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Associated Press
a day ago
- Health
- Associated Press
Engineered ion channel offers precise, non-invasive control of brain activity
FAYETTEVILLE, GA, UNITED STATES, May 30, 2025 / / -- In a breakthrough advancement for neuroscience, researchers have developed RADICAL, a cutting-edge chemogenetic tool that allows for the precise manipulation of neuronal activity using a synthetic chemical, cyclohexanol ( CHXOL ). Unlike traditional methods that rely on invasive optics or slow-acting G-protein coupled receptors, RADICAL utilizes a modified TRPM8 ion channel to enable rapid and targeted control of calcium influx in neurons. This innovative tool has the potential to advance brain function research and open up new therapeutic possibilities for neurological disorders. Current technologies for controlling neuronal activity—such as optogenetics and chemogenetics—have their limitations. Optogenetics requires invasive light delivery, while chemogenetic systems like DREADDs rely on slow and indirect cellular signaling pathways. Additionally, engineered ligand-gated ion channels, such as those based on nicotinic receptors, can result in unintended interactions with native proteins. These challenges have highlighted the need for a more efficient, non-invasive, and precise method of modulating neuronal excitability. In response to this gap, researchers sought to develop RADICAL, a novel chemogenetic tool that addresses these limitations. In a letter (DOI: 10.1093/procel/pwae048 ) published on September 3, 2024, in Protein & Cell, a team from Zhejiang University unveiled RADICAL, an engineered ion channel activated by cyclohexanol (CHXOL). By introducing specific mutations to the TRPM8 ion channel, they created a system that responds with exceptional sensitivity and specificity to CHXOL. This innovation allows for precise neuronal control without interfering with the brain's native functions, marking a significant step forward in chemogenetics. The key modification in RADICAL was the engineering of the TRPM8 ion channel, which is naturally expressed at low levels in the brain, minimizing potential disruptions to endogenous systems. The team introduced two critical mutations (I846F and I985K) to the TRPM8 ion channel. The I846F mutation restored CHXOL binding, while I985K enhanced voltage sensitivity, enabling robust activation even at hyperpolarizing potentials (-80 mV). Patch-clamp recordings and calcium imaging confirmed the double mutant, TRPM8-I846F-I985K's EC50 of 1.17 mmol/L for CHXOL at depolarizing potentials (+80 mV). In vivo, RADICAL demonstrated its potential: CHXOL administration enhanced fear extinction memory in mice by activating neurons in the infralimbic cortex (IL), and also increased locomotor activity when expressed in astrocytes of the ventral tegmental area (VTA). Importantly, the tool's calcium permeability and minimal cell death risk, as shown in HEK293T cells, suggest its suitability for studying calcium-dependent processes such as learning and memory. Dr. Fan Yang, one of the co-corresponding authors of the study, said: RADICAL represents a major breakthrough in chemogenetics. Its ability to modulate neuronal activity with high precision and minimal off-target effects makes it a versatile tool for both basic neuroscience research and the development of therapeutic interventions. With its non-invasive approach and high specificity, RADICAL has substantial potential in both research and clinical settings. It could enhance our understanding of neurological conditions such as memory disorders, addiction, and mood disorders by providing a precise way to manipulate neuronal circuits. Furthermore, future efforts to miniaturize the tool for adeno-associated virus (AAV) delivery could broaden its applicability in gene therapy. RADICAL's unique combination of speed, specificity, and safety positions it as a powerful platform for next-generation treatments of brain diseases. References DOI 10.1093/procel/pwae048 Original Source URL Funding Information This work was supported by funding from the National Natural Science Foundation of China (32122040 and 31971040 to F.Y.; 32071017 and 31922031 to Y.C.); Zhejiang Provincial Natural Science Foundation of China (LR20C050002 to F.Y.); China Postdoctoral Program for Innovative Talents (BX20230323 to H.Z.); China Postdoctoral Science Foundation (2024M752858 to H.Z.); The Fundamental Research Funds for the Central Universities (226-2022-00227 to F.Y.; 226-2022-00149 to Y.C.); Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions (NYKFKT2019001 to Y.C.); The Fundamental Research Funds for the Central Universities (226-2022-00227 to F.Y.). Lucy Wang BioDesign Research email us here Legal Disclaimer: EIN Presswire provides this news content 'as is' without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.
