Latest news with #DavidSinclair
Yahoo
29-05-2025
- Health
- Yahoo
At least 350 Harvard medical grants were terminated by the Trump administration. Here are some of them
Amid the Trump administration's battle with Harvard University, hundreds of grants worth millions of dollars for medical research have been canceled. The White House has accused Harvard of allowing antisemitism to go unchecked on campus and of not ending diversity, equity and inclusion practices. In a letter on April 11, the Trump administration argued Harvard "failed to live up to both the intellectual and civil rights conditions that justify federal investment" and proposed terms including changing the school's governance, adopting merit-based hiring, shuttering any DEI programs and allowing "audits" to ensure "viewpoint diversity." The administration then said it was withholding $2.2 billion in multi-year grants and $60 million in multi-year contract value to the institution. Harvard has taken steps such as renaming the Office for Equity, Diversity, Inclusion and Belonging to the Office of Community and Campus Life. Additionally, Harvard's president said the school is committed to making changes to create a "welcoming and supportive learning environment" but argued the Trump administration's requests go too far. At least 350 grants from the National Institutes of Health (NIH), National Science Foundation (NSF) and elsewhere been canceled at Harvard Medical School, excluding the School of Public Health and the School of Engineering, a Harvard University faculty source told ABC News. MORE: Education Department freezes Harvard's research funding, seeking compliance with Trump administration Harvard has said the loss of research funding interrupts work on topics including tuberculosis, chemotherapy, pandemic preparedness, Parkinson's disease and Alzheimer's disease. The school has also said the Trump administration's threats have endangered its educational mission. The Trump administration did not immediately reply to ABC News' request for comment. This includes research for studying biotic resistance, identifying the earliest precursors of breast cancer, breaking barriers to deliver effective drugs for Alzheimer's disease, studying microbial evolution and researching cures for ALS. Scientists at Harvard say the cancellations of their research grants are collateral damage in the battle with the Trump administration and worry some scientific breakthroughs will never be discovered. "I will say that receiving a grant from the NIH is very challenging," David Sinclair, a professor in the department of genetics at Harvard Medical School, told ABC News. "It takes years of work and a lot of effort. You have to go through peer review, and it can take years to get this money, and when you get it -- I've literally dropped to my knees with gratitude of receiving one of these grants. These are a big deal, and they literally are our lifeblood, and to just have that terminated is devastating." Sinclair was inspired to find a cure for ALS (amyotrophic lateral sclerosis), a debilitating neurological disorder, after his partner's mother was diagnosed with it. "We've watched her descend from an active, healthy lady in her 70s to now, where she's on a breathing machine and being saved by a tube," he said. "And our house is an ICU unit with nurses 24/7 and for us, it's a race against time." Sinclair said within the last month, his lab had a breakthrough using artificial intelligence to find both synthetic and naturally occurring molecules that may reverse the aging process and treat ALS. Sinclair received word on May 15 that two grants of his were being terminated. One was an NIH grant awarded to Sinclair's lab on a project to reverse the aging process and the second was a career award given to a postdoctoral researcher in his lab on the ALS project. The career award grant was paying for the salaries of the researcher and two people working under her. Now all three are effectively without salaries unless another form of funding can be found. Sinclair said in the interview that he had not told his partner's mother that the ALS grant has been canceled. "I just feel so concerned for the patients who, like my partner's mother, are counting on us scientists to find treatments and cures for what ails them," he said. "And what do I say to Serena's mom? I haven't talked to her yet. What do I say? That the research that looked so promising is now terminated? That her life is counting on us, and she's just one of millions of people in this country who are counting on the research at Harvard Medical School to make the breakthroughs that will literally save their lives." MORE: Trump admin freezes billions in funding to Harvard University after rejecting demands Similarly, on a search for stopping debilitating diseases, Joan Brugge, director of the Ludwig Center at Harvard Medical School, was studying how to identify the earliest precursors of breast cancer with a goal of designing treatments to prevent them from becoming cancerous. The work was supported by an approximately seven-year grant from the NIH's National Cancer Institute totaling at about $600,000. The grant was in its sixth year with 1.5 more years left. Another canceled grant was a fellowship for a postdoctoral researcher in Brugge's lab. These grants support costs such as training, tuition and fees and child care, according to the NIH. "These kinds of things are going to affect our ability to make progress in the way we want," Brugge told ABC News. "This is not right. Why should Americans be deprived of potential benefits from this research?" Steven Shuken, a postdoctoral researcher at the Gygi Labs at Harvard Medical School, was studying what the barriers are in developing treatments for Alzheimer's disease. He said drugs don't penetrate the blood-brain barrier very well, resulting in failures to receive FDA approval to treat Alzheimer's disease. "They seem to have some effectiveness at some dose, but once you get up to the high dose that you need to see the effect, there are these terrible side effects that come up," he told ABC News. In order to improve future drugs' efficacy and reduce side effects enough to make them safe and effective for Alzheimer's patients, Shuken teamed up with Boston Children's Hospital to see if they could leverage the chorid plexis, a section of the blood-cerebral spinal fluid barrier as a pathway without side effects. Shuken had been awarded a K99/R00 grant, which is for postdoctoral scientists completing research that will eventually lead to a tenure-track or equivalent faculty position. The K99 portion supports one to two years of postdoctoral research training and the R00 portion supports up to three years "contingent on the scientist securing an independent, tenure track faculty position," according to the NIH. Two weeks ago, he received news that the K99 grant – which was awarded last year for two years – was terminated and there is no policy that supports activating an R00 on a K99 that's been terminated, effectively terminating the R00 as well. Shuken said no reason was given for the grant terminations, but he said he did see the letter sent to Harvard from the NIH citing semitism. Trump and other members of his administration have accused the university of fostering antisemitism on its campus, specifically related to pro-Palestinian demonstrations amid the Israel-Hamas