Latest news with #Dutt
Indian Express
17 hours ago
- Health
- Indian Express
Indian study finds what makes thyroid cancer aggressive, recurrent and treatment-resistant: What this means for precision therapy
In a significant leap for cancer research and precision medicine, an Indian study has decoded the complex genetic architecture of thyroid cancer — one of the most common endocrine malignancies. Researchers from Tata Memorial Centre and the University of Delhi, South Campus, have shed new light on how thyroid cancer behaves in Indian patients, identifying novel risk genes and molecular subtypes that could revolutionise diagnosis and treatment. Published in 'JCO Global Oncology,' the research is spearheaded by graduate student Vaishakhi Trivedi under the mentorship of Dr Kumar Prabhash and Dr Amit Dutt. 'Our work not only adds data to global cancer databases —it also redefines what is known about thyroid cancer in the Indian population,' Dr Dutt said. The rogue gene in the most common thyroid cancer The study concerns papillary thyroid cancer (PTC), which accounts for 80-85 per cent of all thyroid cancer cases in India. This is considered treatable. The team analysed DNA from 100 Indian patients and found mutations in the DUOX2 gene found in nearly nine per cent of cases. 'This gene, previously known for its role in thyroid hormone production, now appears to be a genetic red flag for recurrence and poor prognosis. This is the first time DUOX2 has been implicated as a predisposing factor in PTC. It offers an opportunity for early detection and potentially life-saving interventions,' Dr Dutt said. Study uncovers two distinct molecular subtypes The study even identified two different subtypes associated with aggressive cancer and high recurrence. The BRAF-RAS-driven subtype makes up 62 per cent of cases and is identified by mutations that are often tied to more aggressive tumour behaviour. The iBR (Independent of BRAF-RAS) subtype is a newly-defined category. 'This group lacks traditional mutations but shows alarming signs of treatment resistance and high recurrence. It is marked by alterations in genes like SMAD4 and TG — a previously uncharted territory for thyroid oncologists,' said Dr Dutt. This dual classification signals a new era of care where treatments are tailored to the patient's genetic profile rather than a one-size-fits-all approach. Cracking the genetic code of an aggressive form of thyroid cancer While PTC is common and often curable, anaplastic thyroid cancer (ATC) is its deadly cousin — rare, fast-moving and resistant to nearly every treatment in the book. The research team examined 68 samples and found mutations in the THRA gene in 11 per cent of Indian patients. This is in sharp contrast to Caucasian datasets. 'THRA, a gene tied to thyroid hormone signalling, appears to be a key player in cellular plasticity or the process by which cancer cells morph, lose their identity and become more aggressive. THRA mutations are like flipping the switch. They make the cancer harder to kill but they also give us a target. That's a rare silver lining,' Dr Prabhash explained. What this means for Indian patients — and the world These findings offer practical methods of how thyroid cancers are diagnosed, treated and managed in Indian patients. 'Patients with DUOX2 mutations could be monitored proactively, much like BRCA testing in breast cancer. This may help in diagnosing aggressive PTC early and prevent a relapse,' Dr Dutt said. Researchers also added that therapies that restore THRA function may finally give ATC patients a fighting chance. 'We need a personalised roadmap for thyroid cancer. With the promise of advanced tools like CRISPR gene editing and small-molecule inhibitors, these discoveries could soon migrate from the lab bench to the bedside,' the researchers said. 'Genetic profiling should be as routine as a biopsy,' said Vaishakhi Trivedi. 'We have the science. Now we need the systems to support it.' Anuradha Mascarenhas is a journalist with The Indian Express and is based in Pune. A senior editor, Anuradha writes on health, research developments in the field of science and environment and takes keen interest in covering women's issues. With a career spanning over 25 years, Anuradha has also led teams and often coordinated the edition. ... Read More
Time of India
a day ago
- General
- Time of India
After Michael Madhusudan lesson, KMC goes slow on ‘first widow-remarriage' house
1 2 3 Kolkata: Following a legal dispute over the heritage status of Michael Madhusudan Dutt's residence in Kidderpore, KMC is going slow on conferring the same tag on the "first widow-remarriage building" in north Kolkata. The civic body has paused its move to declare the building at 48A, Kailash Bose Street a heritage structure, where the first widow remarriage in the country was said to have taken place about 168 years ago. The civic body is now looking for evidence to ascertain the fact. Kalimati Devi, daughter of Brahmananda Mukhopadhyay from Palasdanga village in Bankura, became a widow at the age of 10. She was remarried to Srishchandra Vidyaratna, a scholar and a former pupil of Sanskrit College, at this house in the presence of Vidyasagar, who spent Rs 10,000 from his own funds for the wedding. You Can Also Check: Kolkata AQI | Weather in Kolkata | Bank Holidays in Kolkata | Public Holidays in Kolkata The halt comes in the wake of a legal setback suffered by KMC regarding Dutt's house at 20B, Karl Marx Sarani. Now, the civic body is planning to move court to save the structure from being razed. "The HC asked us to delist Dutt's house from the heritage register as documentary evidence could not be produced. After this, we are putting on hold our initiative to turn the building at Kailash Bose Street into a heritage structure now. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Speed up your Mac and free up storage with Space Lens MacPaw Read More Undo Once we get some concrete evidence, we will resume the move," said an official from the KMC's heritage department. In the 19th century, the address of the building was 12 Sukia Street when it belonged to Rajkrishna Bandyopadhyay. Later, the address was changed to 48A Kailash Bose Street, according to KMC sources. As per the KMC's IB register, the name of Soumendranath Bandyopadhyay was updated as the present owner of the building in 2024, but the family, according to local sources, is settled outside the city. In his biography on Akhay Kumar Dutta, a noted figure of the Bengali Renaissance invited to the wedding, writer Mahendranath Roy mentioned in Bengali in 1885 that on Dec 7, 1856, the first widow remarriage in the country happened at Rajkrishna Bandyopadhyay's house at Sukia Street. Swapan Samaddar, Mayor-in-Council member (heritage) at KMC, stated: "A couple of years ago, I proposed to make it a heritage building at Kailash Bose Street. Following the legal dispute over Michael Madhusudan Dutt's building as a heritage structure, we are finding concrete evidence supporting the event of the country's first widow remarriage at the Kailash Bose Street house, also a private property." As for Michael's residence, Samaddar stated: "We will make a fresh appeal in the HC to save it from demolition. "
Time of India
2 days ago
- Entertainment
- Time of India
Sanjay Dutt wishes Ajay Devgn for 'Son of Sardaar 2', says it would've been fun to reunite
Actor Sanjay Dutt revealed it would have been fun doing "Son of Sardaar 2" with Ajay Devgn . Resharing the recently released trailer of the highly anticipated drama on his Instagram, Dutt wished Raju aka Ajay, all the best for his forthcoming venture. "All the best Raju for Son of Sardaar 2, it would've been fun doing this one together too @ajaydevgn," he penned the caption. Dutt and Ajay were seen as frenemies in the first installment of the franchise, "Son of Sardaar", which reached the cinema halls in 2012. While Dutt essayed the role of Balwinder Singh Sandhu or Billu, Ajay was seen as Jaswinder Singh Randhawa or Jassi in the original flick. They were unwillingly pitted against one another due to an old family rivalry. While Ajay will be seen reprising his role in the sequel, Dutt has been replaced by actor and politician Ravi Kishan . Talking about the trailer, the clip opened with Jassi (Played by Ajay) getting married to Dimple (Played by Neeru Bajwa ). Next, he goes on to explain the 4 major troubles of his life. The first trouble is that Dimple has asked for a divorce from him. Explaining the second trouble, Jassi revealed that he is caught in the middle of 4 ladies, one of whom is Rabia (Played by Mrunal Thakur). Although he has fallen in love with her, the problem is that she is from Pakistan. Jassi's third trouble is landing in a Mafia family. His fourth and last trouble is being caught up in his 'bebe's' promise. Made under the direction of Vijay Kumar Arora, "Son of Sardaar 2" boasts a stellar cast featuring Ajay Devgn, Ravi Kishan, Sanjay Mishra, Mrunal Thakur, Neeru Bajwa, Chunky Panday, Kubbra Sait, Deepak Dobriyal, Vindu Dara Singh, Roshni Walia , Sharat Saxena, Ashwini Kalsekar, Sahil Mehta and the late Mukul Dev in key roles.
News18
6 days ago
- News18
Haryana Astrologer Nabbed While Selling Lizard Genitals, Coral In Name Of Tantric Cures
Last Updated: The astrologer allegedly sold banned wildlife parts like monitor lizard genitalia and soft coral as 'spiritual aids'. A self-styled astrologer running a spiritual remedy business from Faridabad has been arrested for allegedly selling banned wildlife parts, including dried monitor lizard genitalia and soft coral which are allegedly used in occult and tantric rituals, according to a report by Hindustan Times. The accused, 38-year-old Yagya Dutt, was picked up on Wednesday in a joint raid by the Haryana Forest Department, Haryana Police, Wildlife Crime Control Bureau (WCCB), and Wildlife Trust of India after a tip-off. Dutt allegedly sold the prohibited items both at his Sector 8 astrology office and through online platforms. Officials told the Hindustan Times that the seized items included three pieces of monitor lizard genitalia, locally called hatha jodi, and five pieces of indrajal or soft coral. The monitor lizard is a Schedule I species under the Wildlife Protection Act, making the possession or trade of its body parts a serious offence. 'This is a serious violation. The accused misused his profession to sell banned wildlife products disguised as spiritual aids," RK Jangra, divisional forest officer, Gurugram, was quoted as saying by the newspaper. Authorities also seized Dutt's phone and digital records, suspecting a wider network of illegal suppliers and buyers. Environmentalist Vaishali Rana was present as an independent observer during the raid, the newspaper said in its report. 'There were price tags, packaging, and digital records showing commercial intent. Wildlife exploitation is being masked behind superstition," she was quoted as saying. A case has been registered under relevant sections of the Wildlife Protection Act. If convicted, Dutt could face three to seven years in prison and a fine of ₹10,000. 'This case highlights the need for stronger awareness and strict monitoring. We are committed to cracking down on illegal wildlife trade," Jangra added. view comments First Published: July 17, 2025, 22:38 IST Disclaimer: Comments reflect users' views, not News18's. Please keep discussions respectful and constructive. Abusive, defamatory, or illegal comments will be removed. News18 may disable any comment at its discretion. By posting, you agree to our Terms of Use and Privacy Policy.
News18
6 days ago
- Entertainment
- News18
Guru Dutt's 100th Birth Anniversary: A Look at His Evergreen Songs
From the movie of the same name – Chaudhavin Ka Chand (1960) – it features Dutt and Waheeda Rehman. Mohammed Rafi did an outstanding job with this song and the portrayal by Dutt is amazing.
