Latest news with #Gore
Business Wire
5 hours ago
- Business
- Business Wire
Gore Launches 0.5 mL Silicone-Free GORE® IMPROJECT® Plunger for Ophthalmic Pre-Filled Syringes
NEWARK, Del.--(BUSINESS WIRE)--W. L. Gore & Associates, Inc. ('Gore'), a global materials science company, recently announced the commercial launch of the 0.5 mL silicone-free* GORE® IMPROJECT® Syringe Plunger within its PharmBIO business. The new offering is specially designed for prefilled syringes used in various applications, including ophthalmic intravitreal injections, and complements the GORE IMPROJECT 1 mLL plunger which Gore launched in mid-2018. Gore's 0.5mL plunger, in combination with a silicone-free glass or advanced polymer syringe barrel, enables pharmaceutical companies to achieve what they've been asking for. To reduce risk associated with silicone by enabling its removal from the syringe. Share Conventional pre-filled syringe systems use silicone to provide a seal and act as a lubricant between the barrel and the plunger. However, peer reviewed literature highlights various problems with silicone including elevated subvisible particulate levels, silicone accumulation in the eye resulting in floaters, silicone-induced protein aggregation resulting in immunological responses, and ocular inflammation and increased intraocular pressure (IOP). In addition, silicone-containing syringes have been associated with particle count increases and fatty acid creation over time. The new plunger enabled syringe systems to achieve particulate levels below the limits of the USP<789> subvisible particle standard in testing performed. The plunger is capable of being terminally sterilized and has been shown to provide suitable break loose and glide force (BL/GF) and CCI performance when used in combination with appropriate syringe components and commercial fill and finish processes. 'Gore's 0.5mL plunger, in combination with a silicone-free glass or advanced polymer syringe barrel, enables pharmaceutical companies to achieve what they've been asking for. To reduce risk associated with silicone by enabling its removal from the syringe plunger and barrel,' emphasized Gore Syringe Business Leader, Emily Oliver. To develop this new product Gore worked closely not only with pharma companies, but also CMOs, terminal sterilization companies, machine companies that design equipment for fill operations, and leading syringe barrel suppliers to bring forth the 0.5 mL silicone-free GORE IMPROJECT Plunger for pre-filled syringes. 'We involved key partners to ensure the product meets the needs of stakeholders throughout the value chain including rigorous fill & finish requirements. This is a breakthrough solution for the industry and was designed with the goal of improving patients' lives,' highlights Russ Hornung, Gore Business Development Manager. The GORE IMPROJECT Plunger may enable today's more challenging ophthalmic injections without the need to introduce silicone oil, cross-linked silicone or resin enhanced silicone. With increasing needs for precise, low-volume injections in ophthalmology, gene therapy, and pediatric care, Gore's 0.5 mL prefilled syringe plunger offers a new alternative. Designed for silicone sensitive applications, this innovation underscores Gore's commitment to enhancing patient outcomes and to driving growth in the evolving injectable therapeutics market. PharmBIO enables life improving therapies of our customers through our leading products and commercial capability. In a highly regulated industry marked by economic pressures and drug development and processing challenges, Gore provides technology-driven products and process components designed for safety, efficiency, reliability and productivity. Gore PharmBIO is focused on satisfying the evolving product, regulatory and quality needs of medical device manufacturers, pharmaceutical and biopharmaceutical customers. The products in the Gore PharmBIO portfolio are tested and manufactured under our stringent quality system. W. L. Gore & Associates is a global materials science company dedicated to transforming industries and improving lives. Since 1958, Gore has solved complex technical challenges in demanding environments — from outer space to the world's highest peaks to the inner workings of the human body. With approximately 13,000 Associates and a strong, team-oriented culture, Gore generates annual revenues of $5 billion.
