Surgery Treats Hypertension in Patients With Adrenal Tumours
In patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (MACS), adrenalectomy was well tolerated and enabled a reduction or cessation of hypertensive treatment while maintaining blood pressure within normal ranges.
METHODOLOGY:
Researchers conducted this clinical trial in university hospitals across Europe to assess the effect of adrenalectomy on hypertension in patients with unilateral benign adrenal incidentalomas and MACS.
They enrolled patients with a unilateral adrenal adenoma (≥ 2 cm) and MACS, in whom hypertension was confirmed through multiple home blood pressure measurements; a standardised stepped-care antihypertensive treatment was implemented until the measurements normalised to less than 135/85 mm Hg.
A total of 52 patients (median age, 63.3 years; 69% women) were then randomly assigned to either undergo adrenalectomy or receive conservative management and were followed up for 13 months; after randomisation, antihypertensive medications were adjusted on the basis of the stepped-care treatment approach.
The primary outcome was the proportion of patients in each group who reduced their antihypertensive treatment by at least one step while maintaining normal home blood pressure measurements (< 135/85 mm Hg).
TAKEAWAY:
A higher proportion of patients in the adrenalectomy group were able to reduce antihypertensive treatment by at least one step while maintaining normal home blood pressure measurements than those in the conservative management group (46% vs 15%; adjusted risk difference, 0.34; P = .0038).
= .0038). Among the patients who underwent adrenalectomy, more than half (52%) were able to discontinue all antihypertensive medications while maintaining normal systolic home blood pressure measurements (< 135 mm Hg); however, none of the patients achieved this after conservative management.
Serious adverse events were reported in 35% of patients who underwent adrenalectomy and 31% of those who received conservative management, with no deaths reported in either group.
IN PRACTICE:
"For individuals with hypertension and clear biochemical evidence of MACS, especially those with larger adrenal adenomas, this study helps support the case for adrenalectomy," experts wrote in a commentary.
SOURCE:
This study was led by Antoine Tabarin, MD, Department of Endocrinology, Diabetology, Metabolism and Nutrition, CHU Bordeaux, Bordeaux, France. It was published online on May 12, 2025, in The Lancet Diabetes & Endocrinology .
LIMITATIONS:
This study was limited by a small sample size. The criteria used for diagnosing adrenal insufficiency might have led to the overdiagnosis and potential overtreatment of patients. The findings cannot be extrapolated to patients with bilateral adrenal incidentalomas and MACS.
DISCLOSURES:
This study was supported by a grant from the French Ministry of Health, and the German part of the study was additionally supported by the German Research Foundation. Some authors reported receiving honoraria, research grants, and support for attending meetings and having several other ties with various pharmaceutical companies and other sources.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Business Wire
3 hours ago
- Business Wire
Workplace Injuries Are Reduced with Employee Appreciation
LOUGHTON, England--(BUSINESS WIRE)--Latest research reveals that frequently recognising employees for their efforts and achievements can decrease the likelihood of workplace injuries among French workers by up to 50%. This is a key finding from O.C. Tanner's 2025 Global Culture Report which gathered data and insights from 38,075 workers from 27 countries including 1,208 from France. The report highlights how feeling unappreciated worsens mental health and this then increases the likelihood of workplace accidents. Robert Ordever, European MD of O.C. Tanner explains: 'There's a clear link between deteriorating mental health and greater instances of workplace injuries, with mental illness often leading to decreased concentration, reduced cognitive function, and impaired decision-making abilities. Workers struggling with their mental health have their condition worsened when they feel unappreciated by their managers and colleagues.' The Report highlights how regularly recognising employees for their efforts and achievements, not only improves workers' wellbeing, but noticeably reduces the odds of them reporting a workplace accident. Employees suffering from burnout are 50% less likely to have a workplace accident when their organisation has a formal recognition programme in place. For those workers with probable depression, their odds of reporting a workplace accident are 11% when their organisation is WITHOUT a recognition programme. For workers with probable depression but WITH a recognition programme in place, their odds of reporting a workplace accident are reduced to just 8%. Ordever says, 'Implementing a recognition