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Cision Canada
17-07-2025
- Health
- Cision Canada
Total Investment of Approx. USD 7.3 Million in Malaria and TB R&D Projects With Partners Including European Vaccine Initiative, University of Copenhagen, and University of Tübingen
TOKYO, /CNW/ -- The Global Health Innovative Technology (GHIT) Fund announced today a total investment of approximately JPY 1 billion (USD 7.3 million 1) in four R&D projects for the development of vaccine, drug, and diagnostics for malaria and tuberculosis (TB). 2 Investment of JPY 800 million (USD 5.5 million 1) in malaria vaccine project Malaria is a serious infectious disease that affects more than 260 million people and claims approximately 600,000 lives worldwide each year. Over 90% of all malaria cases occur in Africa, with more than 70% of those affected being children under the age of five. 3 Malaria is transmitted to humans by mosquitoes. While prevention and treatment methods are available, the efficacy of currently available vaccines remains limited, highlighting the urgent need for the development of vaccines with higher efficacy and longer-lasting protection. To address this challenge, the GHIT Fund has decided to invest JPY 800 million (USD 5.5 million 1) in a malaria vaccine development project currently in the preclinical stage. This project is being led by the European Vaccine Initiative, the Research Institute for Microbial Diseases (RIMD) at Osaka University, the University of Copenhagen, the University of Tübingen, Danish biotechnology company AdaptVac, Ajinomoto Co., Inc., and Nobelpharma Co., Ltd. This investment is a continuation of previous projects supported by GHIT, which has invested a total of approximately JPY 630 million (USD 4.3 million 1) from 2013 to 2022. The present project aims to develop a vaccine that prevents the proliferation of malaria parasites during the blood-stage of infection. The vaccine is designed to achieve higher efficacy and longer-lasting protection with fewer doses. By reducing manufacturing costs, the project also aims to improve access to vaccines in malaria-endemic regions. In addition, the GHIT Fund will invest a total of approximately JPY 260 million (USD 1.8 million 1) in the following three R&D projects: (1) Target research project for malaria diagnostics by Ehime University and Universiti Malaysia Sabah (2) Target research project for TB drug by the University of Auckland and the University of Tokyo (3) Target research project for malaria drug by Medicines for Malaria Venture (MMV), LPIXEL Inc., and University of Dundee This investment brings four new companies and universities on board. Through collaborations with 190 partners across 39 countries — including 64 Japanese and 126 non-Japanese institutions — we aim to contribute to solving global health challenges and accelerating product development. Please refer to Appendix 1 for detailed descriptions on these projects and their development stages. As of July 17, 2025, the GHIT Fund has invested in 37 projects, including 15 discovery projects, 13 preclinical projects, and 9 clinical trials. 4 The total amount of investments since 2013 is JPY 39.3 billion (USD 271 million 1) (Appendix 2). 1 USD1 = JPY144.81, the approximate exchange rate on June 30, 2025. 2 These awarded projects were selected and approved as new investments from among proposals to RFP2023-002 and RFP2024-001 for the Product Development Platform and the Target Research Platform, which were open for applications from June 2023 to July 2024. 3 WHO: 4 This number includes projects in the registration phase. The GHIT Fund is a Japan-based international public-private partnership (PPP) fund that was formed between the Government of Japan, multiple pharmaceutical companies, the Gates Foundation, Wellcome, and the United Nations Development Programme (UNDP). The GHIT Fund invests in and manages an R&D portfolio of development partnerships aimed at addressing neglected diseases, such as malaria, tuberculosis, and neglected tropical diseases, which afflict the world's vulnerable and underserved populations. In collaboration with global partners, the GHIT Fund mobilizes Japanese industry, academia, and research institutes to create new drugs, vaccines, and diagnostics for malaria, tuberculosis, and neglected tropical diseases. Appendix 1. Project Details ID: G2024-201 Project Title Biomanufacture and preclinical development of