Yahoo
5 hours ago
- Business
- Yahoo
Gore Launches 0.5 mL Silicone-Free GORE® IMPROJECT® Plunger for Ophthalmic Pre-Filled Syringes
NEWARK, Del., June 03, 2025--(BUSINESS WIRE)--W. L. Gore & Associates, Inc. ("Gore"), a global materials science company, recently announced the commercial launch of the 0.5 mL silicone-free* GORE® IMPROJECT® Syringe Plunger within its PharmBIO business. The new offering is specially designed for prefilled syringes used in various applications, including ophthalmic intravitreal injections, and complements the GORE IMPROJECT 1 mLL plunger which Gore launched in mid-2018. Conventional pre-filled syringe systems use silicone to provide a seal and act as a lubricant between the barrel and the plunger. However, peer reviewed literature highlights various problems with silicone including elevated subvisible particulate levels, silicone accumulation in the eye resulting in floaters, silicone-induced protein aggregation resulting in immunological responses, and ocular inflammation and increased intraocular pressure (IOP). In addition, silicone-containing syringes have been associated with particle count increases and fatty acid creation over time. The new plunger enabled syringe systems to achieve particulate levels below the limits of the USP<789> subvisible particle standard in testing performed. The plunger is capable of being terminally sterilized and has been shown to provide suitable break loose and glide force (BL/GF) and CCI performance when used in combination with appropriate syringe components and commercial fill and finish processes. "Gore's 0.5mL plunger, in combination with a silicone-free glass or advanced polymer syringe barrel, enables pharmaceutical companies to achieve what they've been asking for. To reduce risk associated with silicone by enabling its removal from the syringe plunger and barrel," emphasized Gore Syringe Business Leader, Emily Oliver. To develop this new product Gore worked closely not only with pharma companies, but also CMOs, terminal sterilization companies, machine companies that design equipment for fill operations, and leading syringe barrel suppliers to bring forth the 0.5 mL silicone-free GORE IMPROJECT Plunger for pre-filled syringes. "We involved key partners to ensure the product meets the needs of stakeholders throughout the value chain including rigorous fill & finish requirements. This is a breakthrough solution for the industry and was designed with the goal of improving patients' lives," highlights Russ Hornung, Gore Business Development Manager. The GORE IMPROJECT Plunger may enable today's more challenging ophthalmic injections without the need to introduce silicone oil, cross-linked silicone or resin enhanced silicone. With increasing needs for precise, low-volume injections in ophthalmology, gene therapy, and pediatric care, Gore's 0.5 mL prefilled syringe plunger offers a new alternative. Designed for silicone sensitive applications, this innovation underscores Gore's commitment to enhancing patient outcomes and to driving growth in the evolving injectable therapeutics market. PharmBIO enables life improving therapies of our customers through our leading products and commercial capability. In a highly regulated industry marked by economic pressures and drug development and processing challenges, Gore provides technology-driven products and process components designed for safety, efficiency, reliability and productivity. Gore PharmBIO is focused on satisfying the evolving product, regulatory and quality needs of medical device manufacturers, pharmaceutical and biopharmaceutical customers. The products in the Gore PharmBIO portfolio are tested and manufactured under our stringent quality system. About Gore W. L. Gore & Associates is a global materials science company dedicated to transforming industries and improving lives. Since 1958, Gore has solved complex technical challenges in demanding environments — from outer space to the world's highest peaks to the inner workings of the human body. With approximately 13,000 Associates and a strong, team-oriented culture, Gore generates annual revenues of $5 billion. Referenced peer-reviewed literature available upon request.*silicone not intentionally added as a raw material or in the manufacturing process View source version on Contacts Media Contacts W. L. Gore & AssociatesNicole Miller, Gore Communications & External AffairsContact by email W. L. Gore & AssociatesErnesto Sosa, Gore PharmBIO Global Marketing LeaderContact by email Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Otago Daily Times
5 hours ago
- Business
- Otago Daily Times
Students make up for canteen loss