Associated Press
a day ago
- General
- Associated Press
THE CLAIRES WORKSHOP OPENS TO PUBLIC: PSYCHIC DEVELOPMENT CIRCLE FOR SOBER WITCHES LAUNCHES JUNE 2025
Designed as a Workshop for Witches, The Claires Workshop is a live, psychic development experience that helps participants strengthen their innate abilities. 'Recovery cracked me open—and what poured out were visions and feelings I couldn't explain. I wasn't broken—I was waking up. The Claires Workshop helps others trust their gifts too.'— Sunshine Witchski DETROIT, MI, UNITED STATES, May 30, 2025 / / -- What if your deepest intuitive gifts were not a distraction from your sobriety, but a path toward it? For many witches in recovery, reconnecting with their psychic senses has become a profound part of healing. Now, for the first time, the Recovery Coven is opening its signature members-only series to the public, beginning with The Claires Workshop in June. This new public event, offered monthly through the Recovery Coven, represents a key milestone for the Sober Witch Life Movement. Designed as a Workshop for Witches in Recovery, The Claires Workshop is a live, two-hour psychic development experience that helps participants strengthen their innate abilities while staying grounded in sobriety. The event is also available via the Sober Witch Mobile App, which has become a vital resource for witches navigating spiritual recovery. By linking recovery with psychic development, Sunshine—founder of the Sober Witch Life Movement and creator of The Recovery Coven—has sparked a national conversation around sober witchcraft and holistic transformation. A NEW CHAPTER IN SOBER WITCH LIFE Founded in 2024, the Sober Witch Life Movement began as a response to the lack of spiritual alignment in traditional recovery spaces. Sunshine, a recovering alcoholic, psychic medium, and spiritual teacher, saw an urgent need for witches and spiritual seekers to heal on their own terms. Since its founding, her programs have guided hundreds through spiritual recovery programs rooted in ritual, intuition, and community support. The Recovery Coven is the core of this growing movement. It offers weekly community circles, monthly workshops, and a mobile app filled with witch's recovery tools, magickal recovery tools, and shadow work in recovery practices. Until now, these offerings were exclusive to members. Beginning June 2025, they will become more accessible through a series of public workshops, each designed to explore witchcraft and sobriety in unique ways. INSIDE THE CLAIRES WORKSHOP The Claires Workshop focuses on psychic development for witches in recovery, guiding attendees through three interactive exercises that support connection to their clair senses—including clairvoyance (clear seeing), clairsentience (clear feeling), and clairaudience (clear hearing). Key features of the June workshop include: Live two-hour format held via Zoom and the Sober Witch Mobile App Rotating development exercises such as intuitive drawing, direct reading, and beginner telepathy Small-group experiences for deeper confidence-building and spiritual connection A 30-minute social integration session for connection with others in recovery This is more than a skills workshop. It is designed to help witches in recovery strengthen their intuition, rebuild self-trust, and feel spiritually grounded without relying solely on external tools like tarot or pendulums. A UNIQUE APPROACH TO RECOVERY Unlike traditional recovery programs, which often focus on abstinence and behavioral change, The Claires Workshop integrates mystical and intuitive practices that honor a participant's spiritual gifts. For witches and spiritually sensitive individuals, this approach fills a critical gap. 'When I first got sober, my psychic abilities came roaring back—and honestly, it felt like I was going crazy,' said Sunshine. 'But when I realized what was happening, everything clicked. I wasn't broken. I was finally hearing myself again. And now? I don't go a day without using my abilities. They're my compass.' This perspective is increasingly resonating with a growing community seeking recovery that affirms their intuitive gifts. The Claires Workshop helps reframe psychic development not as a distraction from sobriety, but as an anchor. REAL STORIES, REAL TRANSFORMATION 'For the first time, I felt understood,' said a Recovery Coven member who first attended the Claires Workshop in 2023. 