the blood-stage malaria vaccine candidate SE36/cVLP Collaboration Partners 1. European Vaccine Initiative (Germany) 2. RIMD, Osaka University (Japan) 3. University of Copenhagen (Denmark) 4. AdaptVac (Denmark) 5. University of Tübingen (Germany) 6. Ajinomoto Co., Inc. (Japan) 7. Nobelpharma Co., Ltd. (Japan) Disease Malaria Intervention Vaccine Stage Preclinical Awarded Amount JPY 800,715,002 (USD 5.5 million) Status Continued project Summary [Project objective] This team's goal is to fast-track the clinical development of the SE36/cVLP vaccine candidate and obtain supporting evidence for a safe and efficacious blood-stage vaccine that could be deployed as a stand-alone or potentially combined in a second- generation multi-stage malaria vaccine. The main objectives are to: 1. Manufacture a large GMP batch of SE36 2. Produce a GMP batch of SE36/cVLP 3. Conduct a GLP-compliant nonclinical toxicology study for SE36/cVLP + Sepivac SWE adjuvant 4. Prepare clinical trial documentation for the conduct of a phase I/IIa (CHMI) trial for SE36/cVLP (+/- Sepivac SWE) to assess safety, immunogenicity, and time-to- first episode of clinical malaria in malaria-naïve vaccinated subjects [Project design] The previous GMP manufacturing process for SE36 was largely based on the E. coli expression system with modest yield after several chromatography steps. Benefiting from recent collaborations and new adaptive vaccine technologies, the project team now proposes to manufacture a larger batch of SE36 using a simplified, high-yield process with Corynex™, which utilizes Corynebacterium glutamicum. Moreover, to increase the vaccine immunogenicity, SE36 antigens will be displayed on capsid virus-like particles (cVLP) ensuring unidirectional and high-density display. A previously manufactured small lab-scale batch of SE36/cVLP showed that coupling was stable and that coupled SE36 was highly immunogenic in the mouse model. Armed with this success, the project team now expands its efforts to manufacture a larger GMP batch of SE36/cVLP, conduct a GLP-compliant nonclinical toxicology study and prepare trial documentation to conduct a phase I/IIa trial with this newly optimised formulation of the SE36 vaccine candidate. A successful completion of these activities will set the stage for a first-in-human safety, immunogenicity and efficacy trial. ID: T2024-153 Project Title ZOO-RDT: Validating a novel biomarker and associated reagents for diagnosis of acute zoonotic malaria in southeast Asia Collaboration Partners 1. Ehime University (Japan) 2. Universiti Malaysia Sabah (Malaysia) Disease Malaria Intervention Diagnostics Stage Target Research Awarded Amount JPY 64,693,198 (USD 0.4 million) Status New project Summary [Project objective] There are no P. knowlesi -specific point-of-care (PoC) tests. Rapid diagnostic tests based on the pLDH biomarker show high cross-reactivity between P. vivax and P. knowlesi making them impossible to distinguish. Current diagnostic practices take time and delay patient access to treatment. Simple, accessible PoC tools are urgently required. Identification of P. knowlesi- specific diagnostic markers has been largely neglected. The serine repeat antigen (sera) multigene family has been extensively studied in P. falciparum and rodent parasite lines and plays critical roles across the parasite life cycle. The P. knowlesi Serine Repeat Antigen 3 (PkSERA3) antigen 2 has been identified as a P. knowlesi -specific exposure marker, with laboratory and population-level evaluations showing no cross-reactivity with P. vivax, a phylogenetically closely related species. The project team will use this antigen to develop reagents for a P. knowlesi PoC diagnostic test. [Project design] Overall aim: Validate novel biomarker(s) and associated monoclonal antibodies for lateral flow assay development for the diagnosis of acute infections. Objective 1: Reagent optimisation: the optimised PkSERA3 ag 2 protein plus two variants will be used in the generation of monoclonal antibodies (mAbs). Objective 2: Analytical and clinical validation of PkSERA3 Ag2 and variants as species-specific indicators of acute P. knowlesi infection across epidemiological zones. Objective 3: Assessment of Technical Feasibility in the lateral flow system. The best performing mAbs will be assayed by ELISA, and further down-selection will lead to selected mAbs being printed onto test strips. Antibody reagents will be provided