war. "Harvard's failure to protect students on campus from anti-Semitic discrimination -- all while promoting divisive ideologies over free inquiry -- has put its reputation in serious jeopardy," Secretary of Education Linda McMahon said in a letter in March. The administration's joint task force, made up of the Department of Education, Department of Health and Human Services and the General Services Administration, is conducting a review of Harvard, saying it is part of an effort to remove alleged antisemitic conduct and harassment. Last year, a federal judge in Boston ruled that Harvard "failed its Jewish students" and must face a lawsuit over antisemitism on campus. Some Jewish students had claimed Harvard had been indifferent to their fears of walking through the campus and facing alleged harassment from pro-Palestinian protesters. However, some Jewish students and faculty members, such as Shuken, said he has not experienced antisemitism during his time at Harvard. He said if there is antisemitism occurring on the main campus, he's not sure why retaliatory grant cuts are affecting the university's medical school. "I will note that I work at the Harvard Medical School quad, which is a half-hour shuttle ride away from the main campus," he said. "So even if there is antisemitism on the main campus, which -- as far as I can tell -- is dramatically exaggerated in certain news outlets, if it's happening over there, it's not happening where I work." Michael Baym was also affected by the grant terminations at Harvard. He said there is a disconnect between the political battle raging between the Trump administration and Harvard and the grants awarded to the medical school that were cut as a result. "Our lab studies bacteria. None of the content of this research is related to a contemporary political or is part of a contemporary political battle," he told ABC News. "There's no sense in it. It's bacteria; how can bacteria be antisemitic?" Harvard has said it is resolved in its commitment to combatting antisemitism and anti-Israeli bias. Baym's laboratory at Harvard Medical School studies the biology of how bacteria become resistant to biotics and what things keep them from gaining resistance. The World Health Organization has called microbial resistance one of the world's top public health and development threats. Earlier this month, Baym learned that five grants to his laboratory and researchers in his lab were being terminated. This included an NIH five-year flexible award to support all basic research in the lab and two NSF grants, one to help study bacteriophages that kill biotic-resistant bacteria, and the other to help study the basic biology of the vectors of biotic resistance. MORE: Harvard hits back 'no legal basis' for Trump move to take away tax-exempt status Additionally, an NIH graduate student grant for a project looking for new bacteriophages was terminated as well as two NIH postdoctoral fellowships that were on the same grant. The total cost of the grants canceled was $4.35 million. Baym said what he thinks many people don't understand is that the grants are not monetary gifts from the government to a rich, private university. They are contracts awarded by panel of impartial experts directly to researchers and to projects. In this case, the researchers happen to conduct their work at Harvard. "That's what's being cut," he said "These grants, this is not a gift to build a dorm. This is a research contract that's being terminated, right." Michael Desai, a professor of organismic and evolutionary biology at Harvard, who was also subject to grant terminations, agreed, saying the grants don't support operations of the university and Harvard's endowment, valued at $53.2 billion, cannot cover all the costs of grants that were terminated. "There's all kinds of specific purposes that donors have designated for their money to be spent on," he told ABC News. "The other thing is that Harvard already spends roughly 5% of the endowment every year. The way to think about it is a retirement account … and it's supposed to last for hundreds of years, rather than dozens." "If they spend more than they already are, then it will, over the course of 10 to 20 years, just be gone, and the university would have to shut down," Desai added. At the time of the terminations, Desai's work was focused on microbial evolution and population genetics, which looks at how microbial populations -- microorganisms -- adapt to new conditions. Desai had three grants terminated on May 15, two from the NIH and one from the NSF. The NIH grants totaled about $300,000 to $350,000 per year in direct costs plus a little under $200,000 per year in indirect costs, and the NSF grant was about $100,000 per year in direct costs and another $69,000 in indirect costs, Desai said. Desai said he wasn't surprised the grants were terminated due to news that the Trump administration was planning on freezing grant money, but he expressed concern for the younger scientists whose research and salaries were being supported on these grants. MORE: Harvard says tuition will be free for families making $200K or less "There's a battle, as we all know, between Harvard and the Trump administration," he said. "It centers around things that have absolutely nothing to do with science. There's broad support for the kind of science we and many other people at Harvard are doing. I don't think it's an intended target, but it's certainly getting caught up in the battle." Desai emphasized the broader impact grant freezing could on have U.S. scientific dominance, highlighting the potential for young American scientists to go aboard or international scientists to not come to the U.S. "Over the past 15 years that I've been at Harvard, I can't think about how many hundreds of emails I've gotten from the smartest people in China and India and Europe and all over the world asking if they could come work with me or my colleagues across the country and basically bring all of their talents to essentially work for us, to work for trying to increase the United States' technological dominance in the world," he said. Desai went on, "I kind of worry that 10 years from now, our smartest students are going to be writing professors in research institutes in China hoping that they can go do science to make China stronger. The bottom line is if we don't invest in this stuff, other people certainly will." At least 350 Harvard medical grants were terminated by the Trump administration. Here are some of them originally appeared on
29-05-2025
- Health
At least 350 Harvard medical grants were terminated by the Trump administration. Here are some of them
