Latest news with #Gehrig
Yahoo
15-07-2025
- Business
- Yahoo
Klotho Neurosciences, Inc. Granted FDA Orphan Drug Designation for KLTO-202 for Treatment of Amyotrophic Lateral Sclerosis ("ALS" or "Lou Gehrig's Disease")
NEW YORK, July 10, 2025 /PRNewswire/ -- Klotho Neurosciences, Inc. (Nasdaq: KLTO), a gene and cell therapy company focused on the treatment of neurodegenerative and other aging-related diseases, today announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to the company's novel secreted-Klotho (s-KL) promoter, gene and delivery system (KLTO-202, or for the treatment of ALS. The FDA grants Orphan Drug Designation to drugs and biologics that are intended for safe and effective treatment, diagnosis or prevention of rare diseases or disorders that affect fewer than 200,000 people in the U.S. The Orphan Drug Designation provides certain incentives, such as tax credits, toward the cost of human clinical trials and a waiver for the payment of the GDUFA User Fee for market applications. Additionally, Orphan Drug Designation of the product provides the developers seven years of US market exclusivity and independent from the Company's intellectual property protection. "Receiving the Orphan Drug Designation for for the early treatment of ALS underscores the importance of bringing new treatment options to patients suffering from this rare, universally fatal disease" said Dr. Joseph Sinkule, Klotho's Chief Executive Officer. "My cousin Karen died from this horrific disease. We aim to deliver the first gene replacement therapy addressing the neurologic insult resulting in motor neuron damage and the potential neurologic protection induced by providing therapeutic blood, brain, and muscle concentrations of the s-KL protein. After the FDA's review of the data leading to the Orphan Drug Designation, we believe this ODD designation provides strong validation of our science and our approach to treat this disease" concludes Dr. Sinkule. ALS is sometimes referred to as Lou Gehrig's disease. Lou Gehrig, who played for the New York Yankees for 17 years in the 1920s and 1930s, stunned players and fans by retiring from baseball at the age of 36 after being diagnosed with ALS. Prior to this diagnosis, Gehrig played in a record-breaking 2,130 consecutive games, was referred to as the "Iron Horse," and was considered one of the greatest baseball players of all time. Less than two years later, at the age of 37, Gehrig died of complications from ALS. ALS is also referred to as Motor Neuron Disease in the UK and elsewhere. ALS is considered a rare disease and affects fewer than 200,000 people in the US, with around 5,000 new cases diagnosed each year. Klotho Neurosciences will have completed "proof of concept" studies in two animal models of human ALS and the Company is currently initiating manufacturing of the ALS-targeted product candidate, followed by meetings with the U.S. FDA and EMA in Europe to concur with the development path going forward. KLTO-202, the company's lead product candidate targeting motor neuron diseases and muscular dystrophies, is composed of a muscle-specific promoter called "desmin," driving the expression of the s-KL gene transcript and s-KL protein, with targeted delivery of the gene therapy to the neuromuscular junction - the interface between the spinal cord and the muscles. At this time, KLTO-202 is not approved for human use by any regulatory authority. About Klotho Neurosciences, Neurosciences, Inc. (NASDAQ: KLTO), is a biogenetics company focused on the development of innovative, disease-modifying cell and gene therapies using a protein derived from a patented form of the "anti-aging" human Klotho gene (s-KL), and its novel delivery systems to transform and improve the treatment of neurodegenerative and age-related disorders such as ALS, Alzheimer's, and Parkinson's disease. The Company's current portfolio consists of its proprietary cell and gene therapy programs using DNA and RNA as therapeutics and genomics-based diagnostic assays. The Company is managed by a team of individuals and advisors who are highly experienced in biopharmaceutical product development and commercialization. For more information, please visit the company's website at Investor Contact and Corporate Communications: - Jeffrey LeBlanc, CFOir@ Cautionary Note Regarding Forward-Looking StatementsThis press release contains forward-looking statements. These statements are made under the "safe harbor" provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements generally are identified by the words "believe," "project," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. Without limiting the generality of the foregoing, the forward-looking statements in this press release include descriptions of the Company's future commercial operations. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, such as the Company's inability to implement its business plans, identify and realize additional opportunities, or meet or exceed its financial projections and changes in the regulatory or competitive environment in which the Company operates. You should carefully consider the foregoing factors and the other risks and uncertainties described in the documents filed or to be filed by the Company with the U.S. Securities and Exchange Commission (the "SEC") from time to time, which could cause actual events and results to differ materially from those contained in the forward-looking statements. Copies of these documents are available on the SEC's website, All information provided herein is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law. View original content to download multimedia: SOURCE Klotho Neurosciences, Inc.
