Latest news with #EndocrineSociety
NDTV
8 hours ago
- Health
- NDTV
High Blood Sugar Can Affect Your Sex Life, Research Reveals
A recent research presented at the ENDO 2025 revealed that high blood sugar levels can impact men's sexual health. The research, which has not yet been peer-reviewed, found that even slight elevations in blood sugar levels, below the diabetic threshold, can lead to a decline in sperm movement and erectile function. The researchers analysed the health records of 110 adult men with obesity or type 2 diabetes being treated with weight-loss medications and who were not on testosterone or hormonal therapy. Along with 10% weight loss, the proportion of men with normal levels of both total and free testosterone rose from 53% to 77%. As per the preliminary research presented this week at the Endocrine Society's annual meeting in San Francisco, high blood sugar can lower testosterone levels, which are crucial for male sexual function. Testosterone levels don't directly impact erectile function but rather correlate with libido assessment. The research found that high glucose levels can damage nerves and blood vessels, which are essential for achieving and maintaining erections, leading to erectile dysfunction. Lifestyle Changes And Prevention A balanced diet rich in whole foods and fibre can help stabilise blood sugar and reduce inflammation. Regular physical activity helps in improving insulin sensitivity, and it supports weight loss. Meditation and yoga can enhance mental and emotional well-being, playing a role in sexual performance. Medications like semaglutide, liraglutide and tirzepatide can help regulate blood sugar. "While it is well known that weight loss from lifestyle changes or bariatric surgery increases testosterone levels, the impact that anti-obesity medications may also have on these levels has not been widely studied," said Shellsea Portillo Canales, M.D., endocrinology fellow at SSM Health St. Louis University Hospital in St. Louis, Mo. "Our study is among the first to provide compelling evidence that low testosterone can be reversed with the use of commonly prescribed anti-obesity medications."
New York Post
9 hours ago
- Health
- New York Post
Start your period before age 10 — or after 15? How it can impact your lifelong health, from obesity to heart issues
Your period could be crampin' your style — and your future health. Girls are reaching puberty faster than previous generations, a phenomenon perplexing researchers. The average age of the start of menstruation decreased slightly from around 12.5 years in the 1950s and 1960s to 11.9 years for those born between 2000 and 2005. Advertisement 4 Girls are reaching puberty faster than previous generations, a phenomenon perplexing researchers. goodluz – Research indicates that approximately 2% of girls begin menstruating after 15 — even fewer experience it before the age of 9. That's good news, as a new study out of Brazil links early or late menstruation onset to health struggles later in life. Advertisement 'We now have evidence from a large Brazilian population that confirms how both early and late puberty can have different long-term health impacts,' said study author Flávia Rezende Tinano of the University of Sao Paulo. 'Most women can remember when they had their first period, but they might not realize that it could signal future health risks.' 4 The timing of a woman's first period may determine the health struggles she will face. KMPZZZ – Tinano's team analyzed data from over 7,600 women 35 to 74 years old. Advertisement The women were divided into three categories based on the timing of their first period — 'early' (less than 10 years old), 'typical' (10 to 15) or 'late' (older than 15). The participants' health was assessed through interviews, physical measurements, lab tests and ultrasound imaging. The researchers determined that women who began menstruating before age 10 were more likely to develop obesity, high blood pressure, diabetes, heart problems and reproductive problems like preeclampsia over time. 4 The average age of the start of menstruation decreased slightly from around 12.5 years in the 1950s and 1960s to 11.9 years for those born between 2000 and 2005. KMPZZZ – Advertisement Women who got their first period after 15 were less likely to be obese but more likely to have irregular periods and certain heart conditions. 'Understanding these links can help women and their doctors be more proactive about preventing conditions like diabetes, high blood pressure and heart disease,' Tinano said. The study was presented this week at the Endocrine Society's annual meeting in San Francisco. Menstruation is the monthly shedding of uterine lining, signaling that the woman is not pregnant. Past research has suggested a link between late menarche and an increased risk of osteoporosis, fractures and Alzheimer's disease. Starting menstruation later means delayed exposure to estrogen, a key hormone that protects and builds bone density. 4 'Understanding these links can help women and their doctors be more proactive about preventing conditions like diabetes, high blood pressure and heart disease,' the author of the new study said. JackF – Advertisement On the other hand, starting menstruation earlier means higher lifetime exposure to estrogen, which stimulates breast tissue growth and development and may create a hormonal imbalance. Early menarche has been associated with elevated risks of heart problems, Type 2 diabetes, breast cancer, anxiety and depression. Researchers haven't pinpointed exactly why girls are going through puberty earlier than before. Some have pointed to increased rates of childhood obesity, greater exposure to endocrine-disrupting chemicals and higher stress levels.
