Latest news with #Diabetology
Medscape
20-05-2025
- Health
- Medscape
Surgery Treats Hypertension in Patients With Adrenal Tumours
In patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (MACS), adrenalectomy was well tolerated and enabled a reduction or cessation of hypertensive treatment while maintaining blood pressure within normal ranges. METHODOLOGY: Researchers conducted this clinical trial in university hospitals across Europe to assess the effect of adrenalectomy on hypertension in patients with unilateral benign adrenal incidentalomas and MACS. They enrolled patients with a unilateral adrenal adenoma (≥ 2 cm) and MACS, in whom hypertension was confirmed through multiple home blood pressure measurements; a standardised stepped-care antihypertensive treatment was implemented until the measurements normalised to less than 135/85 mm Hg. A total of 52 patients (median age, 63.3 years; 69% women) were then randomly assigned to either undergo adrenalectomy or receive conservative management and were followed up for 13 months; after randomisation, antihypertensive medications were adjusted on the basis of the stepped-care treatment approach. The primary outcome was the proportion of patients in each group who reduced their antihypertensive treatment by at least one step while maintaining normal home blood pressure measurements (< 135/85 mm Hg). TAKEAWAY: A higher proportion of patients in the adrenalectomy group were able to reduce antihypertensive treatment by at least one step while maintaining normal home blood pressure measurements than those in the conservative management group (46% vs 15%; adjusted risk difference, 0.34; P = .0038). = .0038). Among the patients who underwent adrenalectomy, more than half (52%) were able to discontinue all antihypertensive medications while maintaining normal systolic home blood pressure measurements (< 135 mm Hg); however, none of the patients achieved this after conservative management. Serious adverse events were reported in 35% of patients who underwent adrenalectomy and 31% of those who received conservative management, with no deaths reported in either group. IN PRACTICE: "For individuals with hypertension and clear biochemical evidence of MACS, especially those with larger adrenal adenomas, this study helps support the case for adrenalectomy," experts wrote in a commentary. SOURCE: This study was led by Antoine Tabarin, MD, Department of Endocrinology, Diabetology, Metabolism and Nutrition, CHU Bordeaux, Bordeaux, France. It was published online on May 12, 2025, in The Lancet Diabetes & Endocrinology . LIMITATIONS: This study was limited by a small sample size. The criteria used for diagnosing adrenal insufficiency might have led to the overdiagnosis and potential overtreatment of patients. The findings cannot be extrapolated to patients with bilateral adrenal incidentalomas and MACS. DISCLOSURES: This study was supported by a grant from the French Ministry of Health, and the German part of the study was additionally supported by the German Research Foundation. Some authors reported receiving honoraria, research grants, and support for attending meetings and having several other ties with various pharmaceutical companies and other sources.
NDTV
15-05-2025
- Health
- NDTV
Your Gut Decides Your Mood: Nutritionist Shares Tips To Heal Your Gut
Ever felt 'butterflies' in your stomach? This might be due to the strong link between the gut and the brain, according to a Harvard study. Anxiety can lead to digestive issues, and gut problems can, in turn, trigger anxiety. Emotions like anger, grief, happiness, and nervousness all have the power to affect your gastrointestinal system. In her latest Instagram post, nutritionist Nmami Agarwal sheds light on this mind-gut connection, stressing that 'poor gut health can trigger anxiety.' She suggests that instead of relying heavily on pills, a few simple lifestyle changes can go a long way in improving your gut health and in turn, your mental well-being. View this post on Instagram A post shared by Nmami - Dietitian|Nutritionist (@nmamiagarwal) The close connection between the gut and the brain makes it easy to understand why you could experience nausea prior to a presentation or intestinal pain when under stress. That said, it doesn't imply that functional gastrointestinal disorders are fictitious or "all in your head." Nmami Agarwal said in her latest post that 90 per cent of serotonin (our happy hormone) is made in our gut. Thus, maintaining good gut health is extremely important. She said that sugar and processed foods feed bad gut bacteria which results in mood dips, and suggested to opt for fermented foods and fibre. 'Happy gut, happy mind,' Nmami Agarwal wrote, before adding that your mood will flow if you nourish your gut. Consuming excessive amounts of sugar may "directly affect the composition and functionality of the gut microbiota," according to a report in Diabetology. Whole foods that contain natural sugars are safe to consume since the body breaks them down gradually and uses them to power its cells. Free sugar is the culprit. Free sugars can be present in fruit juices as naturally occurring sugars or as added sugar, which usually serves to increase sweetness and flavour or extend shelf life. Nutritionist Nmami Agarwal earlier shared that a healthy gut is associated with improved digestion, weight management, and even mental clarity. "Good nutrition = Good gut health = Better mood!" she said at the time, before adding that your gut is home to "trillions of microbes that influence everything—from digestion to mental clarity." Nmami shared 5 tips to improve gut health, which include eating various fruits, vegetables and whole grains for fibre, and including probiotics (curd, kimchi) and prebiotics (garlic, bananas) in your diet. She also advised to limit processed foods and excess sugar; stay hydrated; and eat your meals mindfully. Disclaimer: This content including advice provides generic information only. It is in no way a substitute for a qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.
