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Time of India
35 minutes ago
- Health
- Time of India
Eli Lilly's experimental GLP-1 pill may rival Ozempic and Wegovy? Check how much weight you could lose
Eli Lilly's weight loss pill doesn't appear to work as well as Wall Street had hoped. The drugmaker said Thursday the highest dose of its daily obesity pill helped patients lose almost 12% of their body weight, or roughly 27 pounds, at 72 weeks in a late-stage trial. The result falls on the lower end of Wall Street's expectations. Shares of the company fell around 13% on Thursday, according to CNBC. Meanwhile, shares of rival Novo Nordisk, which is also working to bring an obesity pill to the market, jumped more than 7% on Thursday. Productivity Tool Zero to Hero in Microsoft Excel: Complete Excel guide By Metla Sudha Sekhar View Program Finance Introduction to Technical Analysis & Candlestick Theory By Dinesh Nagpal View Program Finance Financial Literacy i e Lets Crack the Billionaire Code By CA Rahul Gupta View Program Digital Marketing Digital Marketing Masterclass by Neil Patel By Neil Patel View Program Finance Technical Analysis Demystified- A Complete Guide to Trading By Kunal Patel View Program Productivity Tool Excel Essentials to Expert: Your Complete Guide By Study at home View Program Artificial Intelligence AI For Business Professionals Batch 2 By Ansh Mehra View Program Eli Lilly, which makes the injectable drugs Zepbound to treat obesity and Mounjaro and Trulicity to treat diabetes, is among several companies chasing an effective pill form of GLP-1s. The only such pill available so far comes with strict diet restrictions and is approved to treat diabetes. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Web Search search Search Now Undo Lilly says that no food or water restrictions are needed with the experimental oral medication, orforglipron, and it can be taken any time of day. ALSO READ: Firefly Aerospace ignites Wall Street as it raises $868 million in biggest space IPO. All about SpaceX rival Live Events Eli Lily on daily GLP-1 pills Eli Lilly announced that its new orforglipron pill led to an average weight loss of up to 27.3 pounds, based on results from the first of two Phase 3 trials involving over 3,100 overweight or obese adults. "With orforglipron, we're working to transform obesity care by introducing a potential once-daily oral therapy that could support early intervention and long-term disease management, while offering a convenient alternative to injectable treatments," Kenneth Custer, an executive vice president and president of Lilly Cardiometabolic Health, said in a statement. "With these positive data in hand, we are now planning to submit orforglipron for regulatory review by year-end and are prepared for a global launch to address this urgent public health need." ALSO READ: VA terminates major union contracts and it will impact over 400,000 federal workers. What's at stake for you? Investors had high hopes that Lilly's pill, orforglipron, would match the effectiveness of Novo Nordisk's blockbuster weight-loss injection, Wegovy. In key trials, Wegovy helped users lose around 14% to 15% of their body weight — slightly below the weight loss seen with Lilly's competing shot, Zepbound. 'There was hope that this would be a wonder drug,' BMO analyst Evan Seigerman said of Lilly's pill. 'What this shows to me is that it's still a good drug, but it's bound by the limitations of being a GLP-1.' Eli Lilly said that all adults participating in its Phase 3 trials experienced weight loss while taking orforglipron. Participants on the highest dose—36 mg—lost an average of 27 pounds over 72 weeks, equating to about 12% of their body weight. While this result is significant, it falls slightly short of the weight loss typically seen with some injectable treatments with the drugmaker noticing that about 10% of participants on the highest dose chose to discontinue the pill. ALSO READ: $1,702 stimulus check in August: Last chance to apply for PDF closes soon. Check key dates, eligibility, tax implication Beyond weight loss, trial participants saw improvements in cardiovascular markers, including reductions in systolic blood pressure, non-HDL cholesterol, and triglycerides. Negative side effects were similar in frequency and nature to those observed with injectable GLP-1 medications. The most commonly reported side effects were mild to moderate gastrointestinal issues such as nausea, constipation, indigestion, diarrhea, and vomiting. Eli Lilly is also evaluating orforglipron's effectiveness in adults with Type 2 diabetes. In April, the company shared that the pill may help lower hemoglobin A1C levels—a key indicator of average blood sugar over two to three months—while also supporting weight loss. Eli Lilly aims to seek global regulatory approval for its daily oral orforglipron pill by the end of 2025, positioning itself alongside rival Novo Nordisk, which is pursuing approval for an oral form of its Wegovy (semaglutide) treatment. However, federal health regulators are expected to require more comprehensive data on the drug's safety, tolerability, and effectiveness before moving forward with any potential approval.