After the loss of their school canteen, a group of industrious Gore students have seen a gap in the market, selling cheese rolls for charity and school credit. As part of their business studies class, a group of St Peter's College year 12 and 13s have been selling cheese rolls every Wednesday, at morning tea and lunch, and donating the proceeds to charity. The school's canteen used to be run by staff of Rosmini House, the hostel on campus, which closed down last year due to a declining roll. When the hostel closed, the tuck shop went with it, and now students Tori Pont, Nia Robertson, Makayla Taylor and Addi McHaffie are serving southern delicacies to the school's students and teachers. Commerce, economics, business and agribusiness studies teacher Will Byars said the way his students could get around the rules of being able to sell food on campus was to treat the catering as a fundraising drive and donate the money to The Cancer Society. "They've got some financial and social goals around that," he said. The young entrepreneurs were part of a combined class who he said had a particularly "good batch" of businesses this year. He said his student Millie McFadzien was working with Waituna Eel and making eel pate, which she would be serving as an entree at the Southland Business Excellence Awards next month. Another group had the "innovative idea" of a "basketball cube", which was all about improving shooting technique for young basketballers. The business ideas are also part of the national Young Enterprise scheme competition, which is a charity-funded programme that fosters and provides mentoring for business ideas of senior high school students for a year. Next week, the students, along with other schools across Southland, will be heading to Invercargill to do a five-minute pitch of their ideas to Southland Business Chamber members. "They're going to talk about their marketing plan, so it's quite daunting for them to talk to other adults about their idea," Mr Byars said. As students and some teachers lined up for the lunchtime rush, Addi said it could be stressful when everyone comes out as once and they had to go fast, but it was not too bad, as they split the jobs evenly between four of them. In an organised operation, she said they made the rolls the day before and prepared the ham and cheese toasties, which sold for $2 each. They had just started selling sherbert fizzes also. Their goal was to make $500 per term — but they had only been going for three weeks and were yet to crunch the numbers, she said. Mr Byars said he was going to make sure they did their banking and knew their profit margin for the week. Food technology teacher Lisa Perkins, who was popping in on the girls' activities, said they were doing a great job. "They are following all the food safety standards which is good," she said.
Yahoo
2 days ago
- Business
- Yahoo
Why new cannabis companies face high barriers to entry
Listen and subscribe to The Big Idea on Apple Podcasts, Spotify, or wherever you find your favorite podcasts. Securing financing for a small business is no easy feat, but it's even harder for those in industries where there's evolving legislation. On Yahoo Finance's The Big Idea podcast, Erin Gore, the founder of cannabis company Garden Society, detailed the extra hoops those in her industry have to jump through to build a company. 'What we don't have is access to credit, and what we don't have is services around it," Gore told podcast host Elizabeth Gore, who is also her sister-in-law. "So, like, we cannot get a 401(k) — we keep getting denied for 401(k)s for our employees because of the federal illegality of it. We can't get a line of credit for payroll. We can't access any financing services, like equipment financing or mortgages. Our personal bank accounts get shut down.' This embedded content is not available in your region. The cannabis industry was estimated to be worth $38.5 billion in 2024, and marijuana is currently legal for medical use in 39 states and for recreational use in 24 states. However, because marijuana is still classified as a Schedule I drug federally, traditional financial institutions often avoid working with cannabis companies due to the risk of federal penalties and running afoul of anti-money-laundering regulations. One piece of legislation introduced in the House of Representatives in 2023, known as the Secure and Fair Enforcement Regulation (SAFER) Banking Act, would offer protections to federal financial institutions that offer banking services to cannabis companies in states where it's legal. But the bill has stalled in Congress. As a result, while an industry with this much capital and growth may seem like a prime opportunity for some budding entrepreneurs, these owners face significant financial hurdles. Without usual lines of financing, Gore has had to get creative to ensure her business can continue growing. Cash flow has been essential to keeping her company afloat. She shared that a potential investor once asked her what her cash-to-cash cycle time was, meaning how quickly she saw a return after investing in a product. Gore said the cash cycle is around 160 