New York Times
02-07-2025
- Sport
- New York Times
‘The original iPad': Lou Gehrig's replacement helped launch the video revolution
Inside most dugouts these days, a baseball game doubles as a film festival. Follow a frustrated hitter back to the bench and chances are he'll call up the video on an iPad to deconstruct the wayward at-bat. During a World Series game last fall, New York Yankees slugger Aaron Judge, wielding a tablet, approached Austin Wells and coached him through how to attack a high fastball. In Wells' next at-bat, he walloped a high fastball 384 feet into the right-field seats. Advertisement Matt Dahlgren watches scenes like this play out on TV and thinks of his grandfather. 'I smile internally knowing that the concept of studying their mechanics on film, studying their swings, that started with Babe,' he said. Babe Dahlgren is best remembered, if he is remembered at all, as the man who replaced Lou Gehrig as the Yankees' first baseman. You might see him in the background of images on Friday, the anniversary of Gehrig's searing 'luckiest man' speech on July 4, 1939. Dahlgren is the Yankees player positioned closest to Gehrig on the third-base side during the ceremony. Manager Joe McCarthy stationed Dahlgren, a deft fielder, nearest to Gehrig in case the ailing Iron Horse collapsed. 'If he starts to go down,'' McCarthy instructed, 'catch him.' 'Babe always told me that the entire time Gehrig was giving that speech, Lou's legs were trembling,'' Matt Dahlgren, 54, said. 'Babe would get emotional till the day he died talking about that speech. His eyes would well up and his lips would quiver.' But Ellsworth 'Babe' Dahlgren's lasting contribution to baseball goes beyond joining Wally Pipp as the bookends to Gehrig's legendary streak of 2,130 consecutive games played. It involved lugging a Bell & Howell motion picture camera around the ballyard as early as the 1940s, having deduced that recording hitters in action might be useful as a teaching tool. It took decades, and a fateful elevator ride, but Dahlgren became the first major-league coach to implement film study in his instruction, initially with the Kansas City Athletics in 1964. 'I always tell people he's the first guy that I ever knew that started taking pictures of players,'' said Jim Gentile, 91, a six-time All-Star who played for that '64 team, in a recent phone interview. Dahlgren took a job with the St. Louis Cardinals in 1965, reprising his role as a coach who used film. He made one last go with the Oakland A's in 1970, when Dahlgren and his camera were summoned midseason to help stir Reggie Jackson out of a slump. Advertisement Dahlgren bought his first 8-millimeter camera in 1938 to film attractions on Yankee road trips. This apprenticeship would serve him years later when he invested in top-of-the-line equipment and began recording miles of 16mm footage of hitters' swings, as well as filming interviews with 25 legends, including Joe DiMaggio, Ted Williams, Mickey Mantle, Roger Maris, Al Kaline and Rocky Colavito. Such practice is ubiquitous these days. So why isn't Dahlgren recognized as a landmark figure in the history of baseball cinema? Why aren't his invaluable films playing on a continuous loop in Cooperstown? The trouble began with a missed phone call in the middle of the night, and the capricious nature of the Santa Ana winds. Sir Isaac Newton had his apple. Babe Dahlgren had Joe DiMaggio. Dahlgren's origin story as a cameraman can be traced to watching Joltin' Joe from the dugout while they were Yankees teammates in the late 1930s and early '40s. Dahlgren, also a right-handed hitter, wanted to know what made DiMaggio's swing so much better. So, for DiMaggio's at-bats, Babe would take to covering his face with his cap and isolating his view of the hitter by watching through an eyelet – one of the little holes that allows a cap to ventilate. That let Dahlgren block out all distractions and focus on the hitter's mechanics. 'That was the original iPad,'' Matt Dahlgren said. 