Latest news with #FrontiersinEndocrinology
Medscape
14-05-2025
- Health
- Medscape
Genotype-Based FSH Choice Boosts IVF Outcomes
Follicle-stimulating hormone receptor (FSHR) N680S–genotyped women treated with either recombinant FSH or urinary FSH had higher pregnancy rates of 51% vs 40% in non-genotyped control individuals. This personalized approach also improved cumulative live birth rates to 40% vs 29% in non-genotyped control individuals. METHODOLOGY: A total of 475 women undergoing in vitro fertilization (IVF) were randomized to receive either recombinant FSH or urinary FSH for ovarian stimulation, with their FSHR N680S variant analyzed afterward. Researchers compared outcomes between 221 optimally treated women (based on FSHR genotype) and 991 non-genotyped control individuals, with adjustment for age, body mass index, and fertilization method. Clinical data were supported by laboratory experiments where COS-1 cells were transfected with homozygous FSHR variants and stimulated with either urinary FSH or recombinant FSH to evaluate receptor activity. Primary outcomes were cumulative pregnancy rates and clinical live birth rates for all treatments related to the first ovarian stimulation cycle. TAKEAWAY: Women who underwent genotype-guided FSH selection showed significantly higher pregnancy rates (51% vs 40%; odds ratio [OR], 1.40; 95% CI, 1.12-1.75; P = .003) and live birth rates (40% vs 29%; OR, 1.55; 95% CI, 1.23-1.96; P < .001) than non-genotyped control individuals. = .003) and live birth rates (40% vs 29%; OR, 1.55; 95% CI, 1.23-1.96; < .001) than non-genotyped control individuals. Urinary FSH proved optimal for S-allele carriers, while recombinant FSH showed better results for asparagine homozygous carriers, with 33% more oocytes retrieved in NN-genotype women treated with recombinant FSH. In vitro experiments revealed the S variant displayed higher extracellular cyclic adenosine monophosphate when stimulated with urinary FSH vs recombinant FSH (10 IU: 176 vs 39 pmol/mg; P = .002; 90 IU: 227 vs 58 pmol/mg; P = .007). IN PRACTICE: 'In the context of applying precision medicine to OS [ovarian stimulation] prior to IVF, the most important finding was an 11% higher CLBR [cumulative life birth rate] in the first OS cycle in women who had been treated with the type of FSH that best matched their FSHR N680S genotype as compared to non-genotyped controls,' the authors of the study wrote. SOURCE: The study was led by Ida Hjelmér, Department of Translational Medicine, Lund University, Malmö, Sweden. It was published online in Frontiers in Endocrinology . LIMITATIONS: The study was not sufficiently powered to evaluate the effect of the precision medicine concept on miscarriage or ovarian hyperstimulation syndrome risk. Results cannot be extrapolated to women with polycystic ovary syndrome, endometriosis, or other excluded conditions. The study comprised only women undergoing their first ovarian stimulation cycle, limiting its applicability to those requiring multiple treatments. DISCLOSURES: The study was funded by EU Interreg NYPS 20201846 and an ALF government grant. Aleksander Giwercman reported receiving an unrestricted grant from Ferring Pharmaceuticals to the ReproUnion research network and a lecture fee from Merck Serono. Additional disclosures are noted in the original article.
