Latest news with #GaryMathias
Yahoo
05-05-2025
- Business
- Yahoo
Thetis Pharmaceuticals Presents New Preclinical and Clinical Data forTP-317 at DDW 2025
Findings Highlight First-in-Class Potential of TP-317 in Inflammatory Bowel Disease and Colorectal Cancer ESSEX, Conn., May 05, 2025--(BUSINESS WIRE)--Thetis Pharmaceuticals LLC ("Thetis"), a clinical-stage company developing TP-317, a first-in-class, small molecule drug candidate targeting the BLT1 receptor to treat inflammatory bowel disease (IBD) and solid tumor cancers, today announced the presentation of four data sets at Digestive Disease Week (DDW) 2025, held May 3-6 in San Diego, California. The data support TP-317's advancement as a novel oral therapy for both IBD and microsatellite stable (MSS) colorectal cancer (CRC). "These data show how TP-317 can meaningfully impact immune-mediated diseases by activating the BLT1 pathway. In IBD, TP-317 promotes epithelial repair and resolves mucosal inflammation. In solid tumors, TP-317 promotes antigen presentation to enhance the efficacy of immune checkpoint inhibitors in tumors that are resistant to immunotherapy," said Gary Mathias, CEO of Thetis Pharmaceuticals. "With encouraging preclinical results in IBD and MSS colorectal cancer and positive safety and PK/PD data from our Phase 1a study, TP-317 is well-positioned for Phase 2 clinical development in both indications." Colorectal Cancer: Immune Reprogramming and Combination Potential In the oral presentation, "TP-317, an Oral BLT1 Agonist, Enhances Immune Checkpoint Inhibitor Therapy by Stimulating Tumor Antigen Presentation in a Microsatellite Stable (MSS) Tumor Model of Colorectal Cancer (CRC)," TP-317 demonstrated potent anti-tumor activity and synergy with checkpoint inhibitors. Key findings include: TP-317 activated STING and IFN-γ pathways and boosted antigen presentation, converting immunologically "cold" MSS tumors into "hot," immune-responsive ones. TP-317 demonstrated robust single-agent efficacy and enhanced activity in combination with chemotherapy and checkpoint inhibitors in MSS CRC models. Tumor control was BLT1-dependent, with broad innate and adaptive immune activation. IBD: Barrier Protection and Mucosal Homeostasis In a second oral presentation, "TP-317, a Novel BLT1 Agonist Oral Therapy for IBD, Exhibits Anti-Inflammatory and Epithelial Barrier Protective Efficacy in Murine DSS Colitis and TNFΔARE Ileitis," data from multiple colitis models showed TP-317 restored epithelial barrier function and reduced inflammation. Key findings include: In DSS colitis, TP-317 significantly reduced disease activity, histologic inflammation, and crypt damage, demonstrating strong anti-inflammatory and mucosal barrier-protective effects on par with a JAK inhibitor and cyclosporine. In TNFΔARE ileitis, TP-317 lowered intestinal permeability and inflammatory cytokines, reinforcing its potential as a disease-modifying therapy for Crohn's disease and ulcerative colitis. Clinical Safety and PK/PD Profile In the poster presentation, "PK/PD, Safety, and Efficacy of Oral Resolvin E1-based Therapy in IBD: Translating Resolvin E1 Activation of BLT1 in Experimental Models to Healthy Volunteers," data from a Phase 1a study confirmed TP-317's safety and target engagement: Single oral doses up to 80 mg were well tolerated with no treatment-related adverse events. Resolvin E1 (RvE1) exposure was dose-proportional and exceeded the EC50 for BLT1 activation. Transient neutrophil margination that reversed within two hours (a known pharmacodynamic effect of RvE1 at BLT1) was observed at the 80 mg dose in all subjects, indicating target engagement. Inflammation and Pain Biomarkers Modulation A second poster presentation, "TP-317, an Oral BLT1 Agonist, Reduces Abdominal Pain to Colorectal Distension and Reduces Key Biomarkers of Colitis in a Mouse Model of Inflammatory Bowel Disease," further demonstrated TP-317's dual efficacy: Significantly reduced visceral pain responses in DNBS colitis mice. Broad transcriptomic suppression of genes associated with inflammation, epithelial-to-mesenchymal transition (EMT), and enteric nervous system signaling. Compared favorably to prednisolone across visceral pain endpoints and modulation of gene expression pathways. These findings build a compelling case for TP-317 as a Phase 2-ready candidate with broad potential to address unmet needs in IBD. About Thetis Pharmaceuticals Thetis is a clinical-stage pharmaceutical company focused on developing innovative treatments for chronic inflammatory diseases and cancer. Its lead candidate, TP-317, is a first-in-class oral Resolvin E1 drug candidate that targets the LTB4-BLT1 pathway to mobilize the body's natural ability to resolve disease and restore immune homeostasis. For more information, please visit and follow us on LinkedIn. View source version on Contacts Tracy LessorSVP, CommunicationsThetis Pharma617-519-9827tracy@ Sign in to access your portfolio