Amid the Trump administration's battle with Harvard University, hundreds of grants worth millions of dollars for medical research have been canceled. The White House has accused Harvard of allowing antisemitism to go unchecked on campus and of not ending diversity, equity and inclusion practices. In a letter on April 11, the Trump administration argued Harvard "failed to live up to both the intellectual and civil rights conditions that justify federal investment" and proposed terms including changing the school's governance, adopting merit-based hiring, shuttering any DEI programs and allowing "audits" to ensure "viewpoint diversity." The administration then said it was withholding $2.2 billion in multi-year grants and $60 million in multi-year contract value to the institution. Harvard has taken steps such as renaming the Office for Equity, Diversity, Inclusion and Belonging to the Office of Community and Campus Life. Additionally, Harvard's president said the school is committed to making changes to create a "welcoming and supportive learning environment" but argued the Trump administration's requests go too far. At least 350 grants from the National Institutes of Health (NIH), National Science Foundation (NSF) and elsewhere been canceled at Harvard Medical School, excluding the School of Public Health and the School of Engineering, a Harvard University faculty source told ABC News. Harvard has said the loss of research funding interrupts work on topics including tuberculosis, chemotherapy, pandemic preparedness, Parkinson's disease and Alzheimer's disease. The school has also said the Trump administration's threats have endangered its educational mission. The Trump administration did not immediately reply to ABC News' request for comment. This includes research for studying biotic resistance, identifying the earliest precursors of breast cancer, breaking barriers to deliver effective drugs for Alzheimer's disease, studying microbial evolution and researching cures for ALS. Scientists at Harvard say the cancellations of their research grants are collateral damage in the battle with the Trump administration and worry some scientific breakthroughs will never be discovered. "I will say that receiving a grant from the NIH is very challenging," David Sinclair, a professor in the department of genetics at Harvard Medical School, told ABC News. "It takes years of work and a lot of effort. You have to go through peer review, and it can take years to get this money, and when you get it -- I've literally dropped to my knees with gratitude of receiving one of these grants. These are a big deal, and they literally are our lifeblood, and to just have that terminated is devastating." 'What do I say to her'? Sinclair was inspired to find a cure for ALS (amyotrophic lateral sclerosis), a debilitating neurological disorder, after his partner's mother was diagnosed with it. "We've watched her descend from an active, healthy lady in her 70s to now, where she's on a breathing machine and being saved by a tube," he said. "And our house is an ICU unit with nurses 24/7 and for us, it's a race against time." Sinclair said within the last month, his lab had a breakthrough using artificial intelligence to find both synthetic and naturally occurring molecules that may reverse the aging process and treat ALS. Sinclair received word on May 15 that two grants of his were being terminated. One was an NIH grant awarded to Sinclair's lab on a project to reverse the aging process and the second was a career award given to a postdoctoral researcher in his lab on the ALS project. The career award grant was paying for the salaries of the researcher and two people working under her. Now all three are effectively without salaries unless another form of funding can be found. Sinclair said in the interview that he had not told his partner's mother that the ALS grant has been canceled. "I just feel so concerned for the patients who, like my partner's mother, are counting on us scientists to find treatments and cures for what ails them," he said. "And what do I say to Serena's mom? I haven't talked to her yet. What do I say? That the research that looked so promising is now terminated? That her life is counting on us, and she's just one of millions of people in this country who are counting on the research at Harvard Medical School to make the breakthroughs that will literally save their lives." Similarly, on a search for stopping debilitating diseases, Joan Brugge, director of the Ludwig Center at Harvard Medical School, was studying how to identify the earliest precursors of breast cancer with a goal of designing treatments to prevent them from becoming cancerous. The work was supported by an approximately seven-year grant from the NIH's National Cancer Institute totaling at about $600,000. The grant was in its sixth year with 1.5 more years left. Another canceled grant was a fellowship for a postdoctoral researcher in Brugge's lab. These grants support costs such as training, tuition and fees and child care, according to the NIH. "These kinds of things are going to affect our ability to make progress in the way we want," Brugge told ABC News. "This is not right. Why should Americans be deprived of potential benefits from this research?" Claims of antisemitism Steven Shuken, a postdoctoral researcher at the Gygi Labs at Harvard Medical School, was studying what the barriers are in developing treatments for Alzheimer's disease. He said drugs don't penetrate the blood-brain barrier very well, resulting in failures to receive FDA approval to treat Alzheimer's disease. "They seem to have some effectiveness at some dose, but once you get up to the high dose that you need to see the effect, there are these terrible side effects that come up," he told ABC News. In order to improve future drugs' efficacy and reduce side effects enough to make them safe and effective for Alzheimer's patients, Shuken teamed up with Boston Children's Hospital to see if they could leverage the chorid plexis, a section of the blood-cerebral spinal fluid barrier as a pathway without side effects. Shuken had been awarded a K99/R00 grant, which is for postdoctoral scientists completing research that will eventually lead to a tenure-track or equivalent faculty position. The K99 portion supports one to two years of postdoctoral research training and the R00 portion supports up to three years "contingent on the scientist securing an independent, tenure track faculty position," according to the NIH. Two weeks ago, he received news that the K99 grant – which was awarded last year for two years – was terminated and there is no policy that supports activating an R00 on a K99 that's been terminated, effectively terminating the R00 as well. Shuken said no reason was given for the grant terminations, but he said he did see the letter sent to Harvard from the NIH citing semitism. Trump and other members of his administration have accused the university of fostering antisemitism on its campus, specifically related to pro-Palestinian demonstrations amid the Israel-Hamas war. "Harvard's failure to protect students on campus from anti-Semitic discrimination -- all while promoting divisive ideologies over free inquiry -- has put its reputation in serious jeopardy," Secretary of Education Linda McMahon said in a letter in March. The administration's joint task force, made up of the Department of Education, Department of Health and Human Services and the General Services Administration, is conducting a review of Harvard, saying it is part of an effort to remove alleged antisemitic conduct and harassment. Last year, a federal judge in Boston ruled that Harvard "failed its Jewish students" and must face a lawsuit over antisemitism on campus. Some Jewish students had claimed Harvard had been indifferent to their fears of walking through the campus and facing alleged harassment from pro-Palestinian protesters. However, some Jewish students and faculty members, such as Shuken, said he has not experienced antisemitism during his time at Harvard. He said if there is antisemitism occurring on the main campus, he's not sure why