programme that allows all employees to regularly express gratitude to colleagues, not only reduces the likelihood of burnout, anxiety, and depression, but also cuts the number of workplace injuries. But it's important to note that having a recognition programme is not enough in itself. The organisation must champion the giving of appreciation on a daily basis, and encourage recognition that's sincere, tailored to the individual and meaningful. When the importance of recognition is understood and prioiritised, organisations can enjoy truly impactful business outcomes.' About 2025 Global Culture Report The O.C. Tanner Institute uses multiple research methods to support the Global Culture Report, including interviews, focus groups, cross-sectional surveys, and a longitudinal survey. Qualitative findings came from 27 focus groups among employees, leaders, and HR practitioners of larger organisations. About O.C. Tanner O.C. Tanner is the global leader in personalised employee recognition solutions that improve workplace cultures so people feel appreciated, do their best work, and stay. Its Culture Cloud is a suite of apps and solutions, including recognition, service awards, wellbeing, leadership, and celebrations that help people thrive at work. O.C. Tanner provides these and other services for thousands of the most respected companies in the world. For more information visit
Yahoo
6 hours ago
- Yahoo
Shipwreck mystery solved as lost vessel resurfaces 140 years after tragic sinking
This discovery made major waves. Researchers have discovered a vessel that sank over 140 years ago — closing the book on one of the UK's most enduring maritime mysteries. Footage of the long-lost wreckage is currently making waves online. The historic steamer, dubbed the SS Nantes, had sunk in 1888 after colliding with a German boat, resulting in the deaths of most of the crew, Jam Press reported. The freighter then lay undiscovered for nearly a century and a half until 2024, when diver and explorer Dominic Robinson identified the shipwreck by dinnerware he found at the wreck site. 'Even though the wreck had been dived before, it was never identified and this small piece of broken plate allowed us to do exactly that,' the 50-year-old former army officer, who'd been diving for 35 years, told Jam Press. Meanwhile, maritime history expert Dr. Harry Bennett dubbed the recovery the 'underwater archaeological equivalent of a needle in a haystack,' the BBC reported. 'I think the local dive team are to be congratulated on a splendid piece of detective work which reveals this maritime disaster,' said the professor, who teaches at the University of Plymouth. Built in 1874, the SS Nantes was a cargo ship operated by the Cunard Steamship Company. The 14-year-old vessel was traveling from Liverpool, UK, to Le Havre, France, with a load of coal in tow when it was struck by the German sailing vessel Theodor Ruger, which tore a 'big hole in its side,' Bennett recounted to CNN. 'For several hours, the crew tried to save their ship using all manner of materials to try and fill the hole, including mattresses,' he recalled. 'But eventually they lose that fight and the ship goes down very rapidly.' Bennett said that the SS Nantes 'drifted for several hours, before it finally made its way to the bottom, sadly, with many of its crewmen on board.' Their escape efforts were reportedly hindered by the fact that the lifeboats were damaged in the collision. 'There were some 23-odd fatalities,' Bennett told BBC. 'There were three survivors.' Meanwhile, corpses from the wreckage washed ashore in Cornwall, where locals were confronted by the horrific sight of bodies intermingled with pieces of the SS Nantes. Unfortunately, after plunging to the bottom of the ocean, the ship was 'essentially lost' as it was a time period with 'no satellite navigation,' per Dr. Bennett. It wasn't until 2024 that the local dive team identified the sunken vessel. Johnson had caught wind of the unidentified wreck from the UK Hydrographic Office and decided to investigate himself. Toward the end of a mostly fruitless dive, the wreck-plorer saw the broken plate, which provided a major clue as to the vessel's identity. 'I decided to bring it up to the surface [and] we found that [it] had the Cunard Steamship crest on it,' recalled Jonhson. 'It was then bingo, we've found it.' Researchers also identified the sunken ship by the build, technology on board, and dimensions of the vessel — which measured around 240 feet long. After examining the crews' footage and methodology, Dr. Bennett declared that 'beyond any reasonable shadow of a doubt, this is the SS Nantes.' While the sinking of the SS Nantes was an awful tragedy, Robinson hopes that the discovery at least provides a bit of closure to the heartwrenching saga. 'One of the things I like to think is by solving mysteries and telling those stories, I'm ensuring that those people aren't forgotten,' he said.