Time of India
39 minutes ago
- Business
- Time of India
Nebius stock skyrockets 21% after stellar Q2 earnings — new forecast sends Wall Street buzzing
NBIS stock latest news today : Amsterdam-based AI infrastructure company Nebius Group saw its stock soar by 21% on Thursday morning after delivering a blockbuster second-quarter earnings report that blew past Wall Street expectations and reignited investor excitement across the AI sector, as per a report. Nebius Q2 Revenue Surges 600%, Beats Wall Street Expectations The hyperscaler's stock, which has already gained over 140% year-to-date, reported $105.1 million in Q2 revenue, a jaw-dropping 600% increase year-over-year and well ahead of the consensus estimate of $101.2 million, as per a report by Seeking Alpha. The earnings surprise marks yet another milestone in Nebius' rapid rise as a key player in the race to provide AI computing power at scale, according to the report. Productivity Tool Zero to Hero in Microsoft Excel: Complete Excel guide By Metla Sudha Sekhar View Program Finance Introduction to Technical Analysis & Candlestick Theory By Dinesh Nagpal View Program Finance Financial Literacy i e Lets Crack the Billionaire Code By CA Rahul Gupta View Program Digital Marketing Digital Marketing Masterclass by Neil Patel By Neil Patel View Program Finance Technical Analysis Demystified- A Complete Guide to Trading By Kunal Patel View Program Productivity Tool Excel Essentials to Expert: Your Complete Guide By Study at home View Program Artificial Intelligence AI For Business Professionals Batch 2 By Ansh Mehra View Program Nebius founder and CEO Arkady Volozh said that "Nebius is continuing to deliver exceptional results," adding, "In Q2 we more than doubled revenue from the previous quarter, and our core business achieved positive Adjusted EBITDA ahead of plan," as quoted by Seeking Alpha. Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Unsold 2021 Cars Now Almost Free - Prices May Surprise You Unsold Cars | Search Ads Learn More Undo by Taboola by Taboola ALSO READ: Who is Intel CEO Lip-Bu Tan — and why is Donald Trump demanding his resignation? CEO Arkady Volozh Raises 2025 Revenue Forecast to $1.1 Billion Volozh highlighted that, "Because of this strong momentum, we are increasing our annualized run-rate revenue outlook for the year to $900 million to $1.1 billion," as quoted in the report. Live Events Nebius has raised its annualized run-rate revenue guidance for 2025 to between $900 million and $1.1 billion and the company is also in the process of securing more than 1 GW of power by the end of 2026 to support its expansion efforts, as reported by Tipranks. ALSO READ: Microsoft layoffs mount as it cuts 40 jobs - 3,160 fired in Washington since May, employees call it a cultural crisis Nebius Secures Over 1 GW of Power to Support Data Center Expansion Volozh explained that, "Demand for AI infrastructure — compute, software and services — is only going to get stronger as use cases multiply," adding, "We are aggressively scaling up capacity to capture this substantial opportunity and are in the process of securing more than 1 GW of power by the end of 2026," as quoted by the Seeking Alpha report. What Investors Should Know About Nebius' Future Outlook Seeking Alpha analyst Jack Bowman reacted to the positive outlook, saying, "Nebius hit a millstone, reporting over $1B in ARR, following a doubling of its revenue quarter over quarter," as quoted in the report. Bowman highlighted that, "This is the kind of growth necessary to justify its valuation, and is a great sign for shareholders that AI infrastructure demand isn't going anywhere anytime soon. Nebius relies on that demand to fund its hyper-expanding GPU cluster and data center business. Any future weakening of this demand could spell disaster for the stock, but this earnings report shows we are far off from there, and Nebius is still looking incredibly strong from a growth perspective," as quoted in the Seeking Alpha report. According to Tipranks, the latest analyst rating on NBIS stock is a 'Buy' with a $51.00 price target. While, as per Spark, TipRanks' AI Analyst, NBIS is a Neutral, the AI Analyst wrote that, "The overall stock score for Nebius is driven by financial performance challenges, particularly declining revenues and incomplete financial data. Although technical analysis shows bullish momentum and the earnings call highlighted strong growth and partnerships, the lack of profitability and valuation concerns weigh heavily on the score," according to TipRanks report. FAQs Why did Nebius stock rise? The stock surged after Nebius reported an impressive 600% increase in quarterly revenue, beating analyst expectations. What is Nebius' revenue forecast for 2025? The company expects its annual revenue to reach between $900 million and $1.1 billion by the end of 2025.