retaliatory grant cuts are affecting the university's medical school. "I will note that I work at the Harvard Medical School quad, which is a half-hour shuttle ride away from the main campus," he said. "So even if there is antisemitism on the main campus, which -- as far as I can tell -- is dramatically exaggerated in certain news outlets, if it's happening over there, it's not happening where I work." Michael Baym was also affected by the grant terminations at Harvard. He said there is a disconnect between the political battle raging between the Trump administration and Harvard and the grants awarded to the medical school that were cut as a result. "Our lab studies bacteria. None of the content of this research is related to a contemporary political or is part of a contemporary political battle," he told ABC News. "There's no sense in it. It's bacteria; how can bacteria be antisemitic?" Harvard has said it is resolved in its commitment to combatting antisemitism and anti-Israeli bias. Grants are not gifts to Harvard Baym's laboratory at Harvard Medical School studies the biology of how bacteria become resistant to biotics and what things keep them from gaining resistance. The World Health Organization has called microbial resistance one of the world's top public health and development threats. Earlier this month, Baym learned that five grants to his laboratory and researchers in his lab were being terminated. This included an NIH five-year flexible award to support all basic research in the lab and two NSF grants, one to help study bacteriophages that kill biotic-resistant bacteria, and the other to help study the basic biology of the vectors of biotic resistance. Additionally, an NIH graduate student grant for a project looking for new bacteriophages was terminated as well as two NIH postdoctoral fellowships that were on the same grant. The total cost of the grants canceled was $4.35 million. Baym said what he thinks many people don't understand is that the grants are not monetary gifts from the government to a rich, private university. They are contracts awarded by panel of impartial experts directly to researchers and to projects. In this case, the researchers happen to conduct their work at Harvard. "That's what's being cut," he said "These grants, this is not a gift to build a dorm. This is a research contract that's being terminated, right." Michael Desai, a professor of organismic and evolutionary biology at Harvard, who was also subject to grant terminations, agreed, saying the grants don't support operations of the university and Harvard's endowment, valued at $53.2 billion, cannot cover all the costs of grants that were terminated. "There's all kinds of specific purposes that donors have designated for their money to be spent on," he told ABC News. "The other thing is that Harvard already spends roughly 5% of the endowment every year. The way to think about it is a retirement account … and it's supposed to last for hundreds of years, rather than dozens." "If they spend more than they already are, then it will, over the course of 10 to 20 years, just be gone, and the university would have to shut down," Desai added. Fear of losing scientists to other countries At the time of the terminations, Desai's work was focused on microbial evolution and population genetics, which looks at how microbial populations -- microorganisms -- adapt to new conditions. Desai had three grants terminated on May 15, two from the NIH and one from the NSF. The NIH grants totaled about $300,000 to $350,000 per year in direct costs plus a little under $200,000 per year in indirect costs, and the NSF grant was about $100,000 per year in direct costs and another $69,000 in indirect costs, Desai said. Desai said he wasn't surprised the grants were terminated due to news that the Trump administration was planning on freezing grant money, but he expressed concern for the younger scientists whose research and salaries were being supported on these grants. "There's a battle, as we all know, between Harvard and the Trump administration," he said. "It centers around things that have absolutely nothing to do with science. There's broad support for the kind of science we and many other people at Harvard are doing. I don't think it's an intended target, but it's certainly getting caught up in the battle." Desai emphasized the broader impact grant freezing could on have U.S. scientific dominance, highlighting the potential for young American scientists to go aboard or international scientists to not come to the U.S. "Over the past 15 years that I've been at Harvard, I can't think about how many hundreds of emails I've gotten from the smartest people in China and India and Europe and all over the world asking if they could come work with me or my colleagues across the country and basically bring all of their talents to essentially work for us, to work for trying to increase the United States' technological dominance in the world," he said. Desai went on, "I kind of worry that 10 years from now, our smartest students are going to be writing professors in research institutes in China hoping that they can go do science to make China stronger. The bottom line is if we don't invest in this stuff, other people certainly will."
NZ Herald
13-05-2025
- Health
- NZ Herald
Asbestos-laced materials wash up on east Auckland beaches, council urges caution
He said the pieces, about 5-10cm in size, were likely from historical construction waste and posed a low health risk unless picked up. 'We are asking people to take a common-sense approach and to simply leave ACM alone for the council to collect. 'Dogs and children should also be prevented from picking up the material.' He said if the pieces are spotted, they should be left undisturbed for the council to collect. Asbestos is a group of naturally occurring toxic, carcinogenic and fibrous silicate minerals that are often found in older buildings. Exposure to asbestos fibres can pose significant health risks, leading to several serious lung diseases, including asbestosis, lung cancer and mesothelioma. Health New Zealand medical officer of health Dr David Sinclair said the riskiest situation was where dust was being generated from asbestos-containing materials being cut or damaged. 'In outdoor settings such as the affected beaches, we'd expect the level of asbestos dust to be minimal, especially when the material is below the high tide mark and damp. 'However, people should inform Auckland Council if they find ACM so it can be removed, and not disturb the ACM pieces or collect them.' Chetty said the exact source of the asbestos continues to evade councillors due to the age of the material and the ability for it have drift through the ocean over a long period of time. 'The ACM we're finding now is likely to be decades-old construction waste that was dumped near the shoreline, which over time has fragmented and dispersed along beaches due to natural processes like tides and weather.' The council has not identified a likely single source of the material but is continuing to conduct investigations. If any members of the public have information that would assist, they are encouraged to report this to healthenforcement@ This is the second time in a week that asbestos has made headlines, with the Auckland War Memorial Museum being forced to close its doors after asbestos dust was detected in various areas.