Medscape
14 hours ago
- Health
- Medscape
New Guidelines Address Preexisting Diabetes and Pregnancy
San Francisco — A new joint clinical practice guideline (CPG) from two endocrinology societies addresses managing preexisting diabetes and pregnancy, starting with a call to screen for pregnancy intention at every clinical encounter. 'The lack of preconception care for patients with preexisting diabetes is a major focus of this guideline. We know from strong meta-analyses that there is a significant reduction in poor pregnancy outcomes with good preconception care ahead of time. There's a 71% reduction in congenital malformations and reductions in perinatal mortality as well as other negative outcomes. And so, it's really important to have preconception care,' Jennifer A. Wyckoff, MD, CPG writing chair and clinical professor of internal medicine at the University of Michigan, Ann Arbor, Michigan, told Medscape Medical News. 'Preexisting Diabetes and Pregnancy: An Endocrine Society and European Society of Endocrinology Joint Clinical Practice Guideline,' was presented on July 13, 2025, at ENDO 2025: The Endocrine Society Annual Meeting, and was simultaneously published in the Journal of Clinical Endocrinology and Metabolism. Cosponsoring the CPG are the Association of Diabetes Care and Education Specialists, the American Pharmacists Association, and the European Association for the Study of Diabetes. It is supported by the Society for Maternal-Fetal Medicine, while the American College of Obstetricians and Gynecologists was a participating organization. The CPG provides 10 clinical recommendations, covering preconception, pregnancy, labor and delivery, and postpartum care for women with both type 1 diabetes (T1D) and type 2 diabetes (T2D). It was written by a multidisciplinary panel working with a noteworthy absence of data in most areas. 'There are not a lot of randomized controlled trials in diabetes in pregnancy, so there's not a lot of high-quality data. For this particular guideline, there are no strong recommendations. There are only conditional recommendations worded as 'suggestions.'…This serves to highlight some of the areas where research is most needed,' said Wyckoff. The CPG makes the following conditional recommendations: For women with T1D or T2D who have the possibility of becoming pregnant, the CPG suggests that they be asked about pregnancy intention at every medical encounter, including primary care, reproductive, and endocrinology, as well as emergency/urgent care when appropriate. This was based on indirect evidence of the strong association between preconception care and reduced glycated hemoglobin and congenital malformations, Wyckoff said in her presentation. In those with diabetes capable of becoming pregnant, contraception use when pregnancy is not desired is suggested. For those with T2D, the suggestion is to discontinue GLP-1 use before conception, rather than between the start of pregnancy and the end of the first trimester. This is in line with the manufacturer's labeling and is based on limited data of exposure risk during pregnancy. But regardless of when the GLP-1 is discontinued, active glycemic management is needed afterward. For those with T2D already on insulin, the panel suggested against the routine addition of metformin, based on the writing panel's judgment that the benefit of adding metformin doesn't outweigh the potential harm. The recommendation regarding consumption of > 175 g or < 175 g of carbohydrates per day was made as an 'either/or' due to inadequate evidence for or against. 'We had very little data on nutrition…There are data suggesting that extremes of carbohydrate intake, either far too much carbohydrate or far too little carbohydrate, are detrimental. Less than 100 grams of carbs a day would be detrimental. But there is nothing to really clarify what the correct amount should be. It's quite complex, because it also depends on the individual woman, on her BMI, activity level, and other macronutrients in her diet,' Wyckoff told Medscape Medical News. Another either/or suggestion was made for continuous glucose monitoring (CGM) use or fingerstick blood glucose monitoring in those with T2D, given the lack of direct evidence for superiority. (Other guidelines strongly recommend CGM use for T1D, but that wasn't one of the questions addressed in the current CPG.) For those who are using a CGM, the CPG suggests against the use of a single 24-hour CGM target of < 140 mg/dL in place of standard of care pregnancy glucose targets of < 95 mg/dL, 1-hour postprandial < 140 mg/dL, and 2-hour postprandial < 120 mg/dL. However, clinicians should be aware that not all hybrid closed-loop system algorithms can meet those targets. For those with T1D who are pregnant, the use of a hybrid closed-loop insulin delivery system is suggested, rather than separate noncommunicating pump and CGM devices or multiple daily injections. Early delivery is suggested, based on risk assessment rather than expectant management. This is based on indirect evidence that risks may outweigh the benefits of expectant management beyond 38 weeks gestation and that risk assessment criteria could be useful to inform ideal delivery timing. 