Time of India
an hour ago
- Sport
- Time of India
"India used vaseline?" – Ex-Pakistan cricketer Shabbir Ahmed makes explosive ball-tampering claim after Oval Test thriller
Former Pakistan pacer Shabbir Ahmed stirred controversy with serious allegations against Team India after their thrilling win over England in the fifth Test at The Oval. England seemed on course to chase down 374 when Joe Root and Harry Brook were in control, having taken the score to 301/3. But a dramatic turnaround led by Mohammed Siraj and Prasidh Krishna saw India dismiss England for 367, sealing a nail-biting six-run victory. The pitch at The Oval was widely considered the most balanced surface of the series, offering a fair contest between bat and ball. Even on Day 5, the old ball continued to swing significantly, making batting a tough challenge. Though India had the opportunity to opt for a new ball after the 80th over, they chose to stick with the old one due to its movement—and the decision proved crucial. Productivity Tool Zero to Hero in Microsoft Excel: Complete Excel guide By Metla Sudha Sekhar View Program Finance Introduction to Technical Analysis & Candlestick Theory By Dinesh Nagpal View Program Finance Financial Literacy i e Lets Crack the Billionaire Code By CA Rahul Gupta View Program Digital Marketing Digital Marketing Masterclass by Neil Patel By Neil Patel View Program Finance Technical Analysis Demystified- A Complete Guide to Trading By Kunal Patel View Program Productivity Tool Excel Essentials to Expert: Your Complete Guide By Study at home View Program Artificial Intelligence AI For Business Professionals Batch 2 By Ansh Mehra View Program However, Shabbir Ahmed raised suspicions over India's tactics and suggested foul play. Posting on X, he insinuated ball tampering and demanded an investigation: "I think India used Vaseline. After 80 + over Ball still shine like new Umpire should send this ball to lab for examine," he wrote. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Undo — ShabbirTestCric (@ShabbirTestCric) New-Look India Sends a Strong Message India arrived in England missing key players—Rohit Sharma and Virat Kohli were unavailable, Jasprit Bumrah missed two crucial Tests, and Rishabh Pant was ruled out of the final match due to injury. Many members of the squad were playing in England for the first time. Despite the challenges, India maintained an upper hand throughout the series. Live Events While they did suffer two defeats, India arguably played the better cricket in those matches but couldn't seize crucial moments, which led to their losses. Ultimately, the team returned home with a drawn series (2-2), having shown depth, resilience, and promise. A major highlight was how every player who featured in the series managed to justify their selection.
Time of India
an hour ago
- Business
- Time of India
Adani talks up India the "emerging powerhouse", sees economy at $25 trillion by 2050
Gautam Adani , Chairman of the Adani Group , in an address at the Indian Institute of Management Lucknow on August 8, projected that India will evolve into a $25 trillion economic powerhouse by 2050. He shared insights with students, emphasising the shifting global economic landscape towards India and the immense opportunities that lie ahead. Adani urged the students to embrace a mindset that maximises possibilities rather than playing it safe. He pointed out that traditional frameworks like the DC model, Porter's five forces, and SWOT analysis are valuable but often focus on minimising risks based on past experiences. Instead, he advocated for a future-oriented approach that prioritises creativity and boldness. Productivity Tool Zero to Hero in Microsoft Excel: Complete Excel guide By Metla Sudha Sekhar View Program Finance Introduction to Technical Analysis & Candlestick Theory By Dinesh Nagpal View Program Finance Financial Literacy i e Lets Crack the Billionaire Code By CA Rahul Gupta View Program Digital Marketing Digital Marketing Masterclass by Neil Patel By Neil Patel View Program Finance Technical Analysis Demystified- A Complete Guide to Trading By Kunal Patel View Program Productivity Tool Excel Essentials to Expert: Your Complete Guide By Study at home View Program Artificial Intelligence AI For Business Professionals Batch 2 By Ansh Mehra View Program "The future will never belong to those who play it safe. It belongs to those who maximise possibility," he asserted. The industrialist highlighted that the students' careers would align with India's transformative decades, saying, "Your most productive years will coincide with India's most powerful years." He expressed confidence in India's trajectory, indicating that the nation is on the verge of becoming the third-largest economy by 2030, driven by demographic advantages, rising demand, digital innovations, and increasing domestic investment. Live Events Adani identified four key forces behind India's transformation: Demographics: He noted that India has the youngest and most ambitious workforce, ready to harness a billion dreams. Demand: Adani affirmed that India is not merely consuming but actively creating markets on a global scale. Digital Infrastructure: He praised India's advancements, such as Aadhaar and UPI, calling them platforms for innovation and inclusion. Domestic Capital: For the first time, Indian capital is supporting homegrown ideas with unprecedented confidence. Adani encouraged students to think beyond conventional business models and embrace imagination and risk-taking. He cited the Adani Group's ambitious projects as examples of using imagination to shape the future rather than relying solely on predictions. Adani also reminded students of the importance of India's civilisational values. Despite global influences, he stressed the significance of staying rooted in India's unique moral fabric. "You are not just students of globalisation. You are the children of our civilisation," he said, urging them to carry forward this responsibility.