'That's how he studied it. It's amazing how far it's come.' My great-grandpa replaced Lou Gehrig on this day in 1939. Big shoes to fill. I wish I could have met him. #BabeDahlgren ❤️ — Emma Dahlgren (@emmadahlgren2) May 2, 2025 On May 2, 1939, in his first game as the successor, Dahlgren went 2-for-5 with a home run. He later told The Sporting News: '(Gehrig) grabbed me when I got back to the bench and shouted at me, 'Hey, why didn't you tell me you felt that way about it? I woulda got out of there long ago.'' But over his 12 big-league seasons, Dahlgren batted .261 with 82 homers and a .713 OPS. Teams did not have batting coaches when he started playing, but he spent his career looking for someone who could break things down. Advertisement The closest he came to a hitting guru was in 1941, not long after joining the Chicago Cubs. Manager Jimmie Wilson sauntered up to Dahlgren in the clubhouse one day and said, 'Babe, let's talk hitting.' Wilson threw a glove down on the floor of the clubhouse to serve as a makeshift home plate. From there, Wilson demonstrated different stances and had Babe stand next to the glove and do the same. Dahlgren went on to hit 23 home runs that season, the only time in his career he topped 20. Bolstered by his thoughtful new approach, he began keeping detailed notes on 3×5 cards about certain pitchers and stored them away in little metal boxes. But he soon concluded that pictures were worth a thousand words. After two final seasons in the Pacific Coast League, Dahlgren retired from baseball in 1948 and embarked on a second career as an insurance salesman in Arcadia (Los Angeles County), Calif. But the game lured Dahlgren back, and it should surprise no one that the man who studied DiMaggio through the eyelet of his cap became a scout. Hired by the Kansas City Athletics, he had a knack for the job. Dahlgren identified a star in the making after watching a youngster named Roger Maris take batting practice for the Cleveland Indians during spring training in 1957. Maris had yet to play a major-league game, but Dahlgren saw a swing that reminded him of Gehrig's. Two years later, when the Athletics traded Maris to New York, Dahlgren penned a letter to Yankees general manager George Weiss. The Los Angeles Times unearthed that letter for a story published in September 1961, when Maris was on the verge of setting the single-season major-league record with 61 home runs. It read: I think you won several pennants in obtaining Roger Maris. I honestly feel that as time passes, this deal will be considered a masterstroke. That boy is capable of slamming between 60-70 homers a year, and he has the short porch to hit with the ability to pull. Advertisement During this time, Dahlgren was coaching his teenage boys, Ray and Don, and noticed how quickly he sussed out what was working with their swings and what wasn't. He was a mechanic who could spot the problem as soon as he opened the hood. Dahlgren wrote in his unpublished memoirs about the thunderclap feeling of deciding, in 1958, that he wanted to become a hitting coach. 'When you feel in your mind that you can identify the ingredients that must gel in their proper order during the swing progression … you want to shout to the world that you know how it's done, and how to help others. 'To accomplish this feat, I decided to film the action and to learn how to use cameras and sound and how to splice the film and put the story together step by step.' He dedicated the next years to filming the swings of the game's greats, and leaning on his connections to secure one-on-one interviews about their craft. (On the day a retired DiMaggio demonstrated his approach at Yankee spring training camp in 1961, his ex-wife Marilyn Monroe waited patiently on a dugout bench.) Matt Dahlgren remembers visiting his grandparents' house in Bradbury Estates, a gated community in Los Angeles County, in the 1970s and stepping into Babe's 'dark little office' just off the family room. 'I just remember seeing shelves lined with silver film canisters,'' Matt said. 'He was like a mad scientist. It was priceless, priceless film.' Five years after embarking on his quest to film hitters, in December 1963, Dahlgren pulled his car into the Statler Hotel parking lot on Wilshire Boulevard in Los Angeles. This was the site of the Winter Meetings. With a canister containing his life's work, a two-hour film on hitting called 'Half a Second,' Dahlgren wandered the halls, like so many others in Hollywood, looking for his big break. Advertisement 'The lobby was just buzzing with baseball people – GMs, farm directors, owners,'' Matt Dahlgren said. 'He felt that if somebody would be willing to at least listen to him right out of the gate, it would be Charlie Finley. He felt that Finley was just kind of a free-spirited guy.' Dahlgren finally spotted the Athletics executive waiting for an elevator and made a mad dash before the doors opened. Finley apologized; he had plane reservations and was running late. But Dahlgren knew from his days as an insurance salesman how to keep the conversation going, and he stepped inside the elevator. 'Charlie, you are dealing with baseball players every day, and you can't afford to trade away talent. You've got to know what to look for in a batter, and that is what my film is all about!' Dahlgren recalled saying, in his memoirs. 'I could see I struck a nerve, so I shut up, giving him time to think. The elevator stopped at his floor, and we got out. 'He stopped in the hall and asked, 'Where is the film and how long would it take to get it?''' They set up a projector and watched the film in Finley's suite, where the Athletics owner grew so enamored he canceled his flight. The Athletics already had Luke Appling as a batting coach, but Dahlgren came aboard as a second voice, in charge of filming both hitters and pitchers. By spring training in Bradenton, Fla., the media was abuzz about Dahlgren's new approach. Joe McGuff of The Sporting News wrote that this would be the first time baseball would embrace an expanded role for images. Gentile, who was 31 that season and three years removed from leading the American League with 141 RBIs in 1961, was open to anything as Dahlgren made the rounds asking players if they wanted to be filmed for analysis. 'I said, 'You want to do it on me'' Gentile recalled by phone from his home in Edmond, Okla. 'And he did.' Advertisement Dahlgren filmed the 6-foot-3, 210-pound slugger taking his left-handed hacks. Then the two headed underneath the stands, where Dahlgren hung up a white bedsheet to serve as the screen, their version of the video room. 'He'd talk about it: 'Maybe you're pulling your right shoulder too quickly. That's why you're tipping the ball instead of hitting the ball hard,''' Gentile said. Still, the A's performance in '64 did nothing to launch baseball's film revolution. They finished near the bottom in almost every offensive category, and Finley fired most of the coaching staff after a 105-loss season. The Cardinals hired Dahlgren for a similar role in 1965. St. Louis manager Red Schoendienst was an early proponent, recommending that players watch the movies that showed them when they were in the groove. The St. Louis Dispatch at the time underscored the novelty of the approach: 'Dahlgren has been shooting hundreds of feet of film during every game… Thus, a player may study his most recent form on a movie screen before taking the field again, just as easily he may compare his current form with earlier performances.' That Cardinals team, fresh off a World Series victory, went 80-81 and finished 16 1/2 games out, again leaving Dahlgren out of a job. He had one last gasp, reuniting with Finley and the A's midway through the 1970 season. Reggie Jackson, coming off a 9.3 bWAR season in '69 that heralded the arrival of a superstar, slumped out of the gate, batting .228 in the first half with 76 strikeouts in 254 at-bats. Dahlgren was summoned to join the staff on July 23. 'It was kind of a last-ditch effort by Charlie to try to get Reggie going,'' former A's clubhouse manager Steve Vucinich said in a phone interview. Dahlgren quickly discovered he didn't have much to do. Jackson was in a bad place mentally, but his mechanics remained impeccable. 'In all my years in baseball, I've never seen anyone with a better swing,' he told the Cumberland Evening Times, 'and that includes Gehrig.' Advertisement Still, Dahlgren savored one breakthrough. During a trip to Detroit, Reggie called Dahlgren's room. 'Babe, do you have time to show me some film?' So they sat together in a darkened hotel suite as images flickered on a white sheet. 'Geez, I look like horse(bleep),'' Jackson said, according to Dahlgren's notes. As it turns out, Jackson had the same problem Dahlgren once had: He was lunging. Dahlgren suggested a way to avoid getting out on the front foot, the kiss of death for a power hitter. The next day, on Aug. 30, 1970, Jackson walloped his first dinger in a month, a pinch-hit home run that traveled an estimated 440 feet to dead center field against the Tigers. That was the last hurrah for Dahlgren, who retired and headed back to his home in Southern California. Matt, who lived in nearby Irvine, would grow up to visit Bradbury Estates during summers and climb into a reclining chair while Babe spun yarns about baseball gods. 'We'd stay up late into the night and just talk about baseball,'' Matt Dahlgren said. 