India Today
14-05-2025
- Health
- India Today
New saliva test aims to reduce IVF side effects and improve pregnancy rates
A simple saliva test can help improve the chances of IVF, according to a new study by Swedish findings, published in peer-reviewed Frontiers in Endocrinology, has found that a genetic test could reduce harmful side effects for women undergoing fertility by Yvonne Lundberg Giwercman from Lund University, the research highlights how personalised hormone therapy, based on a woman's genetic makeup, can lead to more successful About 15% of couples of reproductive age struggle with infertility. A growing number of people are postponing parenthood, leading to a sharp increase in assisted reproduction methods like IVF treatments come with challenges. The procedure involves hormone therapy to stimulate egg production, but nearly 75% of IVF attempts to 20% of women experience side effects, some requiring emergency care.'A major issue is that doctors currently have to guess which hormone treatment is best for each woman,' said Ida Hjelmr, the study's first author and a laboratory researcher at Lund find a solution, the team analysed the genes of 1,466 women undergoing discovered that women with a specific version of the FSH receptor gene responded better to biological hormones, while others did better with synthetic matching treatment to genetic type, success rates improved significantly.'We saw a 38% increase in births among women who received hormone therapy that matched their gene variation. That's 110 more babies for every 1,000 women treated,' said make this process faster and more accessible, the team developed a simple oral swab test that shows the ideal hormone treatment within an hour, visible as a pink or yellow test is expected to be available by early 2026, said Giwercman, who is also the CEO of the company that developed the oral swab researchers have applied for a patent and launched a company, Dx4Life AB, to bring the product to hope the test will lead to more successful IVF outcomes while reducing health risks and healthcare Watch
Hans India
14-05-2025
- Health
- Hans India
Swab test breakthrough could revolutionise IVF success rates: Swedish scientists lead the way
In a major breakthrough for reproductive medicine, Swedish researchers have developed a simple oral swab test that could significantly improve the success rates of in vitro fertilisation (IVF). The innovation, led by a team at Lund University, aims to personalise IVF treatment by identifying the most suitable hormone therapy for each woman—within just one hour. IVF typically involves stimulating a woman's ovaries to produce multiple eggs, which are then retrieved, fertilised in a laboratory, and implanted into the uterus. However, selecting the appropriate hormone therapy—biological or synthetic—to trigger egg maturation has long posed challenges. The wrong choice not only reduces the chances of a successful pregnancy but may also cause severe side effects that could require intensive care. Traditionally, determining the best hormone treatment required complex and expensive genetic mapping. The new swab test, however, offers a quick and cost-effective alternative. With results visible to the naked eye in either pink or yellow, the test determines which hormone therapy is most compatible with a woman's genetic makeup. 'Our hope is that this will reduce the risk of suffering for women, increase the number of successful treatments, and cut costs for taxpayers,' said Professor Yvonne Lundberg Giwercman, who led the study. 'Our goal is for the test to be available by the start of 2026.' The study, published in Frontiers in Endocrinology, involved 1,466 women undergoing IVF treatment across Sweden. Of these, 475 participants were randomly assigned one of the two hormone therapies, while the remainder served as controls. Researchers used gene sequencing to identify a specific variant of the follicle-stimulating hormone receptor (FSHR) gene that influences response to treatment. Women with this particular gene variant responded better to biological hormones, while others had more success with synthetic alternatives. With this test, clinicians can now tailor treatment plans more effectively, potentially increasing the chances of pregnancy while reducing medical risks. This new advancement is a hopeful sign for couples struggling with infertility and marks a pivotal shift toward personalised reproductive care.
Hans India
13-05-2025
- Health
- Hans India
A simple oral swab test before IVF likely to boost success rate
Swedish researchers have developed a simple oral swab test, which can help boost the success rate of the in vitro fertilization (IVF) procedure. IVF treatment involves stimulating the woman's ovaries to mature many eggs, which are then retrieved and fertilised with sperm in the laboratory before being returned to the uterus. There are two different types of hormone treatments to choose from for egg maturation: biological or synthetic. Besides the risk of serious side effects, the therapies sometimes require women to go into intensive care -- and many attempts at IVF fail. Selecting which therapy is best for the woman has become a major challenge. While mapping genes is costly and takes time, the new simple oral swab test within an hour shows which hormone therapy is most suitable. 'Our hope is that this will reduce the risk of suffering for women, increase the number of successful treatments, and cut costs for taxpayers. Our goal is for the test to be available by the start of 2026,' said Yvonne Lundberg Giwercman, professor at Lund University. A total of 1,466 women undergoing IVF treatment in Sweden were included in the study, and 475 were randomised to two different hormone treatments while the rest were controls. Using gene sequencing, the team mapped the action of the gene follicle-stimulating hormone (FSH), which is known to play an important role in egg maturation. The study identified that women with a particular variant of the FSH receptor (FSHR) gene that mediates the action of the hormone responded best to the biological hormone treatment, while others benefited from receiving the synthetic type of hormone. To decode the genetic profile, the team turned to the oral swab test, which proved to be significantly efficient. Within an hour, it produced results that can be seen with the naked eye as a pink or yellow colour. By knowing the woman's genetic profile in advance, we can increase the number of successful pregnancies, said Giwercman, in the study published in the journal Frontiers in Endocrinology.
