Latest news with #HD-DoE
Cision Canada
05-08-2025
- Business
- Cision Canada
Trailhead Biosystems Expands iPSC-Derived Portfolio with TrailBio® Hematopoietic Progenitor Cells
BEACHWOOD, Ohio, Aug. 5, 2025 /CNW/ -- Trailhead Biosystems, Inc. ( a biotechnology company advancing scalable human cell models derived from induced pluripotent stem cells (iPSCs), announces the commercial release of TrailBio ® Hematopoietic Progenitor Cells. These progenitor cells are derived from a single, well-characterized iPSC line using Trailhead's proprietary High-Dimensional Design-of-Experiments (HD-DoE ®) platform, providing researchers with a consistent, scalable, and ready-to-use tool for hematopoietic research. TrailBio ® Hematopoietic Progenitor Cells express key hematopoietic markers including CD34, CD43 and CD90. Functional characterization confirms their ability to form myeloid and erythroid colonies in colony-forming unit (CFU) assays, differentiate into multiple hematopoietic lineages and demonstrate hematopoietic commitment through transcriptomic profiling. Designed for applications such as hematopoietic disease modeling, drug screening and hematotoxicity studies, TrailBio ® Hematopoietic Progenitor Cells enable a reliable human model system that eliminates donor variability and supports reproducible results. "TrailBio ® Hematopoietic Progenitor Cells strengthen our portfolio by providing researchers with high-quality, human-relevant cellular models," said David Llewellyn, Chief Executive Officer of Trailhead Biosystems. "Their consistency and multipotency enable scientists to advance research in hematopoietic biology and therapeutic development." "These Hematopoietic Progenitor Cells deliver a dependable combination of purity, potency and versatility," said Angelica Gomes Ueltschy, Scientific Director at Trailhead Biosystems. "Their robust marker expression and multilineage differentiation capacity make them well suited for modeling blood disorders and evaluating therapeutic candidates." Cell characterization information and additional data can be found at About Trailhead Biosystems Trailhead Biosystems, Inc. is pioneering an informatics-based approach in regenerative medicine and drug discovery. Founded in 2015 as a spinout from the Cleveland Clinic and Case Western Reserve University, Trailhead emerged from the research of CSO/CTO and founder Dr. Jan Jensen. Trailhead creates optimized human cells at scale with its proprietary High-Dimensional Design-of-Experiments (HD-DoE ®) platform, integrating advanced mathematical modeling with high-throughput robotic manufacturing. This innovative system allows Trailhead to develop specialized, high-quality iPSC-derived human cells for drug discovery and cell-based therapies. TrailBio ® Hematopoietic Progenitor Cells join a growing portfolio of iPSC-derived human cell types designed to bridge the gap between discovery and clinical translation. Learn more about Trailhead Biosystems, TrailBio® Hematopoietic Progenitor Cells and HD-DoE® at For more information, please contact: Tim Mauk, Corporate Communications Trailhead Biosystems Email: [email protected] SOURCE Trailhead Biosystems Inc
Yahoo
23-07-2025
- Business
- Yahoo
Trailhead Biosystems® Expands Human Cell-Based Product Line with iPSC-Derived A9 Dopaminergic Neurons
BEACHWOOD, Ohio, July 23, 2025 /PRNewswire/ -- Trailhead Biosystems, Inc. ( a biotechnology company pioneering the creation of induced pluripotent stem cell (iPSC)-derived human cells at scale for drug discovery and cell therapy, introduces TrailBio® A9 Dopaminergic Neurons, a powerful new tool available off-the-shelf for studying Parkinson's disease and other neurodegenerative conditions. A9 dopaminergic neurons play a critical role in movement regulation and are disproportionately affected in Parkinson's disease. Historically, researchers have lacked access to viable human models, relying instead on animal studies with limited relevance. With TrailBio® A9 Dopaminergic Neurons, scientists now have a human-specific platform to investigate disease mechanisms, develop therapies and accelerate drug discovery. "TrailBio® A9 Dopaminergic Neurons open new possibilities for Parkinson's research," said Dr. Jan Jensen, Chief Scientific Officer, Chief Technology Officer and founder of Trailhead Biosystems. "These cells enable researchers to study the vulnerabilities of A9 neurons, helping drive progress toward more effective treatments." "For decades, the lack of human A9 neurons has limited our ability to truly understand Parkinson's disease," added Dr. Nooshin Amini, Scientific Director at Trailhead Biosystems. "Now, with TrailBio® A9 Dopaminergic Neurons, researchers can directly