Latest news with #Dermatologists
Medscape
4 days ago
- Health
- Medscape
IL-23 Inhibitors Show Highest Drug Survival in Psoriasis
Interleukin (IL)-23p19 inhibitors guselkumab and risankizumab demonstrated the highest drug survival for effectiveness and safety comparable with ustekinumab over 2 years, exceeding that of all other biologics. IL-17 receptor inhibitor brodalumab showed comparable effectiveness and safety with adalimumab and secukinumab. METHODOLOGY: Researchers conducted a cohort study using data from the British Association of Dermatologists Biologics and Immunomodulators Register from November 2007 to June 2023 and compared the drug survival of all current commonly used biologics in patients with chronic plaque psoriasis (median age at therapy initiation, 48 years). The analysis included 19,034 treatment courses across the following biologics: Tumour necrosis factor-alpha inhibitor adalimumab (n = 6815), IL-12/23p40 inhibitor ustekinumab (n = 5639), IL-17A inhibitors secukinumab (n = 3051) and ixekizumab (n = 1072), IL-17 receptor inhibitor brodalumab (n = 367), and IL-23p19 inhibitors guselkumab (n = 1258) and risankizumab (n = 832). Multivariable flexible parametric models assessed drug survival, with discontinuation due to ineffectiveness and adverse effects reported separately. Researchers also calculated the restricted mean survival time (RMST) at 2 years for each biologic and the difference in RMST between all comparator biologics. The overall median follow-up duration was 2.3 years. TAKEAWAY: Guselkumab and risankizumab demonstrated the highest adjusted survival time for effectiveness (RMST, 1.93 years for both; 95% CI, 1.91-1.95 and 1.90-1.96 years, respectively). Risankizumab showed the highest survival for safety (1.94 years; 95% CI, 1.92-1.96 years), followed by guselkumab (1.92 years; 95% CI, 1.90-1.94 years) and ustekinumab (1.92 years; 95% CI, 1.91-1.93 years). Brodalumab exhibited a lower adjusted survival time for effectiveness (1.75 years; 95% CI, 1.69-1.81 years) than most biologics except secukinumab and adalimumab and lower drug survival for safety than all biologics except the IL-17A inhibitors and adalimumab. Among the IL-17A inhibitors, secukinumab exhibited significantly lower adjusted drug survival than ixekizumab for effectiveness but had a significantly higher safety profile. Prior exposure to biologics was associated with a decline in survival, with significantly larger reductions observed for IL-17 inhibitors. IN PRACTICE: "Drug survival is high with IL23p19 inhibitors. People with psoriasis persist with IL23p19 inhibitors up to an estimated 21 weeks more for effectiveness and 13 weeks more for safety compared with other biologics over a 2-year period on average," the authors wrote. "This evidence on the absolute difference in time persisted on biologic may help clinicians and patients make an informed decision on choosing the right biologic, including differentiating between different classes of biologics based on the patient's history of having PsA [psoriatic arthritis] or not, their treatment history, and whether they prioritize treatment longevity," they added. SOURCE: This study was led by Leila Motedayen Aval, The University of Manchester, The Dermatology Centre, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, England. It was published online on May 29, 2025, in the Journal of the European Academy of Dermatology and Venereology . LIMITATIONS: This study was limited by missing data for newer biologics, particularly IL-17A inhibitors and IL-23p19 inhibitors, and shorter follow-up periods for newer treatments. Residual selection bias may have been present. Additionally, researchers could not evaluate dosing regimens due to missing data for over 50% of dosing frequency information for secukinumab, and results may not be generalisable beyond the UK and Republic of Ireland healthcare systems. DISCLOSURES: The British Association of Dermatologists Biologic Register Ltd receives income from AbbVie, Almirall, Eli Lilly, J&J, Leo Pharma, Novartis, Samsung Bioepis, UCB, BI, and BMS for providing pharmacovigilance services. This research was supported by the National Institute for Health and Care Research Manchester, Guy's and St Thomas' and Newcastle's Biomedical Research Centres. Several authors reported receiving grants or personal fees and having other ties with various sources.