days for Garden Society-branded products, 'on a best-case scenario.' But she found that by manufacturing cannabis products for other companies, she could have those firms pay for materials and manufacturing up front, drastically reducing that cash-to-cash cycle timeline and bolstering her profits while diversifying her company's streams of income. "I shortened my cash-to-cash cycle time, which covered my overhead," Gore said. "It allowed me to invest in my brand. I all of a sudden had different revenue channels that offset my business and put a lot of resiliency and cash flow and profitability into my business." Even with these adjustments, which increased her company's cash flow and made Garden Society one of California's biggest cannabis companies, Gore still faces significant risk without the additional protections other businesses can get. "In cannabis, you have no bankruptcy protection," she said, explaining that this became a problem when one of her distributors went out of business unexpectedly while it owed her almost half a million dollars. "I don't have credit," she explained. "I'm dependent on that cash to pay my payroll, pay my employees. I can't go to a bank and ask for help. I'm only dependent on investor contributions." With almost a decade in the industry under her belt, Gore has also spent a fair amount of time lobbying for policy changes on the local, state, and national levels. "Nobody's better suited than the business owner to build policy and build the rules," she said. "But like we always say in the industry, we're building the plane and flying it at the same time." Though she's seen some progress, there are still plenty of challenges in the industry. 'You have to be so resilient and creative and nimble,' she continued. 'And I think people underestimate how opportunistic and open to change you need to be.' Every Thursday, Elizabeth Gore discusses real-life stories and smart strategies for launching a small business on The Big Idea podcast. You can find more episodes on our video hub or watch on your preferred streaming service. Click here for in-depth analysis of the latest stock market news and events moving stock prices
1News
4 days ago
- Entertainment
- 1News
Country music resurges as Gold Guitars strikes golden milestone
The country's prestigious Gold Guitar Awards has reached its own triumphant milestone of the same colour — it's golden anniversary. Many of the past winners of the highly-acclaimed competition returned to Gore's golden stage in Southland to celebrate 50 years. The three-day event is part of 10-day Tussock Country Festival in the south that brings country lovers from New Zealand and the world. On Thursday night, the Gold Guitars held a special gala for more than 20 returning winners to perform — many for the first time in years. Peter Cairns took the coveted prize in 1984. ADVERTISEMENT "This is, literally, the best of the best [in New Zealand country music.]," he told 1News. Around 600 people packed Gore's Town & Country Club venue for the four-hour show this week. "There's been a lot of similar awards that haven't lasted the distance and it's really the tenacity and the hard work of all those involved in putting it together that's led to its success," said Cairns. But it was not just about classic country music. The event organisers have witnessed a resurgence of genre with a record number of entrants this year — 829 in total. That compared to just 38 in the first event back in 1974. Gold Guitar Award convener Phillip Geary has been involved with the competition for 30 years. "Country music is definitely becoming more popular," he said. ADVERTISEMENT Geary added, "we've noticed that over the last, probably five years a big, big increase... in the intermediates [level] which is your teenagers." "With the likes of Taylor Swift and some of the upbeat-type country music artists, [teenagers] are recognising that and enjoying it and I think that's helping," he said. Kylie Price claimed Gold Guitar champion in 2012 and jetted in from the United Kingdom for the show. She told 1News, interest from the younger generation has been felt across the world. "It's like a big family which, I think, is a massive thing when you're trying to bring the future generation in," she said. "We want to be as welcoming as possible." Price said the likes of New Zealander Kaylee Bell's success and others have also helped. ADVERTISEMENT "And you get the overseas artists like Chris Stapleton and Luke Combs and that sort of thing," added Price. She said the resurgence has allowed the genre to evolve. "For a long time, I remember when I was singing and it wasn't deemed as the cool genre to sing... and I think people are starting to realise that country isn't just this one specific sound that they might have always thought country was." With the awards stronger than ever — the next Gold Guitar star would be revealed on Sunday night.