to a diagnostic test developer Contract Research Organization (CRO) to validate the technical feasibility of integrating the developed mAbs into a lateral-flow RDT. Objective 4: Stakeholder consultation to understand the preferred test design, and to inform Product Design and generate evidence for a business case for this novel malaria RDT. Target results: Validated P. knowlesi -specific mAb reagent for use in LFA development. ID: T2024-253 Project Title Harnessing genome mining for novel tuberculosis antibiotics Collaboration Partners 1. The University of Auckland (New Zealand) 2. The University of Tokyo (Japan) Disease Tuberculosis Intervention Drug Stage Target Research Awarded Amount JPY 100,000,000 (USD 0.6 million) Status New project Summary [Project objective] In the short term, this project aims to enhance TB antibiotic discovery by identifying secondary metabolites that specifically target essential metabolic pathways in M. tuberculosis. By focusing on mechanisms absent in mammalian cells, the project team aims to identify secondary metabolites with selective antimicrobial activity and minimal side effects in humans. This selectivity is expected to improve patient experience, compliance, and treatment outcomes. Early identification and testing of these compounds against purified proteins, M. tuberculosis cells, and human macrophage infection models will provide critical insights into their efficacy and potential as new therapeutic agents. In the long term, this project team's goal is to translate these research findings into clinical applications, offering new treatment options for TB patients worldwide. A key strength of this proposal is this project team's established expertise and drug development pipeline, specifically in the TB context, which will be instrumental in advancing subsequent research and development phases. [Project design] Despite significant advances in understanding the metabolic features essential for M. tuberculosis, developing new antibiotics remains a major challenge. Enzyme inhibitors often exhibit limited activity against M. tuberculosis, and many bioactive compounds have unclear modes of action. To overcome these challenges, the project team will (a) identify secondary metabolites that specifically target key metabolic pathways in M. tuberculosis, and (b) test these metabolites against purified proteins and M. tuberculosis cells to assess their effects on bacterial growth and pathogenesis. ID: T2024-268 Project Title Machine learning-based deconvolution of antimalarial drug mechanisms of action through cell painting of compound-treated Plasmodium falciparum -infected erythrocytes Collaboration Partners 1. Medicines for Malaria Venture (MMV) (Switzerland) 2. LPIXEL Inc. (Japan) 3. University of Dundee (UK) Disease Malaria Intervention Drug Stage Target Research Awarded Amount JPY 99,628,772 (USD 0.6 million) Status New project Summary [Project objective] The project ultimately aims to deliver a new high-throughput and information-rich platform for informing and classifying antimalarial modes of action (MoA) and highlighting novel compound-induced phenotypes. This proposal seeks to leverage advances in cellular imaging and machine learning-led pattern recognition. The final goal is to develop a robust, reproducible method to deliver information on a compound's biological impact (whether its MoA or pathway is novel or known) in synchrony with the confirmation of growth inhibition and thus allow clustering on both chemistry and biology, potentially saving months in the context of Hit Generation. [Project design] The project relies on high-content imaging and subsequent analysis of drug-treated Plasmodium falciparum parasites. The initial assay development phase will optimise methodologies for staining, fixation, and imaging of parasite-infected red blood cells, including both healthy untreated parasites and those treated with a pilot set of compounds with defined MoA. This will allow preliminary development of artificial intelligence (AI) models to classify parasite morphology across the 48 hour lifecycle, as well as the phenotypic impact of drug-treatment. Once treatment and imaging parameters have been optimised, data collection will be performed with an expanded set of compounds covering a diverse range of MoA, in order to refine and validate the development of AI models for pattern recognition. AI models will ultimately be packaged into a cloud-based, user-friendly application so that images generated by researchers can be analysed without specialist AI knowledge. *All amounts are listed at an exchange rate of USD1 = JPY144.81, the approximate exchange rate on June 30, 2025. Appendix 2. Investment Overview (as of July 17, 2025) Investments to date Total investments: 39.3 billion yen (USD 271 million 1) Total invested projects: 139 (37 active projects and 102 completed projects)