Time of India
an hour ago
- Business
- Time of India
Sky-high and jaw-dropping: Italy and China race to build the most insane bridges on earth
Bridges have always stood as powerful symbols of human ingenuity connecting not just places, but economies, cultures, and dreams. Today, Italy and China are pushing the limits of what's possible in bridge engineering with two mega projects that could soon shatter world records. Italy is set to build the longest suspension bridge ever constructed, linking the island of Sicily to the mainland. Meanwhile, China is constructing a sky scraping steel truss bridge over one of its deepest canyons. These monumental undertakings are not just about infrastructure, they're declarations of national ambition, technological leadership, and a shared desire to conquer geography. As the world watches, these bridges promise to transform travel, boost economies, and inspire future generations of engineers to dream bigger than ever before. Productivity Tool Zero to Hero in Microsoft Excel: Complete Excel guide By Metla Sudha Sekhar View Program Finance Introduction to Technical Analysis & Candlestick Theory By Dinesh Nagpal View Program Finance Financial Literacy i e Lets Crack the Billionaire Code By CA Rahul Gupta View Program Digital Marketing Digital Marketing Masterclass by Neil Patel By Neil Patel View Program Finance Technical Analysis Demystified- A Complete Guide to Trading By Kunal Patel View Program Productivity Tool Excel Essentials to Expert: Your Complete Guide By Study at home View Program Artificial Intelligence AI For Business Professionals Batch 2 By Ansh Mehra View Program Italy's Messina Strait Bridge: A Historic Connection Italy is pressing ahead with the Messina Strait Bridge, which, once built, will become the longest suspension bridge in the world. The design includes a single 3.3-kilometer span connecting the island of Sicily to the Italian mainland, supporting both cars and trains. The goal is not just connectivity; the project is also expected to bring economic growth, create over 100,000 jobs, and boost tourism and trade. While the project has the backing of Prime Minister Giorgia Meloni, it's not without critics. Concerns range from seismic risks to potential environmental damage and massive budgetary requirements. Still, after decades of false starts, construction is expected to begin by late 2025, aiming for completion within the next decade. China's Huajiang Canyon Bridge: Engineering the Sky On the other side of the world, China is working on the Huajiang Canyon Bridge in Guizhou, which will hold the title of tallest bridge by deck height once completed. Soaring 625 meters (2,051 feet) above the canyon floor taller than many skyscrapers, this steel truss suspension bridge will dramatically shorten travel time across a previously hard-to-reach area. Live Events The bridge not only showcases China's technological prowess but also provides a huge boost to local accessibility and economic development. The project is part of China's broader investment in infrastructure across remote regions, demonstrating its commitment to transforming even the most challenging landscapes. New Era for Mega Infrastructure These two record-breaking bridges highlight a growing global appetite for daring and transformative infrastructure. Whether uniting a country or conquering geography, such projects reflect ambition at a national level. More than concrete and steel, these structures represent vision, resilience, and a desire to push boundaries literally and figuratively. FAQs: Q1. What is the Messina Strait Bridge? A1. It's a proposed suspension bridge in Italy designed to connect the island of Sicily to the mainland. If completed, it will be the world's longest suspension bridge with a span of 3.3 kilometers. Q2. What is the Huajiang Canyon Bridge in China? A2. It is a steel truss suspension bridge under construction in Guizhou, China. Once finished, it will be the tallest bridge by deck height, towering 625 meters above the canyon floor.