'I used to second-guess everything. Now, I listen to my gut—and it's almost always right. I don't even reach for my pendulum anymore. I trust myself.' With hundreds of downloads of the Sober Witch Mobile App and a membership base that continues to grow, the program is showing tangible results. Members report increases in daily ritual use, clarity in decision-making, and long-term sobriety gains when engaging with spiritual tools that feel aligned. WHY THIS MATTERS Witches in recovery face unique challenges. Many traditional recovery paths discourage the exploration of spirituality outside predefined belief systems. The Sober Witch Life model addresses this by offering customized, intuitive pathways that respect spiritual autonomy. The Claires Workshop is the first of many public experiences designed to make this healing more accessible. It also reflects the broader mission of The Recovery Coven: to make witch's recovery tools widely available to anyone who resonates with the blend of mysticism and sobriety. EVENT DETAILS The Claires Workshop Date: Thursday, June 12, 2025 Time: 7 PM EST Location: Live via Zoom Participants must be 18 or older and identify as being in recovery or actively seeking spiritual sobriety. ABOUT THE SOBER WITCH LIFE The Sober Witch Life is a spiritual recovery movement supporting witches in recovery through community, ritual, education, and intuitive development. Founded by Sunshine Witchski in 2020, it is home to the Recovery Coven membership, the Sober Witch Mobile App, and a growing catalog of tools, workshops, and media designed for long-term transformation. Learn more at Sunshine Witchski Illuminate: The Unschool of Sober Witchcraft +1 313-595-4148 email us here Visit us on social media: Facebook YouTube Legal Disclaimer: EIN Presswire provides this news content 'as is' without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.
Associated Press
a day ago
- Business
- Associated Press
Xcel Talent Launches Dance Convention at DansMusik Fest in Albania, Auditioning European Dancers for U.S. Representation
VLORE, GA, ALBANIA, May 30, 2025 / / -- Xcel Talent Agency, a leading boutique agency renowned for representing top-tier dancers, choreographers, and actors, is set to elevate the global dance scene with the launch of a new dance convention at the highly anticipated DansMusik Fest 2025 in Vlorë, Albania. This exciting initiative, announced by agency founder Aris Golemi, aims to bridge European talent with opportunities in the U.S. entertainment industry through auditions, master classes, and performances, solidifying Vlorë's emerging status as 'The City of Dance ' from August 18-23, 2025. A New Chapter for DansMusik Fest Following the resounding success of the inaugural DansMusik Fest in 2024, which drew over 25,000 attendees to witness a headline performance by world-renowned DJ Steve Aoki, Xcel Talent Agency is expanding the festival's scope to include a comprehensive dance convention. The 2024 event, co-organized with Kuadr Events, transformed Vlorë's Lungomare into a vibrant celebration of music and dance, boosting local tourism and establishing the city as an emerging cultural hub. Building on this momentum, the 2025 edition will feature a week-long program of pop-up performances, spontaneous dance battles, live music, and now, a dedicated dance convention designed to spotlight and nurture talent. The convention, a first for DansMusik Fest, will offer European dancers a unique platform to showcase their skills through workshops led by top choreographers, master classes, and exclusive auditions for representation by Xcel Talent Agency in the U.S. market. 'DansMusik Fest is more than a festival—it's a movement to empower artists and foster cultural exchange,' said Aris Golemi, whose vision for Xcel International continues to redefine the entertainment landscape. Auditioning European Dancers for U.S. Representation A cornerstone of the new dance convention is Xcel Talent Agency's auditions, specifically targeting European dancers seeking representation in the U.S. Xcel, known for its rigorous standards and mentorship approach, represents talent for high-profile projects, including music videos, films, television, commercials, and live performances for artists like Beyoncé, Usher, Lady Gaga, Kendrick Lamar, Pitbull, and events such as the Oscars and Grammy Awards. The auditions will focus on a variety of dance styles, including contemporary, jazz, hip-hop, and more, welcoming dancers aged 13 and up from all ethnicities. Successful candidates will have the opportunity to join Xcel's roster, gaining access to the agency's extensive industry connections and personalized career guidance. 'We're looking for dancers who embody passion, professionalism, and a strong work ethic,' Golemi emphasized. 'Our goal is to connect Europe's brightest talents with opportunities to thrive on the global stage.' This initiative aligns with Xcel's mission to discover and nurture the next generation of stars, offering European dancers a rare chance to break into the competitive U.S. market. The agency's strategic partnership with other agencies further amplifies its ability to open doors for its clients across major markets like Atlanta, Los Angeles, New York, and Nashville. A Week of Dance and Cultural Exchange The dance convention at DansMusik Fest 2025 will be a dynamic addition to the festival's lineup, featuring master classes led by internationally acclaimed choreographers, workshops to refine technique, and opportunities for dancers to network with industry professionals. The event will also include pop-up performances and dance battles along Vlorë's scenic Lungomare, creating an immersive experience that celebrates the fusion of dance, music, and Albanian culture. 