Business Wire
05-05-2025
- Business
- Business Wire
Thetis Pharmaceuticals Presents New Preclinical and Clinical Data forTP-317 at DDW 2025
ESSEX, Conn.--(BUSINESS WIRE)--Thetis Pharmaceuticals LLC ('Thetis'), a clinical-stage company developing TP-317, a first-in-class, small molecule drug candidate targeting the BLT1 receptor to treat inflammatory bowel disease (IBD) and solid tumor cancers, today announced the presentation of four data sets at Digestive Disease Week (DDW) 2025, held May 3-6 in San Diego, California. The data support TP-317's advancement as a novel oral therapy for both IBD and microsatellite stable (MSS) colorectal cancer (CRC). 'With encouraging preclinical results in IBD and MSS colorectal cancer and positive safety and PK/PD data from our Phase 1a study, TP-317 is well-positioned for Phase 2 clinical development in both indications.' 'These data show how TP-317 can meaningfully impact immune-mediated diseases by activating the BLT1 pathway. In IBD, TP-317 promotes epithelial repair and resolves mucosal inflammation. In solid tumors, TP-317 promotes antigen presentation to enhance the efficacy of immune checkpoint inhibitors in tumors that are resistant to immunotherapy,' said Gary Mathias, CEO of Thetis Pharmaceuticals. 'With encouraging preclinical results in IBD and MSS colorectal cancer and positive safety and PK/PD data from our Phase 1a study, TP-317 is well-positioned for Phase 2 clinical development in both indications.' Colorectal Cancer: Immune Reprogramming and Combination Potential In the oral presentation, ' TP-317, an Oral BLT1 Agonist, Enhances Immune Checkpoint Inhibitor Therapy by Stimulating Tumor Antigen Presentation in a Microsatellite Stable (MSS) Tumor Model of Colorectal Cancer (CRC), ' TP-317 demonstrated potent anti-tumor activity and synergy with checkpoint inhibitors. Key findings include: TP-317 activated STING and IFN-γ pathways and boosted antigen presentation, converting immunologically 'cold' MSS tumors into 'hot,' immune-responsive ones. TP-317 demonstrated robust single-agent efficacy and enhanced activity in combination with chemotherapy and checkpoint inhibitors in MSS CRC models. Tumor control was BLT1-dependent, with broad innate and adaptive immune activation. IBD: Barrier Protection and Mucosal Homeostasis In a second oral presentation, ' TP-317, a Novel BLT1 Agonist Oral Therapy for IBD, Exhibits Anti-Inflammatory and Epithelial Barrier Protective Efficacy in Murine DSS Colitis and TNF ΔARE Ileitis,' data from multiple colitis models showed TP-317 restored epithelial barrier function and reduced inflammation. Key findings include: In DSS colitis, TP-317 significantly reduced disease activity, histologic inflammation, and crypt damage, demonstrating strong anti-inflammatory and mucosal barrier-protective effects on par with a JAK inhibitor and cyclosporine. In TNF ΔARE ileitis, TP-317 lowered intestinal permeability and inflammatory cytokines, reinforcing its potential as a disease-modifying therapy for Crohn's disease and ulcerative colitis. Clinical Safety and PK/PD Profile In the poster presentation, ' PK/PD, Safety, and Efficacy of Oral Resolvin E1-based Therapy in IBD: Translating Resolvin E1 Activation of BLT1 in Experimental Models to Healthy Volunteers,' data from a Phase 1a study confirmed TP-317's safety and target engagement: Single oral doses up to 80 mg were well tolerated with no treatment-related adverse events. Resolvin E1 (RvE1) exposure was dose-proportional and exceeded the EC50 for BLT1 activation. Transient neutrophil margination that reversed within two hours (a known pharmacodynamic effect of RvE1 at BLT1) was observed at the 80 mg dose in all subjects, indicating target engagement. Inflammation and Pain Biomarkers Modulation A second poster presentation, 'TP-317, an Oral BLT1 Agonist, Reduces Abdominal Pain to Colorectal Distension and Reduces Key Biomarkers of Colitis in a Mouse Model of Inflammatory Bowel Disease,' further demonstrated TP-317's dual efficacy: Significantly reduced visceral pain responses in DNBS colitis mice. Broad transcriptomic suppression of genes associated with inflammation, epithelial-to-mesenchymal transition (EMT), and enteric nervous system signaling. Compared favorably to prednisolone across visceral pain endpoints and modulation of gene expression pathways. These findings build a compelling case for TP-317 as a Phase 2-ready candidate with broad potential to address unmet needs in IBD. About Thetis Pharmaceuticals Thetis is a clinical-stage pharmaceutical company focused on developing innovative treatments for chronic inflammatory diseases and cancer. Its lead candidate, TP-317, is a first-in-class oral Resolvin E1 drug candidate that targets the LTB4-BLT1 pathway to mobilize the body's natural ability to resolve disease and restore immune homeostasis. For more information, please visit and follow us on LinkedIn.
