and multiply inside patients wey get triple negative breast cancer (TNBC). Dis na di most aggressive sub-type of di disease and na one wey no dey respond to therapies. Studies wey dem carry out before suggest say nothing dey link omega 6 fatty acid or any small increase in risk, na so Nikolaos Koundouros tok, im be postdoctoral associate for Weill Cornell Medicine Research Centre for New York. But e add say di studies no take into account say multiple sub-types of breast cancer dey, and e dey different from patient to patient unto how dem dey survive or ontop wetin dey cause dem, plus how dem dey respond to therapy. TNBC be like e dey respond pass for linoleic acid, na so Koundouros tok. Koundouros and oda team of researchers discover for lab say wen pesin take omega 6, TNBC cells go activate protein complex wey dey linked to tumor growth and progression. E get anoda protein wey dey in large amount for TNBC tumours, e dey take fatty acids and lipids throughout di body and inside cells to wia dem suppose be. Koundouros explain say dese proteins, along wit omega 6 fit dey responsible for oda chronic diseases like obesity and diabetes. Dis research fit bring new info about how to treat TNBC patients, but e no get wider implications for everyone, na so Koundouros tok. E say "e dey important to remember say omega 6 fats dey essential for some reasons , if you cut dem off, you fit get bad side effects". Which seed oil? Some seed oils like canola and soya bin oil don get more studies pass odas and e get more balanced evidence base. "All dese dey provide balanced combination of healthy fats, including monounsaturated fats, omega 6 polyunsaturated fats, and omega 3 polyunsaturated fats," na wetin Mozaffarian tok. E add say Canola oil get similar anti inflammatory effects and dey produce better improvements for blood cholesterol levels dan olive oil wey dem dey hail as di healthiest of all oils. One meta analysis dem do 27 trials on show say canola oil dey significantly reduce LDL cholesterol wen you compare am to sunflower oil and saturated fat, while anoda one find out say e dey dramatically reduce body weight especially for pipo wey get type 2 diabetes. "Canola oil dey produce excellent benefits for blood cholesterol levels, and dey modestly reduce body weight. Healthy fats wey dey inside canola oil especially omega 6 polyunsaturated fat dey also improve blood glucose, insulin resistance and insulin production," na so Mozaffarian tok. Dem also find out say soya bean dey improve cholesterol levels when you compare am to saturated fat. One study find out say pipo wey dey consume more of soya bean oil get lower risk of death from all causes; 6% lower risk for every 5kg dem consume daily. Which seed oil be di healthiest? "Seeds na one of natures most nourishing gifts; package of beneficial healthy fats,"na wetin Mozaffarian tok. Why plenty pipo dey attack something like dis dey confuse scientists, some wey dey well studied inside nutrition science. But dis misunderstanding fit dey come from "misplaced combination of partial truths", na wetin Mozaffarian tok. For instance, some pipo dey link seed oils to ultra-processed foods (UPFs), we some times dey contain seed oils, like canola, corn, soyabean and sunflower oils. For recent years, huge focus dey on di health risk of consuming too many UPFs, including risk of developing type two diabetes and heart diseases. More like dis: "But dese dangers dey arise from too much starch, sugar and salt, loss of natural intact food structure and dozens or even hundreds of artificial additives," na so Mozaffarian tok. But if you wan draw line between pipo wey dey eat more seed oils and unhealthy outcomes, na unto say we too dey eat food wey get plenty sugar and sodium,"na wetin Gardner suggest. E say e get plenty ways to consume seed oils for house wey no involve UPFs, like to use salad or stir-fry. "I no dey happy to see pipo troway seed oils sake of dis seed oil war," na so Gardner tok. While some scientists want make dem do more rigorous trials to look into di effects of seed oil consumption ontop our health, odas like Marklund dey argue say already, plenty good quality trials dey ground wey dey show benefits on blood cholesterol, blood glucose and insulin levels for general population. "Omega 6 fatty acids dey excellent for health," na so Marklund tok. "E dey linked to lower onset of heart disease, stroke, diabetes and even death from all causes." For better insight into health and wellbeing matter wey Dey rooted in science, sign up for Health Fix newsletter, while di Essential List dey deliver handpicked selection of features and insights. For more science technology, environment and health stories from BBC, make you follow us for Facebook, X and Instagram.
BBC News
31-05-2025
- Health
- BBC News
Are seed oils really bad for you?