'It is very difficult to construct strong research studies around timing of delivery,' Wyckoff noted. Postpartum endocrine care is suggested in addition to usual obstetric care, based on indirect evidence. 'In the postpartum period, there is often a relapse in care. We emphasize that the postpartum is often preconception for the next pregnancy so that intrapartum care is important. We hope to bring attention to that through this guideline,' she said. Asked to comment, Camille E. Powe, MD, co-director of Diabetes in Pregnancy Programs at Massachusetts General Hospital and Massachusetts General Brigham, Boston, told Medscape Medical News, 'The Endocrine Society guideline answered 10 specific important questions for the management of preexisting diabetes in pregnancy, some of which are very controversial and things that clinicians really want to know about. I applaud them for addressing the questions very specifically, with rigor and evidence.' Powe, who works with the American Diabetes Association (ADA) in several capacities related to diabetes in pregnancy but was not officially speaking for the ADA, noted that this CPG generally aligns with the ADA's guidance on preexisting diabetes in pregnancy published as a section of its annual Standards of Care, although the CPG goes into more detail with some of the specific recommendations. 'Historically, pregnant women have not been included in clinical research, and we are still dealing with the implications of that. It's done for good intentions, but I think the unintended consequences of not including pregnant and lactating women in research is that then we have less of an evidence base for which we can treat our pregnant and lactating patients,' Powe noted. She said the writing panel's inability to make strong recommendations 'speaks to the incredible need for high-quality evidence generation in pregnancy and postpartum for those living with diabetes. It's really a call to action for scientists, investigators, physicians, funders, and industry partners to do this work because we really should have the evidence in women's health research to support high-quality care of people with diabetes in pregnancy.' Wyckoff reported no disclosures. Powe is an associate editor for the ADA journal Diabetes Care and received research support from Dexcom. Miriam E. Tucker is a freelance journalist based in the Washington, DC area. She is a regular contributor to Medscape Medical News, with other works appearing in The Washington Post, NPR's Shots blog, and Diatribe. She can be found on X @MiriamETucker and on BlueSky @
Business Insider
a day ago
- Business
- Business Insider
Ascendis Pharma announces new data from PaTHway Trial at ENDO 2025
Ascendis Pharma (ASND) announced new data from Week 156 of its Phase 3 PaTHway Trial confirming that long-term treatment with TransCon PTH continued to provide a durable response in adults with hypoparathyroidism regardless of its cause, including improvements in biochemistries, kidney function, and quality of life. Results were shared at ENDO 2025, the annual meeting of the Endocrine Society being held in San Francisco. PaTHway was a Phase 3, randomized, double-blind, placebo-controlled 26-week trial of 82 adults with chronic hypoparathyroidism, followed by an open-label extension period through Week 182. During the initial 26-week blinded period, participants were randomized 3:1 TransCon PTH:placebo. Renal function was assessed by estimated glomerular filtration rate. Safety assessments included 24-hour urine-calcium and treatment-emergent adverse events. Hypoparathyroidism-related symptoms, functioning, and well-being were measured by the Hypoparathyroidism Patient Experience Scale. Overall retention in the trial was high, with 73 of the original 82 adults enrolled completing the 3.5-year trial. At Week 156, 64 patients had normal albumin-adjusted serum calcium