Forbes
6 days ago
- Health
- Forbes
11 Products To Help Traveling Dads Improve Their Next Trip
When Dad is home after a trip, reward him with the gift that fits his personal interests and can make his travels more comfortable and feel like his routine at home. These gift ideas can help you make the right Father's Day gift choice for frequent-flying dads. Everyone has their own interests, and when they travel, it can be hard to keep up with their daily routines. These suggestions could prove to be the best present or at least spark an idea for the right gift for the dads in your life. Frequent travel can take a toll on skin, immune functions and the way you look and feel. These gifts can help take some of the pressure off your daily routine by fast-tracking your body's normal behaviors . The health revival supplement powder comes in large containers, but also single-use packets. The travel-friendly ARMRA Colostrum, bioactive food powder is easy to add to a glass or bottle of water anywhere you are. It comes in a variety of combinations that serve different purposes, such as a fitness-focused formula that helps to regenerate and recover muscles and immune revival designed to restore gut health. These formulas help keep toxins, allergens and pollutants from crossing into the bloodstream to improve your overall health and wellness. It comes in a large powder container, but also single-use packets that are easier to use when traveling. This skincare set includes details on the order in which you should use each product throughout the day. Dermatologists helped design these skincare products that support the dad that spends time outdoors, but also in the air. Dry skin and sun damage are two common problems as men age, and this TSA-friendly bundle includes salicylic acid face wash for clean skin, face cream with SPF15, retinol cream for pre-sleep moisturizing and eye cream. The Deluxe Skincare Set from Geologie can help dads fight signs of aging, even when they travel. These products come in eco-friendly glass packaging. This anti-aging serum and all-day moisturizer from Poth Skin comes in TSA-friendly-sized packaging and is both vegan and fragrance-free. Many self-care products may have a scent that means dads are less interested in using it, but not these U.S.-made creams and serums. They also come in sustainable glass packaging and use dermatologist-recommended ingredients like hyaluronic acid and squalane for a refreshed healthy look that does not feel sticky after application. The anti-aging serum uses Vitamins B, C and E plus ferulic acid to firm the skin and help reduce wrinkles. Finding time to exercise, as well as to recover from a workout, during a busy travel schedule can be tough. But, frequent-traveling dads should not have to sacrifice well-being when traveling for work. These gifts can help him keep his routine when on the road. These healing balms are ideally sized for travel, but are not liquid. Forget having to bag small liquids for TSA or security to inspect. Dr. Doug's toxin-free, dermatologist-approved, healing balms are pocket-sized solids that perform a variety of self-care functions. The 'best seller's toolkit' includes the miracle balm designed for dry, itchy skin, magnesium balm for general aches and muscle cramps, and recovery balm that is ideal for athletes. The BULLBAR 2.0 is easy to travel with, especially on road trips, but also to set up as a makeshift home gym. The BULLBAR is a portable, pull-up machine that fits easily into the trunk of a car and takes only minutes to set up. If you don't have a gym to visit when traveling, this is an easy alternative and has been used for years by members of the U.S. Navy and Air Force Special Warfare teams. An online fitness program makes guided workouts an added bonus to learn how to do pull-ups, dips and pushups for maximum strength and core training. Its construction is sturdy and weighs 47 pounds, but when not in use, it can easily be stored in a closet. This classic carry-on bag stands out from the overhead bin pack, which tends to be dominated with hardside bags. The Hartmann Tweed Carry-On Expandable Spinner blends a bit of vintage style with the efficiency that frequent flyers that pack light are looking for on their next trip. Not only does this bag have a distinctive look, it appeals to all ages, too. This 22-inch, four-wheel rollaboard fits into most airline sizers, but can also expand when you do a little extra shopping when away from home. It is made of a 100% Nylon tweed fabric that is also stain resistant, key for fabric-covered bags. Inside, there is a special garment bag to keep suits and dress shirts free from wrinkles. It can also be removed entirely when not needed or if you want to hang it in the closet. Other clothes can stay in place thanks to straps with an easy clasp. The smooth and sturdy wheels roll easily across any surface, and the handle can retract into 12 different positions. All of this comes with Hartmann's 10-year global warranty making this an investment worth the price. This razor has multiple trimming heads for different lengths making it ideal for beard, mustache and body. Dads need not pack extra shaving tools on their next trip because Double Header Electric Trimmer are a multi-purpose trimmer for both beard and body hair. When traveling light, a three-in-one electric trimmer and razor can save space and weight. The power trimmer sits on one end while a multi-razor blade for standard shaving is on the other. It is a fast-charging razor that fits easily into a dopp kit or toiletry bag. These blankets have a variety of uses and are a favorite of dads that like to spend time outdoors. The Outer bug shield blanket solves a problem that camping, barbecue and beach-loving dads and their families experience every summer. It slides easily into the outer pocket of a carry-on bag for any outdoor adventure, but also is a great gift to put into a golf or gym bag, too. This blanket is lightweight and soft, but also treated with a EPA-registered repellant to keep flies, mosquitoes, ticks and fleas at bay. It doubles as a comfy warmer on chilly nights, or a chair cover at the beach or even works as a table cloth for picnics. It comes in a variety of colors and patterns, all made from recycled fibers and machine-washable fabric. This powerful, handheld tool is always connected, thanks to a built-in SIM card, and provides some of the most accurate language translation on the market. While free apps and even Google will translate from most major languages, experts still say there are mistakes (often related to regional vocabulary differences). The Vasco Translator V4 provides lifetime access to translate to or from 112 global languages with far better precision. It uses artificial intelligence to pass phrases and grammar through ten different language engines to achieve a more accurate translation. It comes with a built-in SIM card that works immediately in almost every country without any installation or additional data charges. It can translate 82 languages via voice, 107 via text and 112 just by snapping a photo. You can also learn new languages using its app with vocabulary challenges and chat room features with other users.