Seed oils like canola and sunflower oil have attracted controversial claims about harmful effects in recent times. Is there any truth to them? You might have a bottle of sunflower oil or canola (rapeseed) oil stashed away in a kitchen cupboard somewhere. Whether you cook with them or drizzle them over salads, seed oils are popular across the world. But these unassuming seed oils have become the centre of a heated debate online. In recent years, seed oils have become the target of countless social media posts, with people claiming that they are "toxic", "poisonous" and, ultimately, are damaging our health. Critics have nicknamed some seed oils 'the hateful eight' – referencing eight popular seed oils, canola, corn, cottonseed, grapeseed, soy, rice bran, sunflower and safflower – and blame them for causing heart disease and type 2 diabetes. Are seed oils really the enemy, or is the antagonism towards them unjustified? Are seed oils connected to heart health? Much of the recent criticism of seed oils focuses on their high omega-6 fatty acid content. Omega 6 fatty acids are essential fatty acids, which means we need them, but can't produce them ourselves. In recent years some scientists have argued that omega 6 can cause chronic inflammation (which can increase the risk of developing diseases including heart disease and cancer). But controlled trials have found that omega-6 fatty acids do not increase inflammation, says Dariush Mozaffarian, professor and director of the Food is Medicine Institute at Tufts University in Massachusetts in the US. "New research shows that omega-6 fatty acids give rise to unique natural molecules, like lipoxins, that have powerful anti-inflammatory effects in the body," says Mozaffarian. Recent research studied the diet and health of over 200,000 people in the US for around 30 years. The researchers found that people who consumed more plant oils (including seed oils) were less likely to die from cardiovascular disease or cancer over the course of the study. On the other hand, those with a higher intake of butter were more likely to die during the same period. There are numerous observational studies looking at how omega 6 effects our heart health – where scientists look at data on diet and health, and find associations between the two. But some observational studies rely on people's own accounts of what they eat, says Matti Marklund, assistant professor of human nutrition at Johns Hopkins Bloomberg School of Public Health in the US. And this, he adds, can be problematic because people may misremember, or even be dishonest, about their dietary habits. Another way to measure omega 6 intake is to measure the average amount in the individual components and ingredients in a person's diet. However, Marklund adds, it can be difficult to translate what people say they have eaten into certain quantities. Numerous studies investigating the effects of omega 6 on our health focus on linoleic acid, an omega 6 fatty acid found in high amounts in seed oil, that has been found to lower the 'bad' LDL cholesterol in our blood. In a 2019 study, Marklund instead focused on the levels of fatty acids in the blood of participants from around 30 observational studies – some which followed people for up to 30 years – and looked at how many developed cardiovascular disease and died from it. He found that those with the highest levels of linoleic acid in blood had the lowest risk of developing cardiovascular disease. There is some confusion regarding omega 6 and heart health, says Christopher Gardner, director of nutrition studies at the Stanford Prevention Research Center in the US. This partly stems from omega 6's role in the process of blood clotting, which Gardner says people mistakenly only associate with strokes and heart attacks. Omega 3, he says, tends to be more blood-thinning. "If you had a wound in your hand, you'd want it to clot," he says. "You need balance." Meanwhile, scientists concluded in a 2019 analysis of 30 studies that people with higher amounts of linoleic acid in their blood were 7% less likely to develop heart disease. "Linoleic [acid] might improve cholesterol to reduce the risk of cardiovascular disease, and also improve glucose metabolism, which reduces the risk of type 2 diabetes," Marklund says. Seed oils and the 3:6 ratio Another common accusation levelled at seed oils is that eating too much omega 6 compared to omega 3 is harmful. In the Western world, omega-6 fatty acids account for around 15% of our total energy intake. The average person's ratio of omega 3 to omega 6 can be up to 50:1. However, it should be more like 4:1 to reduce our risk of cardiovascular disease, according to one study. A 2022 World Health Organization review and meta-analysis reported that a higher omega 6:3 ratio was associated with a greater risk of cognitive decline and ulcerative colitis, a chronic inflammatory bowel disease. On the other hand, a higher omega 3:6 ratio was also linked to a 26% reduced risk of depression. Overall, the scientists involved in the WHO study concluded that a high intake of omega 6 fatty acids from seed oils is unlikely to increase your risk of death and disease – but say that more high-quality research is needed. But while some scientists argue that you shouldn't have too much omega 6 compared to omega 3, Marklund says it's better to up your intake of omega 3 rather than consume less omega 6, as both are associated with health benefits. How seed oils are processed Unlike other oils, seed oils are extracted from the seeds of plants. There are some concerns that seed oils are extracted with hexane – a chemical made from crude oil – but there is little evidence so far suggesting that this process can cause issues. While some evidence suggests hexane could be linked to several health conditions, after being extracted, the oil is then deodorised and bleached to remove and additives. "Scientists will say hexane extract is normal in food processing, and the deodorising and