Scoop
26-06-2025
- Health
- Scoop
University Of Auckland's Key Role In Global Fight To Tackle TB
Press Release – University of Auckland A tuberculosis (TB) drug discovery project led by academics from the School of Biological Sciences at the University of Auckland is the first from the University to be selected for a prestigious Japanese public-private partnership (PPP) investment to fight infectious diseases, such as malaria, TB, and neglected tropical diseases. The Global Health Innovative Technology (GHIT) Fund recently announced its latest JPY 1.4 billion (USD 10.1 million) investment focused on five R&D projects for the development of diagnostics, vaccines, and drugs for TB and malaria. TB remains one of the world's most devastating infectious diseases, affecting over 10 million people and causing more than 1.2 million deaths annually. In poorer countries, over 3 million people go undiagnosed each year due to the lack of suitable, accessible diagnostic tools—particularly at the point of first contact with the healthcare system. TB continues to occur in New Zealand with approximately 300 cases diagnosed each year. Of the five projects, Harnessing genome mining for novel tuberculosis antibiotics will be led by Associate Professor Ghader Bashiri, from the School of Biological Sciences in the University's Faculty of Science. Associate Professor Bashiri and his team, alongside Professor Ikuro Abe at the University of Tokyo and Dr Matthew McNeil from the University of Otago, aim to research new drugs to tackle TB by identifying cryptic secondary metabolites that specifically target essential metabolic pathways in the bacterium that causes TB. Secondary metabolites are small molecules that confer a survival advantage to the producing organisms and often exhibit diverse biological properties, such as antimicrobial activity. Associate Professor Bashiri says he is looking forward to the project over the next two years. 'It is an honour and privilege to be part of this project. TB remains the world's leading cause of death from a single infectious agent. Early identification and testing of specific secondary metabolites against our targets using human infection models will provide critical insights into their efficacy and potential as new treatments for TB.' 'While this project focuses on the development of new TB treatments, it has potential spillover effects on malaria, offering new opportunities for developing effective treatments against some of the world's deadliest diseases.' Despite significant advances, developing new antibiotics for TB remains a major challenge as drugs often have limited effect against the infection and serious side effects. Development of drug resistance is a major issue. To overcome this, the project team will (a) identify secondary metabolites that specifically target key metabolic pathways in TB, and (b) test these metabolites against target proteins, bacterial cultures, and infections models to assess their effects on bacterial growth and pathogenesis. This approach offers a unique target for developing safe treatments with new mechanisms of action against TB, with the promise of identifying new generations of antibiotics against TB that can overcome the limitations of existing treatments, such as resistance, side effects, and challenges maintaining patient engagement with treatment. The project team already has established expertise and drug development experience for TB, which will be instrumental in advancing subsequent research and development phases. Long-term, the goal is to create safer and more effective treatment options for TB patients worldwide. The GHIT fund was identified as a pathway to funding for our TB drug pipeline by the UniServices Strategic Growth team who, with the assistance of NZTE Japan, built a relationship with the funder over the past couple of years. This helped to understand GHIT's funding priorities and help the researchers to align their project for a successful application.