Wales Online
06-05-2025
- Entertainment
- Wales Online
The Trial release date and cast unveiled as chilling Channel 5 drama hailed 'chillingly plausible'
The Trial release date and cast unveiled as chilling Channel 5 drama hailed 'chillingly plausible' Channel 5 will air a one-off drama which it describes as a "chillingly plausible" legal thriller, The Trial, which is set in the near future and stars Claire Skinner The Trial will air on Channel 5 Channel 5 is gearing up to premiere The Trial, an upcoming hour-long drama billed as a "thought-provoking" and "chillingly plausible" special. Set in a not-too-distant future, the show introduces "Milligan's Law", where parents are held legally responsible for their offspring's crimes. The unsettling narrative probes deep into themes of justice and parental responsibility while questioning the extent of governmental oversight. Viewers will witness the tense legal dilemma of Dione and David Sinclair, whose world turns upside down when their daughter Teah commits a serious crime. The show's premise sets the scene in the UK's conceivable future, stating: "Set in the United Kingdom in the not too near future, The Trial follows Dione and David Sinclair, a couple thrust into a nightmarish legal battle when their teenage daughter, Teah, commits a serious crime. Under a radical new law, parents are no longer just bystanders in their children's actions they are directly accountable." Claire Skinner and Ben Miles lead as Dione and David Sinclair (Image: (Image: CHANNEL 5) ) As the Sinclairs stand trial, they face piercing examination, with their parenting style, life choices, and previous actions under the spotlight. A guilty verdict could lead to life imprisonment. Paul Testar, Channel 5's commissioning editor for drama, has expressed his enthusiasm for the project: "This marks an exciting new direction in our drama slate, embracing one-off, high-impact storytelling that sparks conversation. We're excited to work with Adorable Media who have put together an exceptional team to tell this fascinating story." Article continues below When does The Trial start? The Trial is set to air on Thursday, May 8 at 9pm on Channel 5 and will also be available for streaming on My5. This drama is a one-off special with only one hour-long episode. Set in Britain in 2035, the story revolves around teenager Teah who commits a serious crime, putting her parents Dione and David Sinclair in the middle of a distressing legal battle. They find themselves in the grip of the Office of Judicial Inquisition, a potent new division of the Ministry of Justice, where they are prosecuted as accomplices to juvenile crimes. Under the scrutiny of Judicial Inquisitor Sarah Willis, a relentless law enforcer, every aspect of their past is under examination. Without any legal representation, Dione and David are left to fend for themselves. Sarah Willis is played by Saoirse-Monica Jackson (Image: (Image: CHANNEL 5) ) Who stars in The Trial? Claire Skinner and Ben Miles take the lead roles as Dione and David Sinclair. Claire is recognised for her role as Sue Brockman in Outnumbered. Ben has previously appeared in Coupling as Patrick Maitland, and he portrayed Montague Dartie in The Forsyte Saga. Saoirse-Monica Jackson, known for her role as Erin Quinn in Derry Girls, plays the relentless and unyielding Sarah Willis. Jaz Hutchins (Canary Black, The Return) takes on the role of Lieutenant Simons, while India Fowler (The Agency, Insomnia) portrays the troubled teenage daughter Teah Sinclair. India Fowler plays troubled teenage daughter Teah (Image: (Image: CHANNEL 5) ) Article continues below The Trial airs on Channel 5 on May 8
Yahoo
22-04-2025
- Health
- Yahoo
Best NAD Supplements for Longevity, According to Experts: Wonderfeel
San Francisco, April 22, 2025 (GLOBE NEWSWIRE) -- Best NAD Supplements for Longevity, According to Experts: WonderfeelContent verified by BrandingEx solutions (support@ As interest in longevity supplements surges, one molecule is drawing major attention: NAD. This cellular fuel, short for nicotinamide adenine dinucleotide, plays a critical role in energy production, DNA repair and healthy aging. Beyond supporting energy and cognition, NAD enhances the body's ability to repair damage at a cellular level. This contributes to healthier skin, organs, and tissues as we age. Think of NAD as a molecular safeguard—working silently in the background to preserve function, delay the onset of age-related decline and help you feel younger, longer. Unfortunately, our NAD levels decline steadily after 30, which researchers believe contributes to fatigue, slower metabolism, and other hallmarks of aging. The good news? Boosting NAD through supplements like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) may help restore youthful levels, supporting better cellular health and vitality. In this comprehensive guide, we'll explain what NAD is and why it matters for longevity, according to scientists. We'll dive into the science behind NAD supplements and how they support cellular health. Most importantly, we'll review the best NAD supplements available – including top-rated NMN capsules and NR formulations – with expert insights on their pros, cons, unique features, pricing, and evidence. What is NAD? NAD (nicotinamide adenine dinucleotide) is a vital coenzyme found in every cell of our bodies. Often described as the cell's 'energy currency,' NAD helps turn nutrients into cellular energy (ATP) and is required for over 500 enzymatic reactions. As we grow older, our natural production of NAD gradually slows down, and so do our NAD levels. This decline begins in our early 30s and continues steadily with age. By the time we hit 50, our NAD levels are typically reduced to about half of what they were in our early 20s. While this is a normal part of aging, it's also closely tied to the onset of cellular dysfunction that can pave the way for chronic conditions like cancer, metabolic disorders, and neurodegenerative diseases. According to Dr. Andrew Salzman—a Harvard-trained physician-scientist and prolific inventor whose research includes pioneering work on PARP inhibition and NAD's role in DNA repair for BRCA-related cancers—NAD is nothing short of essential. In his words, it's the core of biology:It powers our energy systems. It helps protect against cancer. And it shields us from age-related decline. Scientifically speaking, NAD enables the creation of ATP (the energy currency of our cells), activates PARP enzymes for DNA repair, and helps defend against oxidative stress, reducing the risk of inflammation, heart issues, gut problems, and more. Leading longevity experts like Harvard geneticist Dr. David Sinclair have publicly championed NAD supplementation, and many research and studies suggest that maintaining higher NAD levels helps support healthy aging. Benefits of NAD Supplements Enhancing NAD levels may lead to numerous health benefits, such as increased energy, sharper cognitive function, support against metabolic issues, and better overall wellness. Below are the key benefits of NAD that are reshaping the way we think about longevity: NAD Boosts Energy and Restores Vitality Many individuals who start taking NAD supplements often experience a noticeable surge in energy. This rapid improvement happens because NAD is essential for powering mitochondrial energy production. As a result, people commonly report feeling less fatigued and more energized, allowing them to stay active and engaged throughout the day. NAD works by increasing cellular energy, which in turn reduces fatigue and enhances overall vitality. In a study consisting of 48 amateur runners, participants who supplemented between 600-1200 mg of NMN, direct NAD precursor, were able to run longer distances and showed better aerobic performance, thanks to their skeletal muscles using oxygen more efficiently. Additionally, anecdotal evidence supports NAD supplements' reputation as a potent energy booster, with many users reporting higher energy levels after consistent use. Other benefits mentioned include relief from aches and pains, faster recovery from hangovers, and reduced jet lag. Since physical discomfort can diminish energy and limit activity—especially in older adults—NAD's ability to alleviate pain may also contribute to improved energy levels overall. NAD Supports Healthy Aging and Cellular Resistance Aging is now officially recognized by the World Health Organization as a health condition—one that involves a gradual decline in cellular function. At the heart of this process is a drop in systemic NAD levels. It's possible to replenish these levels and support the body's natural resilience to aging with NAD. Studies show that boosting NAD helps counteract age-related inflammation, restore mitochondrial function, and protect neurons, all of which are critical for maintaining vitality over time. As we age, the body's ability to repair DNA naturally declines, increasing our susceptibility to diseases and the aging process. Increasing NAD stimulates the activity of sirtuins—powerful protein enzymes that regulate functions like aging, inflammation, detoxification, stress resistance, metabolism, and mitochondrial biogenesis. Sirtuins not only help maintain cellular balance but also influence various genes and respond to environmental factors, making them essential for aging well. Their performance depends on the level of NAD, making it increasingly important to sustain higher NAD levels as we age. Through the activation of sirtuins, NMN can help lower the risk of age-related diseases and support a longer, healthier life by keeping cells in peak condition. NAD Improves Hormonal Balance and Fertility While the initial benefits of NAD supplements are promising, it's important to note that the more significant improvements come with long-term use. Over time, increasing NAD levels can lead to more profound enhancements in overall well-being, especially in key areas like reproductive health, hormonal balance, and fertility. NAD has shown remarkable potential in improving fertility, particularly in aging women. NAD is essential for supporting the body's DNA repair processes, helping to keep the genetic material in oocytes intact and healthy. By preserving this genetic integrity, NAD not only enhances the quality of oocytes but also increases the likelihood of a successful and healthy pregnancy. Ultimately, protecting the DNA in these cells is vital for fertility and the healthy development of future generations. Hence, NAD supplements can extend the reproductive window by boosting ovarian function and maintaining oocyte health. Hormonal balance is also the key to reproductive health and fertility, and NAD plays an important role in regulating levels of hormones such as estrogen. By supporting a healthy menstrual cycle, promoting regular ovulation, and aiding the development of ovarian follicles, NAD may help enhance fertility. While most of the research has been conducted on animal models, the results suggest a promising path for using NAD to improve hormonal balance and support reproductive health in women. NAD Offers Better Sleep Quality If you find yourself tossing and turning at night, desperately seeking a way to achieve restorative sleep and more energized days, NAD might be the solution you need. Research indicates that it significantly reduces insomnia, enhances sleep quality, and boosts daytime performance. With regular use, NMN can help reset your body's natural rhythm and regulate your internal clock. NAD plays a crucial role in managing our sleep-wake cycles, with its levels varying throughout the day. Maintaining optimal NAD levels is essential for improving sleep quality and ensuring stable energy throughout the day. By increasing NAD levels, these supplements enhance sleep quality and help regulate circadian rhythms. A 2022 study spanning 12 weeks found that older adults who took NAD supplements in the evening reported improved sleep quality and felt less fatigued during the day compared to those receiving a placebo. By stabilizing circadian rhythms, NAD seems to optimize our sleep cycles, making it easier to enjoy restful nights and feel revitalized during the day. NAD Improves Metabolic Health and Aids Weight Management Struggling with weight or sluggish metabolism? NAD may offer a surprising solution. Emerging research highlights its role in improving metabolic health by enhancing insulin sensitivity and energy utilization. In one clinical trial, women with prediabetes who took NMN for 10 weeks showed better muscle glucose regulation, indicating stronger insulin action and metabolic balance. Since both aging and poor diet can reduce NAD production, supplementation may help restore balance, reduce fat storage, and improve overall metabolic function. Whether you're trying to prevent metabolic disorders or simply improve how your body processes energy, NAD can be a powerful ally. NAD Protects Skin and Enhances Hair Health Who wouldn't want the secret to youthful, radiant skin? Research from Japan shows that NAD can reverse visible signs of aging by tackling glycation, a process that weakens collagen and elastin. By reducing advanced glycation end products (AGEs), NAD helps keep skin firm and smooth, especially in postmenopausal women. What's more, NAD boosts the production of hyaluronic acid and ceramides—key ingredients for deep