levels and 70 patients were independent from conventional therapy. Reflecting clinically meaningful improvements in kidney function, improvements in eGFR from baseline were sustained through Week 156: mean eGFR increased by 8.76 mL/min/1.73 m2 across all participants and by 13.98 mL/min/1.73 m2 in participants with baseline eGFR less than 60. Patients in the trial reported continued improvements from baseline in their hypoparathyroidism-related symptoms and health-related quality of life and showed continued normalization of 24-hour urine calcium excretion through Week 156. In the trial, TransCon PTH treatment was generally well-tolerated, with no new safety signals identified. TEAEs were mostly mild or moderate and no serious TEAEs or discontinuations were related to study drug. Elevate Your Investing Strategy:
Time of India
a day ago
- Health
- Time of India
Shocking! Loneliness can be linked to Diabetes; here's how
A recent study presented at ENDO 2025 reveals a significant link between social isolation and increased risk of diabetes and poor blood sugar control in older adults. Analyzing data from the National Health and Nutrition Examination Survey (NHANES), researchers found that isolated individuals were significantly more likely to develop diabetes and struggle with blood sugar management. Loneliness may not only affect your mental health, but may also affect your physical health. It might not just hurt your feelings, but may harm your health, and even lead to diabetes. Yes, that's right. A recent study has found that socially isolated individuals have an increased risk of developing certain diseases. A recent study presented at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, California, found that people who are isolated have an increased risk of developing diabetes and high blood sugar. Isolation and diseases The researchers looked at how social isolation is a growing concern since the COVID-19 pandemic, and it is emerging as a major health risk, especially for older adults. They found that isolation could even be linked to diabetes and high blood sugar in older adults. Diabetes is a chronic condition that occurs when the body either doesn't produce enough insulin or can't effectively use the insulin it does produce. This could lead to high blood sugar levels, which can cause serious health complications if not managed properly, including heart disease, kidney damage, and vision problems. High blood pressure, on the other hand, is a 'silent killer', and goes undetected for years. Hypertension is one of the leading causes of chronic illnesses, including heart disease, stroke, and kidney failure, worldwide. 'Social isolation and loneliness have been increasingly recognized as important health risk factors after the COVID-19 pandemic. Our findings underscore the importance for clinicians to recognize social isolation as a critical social determinant of health when caring for older patients,' lead researcher Samiya Khan, M.D., of the Keck School of Medicine at the University of Southern California, said. 'These findings are especially relevant given the rapidly growing aging population in the United States and globally, alongside the widespread prevalence of social isolation and loneliness among older adults,' Khan added. BELLY FAT BLUES: The Waistline Warning Sign of Diabetes The researchers also added that though previous studies have looked at the connection between social isolation and diabetes, this recent study is among the first to examine its link to poor glycemic control using a nationally representative sample of data that reflects the broader US population. The study The researchers analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2003-2008. NHANES is a survey program to assess the health and nutritional status of adults and children in the US. Analysing that, the researchers looked at the data of 3,833 adults aged 60 to 84. This represents about 38 million older people in the US. They found that socially isolated older adults were 34% more likely to have diabetes and 75% more likely to have poor blood sugar control than those who were not isolated. This study has pointed out that isolation could be a vital factor, which is often overlooked when it comes to diabetes and poor blood sugar management in older adults. 'These findings underscore the importance of social connections for the well-being of older adults. Physicians should recognize social isolation as a potential risk factor among elderly patients for both diabetes and high blood sugar,' Khan added.
