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Time of India
16-07-2025
- Politics
- Time of India
Lack of accountability for crimes against UN peacekeepers undermines peace efforts: India
India has underscored the urgent need for accountability in crimes against UN peacekeepers , asserting that impunity emboldens perpetrators and undermines global peace efforts. "United Nations peacekeepers face tremendous obstacles while working in increasingly dangerous areas. But for the most part, these crimes continue to go unpunished,' India's Permanent Representative to the United Nations, Ambassador P Harish, said on Tuesday. Explore courses from Top Institutes in Select a Course Category MBA healthcare Technology MCA Finance Public Policy Data Analytics Leadership Digital Marketing PGDM Others Cybersecurity Degree Project Management Product Management Data Science Design Thinking others CXO Healthcare Management Artificial Intelligence Operations Management Data Science Skills you'll gain: Analytical Skills Financial Literacy Leadership and Management Skills Strategic Thinking Duration: 24 Months Vellore Institute of Technology VIT Online MBA Starts on Aug 14, 2024 Get Details Skills you'll gain: Financial Management Team Leadership & Collaboration Financial Reporting & Analysis Advocacy Strategies for Leadership Duration: 18 Months UMass Global Master of Business Administration (MBA) Starts on May 13, 2024 Get Details This lack of accountability severely undermines international peace efforts by giving assailants more confidence, he said. Harish was addressing a high-level meeting of the Group of Friends (GoF) to Promote Accountability for Crimes Against Peacekeepers. The GoF for Accountability of Crimes against Peacekeepers is co-chaired by India and other leading nations. 'Accountability is a strategic necessity... Ensuring responsibility for crimes against UN personnel is essential to the integrity and efficacy of international peacekeeping efforts,' he said. Live Events Peacekeepers' safety is directly improved by justice, allowing them to carry out their vital missions, and it is "our common duty to fulfil this obligation", Harish said. The meeting reaffirmed the steadfast dedication of the GoF to ensuring justice for those who bravely serve under the UN flag. It also underscored the critical imperative to combat impunity for attacks against peacekeepers, emphasising that accountability is not merely a matter of justice for individuals but a basis for the effectiveness, credibility, and future of UN Peace Operations worldwide. The Indian mission in a press release said that senior representatives from around 40 member states, senior UN officials, and experts, including those from field missions, deliberated on enhanced strategies, operational frameworks, and fostering greater international cooperation to bring perpetrators of crimes against peacekeepers to justice, in a powerful demonstration of concerted international will. The discussions highlighted the escalating threats faced by peacekeepers in increasingly volatile environments and the undeniable link between impunity and the continued targeting of these front-line protectors. The group's deliberations centred on understanding these intricate linkages, recognising that a holistic approach is required involving not only punitive measures but also preventative strategies, alongside unwavering political will from all stakeholders, the statement said. The Group of Friends for Accountability of Crimes against Peacekeepers was formally launched in December 2022 during India's Presidency of the UN Security Council, building upon the landmark Security Council Resolution 2589 (2021) that specifically called for facilitating accountability for crimes committed against peacekeepers and requested updates from the Secretary-General on progress. The GoF is dedicated to advancing legal frameworks, promoting investigations, and supporting measures to ensure accountability for crimes committed against United Nations peacekeepers. Its mission is to deter future attacks and provide justice to peacekeepers and their families. The release said that as a co-chair of the GoF, India continues to demonstrate leadership and commitment to the cause of peacekeeping and accountability. India is the largest cumulative troop-contributing country to the United Nations, having deployed more than 300,000 peacekeepers to date, with 182 Indian peacekeepers having made the supreme sacrifice in the line of duty. Economic Times WhatsApp channel )
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Business Standard
16-07-2025
- Politics
- Business Standard
Unaccountability for crimes against UN troops hampers peace efforts: India
India has underscored the urgent need for accountability in crimes against UN peacekeepers, asserting that impunity emboldens perpetrators and undermines global peace efforts. "United Nations peacekeepers face tremendous obstacles while working in increasingly dangerous areas. But for the most part, these crimes continue to go unpunished, India's Permanent Representative to the United Nations, Ambassador P Harish, said on Tuesday. This lack of accountability severely undermines international peace efforts by giving assailants more confidence, he said. Harish was addressing a high-level meeting of the Group of Friends (GoF) to Promote Accountability for Crimes Against Peacekeepers. The GoF for Accountability of Crimes against Peacekeepers is co-chaired by India and other leading nations. Accountability is a strategic necessity... Ensuring responsibility for crimes against UN personnel is essential to the integrity and efficacy of international peacekeeping efforts, he said. Peacekeepers' safety is directly improved by justice, allowing them to carry out their vital missions, and it is "our common duty to fulfil this obligation", Harish said. The meeting reaffirmed the steadfast dedication of the GoF to ensuring justice for those who bravely serve under the UN flag. It also underscored the critical imperative to combat impunity for attacks against peacekeepers, emphasising that accountability is not merely a matter of justice for individuals but a basis for the effectiveness, credibility, and future of UN Peace Operations worldwide. The Indian mission in a press release said that senior representatives from around 40 member states, senior UN officials, and experts, including those from field missions, deliberated on enhanced strategies, operational frameworks, and fostering greater international cooperation to bring perpetrators of crimes against peacekeepers to justice, in a powerful demonstration of concerted international will. The discussions highlighted the escalating threats faced by peacekeepers in increasingly volatile environments and the undeniable link between impunity and the continued targeting of these front-line protectors. The group's deliberations centred on understanding these intricate linkages, recognising that a holistic approach is required involving not only punitive measures but also preventative strategies, alongside unwavering political will from all stakeholders, the statement said. The Group of Friends for Accountability of Crimes against Peacekeepers was formally launched in December 2022 during India's Presidency of the UN Security Council, building upon the landmark Security Council Resolution 2589 (2021) that specifically called for facilitating accountability for crimes committed against peacekeepers and requested updates from the Secretary-General on progress. The GoF is dedicated to advancing legal frameworks, promoting investigations, and supporting measures to ensure accountability for crimes committed against United Nations peacekeepers. Its mission is to deter future attacks and provide justice to peacekeepers and their families. The release said that as a co-chair of the GoF, India continues to demonstrate leadership and commitment to the cause of peacekeeping and accountability. India is the largest cumulative troop-contributing country to the United Nations, having deployed more than 300,000 peacekeepers to date, with 182 Indian peacekeepers having made the supreme sacrifice in the line of duty.