bleaching removes potentially harmful compounds," says Gardner. Cold-pressed seed oils avoid this process entirely, as it involves squeezing the seeds to extract the oil – but this results in a more expensive product. Can seed oils fuel tumour growth? Despite an abundance of research showing the potential benefits omega 6 might have to our health, researchers have recently found that this fatty acid can fuel the growth of a specific type of breast cancer. The findings may have implications for the impact of omega 6 consumption on other diseases, too. Cancer cells use nutrients as fuel to grow and multiply, but until now, there was limited research looking at the role omega 6 fatty acids play. But a study published in March this year found a mechanism by which linoleic acid, an omega 6 fatty acid, helps cancer cells to grow and multiply in patients with triple negative breast cancer (TNBC). This is the most aggressive sub-type of the disease, and one that doesn't respond well to targeted therapies. Previous studies suggest there is no association with omega 6 fatty acids, or a small increase in risk, says Nikolaos Koundouros, postdoctoral associate at Weill Cornell Medicine research centre in New York. But these studies, he says, haven't taken into account that there are multiple sub-types of breast cancer, and that they all differ in terms of a patient's survival and prognosis, and how they might respond to targeted therapy. TNBC seems to respond the most to omega 6 linoleic acid, Koundouros says. Along with a team of researchers, Koundouros discovered in the lab that, when fed omega 6, TNBC cells activate a protein complex linked to tumour growth and progression. Another protein, which is found in larger amounts in TNBC tumours compared to other breast cancer subtypes, is known to take fatty acids and lipids throughout the body and within cells to exactly where they need to be. Koundouros explains that these proteins, along with omega 6, may also be relevant in other chronic diseases, such as obesity and type 2 diabetes. This research could potentially inform treatment options for TNBC patients, but it doesn't necessarily have wider implications for everyone, Koundouros says. "It's important to remember omega 6 fats are essential for a reason; if you completely cut them out, you could have detrimental side effects," he says. Which seed oil? Some seed oils – such as canola oil and soybean oil – have been studied more than others, so have a more rigorous evidence base. "These each provide a balanced combination of healthy fats, including monounsaturated fats, omega-6 polyunsaturated fats, and omega-3 polyunsaturated fats," Mozaffarian says. Canola oil, Mozaffarian adds, has similar anti-inflammatory effects and produces better improvements in blood cholesterol levels than olive oil, which has long been hailed the healthiest of all oils. One meta-analysis of 27 trials found that canola oil was found to significantly reduce LDL cholesterol compared to sunflower oil and saturated fat, while another found that it dramatically reduced body weight, especially in in those with type 2 diabetes. "Canola oil produces excellent benefits for blood cholesterol levels, and also modestly reduces body weight. The healthy fats in canola oil, especially the omega 6 polyunsaturated fats, also improve blood glucose, insulin resistance, and insulin production," says Mozaffarian. Soybean oil has also been found to improve cholesterol levels compared to saturated fats. One study found that people who consumed more soybean oil had lower risk of death from all causes; a 6% lower risk for every 5g they consumed daily. Which seed oil is healthiest? "Seeds are one of nature's most nourishing gifts; a package of beneficial healthy fats," says Mozaffarian. That something so well studied within nutrition science has had such a backlash has been a source of confusion for some scientists. But this misunderstanding may come from a "misplaced combination of partial truths", Mozaffarian says. For instance, some people may link seed oils to ultra-processed foods (UPFs), which often contain seed oils, particularly canola, corn, soybean, and sunflower oils. In recent years there has been a huge focus on the health risks of consuming too many UPFs, including increased risk of developing type two diabetes and heart disease. More like this:• What is the healthiest cooking oil?• The truth about saturated fat• Cod liver oil: The fishy fix that was surprisingly healthy "But these dangers arise from too much starch, sugar, and salt, loss of natural intact food structure and dozens, or even hundreds, of artificial additives," Mozaffarian says. Some people have also drawn a correlation with increased consumption of seed oils in recent years and the rise in obesity and diabetes. "But if you want to draw parallels with people eating more seed oils and unhealthy outcomes, it's because we're eating food that tends to contain a lot of sugar and sodium," Gardner suggests. He says there are many ways to consume seed oils at home that don't involve UPFs, such as with a salad or stir-fry. "I'd hate to see people tossing out seed oils because of this seed oil war," says Gardner. Ultimately, while some scientists call for more rigorous trials looking into the effects of seed oil consumption on our health, others, including Marklund, argue that there is already a wealth of good quality trials showing benefits on blood cholesterol, blood glucose and insulin levels for the general population. "Omega-6 fatty acids are excellent for health," says Marklund. "They have been linked to lower onset of heart disease, stroke, diabetes, and even death from all causes." -- For trusted insights into better health and wellbeing rooted in science, sign up to the Health Fix newsletter, while The Essential List delivers a handpicked selection of features and insights. For more science, technology, environment and health stories from the BBC, follow us on Facebook, X and Instagram.