'Vlorë's rich cultural heritage and vibrant energy make it the perfect backdrop for this convention,' Golemi noted. 'We want dancers to leave inspired, empowered, and connected to a global community of creators.' The convention will also foster cultural exchange, with international artists and attendees collaborating to create memorable performances that highlight Vlorë's growing reputation as a cultural destination. Economic and Cultural Impact The addition of the dance convention is expected to further amplify the economic benefits seen during the 2024 festival, which saw sold-out accommodations and increased patronage for local businesses. By attracting dancers, choreographers, and industry professionals from across Europe and beyond, DansMusik Fest 2025 aims to position Vlorë as a must-visit destination for dance enthusiasts and tourists alike. A Vision for the Future Under Aris Golemi's leadership, Xcel Talent Agency continues to push boundaries in the entertainment industry. A former dancer and choreographer with a Bachelor's Degree in Choreography from the Academy of Fine Arts in Tirana, Golemi's achievements have earned him recognition as one of the top dance agents in US. His agency's boutique approach, emphasizing quality and mentorship, has made it a trusted name for artists worldwide. The launch of the dance convention at DansMusik Fest marks a bold step in Xcel's mission to empower artists and redefine global entertainment. As Vlorë prepares to become 'The City of Dance' in August 2025, dancers across Europe have a unique opportunity to take their careers to new heights with Xcel Talent Agency. For more information about DansMusik Fest and the dance convention, including audition details, visit For inquiries about Xcel Talent Agency and representation opportunities, visit Aris Golemi XCEL TALENT AGENCY +1 4045144258 email us here Visit us on social media: Instagram Legal Disclaimer: EIN Presswire provides this news content 'as is' without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.
Associated Press
2 days ago
- Business
- Associated Press
TTA, a Certified Women-Owned Business, Named Top Learning Services Company for Fourth Consecutive Year
TTA proudly announces its recognition as a Top 20 Learning Services Company, marking the fourth consecutive year the company has received this award. 'We are committed to helping organizations achieve their learning goals. This recognition reflects the services we offer and how they help clients be agile and achieve results with on-demand talent.'— Maria Melfa, President and CEO MARLBOROUGH, MA, UNITED STATES, May 29, 2025 / / -- TTA proudly announces its recognition as a Top 20 Learning Services Company by Training Industry for 2025, marking the fourth consecutive year the company has received this prestigious distinction. This honor reflects our commitment to excellence and innovation in learning and development services. For over 30 years, TTA has been a trusted partner to organizations of all sizes, from small businesses to Fortune 500 companies, across all industries. Organizations rely on us for strategic learning solutions, including learning strategy, instructional design, training delivery, and expert L&D talent matched to each initiative. Our extensive network of highly qualified learning and development talent leverages the latest technologies and learning techniques to meet the unique needs of our clients, supporting their most innovative projects and initiatives. Training Industry, the leading research and information resource for corporate learning leaders, prepares the Training Industry Top 20 and Training Industry Watch List reports on critical sectors of the training marketplace to better inform professionals about the best and most innovative providers of training services and technologies. Selection to the 2025 Training Industry Top Learning Services Companies lists was determined on the following criteria: • Scope and quality of learning services. • Market presence, brand visibility, innovation, and impact. • Strength of client portfolio and customer relationships. • Business performance and growth trajectory. In addition to this recognition, TTA has received multiple accolades, including Top 20 Outsourcing Company (12 years), Watch List Leadership Training Company (8 years), Top 20 IT and Technology Company (13 years), Top Custom Content Development Company (9 years), and Top Staffing and Temporary Resources Company (2 years), and has received numerous Brandon Hall awards with our clients for innovation. 'At TTA, we are deeply committed to helping organizations achieve their learning goals, and we are honored to be recognized once again for Learning Services,' said Maria Melfa, President and CEO of TTA. 'This recognition reflects the wide range of services we offer and how they enable clients to be more agile and achieve results with on-demand talent. We are truly thankful for our clients who trust us as their training partner.' 