Yahoo
13 hours ago
- Yahoo
3 Healthcare Stocks in Hot Water
Personal health and wellness is one of the many secular tailwinds for healthcare companies. Despite the rosy long-term prospects, short-term headwinds such as COVID inventory destocking have harmed the industry's returns - over the past six months, healthcare stocks have collectively shed 12.3%. This drawdown was noticeably worse than the S&P 500's 1.9% loss. Investors should tread carefully as the influx of venture capital has also ushered in a new wave of competition. Keeping that in mind, here are three healthcare stocks we're swiping left on. Market Cap: $12.17 billion With a network spanning 39 states and three countries, Universal Health Services (NYSE:UHS) operates acute care hospitals and behavioral health facilities across the United States, United Kingdom, and Puerto Rico. Why Are We Hesitant About UHS? Poor comparable store sales performance over the past two years indicates it's having trouble bringing new patients into its facilities Expenses have increased as a percentage of revenue over the last five years as its adjusted operating margin fell by 1.2 percentage points Free cash flow margin shrank by 3.1 percentage points over the last five years, suggesting the company is consuming more capital to stay competitive Universal Health Services's stock price of $188.81 implies a valuation ratio of 9.5x forward P/E. Dive into our free research report to see why there are better opportunities than UHS. Market Cap: $512.5 million With roots dating back to 1882 and operations spanning approximately 80 countries, Owens & Minor (NYSE:OMI) is a healthcare solutions company that manufactures medical supplies, distributes products to healthcare providers, and delivers medical equipment directly to patients. Why Does OMI Give Us Pause? Scale is a double-edged sword because it limits the company's growth potential compared to its smaller competitors, as reflected in its below-average annual revenue increases of 3.2% for the last two years Underwhelming 3.8% return on capital reflects management's difficulties in finding profitable growth opportunities, and its falling returns suggest its earlier profit pools are drying up Diminishing returns on capital from an already low starting point show that neither management's prior nor current bets are going as planned Owens & Minor is trading at $6.67 per share, or 3.7x forward P/E. If you're considering OMI for your portfolio, see our FREE research report to learn more. Market Cap: $132.8 billion With roots dating back to 1849 when two German immigrants opened a fine chemicals business in Brooklyn, Pfizer (NYSE:PFE) is a global biopharmaceutical company that discovers, develops, manufactures, and sells medicines and vaccines for a wide range of diseases and conditions. Why Are We Cautious About PFE? Core business is underperforming as its organic revenue has disappointed over the past two years, suggesting it might need acquisitions to stimulate growth Free cash flow margin shrank by 8.9 percentage points over the last five years, suggesting the company is consuming more capital to stay competitive Diminishing returns on capital suggest its earlier profit pools are drying up At $23.40 per share, Pfizer trades at 7.8x forward P/E. To fully understand why you should be careful with PFE, check out our full research report (it's free). Donald Trump's victory in the 2024 U.S. Presidential Election sent major indices to all-time highs, but stocks have retraced as investors debate the health of the economy and the potential impact of tariffs. While this leaves much uncertainty around 2025, a few companies are poised for long-term gains regardless of the political or macroeconomic climate, like our Top 6 Stocks for this week. This is a curated list of our High Quality stocks that have generated a market-beating return of 183% over the last five years (as of March 31st 2025). Stocks that made our list in 2020 include now familiar names such as Nvidia (+1,545% between March 2020 and March 2025) as well as under-the-radar businesses like the once-small-cap company Exlservice (+354% five-year return). Find your next big winner with StockStory today for free.