Jordan News
01-03-2025
- Health
- Jordan News
How Fasting Purifies the Body and Skin - Jordan News
Fasting during the month of Ramadan is one of the most spiritually and health-beneficial practices for both the body and skin. During the long fasting hours, the body undergoes a series of vital changes that contribute to detoxification, improve digestive health, and enhance skin radiance. اضافة اعلان Fasting is not just about abstaining from food and drink; it represents an opportunity to reset the body's processes, which positively affects overall health and external appearance. 1. Detoxification Process: Fasting helps promote detoxification. Normally, the body is busy digesting food throughout the day, but when food intake stops for long hours, the cells start working effectively to get rid of accumulated toxins. Scientific studies, such as those published in the Journal of Clinical Investigation, confirm that fasting enhances the process of autophagy. This is when the body recycles damaged cells and produces new ones, which helps delay aging and improve skin function. 2. Improving Liver and Digestive Health: Fasting allows the digestive system to rest. The liver, the body's primary detoxifying organ, becomes more efficient in eliminating waste and converting stored fats into energy. This helps improve metabolic processes and prevents the accumulation of harmful substances in the body. According to a study in the American Journal of Physiology, intermittent fasting also promotes gut health and reduces chronic inflammation, which can cause skin problems like acne and eczema. 3. Skin Radiance and Acne Reduction: The skin is a reflection of the body's internal health, and fasting helps improve skin radiance and reduce its problems. During fasting, the body reduces insulin secretion, which helps lower inflammation that leads to acne. Also, the reduction of free radicals in the body during fasting contributes to minimizing oxidative damage that accelerates aging and causes premature wrinkles. A study published in the Journal of Dermatological Science confirmed that fasting regulates the production of oils in the skin, reducing excess oil secretion and preventing clogged pores. 4. Skin Hydration: Hydration plays a vital role in skin health during fasting. Dehydration can lead to dry skin and loss of vitality. However, balanced fasting, with sufficient water intake between Iftar and Suhoor, helps maintain skin hydration and enhance its elasticity. Water-rich fruits like watermelon and cucumber assist in keeping the skin hydrated, giving it a healthy, radiant appearance. 5. Hormonal Regulation and Hair and Nail Health: Fasting not only cleanses the skin but also helps regulate hormones, which benefits hair and nail health. Fasting lowers cortisol levels, a stress hormone linked to hair loss and weak nails. Research published in Frontiers in Endocrinology shows that regular fasting helps balance hormones, which positively impacts the overall health of the body, including the skin and hair. 6. Enhancing Collagen and Elastin Production: Fasting can also boost collagen and elastin production, essential elements for maintaining skin elasticity and youthfulness. When the body removes excess toxins and regenerates cells, the skin becomes softer and more radiant. Foods rich in Vitamin C, such as citrus fruits, which are recommended during Iftar, help support collagen production and accelerate skin cell renewal. Conclusion: Fasting during Ramadan is not just a religious practice but also a natural system for cleansing the body and renewing its youth. By giving the digestive system a break, enhancing detoxification processes, reducing inflammation, and stimulating the production of healthy new cells, the body becomes more energetic, and the skin becomes fresher and healthier. If done in balance with proper nutrition and hydration, fasting can be an effective natural method to enhance both inner and outer beauty simultaneously.