'The companies selected for this year's Top 20 Learning Services list demonstrated a remarkable range of capabilities, delivering high-quality, end-to-end solutions including content development, learning technologies, strategic guidance, delivery support, and administrative services,' said Jalen Banks, Market Research Analyst at Training Industry, Inc. 'Through their innovation and measurable impact in the corporate training space, these providers are well-positioned to craft effective learning solutions tailored to any organization's needs.' About TTA TTA is a globally recognized, women-owned, certified business known for its agility in supporting learning and development initiatives of all sizes across diverse training modalities. Leveraging a vast network of on-demand, top-tier training talent, TTA expertly addresses all design, development, and delivery requirements using advanced technologies and contemporary learning strategies. In addition to this honor, TTA has consistently been recognized across multiple categories, including: • Top 20 Outsourcing Company (12 years) • Top 20 Learning Services Company (4 years) • Top 20 Staffing and Temporary Resources Company (2 years) • Top 20 IT and Technology Company (13 years) • Watch List Leadership Training Company (8 years) • Top Custom Content Development Company (9 years) TTA has also secured numerous Brandon Hall awards in partnership with its clients for innovation in learning. For more information, visit About Training Industry, Inc. Training Industry ( ) is the most trusted source of information on the business of learning. Our authority is built on deep ties with more than 450 expert contributors who share insights and actionable information with their peers. Training Industry's courses, live events, articles, magazines, webinars, podcasts, research, and reports generate more than 10 million industry interactions each year, while the Top 20 Training Companies Lists help business leaders find the right training partners. For a complimentary referral, visit Rebecca Gendron TTA (The Training Associates) +1 508-890-8500 email us here Visit us on social media: LinkedIn Instagram Facebook YouTube X Legal Disclaimer: EIN Presswire provides this news content 'as is' without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.
Associated Press
2 days ago
- Business
- Associated Press
Saivion India Emerges as a Trusted Partner for Global Brands in eCommerce Product Management
Saivion India offers trusted eCommerce solutions like data entry, product listing, and photo editing, helping global brands grow efficiently and accurately. 'At Saivion India, we're committed to delivering precision-driven eCommerce solutions that help global brands scale faster, smarter, and more efficiently.'— Kabindra Sharma NEW DELHI, DELHI, INDIA, May 29, 2025 / / -- In a time when online businesses are booming, Saivion India has quietly positioned itself as a go-to agency for companies seeking reliable data entry, product listing, and eCommerce content management solutions. With over a decade of experience, Saivion India has built a reputation for delivering accurate, scalable, and affordable backend support services, helping brands streamline their operations across platforms like Amazon, Shopify, eBay, and BigCommerce. 'Our mission has always been to simplify complexity for eCommerce businesses,' says Kabindra Sharma, Founder of Saivion India. 'Whether it's managing thousands of SKUs, cleaning up product data, or enhancing product photos, our clients rely on us as an extension of their in-house teams.' While automation and AI tools have transformed many aspects of online business, there remains a crucial need for human-powered precision in areas like: - Product catalog management - Amazon listing optimization - Bulk image editing and background removal - Data cleaning and enrichment - Website scraping and market research Learn more about Saivion India's offerings at – one of the leading data entry service providers for global online businesses. By outsourcing routine but essential tasks to Saivion India, businesses have reported: - Faster product go-live times - Lower operational costs - Better search visibility (SEO) - Improved product image quality - Higher marketplace conversion rates The company is now expanding its reach to serve agencies, SaaS startups, retailers, and wholesalers across North America, Europe, and Southeast Asia. About Saivion India Founded in 2010, Saivion India provides end-to-end eCommerce support services such as product data entry, image editing, digital marketing, catalog processing, and website scraping. With a client-first approach and a detail-oriented team, Saivion India helps digital businesses scale with speed and confidence. Suraj Kumar Saivion India +91 93117 59707 [email protected] Visit us on social media: LinkedIn Instagram Facebook YouTube X Legal Disclaimer: EIN Presswire provides this news content 'as is' without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.