'That's all I wanted to do was hear his stories.' They were lucky to get out alive. The phone call came in the wee hours of Nov. 16, 1980, prompting Babe, nearly 70, to hoist himself out of bed, shuffle to the phone and lift the receiver just as it stopped ringing. As Dahlgren tottered back toward bed, he noticed a red haze radiating through the skylight. 'That's odd,'' he thought. Dahlgren returned to his bedroom and tugged on the blinds for a better look. That's when he saw the inferno. His two-acre property was ablaze, engulfed by a hard-charging Southern California wildfire. Gusts from the Santa Ana winds that night hit 90 mph. 'He screamed at my grandma. 'Mabel, get up! Get up! We got to get outta here!'' Matt recounted. 'So he grabbed the clothes they had had on the night before that he had draped over a chair.' Advertisement There wasn't time to grasp much else. Dahlgren snatched a handful of Mabel's jewelry off her dresser. He wrapped his hands around his 1938 World Series ring. But all that film? All those silver canisters? Matt Dahlgren responded to those questions by texting a picture. Like his grandfather, he knows the power of images. It's a grainy photo of Babe Dahlgren standing by a brick fireplace, the only structure of the home still standing. Elsewhere in the image, shellshocked children walk on a floor of ash. One of those children is Matt. 'It was still smoldering,'' he said softly. 'I can still smell it to this day.' One person died and 62 homes were destroyed in those Bradbury-Duarte fires, which blackened an estimated 6,200 acres. The lone fatality was Dr. John Hervey, 47, who died of a heart attack while trying to evacuate. Hervey's wife, Mercedes, is the one who tried calling Babe and Mabel at 3:30 a.m., trying to warn them to get out. 'That woman saved my grandparents' lives,'' Matt said. Dahlgren's life's work, however, melted into the ashy rubble. Those silver canisters, the treasure trove of Cooperstown legends showing off their swings, the interviews with DiMaggio and Williams, all lost. 'Everything he had — 18 years of professional memorabilia, all of his film, his book he was writing, the bat he hit a home run in the World Series with — everything gone. Gone,'' Matt Dahlgren said. Late in life, Dahlgren developed advanced dementia and ultimately died of natural causes in Arcadia on Sept. 4, 1996. He was 84. His final years remained happy, though, even if his movie's ending wasn't. 'He didn't lose his will to live,'' Matt said. 'He rebuilt. He enjoyed the hell out of his family and watching us grow. And he never complained.' When baseball remembers Gehrig this week, there ought to also be a tip of the cap to the man who followed him. Nearly a century ago, Babe Dahlgren looked through the eyelet of his cap to watch DiMaggio's swing. What he saw was the future. (Illustration: Dan Goldfarb / The Athletic; Associated Press photo, additional imagery courtesy of Matt Dahlgren)
Yahoo
04-06-2025
- Entertainment
- Yahoo
Topps releases Lou Gehrig Day set in support of ALS research
The Lou Gehrig Day complete set is available until June 12 and retails for $59.99. (Credit: Topps) Topps has partnered with Major League Baseball and reporter Sarah Langs for a trading card set that commemorates Lou Gehrig Day and supports ALS research. The Lou Gehrig Day complete set will retail for $59.99 and is available until June 12 at 4 p.m. ET. Randomly inserted parallels include 'Iron' Dark Silver /25, Dark Blue /4 and Gold 1/1s. Advertisement MLB is also hosting an auction with 1/1 autograph cards from the set representing each team. Each player was selected by Langs, an MLB reporter and researcher battling ALS. Net proceeds from the set and auctions will be donated to the Sean M. Healey Center for ALS at Massachusetts General Hospital. MLB established June 2 as Lou Gehrig Day in 2021 with an annual commemoration involving all 30 teams. Known as the 'Iron Horse,' Gehrig played 17 seasons for the New York Yankees before retiring due to an ailment that would later be identified as ALS. Gehrig retired as a seven-time All-Star, six-time World Series champion and two-time American League MVP. Advertisement Sunday marked the 100th anniversary of the beginning of Gehrig's streak of 2,130 consecutive games played. Ben Burrows is a reporter and editor for cllct, the premier company for collectible culture. He was previously the Collectibles Editor at Sports Illustrated. You can follow him on X and Instagram @benmburrows.
Time of India
02-06-2025
- Sport
- Time of India
The story behind the No. 4 patch worn by Yankees and Dodgers in Los Angeles
Image Source: Getty On June 1, 2025, the New York Yankees and Los Angeles Dodgers wore special No. 4 patches on their jerseys at Dodger Stadium to remember baseball hero Lou Gehrig. This was part of the fifth yearly Lou Gehrig Day, a big baseball event to tell people about Amyotrophic Lateral Sclerosis, called Lou Gehrig's Disease. It brings fans and players together for an important reason. Yankees and Dodgers honor Lou Gehrig with No. 4 patch The No. 4 patch on the Yankees' and Dodgers' jerseys was a special way to show love for Lou Gehrig, a great Yankees player. On June 1, 2025, both teams wore it during their game in Los Angeles, using the Yankees' blue style. The Yankees didn't play on June 2, the real Lou Gehrig Day, so they celebrated early. All baseball players, coaches, and umpires wore the patch on the top left side of their uniforms. Many also wore red '4-ALS' wristbands to help ALS research. Special bases and scorecards were used, and stadiums showed a bright '4' logo. ALS hurts about 20,000 Americans and has no cure yet. The patch honors Gehrig and raises money for research. The Yankees and Dodgers showed how baseball remembers Gehrig and fights ALS, bringing everyone together to work for a future where ALS can be treated and people can live better. Also Read: Why is everyone suddenly talking about Dillon Dingler as the reason behind Detroit's unexpected MLB dominance? The legacy of Lou Gehrig and the fight against ALS Lou Gehrig, called the Iron Horse, was a baseball star who made many people happy. Starting June 1, 1925, he played 2,130 games in a row for the Yankees, a record for over 50 years. He won six World Series and two best player awards, but ALS stopped him in 1939. He died on June 2, 1941, at age 37. His 'Luckiest Man' speech on July 4, 1939, at Yankee Stadium showed his big heart. Baseball started Lou Gehrig Day in 2021 to honor him and talk about ALS. In 2025, selling signed cards helped raise money for the Sean M. Healey & AMG Center for ALS. Players like Sam Hilliard, whose family knows ALS, wore special gear to help. The No. 4 patch keeps Gehrig's memory alive and supports research. The No. 4 patch is a big sign of Lou Gehrig's amazing life and bravery. Worn by the Yankees and Dodgers in Los Angeles, it was part of a big baseball effort to honor him. Baseball held events and showed videos, like one by reporter Sarah Langs, who has ALS. The patch connects baseball's past with its goal to help ALS patients. The Yankees and Dodgers showed they care by wearing it. Lou Gehrig Day gives hope to people with ALS and their families, showing we can make progress.
Yahoo
31-05-2025
- Entertainment
- Yahoo
This Date in Baseball-Week Ahead
June 3 1918 — Dutch Leonard of the Boston Red Sox pitched his second no-hitter, blanking the Detroit Tigers 5-0. 1932 — Lou Gehrig became the first American League player to hit four home runs in a game, helping the New York Yankees beat the Philadelphia A's 20-13. The event was overshadowed by the resignation of John McGraw as manager of the New York Giants. Advertisement 1954 — Henry Thompson of the New York Giants hit three home runs and drove in eight runs in a 13-8 win against the St. Louis Cardinals. Willie Mays drove in the other five runs with two homers. 1971 — Ken Holtzman of the Chicago Cubs pitched his second no-hitter, beating the Cincinnati Reds 1-0. 1978 — Dave Johnson became the first major leaguer to hit two pinch-hit grand slams in a season. His grand slam in the ninth inning gave the Philadelphia Phillies a 5-1 victory over the Los Angeles Dodgers. 1989 — Los Angeles and Houston played 22 innings at the Astrodome in the longest night game in National League history -- 7 hours and 14 minutes. The Astros won the game on Rafael Ramirez's RBI single off Jeff Hamilton, normally the Dodgers' third baseman. When the game ended, Fernando Valenzuela was playing first and Eddie Murray was at third. Advertisement 1989 — Nolan Ryan pitched his 11th career one-hitter and struck out 11 as Texas beat Seattle 6-1. It was Ryan's 16th low-hit game (no-hitter or one-hitter), breaking Bob Feller's record of 15. 1995 — Pedro Martinez of Montreal pitched nine perfect innings against San Diego before giving up a leadoff double to Bip Roberts in the 10th inning of the Expos 1-0 win. 2003 — Sammy Sosa was ejected in the first inning of Chicago's 3-2 win over the Tampa Bay Devil Rays after umpires found cork in his shattered bat. 2006 — Damion Easley hit three homers and had seven RBIs in Arizona's 13-9 victory over Atlanta. Advertisement 2008 — Randy Johnson took sole possession of second place on baseball's career strikeout list after getting the Milwaukee Brewers' Mike Cameron to go down swinging in the first inning. It was Johnson's 4,673rd career strikeout, breaking a tie with Roger Clemens and leaving the Arizona Diamondbacks' veteran ace behind only Nolan Ryan, who had 5,714 strikeouts in his career. 2017 — Albert Pujols hits his 600th home run of his career, the historic blast being a 4th-inning grand slam off Ervin Santana of the Twins in a 7 - 2 Angels win. He is the ninth player to join the exclusive fraternity. 2017 — Endinson Volquez of the Mets throws the first no-hiitter of the year, defeating the Diamonbacks 3-0. 2018 — Blake Snell ties an American League record by striking out the first 7 batters he faces for the Rays against the Mariners. Advertisement 2022 — With a disappointing 22-29 record after splurging on free agents over the past few years, the Phillies fire manager Joe Girardi, who has failed to take them to the postseason in his two-plus seasons at the helm. Bench coach Rob Thomson is named manager on an interim basis to finish the season. 2024 —Padres player Tucupita Marcano faces a lifetime ban from baseball after an investigation by MLB found that he has placed bets on a large number of major league games, in contravention of very clear rule. He is suspected of having bet on Pirates games while injured last season; he has not played this season, also due to injury. The lifetime ban will be confirmed tomorrow and four other players will receive one-year suspensions for placing bets while they were in the minor leagues: Michael Kelly, Jay Groome, José Rodríguez and Andrew Saalfrank. _____ June 4 Advertisement 1940 — The Pirates beat the Boston Bees 14-2 in the first night game at Pittsburgh's Forbes Field. 1940 — The St. Louis Cardinals play their first night game at Sportsman's Park, defeating the Brooklyn Dodgers 10-1. 1951 — Pittsburgh's Gus Bell hit for the cycle to lead the Pirates to a 12-4 victory over the Phillies at Philadelphia. 1964 — Sandy Koufax pitched his third no-hitter, striking out 12, as the Los Angeles Dodgers beat the Phillies 3-0 in Philadelphia. 1968 — Don Drysdale of the Dodgers blanked the Pirates 5-0 for his sixth straight shutout en route to a record 58 2-3 scoreless innings. Advertisement 1972 — A major league record eight shutouts were pitched in 16 major league games: five in the American League, three in the National League. The Oakland Athletics swept a pair from the Baltimore Orioles by identical 2-0 scores. 1974 — The game between the Cleveland Indians and the Texas Rangers at Cleveland's Municipal Stadium was forfeited to Texas. Umpire Nestor Chylak had problems with fans all night on 10-cent beer night. The crowd got out of control when Cleveland tied the score 5-5 in the bottom of the ninth. 1989 — Toronto beats Boston 13-11 in 12 innings after trailing 10-0 after six inngs. Red Sox starter Mike Smithson threw six scoreless innings before leaving in the seventh because of a foot blister. The Jays then scored two in the seventh, four in the eighth and five in the ninth and two more in the 11th on Junior Felix's home run. It was the biggest lead the Red Sox have blown and their 12th consecutive loss to the Blue Jays at Fenway Park. 1990 — Ramon Martinez struck out 18 and pitched a three-hitter, sending the Los Angeles Dodgers past the Atlanta Braves 6-0. Advertisement 1996 — Pamela Davis pitched one inning of scoreless relief and got the win in a minor league exhibition game. She is believed to be the first woman to pitch for a major league farm club under the current minor league system. The 21-year-old right-hander pitched for the Jacksonville Suns, a Double-A affiliate of the Detroit Tigers, against the Australian Olympic team. 2000 — Esteban Yan of the Tampa Bay Devil Rays becomes the 77th major league player to hit a home run in his first at bat, but just the fourth American League pitcher and the first since the Angels' Don Rose in 1972, the year before the designated hitter rule took the bat out of AL pitchers' hands. 2005 — Rafael Palmeiro and Melvin Mora each hit grand slams to help Baltimore rally for a 14-7 win over Detroit. 