study the exact cells that are most affected, offering hope for groundbreaking insights and future therapies." About Trailhead Biosystems Trailhead Biosystems, Inc. is pioneering an informatics-based approach in regenerative medicine and drug discovery. Founded in 2015 as a spinout from the Cleveland Clinic and Case Western Reserve University, Trailhead emerged from the research of CSO/CTO and founder Dr. Jan Jensen. Trailhead creates optimized human cells at scale with its proprietary High-Dimensional Design-of-Experiments (HD-DoE®) platform, integrating advanced mathematical modeling with high-throughput robotic manufacturing. This innovative system allows Trailhead to develop specialized, high-quality iPSC-derived human cells for drug discovery and cell-based therapies. TrailBio® A9 Dopaminergic Neurons represent one of many specialized human cell types emerging from this platform, with additional cell models expected in the near future. Learn more about Trailhead Biosystems, TrailBio® A9 Dopaminergic Neurons and HD-DoE® at For more information, please contact: Tim Mauk, Corporate CommunicationsTrailhead BiosystemsEmail: info@ View original content to download multimedia: SOURCE Trailhead Biosystems Inc Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
06-05-2025
- Business
- Yahoo
Trailhead Biosystems Secures $20 Million to Drive Innovation and Accelerate Growth
BEACHWOOD, Ohio, May 6, 2025 /PRNewswire/ --Trailhead Biosystems Inc. ( a biotechnology company advancing human cell innovation, has secured $20 million in financing. Trailhead specializes in precisely differentiating induced pluripotent stem cells (iPSCs) into functional human cell types—unlocking new possibilities for research and cell therapy. Through its proprietary High-Dimensional Design of Experiments (HD-DoE®) platform, Trailhead optimizes differentiation with exceptional accuracy, enabling scalable solutions for both drug discovery and regenerative medicine. The investment, led by MAK Capital with participation from additional investors, comes at a critical phase of Trailhead's growth, enabling expansion in personnel, manufacturing and strategic partnerships. Trailhead Biosystems, Inc. is pioneering the informatics-based approach in regenerative medicine and drug discovery. Founded in 2015 as a spinout from the Cleveland Clinic and Case Western Reserve University, Trailhead emerged from the research of CEO/CSO Dr. Jan Jensen during his tenure as an endowed professor at the Cleveland Clinic. Trailhead creates optimized human cells at scale with its proprietary High-Dimensional Design of Experiments (HD-DoE®) platform. HD-DoE® integrates advanced math (PRNewsfoto/Trailhead Biosystems Inc) Accelerating Growth in Research Markets The funding will enhance Trailhead's rapidly expanding portfolio of iPSC-derived cells for research applications, advancing preclinical drug discovery and disease modeling. The company recently introduced TrailBio® Vascular Leptomeningeal Cells (VLMCs) for blood-brain barrier research, addressing a critical need in neuroscience and drug delivery. Upcoming product introductions include iPSC-derived pancreatic islets, hepatocytes, dopaminergic neurons and hematopoietic progenitors, providing researchers with highly specialized human cell models to drive breakthroughs. Beyond its off-the-shelf offerings, Trailhead remains dedicated to custom cell differentiation services, enabling scientists to refine existing models or develop novel cell types with precise biological fidelity. As the FDA shifts toward human-based lab models as alternatives to animal testing, Trailhead's human-relevant cell products provide a scalable and predictive solution for modern drug development and safety testing. These new approaches enhance high-throughput screening, disease modeling and the development of organoid and organ-on-a-chip research platforms. Strengthening Therapeutic Partnerships This funding also strengthens Trailhead's ability to support therapeutic partners, driving innovation and scalability in cell-based therapies. Investments in infrastructure and personnel will enhance manufacturing capabilities, streamline production workflows and deepen collaborations with leading industry partners in regenerative medicine. "This investment allows us to further advance how iPSCs are differentiated into precise human cell types for both drug discovery and therapeutic development," said Jan Jensen, Ph.D., CEO/CSO and founder of Trailhead Biosystems. "By optimizing scalable differentiation processes, we are enabling researchers to accelerate discovery and develop more predictive models, while also supporting the next generation of cell-based therapies."
