Latest news with #DorairajPrabhakaran
Hans India
02-08-2025
- Health
- Hans India
AIIMS-led study shows two-medicine combination therapy effective in controlling high BP
Using a single pill comprising two blood pressure medicines is a safe and highly effective way to treat hypertension among South Asians, particularly Indians, finds a study led by the All India Institute of Medical Sciences (AIIMS), New Delhi. The study, in partnership with the Centre for Chronic Disease Control (CCDC) and Imperial College London, UK, compared three widely used drug combinations: amlodipine plus perindopril, amlodipine plus indapamide, and perindopril plus indapamide. The first randomised trial to test three different two-drug combination pills among South Asians involved over 1,200 patients with uncontrolled hypertension across 32 hospitals in India. 'All three combinations worked equally well in reducing blood pressure and were safe for patients,' revealed the study, published in the journal Nature Medicine. The findings showed that either of the two-drug combinations led to a significant drop in blood pressure after 6 months -- by around 14/8 mmHg when measured over 24 hours and about 30/14 mmHg in clinic settings. 'Nearly 70 per cent of patients got their blood pressure under control, a huge improvement over the current national average. And the pills were safe and easy to use. This study gives clear guidance for better hypertension care,' said Dr Ambuj Roy, Professor of Cardiology at AIIMS Delhi. 'This study shows that a single daily pill with two drugs can be a simple and powerful way to manage blood pressure in Indian and South Asian patients,' said Dr Dorairaj Prabhakaran, Executive Director of CCDC. High blood pressure (hypertension) is the leading risk factor for death worldwide and affects over 300 million people in India alone. Treating it early and effectively can prevent heart attacks, strokes, and kidney failure. Doctors often recommend starting with two medications in one pill to control blood pressure better and help patients stick to treatment. But until now, no large study had tested which combinations worked best for South Asians, who make up a quarter of the world's population. The results revealed that nearly 70 per cent of patients with any of the dual drug therapy reached the recommended blood pressure target of below 140/90 mmHg -- five times higher than India's current average control rate. Less than 3 per cent of patients reported side effects serious enough to stop treatment. 'These findings can help guide doctors and policymakers. If added to India's list of essential medicines and made available at primary health centres, these pills could greatly improve blood pressure control in the country,' Prabhakaran said.
Business Standard
30-07-2025
- Health
- Business Standard
TOPSPIN Study by the Centre for Chronic Disease Control (CCDC) Finds Two-drug Combination Therapies Effective in Improving Blood Pressure Control in Indians
NewsVoir New Delhi [India], July 30: A new study, entitled TOPSPIN, coordinated by the Centre for Chronic Disease Control (CCDC) New Delhi, in collaboration with the All India Institute of Medical Sciences (AIIMS) New Delhi, and Imperial College London, examined 1,981 patients with uncontrolled hypertension across 32 hospitals in India. The findings showed that three two-drug combination therapies - Amlodipine plus Perindopril, Amlodipine plus Indapamide, and Perindopril plus Indapamide - were equally effective and safe in lowering both ambulatory and office blood pressure. TOPSPIN is the first-ever randomised study to test the choice of first-line two-drug combination therapy in a single pill among South Asians. The study findings are published in Nature Medicine, one of the top medicine journals. South-Asians represent one-fourth of the world population, and India alone constitutes one-sixth of the global population. Hypertension is a public health crisis affecting over one billion adults worldwide, including over 300 million living in India. Innovative solutions are needed to curb the growing tide of high blood pressure, which is the single highest risk factor for global deaths, and which requires effective management solutions. Current guidelines widely recommend initiating treatment with two-drug combinations, preferably in a single-pill formulation, to enhance blood pressure control. However, the suitability of these combinations for the South-Asian population remains unknown, as there are no studies in this regard. The key takeaways are that all three combinations were equally effective in reducing blood pressure and were safe for patients. What did the TOPSPIN study find? - Blood pressure dropped significantly after 6 months, by around 14/8 mmHg when measured over 24 hours and about 30/14 mmHg in clinic settings. - Nearly 70% of patients reached the recommended blood pressure target below 140/90 mmHg, five times higher than India's current average control rate. - The pills were well-tolerated, with less than 3% of patients reporting side effects serious enough to stop treatment. What do the Study leaders say? "This study shows that a single daily pill with two drugs can be a simple and powerful way to manage blood pressure in Indian and South Asian patients," said Prof. Dorairaj Prabhakaran, Executive Director of CCDC and one of the study's lead authors. "These findings can help guide doctors and policymakers. If added to India's list of essential medicines and made available at primary health centres, these pills could greatly improve blood pressure control in the country." Prof. Ambuj Roy, Professor of Cardiology at AIIMS Delhi, added, "Nearly 70% of patients got their blood pressure under control, a huge improvement over the current national average. And the pills were safe and easy to use. This study gives clear guidance for better hypertension care." Prof. Neil Poulter, Professor at Imperial College London, emphasized the importance of studying how medicines work in different populations. "Just as earlier research in Africa showed different results, this study gives strong evidence on what works best in South Asians." The TOPSPIN study results could help improve treatment not only in India, but also for South Asians living around the world.
Fashion Value Chain
30-07-2025
- Health
- Fashion Value Chain
TOPSPIN Study by the Centre for Chronic Disease Control (CCDC) Finds Two-drug Combination Therapies Effective in Improving Blood Pressure Control in Indians
A new study, entitled TOPSPIN, coordinated by the Centre for Chronic Disease Control (CCDC) New Delhi, in collaboration with the All India Institute of Medical Sciences (AIIMS) New Delhi, and Imperial College London, examined 1,981 patients with uncontrolled hypertension across 32 hospitals in India. The findings showed that three two-drug combination therapies – Amlodipine plus Perindopril, Amlodipine plus Indapamide, and Perindopril plus Indapamide – were equally effective and safe in lowering both ambulatory and office blood pressure. TOPSPIN is the first-ever randomised study to test the choice of first-line two-drug combination therapy in a single pill among South Asians. The study findings are published in Nature Medicine, one of the top medicine journals. A doctor checking the blood pressure of a patient South-Asians represent one-fourth of the world population, and India alone constitutes one-sixth of the global population. Hypertension is a public health crisis affecting over one billion adults worldwide, including over 300 million living in India. Innovative solutions are needed to curb the growing tide of high blood pressure, which is the single highest risk factor for global deaths, and which requires effective management solutions. Current guidelines widely recommend initiating treatment with two-drug combinations, preferably in a single-pill formulation, to enhance blood pressure control. However, the suitability of these combinations for the South-Asian population remains unknown, as there are no studies in this regard. The key takeaways are that all three combinations were equally effective in reducing blood pressure and were safe for patients. What did the TOPSPIN study find Blood pressure dropped significantly after 6 months, by around 14/8 mmHg when measured over 24 hours and about 30/14 mmHg in clinic settings. Nearly 70% of patients reached the recommended blood pressure target below 140/90 mmHg , five times higher than India's current average control rate. The pills were well-tolerated, with less than 3% of patients reporting side effects serious enough to stop treatment. â What do the Study leaders say 'This study shows that a single daily pill with two drugs can be a simple and powerful way to manage blood pressure in Indian and South Asian patients,' said Prof. Dorairaj Prabhakaran, Executive Director of CCDC and one of the study's lead authors. 'These findings can help guide doctors and policymakers. If added to India's list of essential medicines and made available at primary health centres, these pills could greatly improve blood pressure control in the country.' Prof. Ambuj Roy, Professor of Cardiology at AIIMS Delhi, added, 'Nearly 70% of patients got their blood pressure under control, a huge improvement over the current national average. And the pills were safe and easy to use. This study gives clear guidance for better hypertension care.' Prof. Neil Poulter, Professor at Imperial College London, emphasized the importance of studying how medicines work in different populations. 'Just as earlier research in Africa showed different results, this study gives strong evidence on what works best in South Asians.' â The TOPSPIN study results could help improve treatment not only in India, but also for South Asians living around the world.
Hans India
28-07-2025
- Health
- Hans India
AIIMS-led study shows two-drug combination therapy effective in controlling high BP
New Delhi: Using a single pill comprising two blood pressure medicines is a safe and highly effective way to treat hypertension among South Asians, particularly Indians, finds a study led by the All India Institute of Medical Sciences (AIIMS), New Delhi. The study, in partnership with the Centre for Chronic Disease Control (CCDC) and Imperial College London, UK, compared three widely used drug combinations: amlodipine plus perindopril, amlodipine plus indapamide, and perindopril plus indapamide. The first randomised trial to test three different two-drug combination pills among South Asians involved over 1,200 patients with uncontrolled hypertension across 32 hospitals in India. "All three combinations worked equally well in reducing blood pressure and were safe for patients,' revealed the study, published in the journal Nature Medicine. The findings showed that either of the two-drug combinations led to a significant drop in blood pressure after 6 months -- by around 14/8 mmHg when measured over 24 hours and about 30/14 mmHg in clinic settings. 'Nearly 70 per cent of patients got their blood pressure under control, a huge improvement over the current national average. And the pills were safe and easy to use. This study gives clear guidance for better hypertension care,' said Dr Ambuj Roy, Professor of Cardiology at AIIMS Delhi. 'This study shows that a single daily pill with two drugs can be a simple and powerful way to manage blood pressure in Indian and South Asian patients,' said Dr Dorairaj Prabhakaran, Executive Director of CCDC. High blood pressure (hypertension) is the leading risk factor for death worldwide and affects over 300 million people in India alone. Treating it early and effectively can prevent heart attacks, strokes, and kidney failure. Doctors often recommend starting with two medications in one pill to control blood pressure better and help patients stick to treatment. But until now, no large study had tested which combinations worked best for South Asians, who make up a quarter of the world's population. The results revealed that nearly 70 per cent of patients with any of the dual drug therapy reached the recommended blood pressure target of below 140/90 mmHg -- five times higher than India's current average control rate. Less than 3 per cent of patients reported side effects serious enough to stop treatment. 'These findings can help guide doctors and policymakers. If added to India's list of essential medicines and made available at primary health centres, these pills could greatly improve blood pressure control in the country,' Prabhakaran said.