hydration—giving your skin that plump, dewy look while enhancing elasticity and firmness. But that's not all—NAD will offer protection from UV damage, strengthening your skin's DNA repair system and reducing the risk of photoaging and skin cancer through the nucleotide excision repair (NER) process. It also shows promise in minimizing stubborn age spots and hyperpigmentation by lowering melanin production in older skin cells. Whether you're aiming to defend your skin against the sun or even out your complexion, NAD could be the multitasking molecule your skincare routine has been missing. Tired of battling hair loss and missing fuller, thicker hair? NAD can take care of both! A 2023 study revealed that NAD combats hair follicle shrinkage, thinning, and reduced density, delivering results similar to those of minoxidil, a popular hair loss treatment. This breakthrough suggests that NAD could be a game-changer for tackling hair loss while encouraging healthier, more vibrant hair growth. NAD Enhances Cardiovascular Health and Heart Function Your heart works around the clock, and NAD may be one of its strongest supporters. Research indicates that raising NAD levels can improve a wide range of heart-related conditions, including high blood pressure, ischemic heart disease, and various forms of cardiomyopathy. These benefits stem from NAD's role in promoting cellular repair, reducing oxidative stress, and improving mitochondrial performance within cardiac tissue. Moreover, NAD activates sirtuins—enzymes that regulate inflammation, metabolic efficiency, and aging. This activation has downstream effects on vascular health, potentially reducing arterial stiffness and supporting a healthy heartbeat. In short, NAD doesn't just benefit your energy levels—it's working behind the scenes to support one of your most vital organs, too. NAD Helps with Detoxification, Including Mold Exposure If you've been exposed to mold or environmental toxins, your body relies on specific enzymes to break these compounds down. Many of these enzymes are NAD-dependent, meaning they require adequate NAD levels to function efficiently. By supplementing with NAD, you may improve your body's ability to detoxify and clear harmful substances like mycotoxins, which can otherwise disrupt hormone levels and immune function. NAD's detoxifying properties are especially important for those living in damp environments or dealing with chronic inflammation related to mold exposure. Supporting NAD levels can strengthen your natural defense systems and help you recover from toxin-related fatigue or illness more effectively. NAD Aids in Menopausal Changes of Body As women navigate the challenges of menopause, symptoms like hot flashes, fatigue, and brain fog can disrupt daily life. One of the underlying causes is a drop in NAD levels, a molecule critical for cellular repair and energy. Boosting NAD offers a promising way to restore vitality during this stage of life. Findings suggest that it not only helps improve hormonal balance and cognitive function but also supports overall well-being, making it a powerful ally for women seeking relief from menopause-related discomfort. Menopause also brings a decline in estrogen, which plays a vital role in managing inflammation and supporting cellular repair. Lower estrogen levels can lead to chronic inflammation and slower tissue recovery, resulting in joint pain, skin changes, and even cardiovascular risks. NAD helps by ramping up the body's ability to repair damaged cells and reduce inflammation, promoting healthier aging. Additionally, it supports bone health by lowering oxidative stress, which in turn could reduce the risk of osteoporosis. Incorporating NAD supplements into your daily routine does more than just boost energy and vitality—it provides the body with the resources to age gracefully, helping you feel rejuvenated from within! How do NAD Supplements Work? If NAD itself is so important, why not just take NAD directly? The catch is that NAD is a large molecule that is not absorbed efficiently when taken orally or intravenously. It cannot enter inside the cells. Instead, most NAD supplements provide NAD precursors – smaller building blocks that your cells readily take up and convert into NAD. The two most popular are NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside). The body relies on these precursors which are absorbed more efficiently and utilize natural biological pathways to boost NAD levels within cells. On a molecular level, both NMN and NR are safe. NMN serves as the direct building block for NAD, acting as an intermediary between NR and NAD. When you take NR, your body first needs to convert it into NMN before it can become NAD. While the conversion process is complex, taking NMN skips a step and gets you closer to the final stage of NAD production. That said, both NMN and NR have been clinically shown to effectively increase NAD levels in the body. Another way people choose to boost NAD is through NAD IV therapy – intravenous infusions of NAD. NAD IV drips have popped up in wellness clinics, and thıs therapy has become pretty trendy lately, with some people turning to it for everything from more energy and better focus to weight loss, addiction and brain trauma recovery. Clinics tout IV NAD for things like addiction detox, chronic fatigue and even anti-aging skin treatments. If you do try NAD IV, know that it's costly (often $500+ per infusion), time-consuming, and any claimed benefits are largely anecdotal at this point. Does NAD IV really work? There's limited scientific evidence. The idea is that by delivering NAD straight into your bloodstream, you'll get an instant boost to your cells. Sounds great in theory—but the research doesn't totally back it up yet. Studies are still pretty limited, and one even found that most of the NAD given through IV just got flushed out in urine, meaning it never made it to the cells where it's actually needed. Plus, some of the studies showing benefits are small or linked to the clinics offering the treatment, which makes them less trustworthy. The most proven and researched way to raise NAD for longevity is by taking oral NAD precursor supplements like NMN or NR. These are generally safe and well-tolerated – human trials report minimal side effects even up to 2000 mg doses per day. These capsules are widely recognized for their convenient and non-invasive approach to increasing NAD levels, particularly appealing for those seeking a safe, gradual increase in NAD levels over time, making it well-suited for long-term use. Best NAD Supplements of 2025 When choosing a high-quality NAD supplement, it's important to look beyond the marketing buzz