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Business Standard
16-07-2025
- Politics
- Business Standard
Accountability for crimes against UN Peacekeepers a necessity: India at UN
India has reiterated its firm commitment to ensuring accountability for crimes committed against United Nations peacekeepers, calling it a "strategic necessity" for global peacekeeping operations. Speaking at a high-level meeting of the Group of Friends (GoF) for promoting accountability for crimes against peacekeepers held at the United Nations Headquarters in New York on Tuesday, India's Permanent Representative to the UN, Ambassador P Harish, highlighted the "tremendous obstacle " faced by UN peacekeepers while working. "United Nations peacekeepers face tremendous obstacles while working in increasingly dangerous areas. But for the most part, these crimes continue to go unpunished. This lack of accountability severely undermines international peace efforts by giving assailants more confidence," he said. Emphasising the need for accountability, he affirmed, "Therefore, accountability is a strategic necessity. In addition to being required by law, ensuring responsibility for crimes against UN personnel is essential to the integrity and efficacy of international peacekeeping efforts." "Peacekeepers' safety is directly improved by justice, allowing them to carry out their vital missions. It is our common duty to fulfil this obligation," he added The High Level Meeting of the Group of Friends for Accountability of Crimes against Peacekeepers, co-chaired by India and other leading nations, reaffirmed the steadfast dedication of the GoF to ensuring justice for those who bravely serve under the UN flag. "It also underscored the critical imperative to combat impunity for attacks against peacekeepers, emphasising that accountability is not merely a matter of justice for individuals but a basis for the effectiveness, credibility, and future of UN Peace Operations worldwide," Permanent Mission of India to the United Nations, New York said in a statement. "In a powerful demonstration of concerted international will, senior representatives from around 40 Member States, senior UN officials and experts, including from field missions, deliberated on enhanced strategies, operational frameworks, and fostering greater international cooperation to bring perpetrators of crimes against peacekeepers to justice," it added. The discussions highlighted the escalating threats faced by peacekeepers in increasingly volatile environments and the undeniable link between impunity and the continued targeting of these front-line protectors. Further, the statement noted that the Group's deliberations "centred on understanding these intricate linkages, recognising that a holistic approach is required, involving not only punitive measures but also preventative strategies, alongside unwavering political will from all stakeholders." The GoF for Accountability of Crimes against Peacekeepers was formally launched in December 2022 during India's Presidency of the UN Security Council, building upon the landmark Security Council Resolution 2589 (2021), a resolution that specifically called for facilitating accountability for crimes committed against peacekeepers and requested updates from the Secretary-General on progress. The GoF is dedicated to advancing legal frameworks, promoting investigations, and supporting measures to ensure accountability for crimes committed against United Nations peacekeepers. Its mission is to deter future attacks and provide justice to peacekeepers and their families. As a Co-Chair of the GoF, India continues to demonstrate leadership and commitment to the cause of peacekeeping and accountability. With a history spanning over seven decades, India is the largest cumulative troop-contributing country to the United Nations, having deployed more than 300,000 peacekeepers to date. The Permanent Mission of India to the UN highlighted that "Indian peacekeepers have served with distinction and courage in virtually every major UN mission, enduring significant sacrifices, with 182 Indian peacekeepers having made the supreme sacrifice in the line of duty.