Scoop
26-06-2025
- Health
- Scoop
University Of Auckland's Key Role In Global Fight To Tackle TB
Press Release – University of Auckland The Global Health Innovative Technology (GHIT) Fund recently announced its latest JPY 1.4 billion (USD 10.1 million) investment focused on five R&D projects for the development of diagnostics, vaccines, and drugs for TB and malaria. A tuberculosis (TB) drug discovery project led by academics from the School of Biological Sciences at the University of Auckland is the first from the University to be selected for a prestigious Japanese public-private partnership (PPP) investment to fight infectious diseases, such as malaria, TB, and neglected tropical diseases. The Global Health Innovative Technology (GHIT) Fund recently announced its latest JPY 1.4 billion (USD 10.1 million) investment focused on five R&D projects for the development of diagnostics, vaccines, and drugs for TB and malaria. TB remains one of the world's most devastating infectious diseases, affecting over 10 million people and causing more than 1.2 million deaths annually. In poorer countries, over 3 million people go undiagnosed each year due to the lack of suitable, accessible diagnostic tools—particularly at the point of first contact with the healthcare system. TB continues to occur in New Zealand with approximately 300 cases diagnosed each year. Of the five projects, Harnessing genome mining for novel tuberculosis antibiotics will be led by Associate Professor Ghader Bashiri, from the School of Biological Sciences in the University's Faculty of Science. Associate Professor Bashiri and his team, alongside Professor Ikuro Abe at the University of Tokyo and Dr Matthew McNeil from the University of Otago, aim to research new drugs to tackle TB by identifying cryptic secondary metabolites that specifically target essential metabolic pathways in the bacterium that causes TB. Secondary metabolites are small molecules that confer a survival advantage to the producing organisms and often exhibit diverse biological properties, such as antimicrobial activity. Associate Professor Bashiri says he is looking forward to the project over the next two years. 'It is an honour and privilege to be part of this project. TB remains the world's leading cause of death from a single infectious agent. Early identification and testing of specific secondary metabolites against our targets using human infection models will provide critical insights into their efficacy and potential as new treatments for TB.' 'While this project focuses on the development of new TB treatments, it has potential spillover effects on malaria, offering new opportunities for developing effective treatments against some of the world's deadliest diseases.' Despite significant advances, developing new antibiotics for TB remains a major challenge as drugs often have limited effect against the infection and serious side effects. Development of drug resistance is a major issue. To overcome this, the project team will (a) identify secondary metabolites that specifically target key metabolic pathways in TB, and (b) test these metabolites against target proteins, bacterial cultures, and infections models to assess their effects on bacterial growth and pathogenesis. This approach offers a unique target for developing safe treatments with new mechanisms of action against TB, with the promise of identifying new generations of antibiotics against TB that can overcome the limitations of existing treatments, such as resistance, side effects, and challenges maintaining patient engagement with treatment. The project team already has established expertise and drug development experience for TB, which will be instrumental in advancing subsequent research and development phases. Long-term, the goal is to create safer and more effective treatment options for TB patients worldwide. The GHIT fund was identified as a pathway to funding for our TB drug pipeline by the UniServices Strategic Growth team who, with the assistance of NZTE Japan, built a relationship with the funder over the past couple of years. This helped to understand GHIT's funding priorities and help the researchers to align their project for a successful application.
Scoop
26-06-2025
- Health
- Scoop
University Of Auckland's Key Role In Global Fight To Tackle TB
A tuberculosis (TB) drug discovery project led by academics from the School of Biological Sciences at the University of Auckland is the first from the University to be selected for a prestigious Japanese public-private partnership (PPP) investment to fight infectious diseases, such as malaria, TB, and neglected tropical diseases. The Global Health Innovative Technology (GHIT) Fund recently announced its latest JPY 1.4 billion (USD 10.1 million) investment focused on five R&D projects for the development of diagnostics, vaccines, and drugs for TB and malaria. TB remains one of the world's most devastating infectious diseases, affecting over 10 million people and causing more than 1.2 million deaths annually. In poorer countries, over 3 million people go undiagnosed each year due to the lack of suitable, accessible diagnostic tools—particularly at the point of first contact with the healthcare system. TB continues to occur in New Zealand with approximately 300 cases diagnosed each year. Of the five projects, Harnessing genome mining for novel tuberculosis antibiotics will be led by Associate Professor Ghader Bashiri, from the School of Biological Sciences in the University's Faculty of Science. Associate Professor Bashiri and his team, alongside Professor Ikuro Abe at the University of Tokyo and Dr Matthew McNeil from the University of Otago, aim to research new drugs to tackle TB by identifying cryptic secondary metabolites that specifically target essential metabolic pathways in the bacterium that causes TB. Secondary metabolites are small molecules that confer a survival advantage to the producing organisms and often exhibit diverse biological properties, such as antimicrobial activity. Associate Professor Bashiri says he is looking forward to the project over the next two years. 