Times
08-05-2025
- Health
- Times
The best LED face masks of 2025
Once upon a time LED masks and red light therapy were reserved for fancy facials, exclusive spas and the hands of highly-qualified dermatologists. But now, thanks to the beauty tech revolution, you no longer have to visit clinics for that hit of red light. Easy-to-use LED face masks are dominating the at-home beauty gadget market and becoming a non-negotiable in skincare devotees' weekly routines. With more options out there than ever before and some devices costing over £1,000, we've consulted dermatologists and skincare experts to bring you the ultimate guide to the best LED face masks money can buy in 2025. • This article contains affiliate links that earn us revenue Red light therapy for skin — the basics Right light therapy (RLT) is a non-invasive treatment that uses red light to improve skin appearance. How does it work? It uses low levels of red light to stimulate skin cells, helping them produce more energy and repair themselves. Advertisement What is it used for? Red light therapy and the consistent use of LED masks at home can help with many skin concerns. Red light works to soothe inflammation so results can be especially visible on those with pigmentation, redness and skin conditions such as eczema. It can also help with signs of acne and ageing. Who uses it? While light therapies used to be exclusively reserved for dermatologists as part of clinical treatments, at-home devices that use red and near-infrared light in LEDs face masks now mean you don't even have to leave the house. LED face mask types During fancy facials you would usually lie beneath a curved red light panel, whereas at-home LED masks can be fitted and adjusted to your face shape which in turn can improve outcomes. Medical aesthetics expert Dr Hany Abi Ghosn recommends choosing an LED mask that's flexible and made of medical-grade material rather than a hard-shelled mask. 'This ensures that the device can mould around the curves of the treatment areas and absorb as much of the emitted light as possible,' he says. While a full sheet that wraps across the face is the most commonplace, new innovations in the LED world include under-eye LEDs like MZ Skin by Dr Maryam Zamani's eye patches which target under-eye lines, wrinkles and visible signs of fatigue. Other designs include LEDs for the neck and décolletage and even helmets that emit red-light wavelengths to potentially help with hair growth. There are specialist designs to target blemishes, anti-ageing and portable options perfect for travelling, too. LED face masks — a dermatologist's view Dr Hany Abi Ghosn, an expert in medical aesthetics with a focus in non-surgical procedures including light therapy, has partnered with leading LED face mask brand Omnilux on a skincare range that optimizes light therapy results before, during and after treatments. Advertisement 'LED therapy is non-invasive and works naturally with the skin's healing process. Unlike UV light, LED light does not damage the skin but enhances its ability to repair itself, making it a safe and effective treatment for a wide range of conditions like acne, pigmentation, and ageing,' he says. 'These masks stimulate collagen production helping improve skin elasticity and reduce the appearance of ageing.' When it comes to LEDs, more lights aren't necessarily better, Dr Hany adds, as the irradiance in each LED bulb will spread across the skin. 'However, when the LEDs are positioned with too much space between them, it lowers the light concentration. Your skin must absorb the optimised wavelengths of light to reap the complete benefits of LED therapy,' he says. 'To ensure optimal absorption, consider the device's output intensity and proximity to your skin.' The best LED face masks to buy now The dermatologist-approved LED mask: Omnilux Contour Face This dermatologist-recommended LED mask from Omnilux reduces the appearance of fine lines and wrinkles. Unlike some hard shell face masks, this device is crafted from a flexible silicone designed to hug the contours of the face and target those hard to reach areas. It uses both red (633nm) and near-infrared (830nm) wavelengths and is one of the most powerful LED devices on the market, equipped with 132 medical-grade LEDs. The brand recommends using it 3 to 5 times a week to see the best results. £348, Omnilux The latest LED face mask: UKSkin LED dual light pro-therapy face mask UKlash, one of the leading lash serum brands, has released a hotly anticipated LED face mask, which attracted a waitlist of more than 1,000 people ahead of its launch. A combination of red and near-infrared light using 112 medical grade LEDs, it is crafted from a soft-touch silicone and ergonomically designed to mould to different shapes and sizes. The mask has been developed