2007 — Mark Ellis hit for the cycle and Eric Chavez had a two-out homer in the 11th inning to lift Oakland to a 5-4 win over Boston. Advertisement 2009 — Randy Johnson became the 24th major league pitcher to win 300 games by leading San Francisco to a 5-1 victory over the Washington Nationals in the first game of a doubleheader. 2012 — Mike Scioscia of the Los Angeles Angels manager became the ninth manager in AL history to manage 2,000 games with one club. The Mariners beat the Angels 8-6. 2018 — In a doubleheader with the Detroit Tigers, New York Yankees OF Aaron Judge sets a record by striking out eight times. 2019 — San Francisco Giant Manager Bruce Bochy wins his 1,000th game as the manager of the Giants with a 9-3 victory over the New York Mets. Advertisement 2022 — The rule preventing position players from pitching in a close game is invoked for the first time when Crew chief C.B. Bucknor objects to Dodgers manager Dave Roberts calling on OF Zach McKinstry to pitch the 9th inning gainst the Mets with his team trailing, 9 - 4. The rule, adopted before the 2020 season but not implemented until this year due to the upheavals caused by the coronavirus pandemic, states that a team cannot use a position player on the mound unless there is a difference of six or more runs between the two teams. Roberts is thus forced to use a real pitcher, Evan Phillips, to pitch the final inning. In spite of the rule, the practice of using such 'mystery pitchers' is continuing undiminished, with teams even resorting to them when they have built a huge lead late in the game, in order to rest their bullpens, something that was completely unseen before the decade started. _____ June 5 1915 — Philadelphia's Grover Cleveland Alexander lost his no-hitter when Artie Butler punched a single with two outs in the ninth. Alexander struck out Bob Bescher for the final out to beat St. Louis 3-0. Alexander went on to pitch three more one-hitters during the season. Advertisement 1929 — The Cincinnati Reds scored nine runs in the sixth inning en route to a 21-4 romp over the Chicago Cubs. 1935 — Chicago White Sox rookie John Whitehead loses to St. Louis 2-0. It was his first loss after winning his first eight starts, an AL record for the start of a career. 1949 — Commissioner Happy Chandler lifted the ban on all players who jumped to Mexico, starting in 1946. 1955 — Mickey Mantle of the New York Yankees hit a home run off Chicago's Billy Pierce that traveled about 550 feet. The ball cleared the left-field upper deck at Comiskey Park. 1959 — Pittsburgh's Dick Stuart hit the longest home run at Forbes Field. Stuart smashed a shot over the center-field wall off Chicago pitcher Glenn Hobbie. Advertisement 1966 — Leo Cardenas of the Reds hit four home runs in a doubleheader against the Chicago Cubs. Cardenas hit two home runs in each game as Cincinnati won the opener 8-3 but dropped the second game 9-5. 1986 — San Diego's Steve Garvey was ejected for the first time in his career when he argued a play at home plate. Garvey, the on-deck hitter, protested the last out of a triple play by the Atlanta Braves. Television replays showed that Bip Roberts was indeed safe. The Padres lost 4-2. 1989 — The Blue Jays lost their debut in the SkyDome as Glenn Braggs hit a two-run homer to lead the Milwaukee Brewers past Toronto 5-3. The $375 million complex featured a $100 million, four-section, retractable roof. 1997 — Alex Rodriguez of the Mariners became the first Seattle player to hit for the cycle in a nine-inning game. He completed the cycle with a double in the ninth of a 14-6 win at Detroit. Advertisement 2001 — Colorado pitcher Mike Hampton had two homers, three RBIs and recorded his eighth win as Colorado defeated Houston 9-4. 2008 — Atlanta's Chipper Jones became the third switch-hitter in major league history to hit 400 career home runs. Jones' homer off Ricky Nolasco was one of his four hits in the 7-5 comeback win over Florida. Mickey Mantle and Eddie Murray were the first two reach the milestone. 2013 — The Chicago White Sox and Seattle Mariners played the first game in major league history when each team scored five or more runs in the game when it was scoreless through the ninth. Alejandro De Aza and Alex Rios each had an RBI single in the 16th inning, and Chicago won 7-5. 2015 — Oakland's Pat Venditte became the first pitcher in 20 years to throw with both arms in the same game, but the Boston Red Sox beat the Athletics 4-2 on a night a fan sustained life-threatening injuries when she was struck by a broken bat. 2021 — Team USA secured a spot in the Tokyo Olympics by winning the Americas Olympic Qualifier. _____