'It is an honour and privilege to be part of this project. TB remains the world's leading cause of death from a single infectious agent. Early identification and testing of specific secondary metabolites against our targets using human infection models will provide critical insights into their efficacy and potential as new treatments for TB.' 'While this project focuses on the development of new TB treatments, it has potential spillover effects on malaria, offering new opportunities for developing effective treatments against some of the world's deadliest diseases.' Despite significant advances, developing new antibiotics for TB remains a major challenge as drugs often have limited effect against the infection and serious side effects. Development of drug resistance is a major issue. To overcome this, the project team will (a) identify secondary metabolites that specifically target key metabolic pathways in TB, and (b) test these metabolites against target proteins, bacterial cultures, and infections models to assess their effects on bacterial growth and pathogenesis. This approach offers a unique target for developing safe treatments with new mechanisms of action against TB, with the promise of identifying new generations of antibiotics against TB that can overcome the limitations of existing treatments, such as resistance, side effects, and challenges maintaining patient engagement with treatment. The project team already has established expertise and drug development experience for TB, which will be instrumental in advancing subsequent research and development phases. Long-term, the goal is to create safer and more effective treatment options for TB patients worldwide. The GHIT fund was identified as a pathway to funding for our TB drug pipeline by the UniServices Strategic Growth team who, with the assistance of NZTE Japan, built a relationship with the funder over the past couple of years. This helped to understand GHIT's funding priorities and help the researchers to align their project for a successful application.
Business Wire
23-04-2025
- Health
- Business Wire
Grant Award from GHIT Fund for Development of an Ultrasensitive Urine Test for Tuberculosis
TOKYO--(BUSINESS WIRE)--H.U. Group Holdings, Inc. and its wholly-owned subsidiary Fujirebio Holdings, Inc. today announced that the Global Health Innovative Technology (GHIT) Fund has awarded a two-year, approximately $4.5 million grant to Fujirebio's wholly-owned subsidiary, Fluxus, Inc. (Location: Sunnyvale, California), to develop an ultrasensitive point-of-care (POC) urine test for tuberculosis (TB). The test will utilize Fluxus' novel single-molecule counting technology, with the potential to be used for both pulmonary and extrapulmonary TB in all patient populations. According to the World health Organization (WHO)* 1, up to two million people die from TB each year, making it one of the leading causes of infectious disease death worldwide. Diagnostic tests are typically performed in sputum, a sample type that is difficult to collect and which severely limits the types of TB and patient populations that can be tested. A sensitive, accurate, and accessible non-sputum-based test is urgently needed to reduce the global burden of TB. The new POC test will measure lipoarabinomannan (LAM), a TB biomarker in urine. Fluxus currently has an ultrasensitive LAM assay prototyped on its benchtop analyzer platform* 2. The GHIT award will fund development towards the launch of the POC instrument and adaptation of the LAM assay to POC test format. The work will be done by Fluxus in partnership with Rapid Research in Diagnostics Development (R2D2) for TB Network, as represented by Heidelberg University Hospital, and Stanford University and Health Care. This grant enables Fujirebio to further contribute to addressing global health needs and delivering critical improvements in access to healthcare. *1 WHO. Global Tuberculosis Report 2023, issued on November 7, 2023 *2 The GHIT Fund is a Japan-based international public-private partnership (PPP) fund that was formed between the Government of Japan, multiple pharmaceutical companies, the Gates Foundation, Wellcome, and the United Nations Development Programme (UNDP). The GHIT Fund invests in and manages an R&D portfolio of development partnerships aimed at addressing neglected diseases, such as malaria, tuberculosis, and neglected tropical diseases, which afflict the world's vulnerable and underserved populations. In collaboration with global partners, the GHIT Fund mobilizes Japanese industry, academia, and research institutes to create new drugs, vaccines, and diagnostics for malaria, tuberculosis, and neglected tropical diseases.