Associated Press
17-03-2025
- Business
- Associated Press
GRIN Therapeutics Receives FDA Orphan Drug Designation for Radiprodil for the Treatment of GRIN-Related Neurodevelopmental Disorder
Announcement follows FDA's February 2025 decision to grant radiprodil Breakthrough Therapy designation Company remains on track to initiate Phase 3 pivotal trial of radiprodil in mid-2025 NEW YORK, March 17, 2025 /PRNewswire/ -- GRIN Therapeutics, Inc., a leader in the development of therapies to treat serious neurodevelopmental disorders, today announced that the U.S. Food and Drug Administration (FDA) granted Orphan Drug designation for its investigational drug, radiprodil, for the treatment of GRIN-related neurodevelopmental disorder (NDD). Radiprodil is designed as a potent negative allosteric modulator selectively targeting the N-methyl-D-aspartate receptor subtype 2B (NR2B or GluN2B). The company is on track to initiate a pivotal Phase 3 trial for radiprodil in mid-2025 for the treatment of GRIN-related NDD with GoF mutations and has an ongoing global open-label clinical trial of radiprodil for the treatment of tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) type II. 'We are making rapid progress in our efforts to bring a first-ever treatment for GRIN-related neurodevelopmental disorder to patients. Supported by our promising clinical data, the FDA's decision to grant Orphan Drug designation to radiprodil is the latest milestone in that effort,' said Michael A. Panzara, MD, MPH, Chief Medical Officer at Neurvati Neurosciences and GRIN Therapeutics. 'As we plan to launch our pivotal Phase 3 clinical trial to evaluate the impact of radiprodil on seizures, behavioral abnormalities and functional outcomes associated with GRIN-related NDD in the coming months, we are very grateful to the patients and their families who continue to support this important research effort.' Orphan Drug designation is designed to support innovation and research that can lead to more new treatments for diseases that affect fewer than 200,000 people in the United States. The designation grants drug developers the potential for seven years of market exclusivity for their drug after approval, during which time the FDA will generally not approve an application for the same drug targeting the same disease or condition. In February 2025, the FDA granted radiprodil Breakthrough Therapy designation for the treatment of seizures associated with GRIN-related NDD in patients with GoF mutations. 'We look forward to continuing to engage with the FDA through the means offered by Breakthrough Therapy designation, as we advance our Phase 3 program with a goal of bringing radiprodil to patients,' said Anne-Marie Li-Kwai-Cheung, MChem, MTOPRA, RAPS, Senior Vice President, Development, Regulatory, and Quality at Neurvati Neurosciences and GRIN Therapeutics. 'We have heard from so many clinicians and patients about the urgent unmet need in the treatment of GRIN-related disorders and our entire team is dedicated to advancing this development program through late-stage clinical research and regulatory review as rapidly as possible.' About GRIN-related neurodevelopmental disorder GRIN-related neurodevelopmental disorder is a family of rare, genetically defined pediatric neurodevelopmental disorders caused by mutations in GRIN genes. While symptoms of GRIN-related neurodevelopmental disorder can present as early as infancy, a diagnosis is often not confirmed until age two or later when a child fails to reach developmental milestones. Individuals may experience developmental delay, intellectual disabilities, epilepsy, muscular hypotonia, movement disorders, spasticity, feeding difficulties and behavioral problems. There are currently no approved therapies for GRIN-related neurodevelopmental disorder. About Radiprodil Radiprodil is an investigational, selective and potent negative allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor subtype 2B (NR2B or GluN2B). In nonclinical studies, radiprodil has been shown to potently and selectively modulate GluN2B. Radiprodil has also demonstrated an antiseizure effect in a number of in vitro and in vivo preclinical seizure and epilepsy models and specifically in models characterized by an enhanced GluN2B NMDA transmission, which can occur with gain-of-function (GoF) mutations in GRIN-related neurodevelopmental disorder. In vitro analysis of brain tissues extracted from both tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) lesions has shown enhanced GluN2B NMDA expression supporting the potential ability of radiprodil to control seizures in these conditions. About GRIN Therapeutics GRIN Therapeutics is dedicated to the research and development of precision therapeutics for pediatric neurodevelopmental disorders with the goal of bringing hope to patients and caregivers. Late last year, GRIN Therapeutics reported promising topline data from a Phase 1b/2a clinical trial (the Honeycomb Trial) evaluating radiprodil in GRIN-related neurodevelopmental disorder in patients with GoF variants, leading to the decision to advance to a Phase 3 trial. The company has an additional ongoing clinical trial to evaluate radiprodil for the potential treatment of tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) type II. GRIN Therapeutics is an affiliate of Neurvati Neurosciences, a portfolio company of Blackstone Life Sciences (BXLS). For more information, please visit About Neurvati Neurosciences Neurvati Neurosciences, a portfolio company of Blackstone Life Sciences, identifies and advances the development of high-potential drug candidates across the neuroscience landscape. Neurvati employs a collaborative model that establishes fit-for-purpose affiliate companies, aligning dedicated resources with long-term strategic capital to catalyze innovative treatment options in areas of unmet need. Neurvati's team of experienced operators and drug developers seeks opportunities to challenge current treatment paradigms and make a difference for patients suffering from a wide range of neurological and psychiatric disorders. For more information, please visit About Blackstone Life Sciences Blackstone Life Sciences is an industry-leading private investment platform with capabilities to invest across the life cycle of companies and products within key life science sectors. By combining scale investments and hands-on operational leadership, Blackstone Life Sciences helps bring to market promising new medicines and medical technologies that improve patients' lives and currently has more than $12 billion in assets under management.