30-05-2025
- Health
Food and fitness make or break success on weight loss meds, report finds
Drugs like Wegovy and Zepbound -- GLP-1 medications typically used to treat obesity -- can lead to impressive weight loss. But a new joint advisory from four major medical groups warns that without proper nutrition and lifestyle support, people may face muscle loss, weight regain, and high long-term costs once they take themselves off GLP-1 medications. Experts from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association and The Obesity Society contributed to the report, which noted that only about half of users continue taking their GLP-1 medication after one year and only about 15% remain on treatment after two years. Many people stop taking GLP-1 medications due to side effects, cost or disappointing results -- and when they do, they often regain weight, making long-term success depend on consistent use and a healthy diet, the report stated. The report aims to guide both clinicians and patients on nutrition and lifestyle changes to improve long-term outcomes while taking a GLP-1. "We really wanted to bring in four major societies together that focus on nutrition, lifestyle, [and] obesity and come with a consensus statement on how nutrition should be thought about when prescribing these drugs," Dr. Dariush Mozaffarian, a cardiologist, director of the Food is Medicine Institute at Tufts University, and the report's lead author, told ABC News. Mozaffarian explained that for someone to achieve success on a GLP-1, they need to commit to comprehensive lifestyle changes. "The FDA says these drugs are approved for use as an adjunct to lifestyle therapy," he said. "In fact, they are prescribed the other way around with lifestyle therapy being the adjunct if being thought about at all. Doctors are not following either society guidelines or FDA guidelines if they are prescribing [GLP-1s] without lifestyle therapy." Before starting GLP-1 medications, the report recommended that patients work with their doctors to set goals that focus on overall health, not just weight loss. It's also important to check for any stomach or bone issues that could lead to side effects like nausea, vomiting, or muscle and bone loss, the report stated. "Registered dietitians can play really key roles in comprehensive obesity care by providing medical nutrition therapy to support GLP-1 therapy," said Emily A. Callahan, registered dietitian nutritionist and director of policy strategy for the Food is Medicine Institute. "The evidence space is growing that shows when registered dietitians deliver medical nutrition therapy, it has been associated with improvements in body weight, waist circumference, blood pressure and glycemic control." People should usually start GLP-1 medications at the lowest dose and slowly increase as needed, the report said. Patients should also be aware that nausea is common when taking these drugs and this may trigger cravings for sugary, high-calorie comfort foods that work against weight loss. To stay on track, the report recommended eating small, frequent meals and focusing on minimally processed, nutrient-rich foods. The report called for exercising special caution for anyone following an intermittent fasting diet or a low-carbohydrate "keto diet" that limits foods like breads, pastas and fruit to put the body into a state called ketosis, where it burns fat for fuel instead of carbs. These individuals might be especially vulnerable to gastrointestinal side effects, the report said. The report also advised people who may not be getting enough nutrients to consider taking supplements like vitamin D, calcium and multivitamins, while increasing protein intake by 50-100% from foods such as fish, eggs, nuts and seeds. This is especially important for those eating less while on GLP-1s, since lower food intake can make it harder to get all the nutrients the body needs. The report also underscored the importance of maintaining muscle mass and bone density while losing weight. Since weight loss can also lead to muscle loss -- especially in older adults -- the report advised doing a full body strength training routine at least three times a week and getting 150 minutes of moderate cardio each week. Focusing on nutrition, physical activity and other healthy lifestyle habits should give GLP-1 users a greater chance of achieving their goals, the report concluded. "GLP-1s have the best chance of helping people achieve and sustain lasting weight reduction when they are paired with strong nutrition guidance and lifestyle support," said Callahan.