in collaboration with experts with more than 25 years experience to mimic the quality of salon treatments and help you achieve your skin goals — whether that be helping potentially brighten or tighten skin — from the comfort of your own home. £199, UKSkin The luxury LED face mask:Déesse Pro LED phototherapy mask One of the most expensive LED masks in the beauty gadget space is the Déesse Pro and for good reason — it is the most versatile with four different wavelengths across six different treatment modes to suit all skin concerns. The classic red light is supposed to purify, while the bacteria-killing blue can help reduce signs of acne. A brightening green, is a soothing post-procedure setting according to the brand, which can help boost circulation to promote skin healing. £1,440, Déesse Pro at Cult Beauty Advertisement The anti-ageing LED face mask: FAQ 201 ultra-lightweight silicone LED Mutlitaskers will love FAQ's ultra-lightweight, wireless LED mask, which is cleverly designed with an open eye area so you can read, work and scare your postman while reaping the benefits of red, green and blue light that target dark spots, fine lines and potentially help increase plumpness. Crafted from a unique flexi-silicon, this mask comfortably molds to your face like a second skin and features 600 optimized points of light. The brand also has LEDs specifically for your hands, neck and decolletage available. £449, FAQ at Harrods The acne LED face mask: Dr Dennis Gross DRx SpectraLite FaceWare Pro Former skin cancer researcher turned leading dermatologist, Dr Dennis Gross's best-selling LED mask uses both red and blue light, with the latter setting helping reduce acne-causing bacteria and the former aiming to reduce texture. In contrast to other masks that offer on average 10 to 15 minutes of treatment time, Dr Dennis Gross's version runs for a speedy 3 to 5 minutes. 'If acne reduction or collagen stimulation are your desired outcome, multiple sessions won't hurt you, but they also won't help,' he says. 'Skin cells become fully saturated after one three-minute session and can't absorb any additional light energy.' £465, Dr Dennis Gross at Look Fantastic The hair LED mask:CurrentBody LED Hair Growth Helmet Powered by red light (at 620-680nm wavelengths) this unique helmet covers the whole scalp. The idea is the light will help stimulate blood flow in the scalp and ensure hair follicles are kept in the hair growth phases to counteract hair thinning and shedding. CurrentBody's LED for hair also features built-in headphones which you can connect via bluetooth if you can't stand to sit through the 10-minute session in silence. £650, CurrentBody The portable LED skincare light: Solawave 4-in-1 radiant renewal skincare wand A futuristic, robo-esque mask is all well and good but to see the real benefits of red light therapy, dermatologists recommend using an LED mask consistently, and not taking a break every time you go on holiday. Thankfully, Solawave's nifty little wand is no bigger than a shaving razor so is pretty portable. As well as emitting red light which works on fine lines, dark circles and unwanted texture, the tool also gently massages the face which will hopefully promote better circulation. £119.99, Solawave at Healf The LED under eye patches:MZ SKIN LightMAX MiniPro Eyeconic LED eye device Combining the soothing element of a traditional under eye mask with the new tech of red light, this MZ Skin LED eye device is designed to stimulate collagen production and reduce the look of under-eye lines and dark circles. It features a hydrocolloid patch on the inside of the tool which includes skin-loving ingredients like niacinamide to brighten and hydrating sodium hyaluronate. £300, MZ Skin Advertisement LED mask colours — explained Blue Blue light penetrates the skin and can help kill acne-causing bacteria. It can also be used to reduce inflammation of active spots and the redness of scarring, as well as helping to prevent future breakouts as it regulates the sebaceous glands which are responsible for the production of oil. Red The most widely used light therapy, red LEDs are used to calm and plump the skin. Infrared light is found in most home LED masks and have longer wavelengths that in theory penetrate deeper than any other shade so it is ideal for treatments for the signs of aging. Green Although a green light setting isn't available on all at-home LED masks, if your main skin concern is pigmentation, it would be wise to invest in a device that has one. The light gets to work targeting any excess melanin (the pigment responsible for dark spots) clusters within the skin cells. Yellow You might struggle to find an at-home LED device that offers a yellow or amber setting, but it is believed to reduce swelling and create a more radiant complexion when used.