Yahoo
19-02-2025
- Business
- Yahoo
Thetis Pharmaceuticals Presents New Preclinical and Clinical Data for TP-317 at ECCO 2025
Phase 1a Clinical Results Demonstrate a Favorable Safety Profile and BLT1 Engagement In Healthy Volunteers Preclinical Data Highlight TP-317's Anti-Inflammatory, Epithelial Barrier-Protective Effects ESSEX, Conn., February 19, 2025--(BUSINESS WIRE)--Thetis Pharmaceuticals LLC ("Thetis"), a clinical-stage company developing TP-317, a first-in-class, small molecule drug candidate targeting the BLT1 receptor to treat inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis, today announced the presentation of new preclinical and clinical data at the 20th Congress of the European Crohn's and Colitis Organization (ECCO) in Berlin, Germany, February 19-22, 2025. "These new data further validate TP-317's unique mechanism of action and its potential as an oral, first-in-class therapy for IBD," said Gary Mathias, CEO of Thetis Pharmaceuticals. "The preclinical results demonstrate gut barrier protection, inflammation reduction, and pain relief, while our clinical data confirm safety, predictable PK, and BLT1 engagement in humans. We're excited to advance TP-317 into Phase 1b/2a trials in IBD patients." The poster presentations include: Pharmacokinetics, Pharmacodynamics, Safety, and Efficacy of Oral Resolvin E1-based Therapy in Inflammatory Bowel Disease (IBD): Translating Resolvin E1 Activation of BLT1 in Experimental Models to Healthy Volunteers Abstract Number: P0627, Abstract Session: Friday, February 21 from 12:40 PM - 1:40 PM CEST (6:40 AM-7:40 AM EST) This Phase 1a clinical trial evaluated the pharmacokinetics, pharmacodynamics, and safety profile of oral TP-317 in healthy volunteers. Key findings include: Single ascending doses (10, 40, and 80 mg) of TP-317 were well tolerated, with no treatment-related adverse events. TP-317 achieved systemic Resolvin E1 (RvE1) levels well above the EC50 for BLT1 activation, confirming target engagement. At the 80 mg dose, transient neutropenia (a known pharmacodynamic effect of RvE1 at BLT1) was observed but quickly rebounded within two hours in all subjects. PK analysis showed dose-proportional increases in RvE1 exposure, supporting a predictable oral dosing profile. "The data from this first-in-human study provide support for target engagement by TP-317 in humans and establish a strong foundation for further clinical development in ulcerative colitis and Crohn's disease," said Silvio Danese, M.D., Ph.D., Gastroenterologist and Professor of Gastroenterology at Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan. "This compound presents a unique therapeutic profile distinct from and complementary to current IBD therapies." TP-317, a Novel BLT1 Agonist Oral Therapy for Inflammatory Bowel Disease, Exhibits Anti-Inflammatory and Epithelial Barrier Protective Efficacy in Murine DSS Colitis and TNFΔARE Ileitis Abstract Number: P0069, Abstract Session: Friday, February 21 from 12:40 PM - 1:40 PM CEST (6:40 AM-7:40 AM EST) This study assessed the efficacy and mechanism of action of TP-317 in preclinical models of colitis. Key findings include: In a two-cycle DSS colitis model, oral TP-317 treatment significantly reduced disease activity index (DAI) scores, histologic inflammation, and crypt damage, demonstrating strong anti-inflammatory and mucosal barrier-protective effects. In TNFΔARE ileitis models, TP-317 lowered intestinal permeability and reduced pro-inflammatory cytokines, reinforcing its potential as a disease-modifying therapy for Crohn's disease and ulcerative colitis. In a visceral pain study, TP-317 reduced pain responses to colorectal distension to levels comparable to prednisolone, suggesting potential benefits for IBD-associated abdominal pain. "These findings highlight TP-317's ability to restore gut barrier integrity, suppress inflammation, and alleviate visceral pain, reinforcing its promise as a novel oral therapy for both ileal and colonic forms of IBD," said Bram Verstockt, M.D., Ph.D., Consultant Gastroenterologist IBD, University Hospitals Leuven, Belgium. About Thetis Pharmaceuticals Thetis is a clinical-stage pharmaceutical company focused on developing innovative treatments for chronic inflammatory diseases and cancer. Its lead candidate, TP-317, is a first-in-class oral RvE1 drug candidate that targets the LTB4-BLT1 pathway to mobilize the body's natural ability to resolve disease and restore immune homeostasis. For more information, please visit and follow us on LinkedIn. View source version on Contacts Tracy LessorSVP, CommunicationsThetis Pharma617-519-9827tracy@ Sign in to access your portfolio