Cision Canada
06-05-2025
- Business
- Cision Canada
Trailhead Biosystems Secures $20 Million to Drive Innovation and Accelerate Growth
BEACHWOOD, Ohio, May 6, 2025 /CNW/ --Trailhead Biosystems Inc. ( a biotechnology company advancing human cell innovation, has secured $20 million in financing. Trailhead specializes in precisely differentiating induced pluripotent stem cells (iPSCs) into functional human cell types—unlocking new possibilities for research and cell therapy. Through its proprietary High-Dimensional Design of Experiments (HD-DoE®) platform, Trailhead optimizes differentiation with exceptional accuracy, enabling scalable solutions for both drug discovery and regenerative medicine. The investment, led by MAK Capital with participation from additional investors, comes at a critical phase of Trailhead's growth, enabling expansion in personnel, manufacturing and strategic partnerships. Accelerating Growth in Research Markets The funding will enhance Trailhead's rapidly expanding portfolio of iPSC-derived cells for research applications, advancing preclinical drug discovery and disease modeling. The company recently introduced TrailBio® Vascular Leptomeningeal Cells (VLMCs) for blood-brain barrier research, addressing a critical need in neuroscience and drug delivery. Upcoming product introductions include iPSC-derived pancreatic islets, hepatocytes, dopaminergic neurons and hematopoietic progenitors, providing researchers with highly specialized human cell models to drive breakthroughs. Beyond its off-the-shelf offerings, Trailhead remains dedicated to custom cell differentiation services, enabling scientists to refine existing models or develop novel cell types with precise biological fidelity. As the FDA shifts toward human-based lab models as alternatives to animal testing, Trailhead's human-relevant cell products provide a scalable and predictive solution for modern drug development and safety testing. These new approaches enhance high-throughput screening, disease modeling and the development of organoid and organ-on-a-chip research platforms. Strengthening Therapeutic Partnerships This funding also strengthens Trailhead's ability to support therapeutic partners, driving innovation and scalability in cell-based therapies. Investments in infrastructure and personnel will enhance manufacturing capabilities, streamline production workflows and deepen collaborations with leading industry partners in regenerative medicine. "This investment allows us to further advance how iPSCs are differentiated into precise human cell types for both drug discovery and therapeutic development," said Jan Jensen, Ph.D., CEO/CSO and founder of Trailhead Biosystems. "By optimizing scalable differentiation processes, we are enabling researchers to accelerate discovery and develop more predictive models, while also supporting the next generation of cell-based therapies." About Trailhead Biosystems Trailhead Biosystems, Inc. is pioneering the informatics-based approach in regenerative medicine and drug discovery. Founded in 2015 as a spinout from the Cleveland Clinic and Case Western Reserve University, Trailhead emerged from the research of CEO/CSO Dr. Jan Jensen during his tenure as an endowed professor at the Cleveland Clinic. Trailhead creates optimized human cells at scale with its proprietary High-Dimensional Design of Experiments (HD-DoE®) platform. HD-DoE® integrates advanced mathematical modeling with high-throughput robotic manufacturing. Trailhead operates facilities in Beachwood, Ohio, with a business development office in Kendall Square, Cambridge, MA. For more information, please contact:
