Latest news with #GUTS
Business Insider
5 days ago
- Health
- Business Insider
Fractyl Health announces two-year follow-up data from Revita study
Fractyl Health (GUTS) announced two-year follow-up data from the Germany Real-World Registry study that showed a single Revita procedure led to durable weight loss and improved glucose control in people with obesity and advanced T2D. These data underscore Revita's potential to provide a potent and durable non-drug alternative for patients struggling with long-term metabolic control. The Germany Real-World Registry study is a prospective, post-market, clinical follow-up study to evaluate the Revita procedure in patients with inadequately controlled T2D. Participants had a baseline HbA1c between 7%-10%, BMI of 45 kg/m, and were on at least one glucose-lowering agent. At baseline, the first nine participants with two years of follow-up had a median age of 62 years, median weight of 104 kg, and a median HbA1c of 9.6%, despite being on up to three GLAs. After a single Revita procedure, these nine participants achieved a median weight loss of 9.6% with weight decreasing from 104 kg to 97 kg at 1 year, a result that was sustained throughout 2 years. Notably, 7 of 8 participants experienced at least a 5% weight reduction, and 5 of 8 saw reductions of 10%. Only one participant, with a history of cortisone therapy known to cause weight gain, experienced modest weight gain. In parallel, median HbA1c reduced by 1.6%, from 9.6% at baseline to 7.2% at 1 year, and this improvement was sustained throughout two years, even as participants reduced or stabilized their use of GLAs. Three patients were on a GLP-1 drug at the time of study entry and were still on a GLP-1 drug through two years of follow-up. No device- or procedure-related serious adverse events have been reported to date. In this cohort, weight loss and glucose improvements began as early as one month after the Revita procedure and were sustained through two years of follow-up. These findings highlight the potential of a single Revita treatment to deliver durable weight maintenance in a real-world setting. Thirty-four participants are currently enrolled in the Germany Real-World Registry study. While the study is no longer enrolling new patients, Fractyl will continue protocol-defined follow-up of participants and share outcomes on an ongoing basis. Revita is being studied in an ongoing IDE-approved REMAIN-1 pivotal study to evaluate its potential safety and efficacy in post-GLP-1 weight maintenance. These new findings from Germany add real-world momentum to Fractyl's upcoming pivotal trial readouts, including Midpoint Cohort data from its ongoing REMAIN-1 study, which is expected in Q3 2025, and primary endpoint data from the Pivotal Cohort, anticipated in H2 2026. Together, these clinical milestones are designed to demonstrate Revita's potential to help maintain weight loss after GLP-1 discontinuation and inform its possible role in supporting durable metabolic outcomes for patients with obesity.
Express Tribune
6 days ago
- Entertainment
- Express Tribune
Olivia Rodrigo marks GUTS tour finale with Weezer throwback in full-circle Instagram post
Olivia Rodrigo concluded her GUTS world tour on a nostalgic note by sharing a full-circle moment with Weezer. The singer took to Instagram to post a series of sentimental photos that highlighted how far she's come, starting with an image of a young Olivia wearing Weezer merch at her very first concert. She captioned the post, 'my first concert and my last weekend of the GUTS tour,' and added, 'Thank u to everyone who came out and thank u @weezer for still making me this excited all these years later!!! Cannot believe how lucky I am to be able to play these shows with yall!!!!' Another photo captured her performing Buddy Holly with the band at Lollapalooza 2025, creating a moment fans quickly labelled iconic. Rodrigo wrapped her global run with a final show at Osheaga 2025 after performing 95 concerts across 22 countries. At the final stop, she surprised fans by handing out Guts-themed rings while stepping into the audience. Fans also speculated after Rodrigo wore a shirt with a bedazzled '3' during the concert potentially dropping hints about her third studio album.
Express Tribune
04-08-2025
- Entertainment
- Express Tribune
Olivia Rodrigo sparks speculation about new music at Osheaga 2025 festival finale
Olivia Rodrigo may have quietly teased her highly anticipated third studio album during the closing show of her GUTS tour at Osheaga 2025 in Montreal. In her final encore, the singer appeared on stage wearing a simple red shirt printed with a bedazzled '3' on the torso, instantly sparking speculation among fans and media alike. The unspoken gesture was interpreted by many as a sign that her next album, often referred to as OR3, is on the horizon. Rodrigo has not publicly commented on the shirt, but her history of planting subtle visual cues during performances lends credibility to the theory. In a 2023 interview, Rodrigo confirmed she had begun early work on her next album and intended to maintain her signature four-letter title format, following SOUR and GUTS. Among fan predictions are titles such as 'LUCK', 'BURN', and 'SWEET', though none have been confirmed. She previously revealed that around 25 tracks were written but not included on GUTS, leaving ample material for future releases. Combined with her ongoing songwriting habit and growing personal experiences, many believe Rodrigo's third album could take a new thematic turn, possibly focusing on love and maturity. Additionally, her shift in stage aesthetics, from the purple tones of SOUR and GUTS to vibrant reds, has fuelled theories about a new album era, perhaps exploring romantic themes. Though no official release date has been announced, Rodrigo's history of two-year album cycles points to a likely late 2025 or early 2026 drop.
Perth Now
03-07-2025
- Entertainment
- Perth Now
Global celebrities everywhere in iconic Wimbledon photo
Olivia Rodrigo. John Cena. Dave Grohl. Priyanka Chopra and Nick Jonas. There was as much star power — or maybe even more? — in the Royal Box at Wimbledon as there was down below on the Centre Court grass on Wednesday. And that was on an afternoon that featured two-time defending men's champion Carlos Alcaraz, No. 1-ranked woman Aryna Sabalenka, and 2021 US Open champion Emma Raducanu of Britain all winning matches at the grass-court grand slam tournament's main stadium to reach the third round. 'It's so special in the Royal Box to have those kind of people in there. It definitely adds a bit of pressure, I guess, if you look up and you kind of recognise (them),' Raducanu said. 'That's why I try and stay with my eyes on the court as much as possible. Only after, you kind of look up and take it all in, if they're still there.' The seats in the Royal Box behind one of the baselines are by invitation only, and there was quite a list of celebrities on hand for Day 3 of competition. 'I was trying not to look today,' Sabalenka said about the collection of boldfaced names, explaining that she might be distracted while competing. 'I was just trying to focus on my game. Later on, I'm going to open the social media (and ask), 'OK, who was there?'' Well, Aryna, here's a rundown: Rodrigo, fresh off headlining at music festival Glastonbury while on tour for her GUTS album, sat next to Cena, the professional wrestler and movie star. Olivia Rodrigo, Tom Daley and John Cena all in one photo. Credit: AAP Rodrigo chatted at one point with former England soccer coach Roy Hodgson, while the current person in that job, Thomas Tuchel, also was in attendance. Grohl, a member of the rock bands Foo Fighters and Nirvana, made an appearance, too, as did the married couple Chopra and Jonas. Priyanka Chopra and husband Nick Jonas Credit: AAP Dave Grohl and wife Jordyn enjoying the action. Credit: AAP Hollywood's Judd Apatow and Leslie Mann, who also are married, were on the Royal Box list, along with actor Dominic Cooper. Others taking in a day of tennis at the most famous court in the world included British athletes from other sports, such as Olympic gold medalists Sophie Bray (field hockey) and Tom Daley (diving), and Paralympic gold medalist William Ellard (swimming). Oh, and there was actual British royalty there Wednesday: Princess Michael of Kent.
7NEWS
03-07-2025
- Entertainment
- 7NEWS
Olivia Rodrigo, John Cena and Dave Grohl among many celebrities in Wimbledon's Royal Box
Olivia Rodrigo. John Cena. Dave Grohl. Priyanka Chopra and Nick Jonas. There was as much star power — or maybe even more? — in the Royal Box at Wimbledon as there was down below on the Centre Court grass on Wednesday. And that was on an afternoon that featured two-time defending men's champion Carlos Alcaraz, No. 1-ranked woman Aryna Sabalenka, and 2021 US Open champion Emma Raducanu of Britain all winning matches at the grass-court grand slam tournament's main stadium to reach the third round. 'It's so special in the Royal Box to have those kind of people in there. It definitely adds a bit of pressure, I guess, if you look up and you kind of recognise (them),' Raducanu said. 'That's why I try and stay with my eyes on the court as much as possible. Only after, you kind of look up and take it all in, if they're still there.' The seats in the Royal Box behind one of the baselines are by invitation only, and there was quite a list of celebrities on hand for Day 3 of competition. 'I was trying not to look today,' Sabalenka said about the collection of boldfaced names, explaining that she might be distracted while competing. 'I was just trying to focus on my game. Later on, I'm going to open the social media (and ask), 'OK, who was there?'' Well, Aryna, here's a rundown: Rodrigo, fresh off headlining at music festival Glastonbury while on tour for her GUTS album, sat next to Cena, the professional wrestler and movie star. Rodrigo chatted at one point with former England soccer coach Roy Hodgson, while the current person in that job, Thomas Tuchel, also was in attendance. Grohl, a member of the rock bands Foo Fighters and Nirvana, made an appearance, too, as did the married couple Chopra and Jonas. Hollywood's Judd Apatow and Leslie Mann, who also are married, were on the Royal Box list, along with actor Dominic Cooper. Others taking in a day of tennis at the most famous court in the world included British athletes from other sports, such as Olympic gold medalists Sophie Bray (field hockey) and Tom Daley (diving), and Paralympic gold medalist William Ellard (swimming). Oh, and there was actual British royalty there Wednesday: Princess Michael of Kent.