and focus on a few key criteria. Purity and bioavailability should come first—supplements made with clean, transparent ingredients and formulated for effective absorption are more likely to deliver real benefits. Third-party testing and certifications, like NSF or GMP, are also good indicators that a product meets safety and quality standards. And while premium options may come with a higher price tag, it's worth weighing the cost against the dosage, number of servings, and overall formulation to make sure you're getting solid value for what you pay. Below, we'll review the best NAD supplements available in 2025, according to experts and research, to help you choose the right option for your longevity Youngr™ NMN — Best Overall NAD Supplement Wonderfeel Youngr™ NMN has quickly earned a reputation as one of the most advanced NAD supplements on the market – and for good reason. This patented formula was engineered by Dr. Andrew Salzman, a Harvard-trained MD with over 50 medical patents and nearly 30 years of experience in NAD and cellular health. Wonderfeel Youngr™ NMN stands out with its thoughtful formulation designed to boost cellular energy and support healthy aging. At its core is 900 mg of bioavailable NMN per serving—an effective, direct precursor for raising NAD levels in the body. But what really sets it apart is the synergy of its added ingredients: Hydroxytyrosol from olives, resveratrol from grapes, ergothioneine from mushrooms, and a daily dose of Vitamin D3. Together, these antioxidants not only promote NAD production, but also enhance mitochondrial function, improve energy metabolism, and support brain health. The formula was developed and crafted with maximum absorption and purity in mind. Each batch is made in the USA, third-party tested, and comes with a certificate of analysis to ensure 99% purity. The supplement's antioxidant-rich blend helps protect against oxidative stress and inflammation—two major drivers of aging—making it a compelling option for anyone seeking long-term wellness support, not just a temporary energy lift. Whether you're aiming to stay sharp, feel more energetic throughout the day, or simply age more gracefully, Wonderfeel Youngr™ NMN offers a comprehensive approach. Users may notice improved focus and mental clarity alongside physical vitality. With a price point starting at $73 for a monthly subscription, and the quality of ingredients and the science-backed formulation make it a worthy investment for those prioritizing long-term cellular health and overall well-being. Subscribe and save $15 to experience the benefits of this top-tier supplement. Wonderfeel NMN Capsuls™ Wonderfeel NMN Capsuls™ offers a clean, potent formula for those looking to boost their NAD levels and support healthy aging from the inside out. With 1000 mg of high-purity NMN per daily serving (two 500 mg capsules), this supplement focuses on delivering results without the noise of added fillers or unnecessary ingredients. This daily dosage aligns with the recommendations of longevity expert David Sinclair. These capsules are ideal for those who want a simple, high-dose NAD boost backed by science. They're crafted with bioavailable NMN to ensure effective absorption, and the formula supports a range of benefits—from restoring skin elasticity and improving sleep quality to promoting organ health and brain function. The clean label and minimalist design make it especially appealing for users who want a targeted supplement they can trust, without unnecessary extras. Plus, the capsule format allows for flexibility: beginners can start with one 500 mg pill and gradually increase to the full 1000 mg dose as their body adjusts. Price-wise, Wonderfeel NMN Capsuls™ stands out in the NAD category. At $58 for a one-time purchase or $52 with a subscription, it offers an unbeatable value—just $1.73 per gram of NMN, the lowest price point on the market. Because it's pure NMN, you can easily combine it with other supplements in your regimen (like resveratrol or quercetin) as you see fit. Wonderfeel's NMN Capsuls™ plays nicely in any longevity stack, and provide an accessible way to support vitality and well-being into the Asked Questions What's the ideal daily dose for NAD supplements? Most experts recommend taking between 900 to 1000 mg of NMN per day to see the best results from NAD supplements. Clinical studies show that doses in this range can significantly boost energy, improve endurance, and support healthy aging. While smaller doses like 300–600 mg can still offer benefits, higher amounts tend to be more effective. Research also shows that even doses up to 2000 mg daily are well-tolerated, so the ideal dose can vary based on your personal health goals. When Should I Start Using a NAD Supplement? It is often suggested to begin NAD supplementation around the age of 30, as this is when the body's natural production of NAD starts to decrease. This decline generally begins in the late 20s or early 30s and accelerates with age. NAD plays a critical role in various biological processes, including energy metabolism and DNA repair. As we age, maintaining adequate levels of NAD becomes increasingly important for sustaining cellular health. Are NAD Supplements Safe? Yes, NAD supplements like NMN and NR are considered safe when taken as directed. Clinical studies have shown they are well tolerated, even at higher doses up to 2000 mg, with only mild side effects like flushing or stomach discomfort reported in some cases. However, it's always best to consult your healthcare provider before starting any supplement, especially if you have existing health conditions. When Will NAD Supplements Take Effect? Most people begin to notice subtle improvements—like increased energy, better focus, or improved sleep—within a few weeks of consistent use. However, the most significant benefits, such as enhanced endurance, metabolic health, or cognitive support, tend to build gradually over time. NAD supplements work at the cellular level, so while changes may not be dramatic overnight, many users report meaningful improvements over the course of one to two months. Keeping a journal can help track these gradual shifts and better understand how your body responds. Final Thoughts NAD is more than a wellness trend; it is a cornerstone of cellular health and healthy aging. As research continues to highlight the link between NAD levels and longevity, more individuals are turning to trusted precursors like NMN and NR. Whether you're just beginning your journey or fine-tuning an existing routine, the best NAD supplements combine clean formulations, solid science, and proven efficacy. 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