Latest news with #HEROES
Yahoo
3 days ago
- Politics
- Yahoo
Riley supporting loan forgiveness for volunteer first responders
WASHINGTON, FC (WIVT/WBGH) — Congressman Josh Riley is making sure volunteer heroes receive the respect and support that they deserve. Riley announced his co-sponsorship of the Helping Emergency Responders Overcome Emergency Situations, or HEROES, Act. The initiative is a bipartisan bill that would extend eligibility for the federal Public Service Loan Forgiveness program to include volunteer firefighters and emergency medical responders. 'If you've put on the gear and answered the call, you shouldn't be buried in debt,' said Riley. 'The HEROES Act gives volunteer firefighters the respect they've earned by making their service count toward student loan forgiveness. They don't do it for the money—they do it because they love their communities and want to keep their neighbors safe.' According to Riley, the HEROES Act would amend the Higher Education Act of 1965 to recognize the service of unpaid emergency responders as qualifying public service under the PSLF program, making them eligible for federal student loan forgiveness after ten years of service and qualifying payments. Riley supporting loan forgiveness for volunteer first responders P. East Trading Corp recalls Salted Smoked Split Herring 'It Ain't Necessarily So' discusses American Black history A mix of sun and showers today News 34 Pizza Week returns Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
Yahoo
10-03-2025
- Business
- Yahoo
Natera Announces Enrollment of First Patients in the HEROES Clinical Trial in Metastatic HER2+ Breast Cancer
HEROES is Natera's first clinical trial using Signatera™ to guide de-escalation of therapy in patients with metastatic HER2+ breast cancer Approximately 170 patients are expected to enroll in up to 35 sites in France AUSTIN, Texas, March 10, 2025--(BUSINESS WIRE)--Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA and genetic testing, today announced the enrollment of the first patients in the HEROES clinical trial. HEROES is a multi-center, phase II trial that explores the discontinuation or de-escalation of anti-HER2 targeted therapy among patients with metastatic HER2+ breast cancer. The trial is supported by funding from the French Ministry of Health through the Hospital Clinical Research Program (PHRC) and is being sponsored by Unicancer. It is being developed within Unicancer's French Breast Cancer Intergroup (UCBG) network. Human epidermal growth factor receptor 2 (HER2) is a type of protein found in cancer cells that can cause rapid cancer growth when higher than normal levels are present. Between 15%-20% of breast tumors are HER2+.¹ Current standard-of-care (SOC) recommendations for maintenance treatment include the use of anti-HER2 therapies, which for many patients means remaining on the drug for life. The HEROES (NCT06450314) trial will enroll approximately 170 metastatic HER2+ breast cancer patients who have discontinued anti-HER2 maintenance therapy. The primary endpoint of the study is 1-year progression-free survival in the Signatera-negative cohort. It will also assess ctDNA dynamics and quality-of-life measures to gain deeper insights into the potential for ctDNA-guided de-escalation of treatment in patients with no detectable molecular disease burden. Highlights from the study protocol include: At baseline, all patients are currently being treated with SOC anti-HER2 targeted therapies and have been on therapy for two or more years. Signatera-negative patients at baseline will stop treatment and will be monitored with serial Signatera testing and diagnostic imaging. If at any point during the trial radiological progression is confirmed or a patient becomes Signatera-positive, prior drug therapy will resume or a new treatment will begin. Signatera-positive patients at baseline will continue maintenance therapy and will not move forward in the trial. "The HEROES study could significantly reshape the way oncologists treat patients with metastatic HER2+ breast cancer," said Thibault de la Motte Rouge, M.D., Ph.D., principal investigator of the trial and medical oncologist at the Comprehensive Cancer Centre Eugène Marquis (Rennes, France), where he currently holds the position of research director. "This could also pave the way for future research into ctDNA-guided treatment de-escalation in breast cancer." "We are excited to see the first patients enrolled in the HEROES clinical trial," said Angel Rodriguez, M.D., senior medical director of oncology at Natera. "Safely discontinuing treatment has been a long-lasting dilemma in HER2 metastatic breast cancer. With Signatera monitoring, we hope oncologists can identify the patients without detectable disease who may be able to avoid additional therapy that can be costly and potentially harmful to their care." About Signatera Signatera is a personalized, tumor-informed, molecular residual disease test for patients previously diagnosed with cancer. Custom-built for each individual, Signatera uses circulating tumor DNA to detect and quantify cancer left in the body, identify recurrence earlier than standard-of-care tools, and help optimize treatment decisions. The test is available for clinical and research use and is covered by Medicare for patients with colorectal cancer, breast cancer, ovarian cancer, and muscle-invasive bladder cancer, as well as for immunotherapy monitoring of any solid tumor. Signatera has been clinically validated across multiple cancer types and indications, with published evidence in over 100 peer-reviewed papers. About Natera Natera™ is a global leader in cell-free DNA and genetic testing, dedicated to oncology, women's health, and organ health. We aim to make personalized genetic testing and diagnostics part of the standard of care to protect health and inform earlier, more targeted interventions that help lead to longer, healthier lives. Natera's tests are validated by more than 250 peer-reviewed publications that demonstrate high accuracy. Natera operates ISO 13485-certified and CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in Austin, Texas, and San Carlos, California. For more information, visit About Unicancer Unicancer is the only French hospital network 100% dedicated to the fight against cancer and the only national hospital federation dedicated to oncology. It brings together 18 Centres de lutte contre le cancer (CLCC), private non-profit healthcare establishments, spread over 20 hospital sites in France, as well as two affiliated member establishments. The CLCCs treat nearly 530,000 patients per year (in short stays, home hospitalisation and outpatient procedures). Unicancer is also the leading academic promoter of clinical trials in oncology at the European level, with 106 active clinical trials promoted in 2020 and nearly 7,600 patients included. Unicancer also runs flagship programmes that use real-life data to improve knowledge and the evaluation of therapeutic strategies, particularly through the ESME platforms, which bring together data from more than 76,000 cancer patients. Recognised as a leader in research in France, the Unicancer network enjoys a worldwide reputation with the production of one third of French publications of international scope in oncology (source: bibliometric study/Thomson Reuters). In total, nearly 700 clinical trials (inclusions or follow-ups) were promoted in 2020 by the Unicancer network, more than 14% of CLCC patients are included in clinical trials and more than half of the PHRCs are allocated to CLCCs. The 18 CLCCs and the Unicancer R&D department are ISO 9001:2015 certified for their clinical research. Forward-Looking Statements All statements other than statements of historical facts contained in this press release are forward-looking statements and are not a representation that Natera's plans, estimates, or expectations will be achieved. These forward-looking statements represent Natera's expectations as of the date of this press release, and Natera disclaims any obligation to update the forward-looking statements. These forward-looking statements are subject to known and unknown risks and uncertainties that may cause actual results to differ materially, including with respect to whether the results of clinical or other studies will support the use of our product offerings, the impact of results of such studies, our expectations of the reliability, accuracy, and performance of our tests, or our expectations of the benefits of our tests and product offerings to patients, providers, and payers. Additional risks and uncertainties are discussed in greater detail in "Risk Factors" in Natera's recent filings on Forms 10-K and 10-Q, and in other filings Natera makes with the SEC from time to time. These documents are available at and References American Cancer Society. Breast Cancer HER2 Status. View source version on Contacts Investor Relations: Mike Brophy, CFO, Natera, Inc., 510-826-2350, investor@ Media: Lesley Bogdanow, VP of Corporate Communications, Natera, Inc., pr@ Sign in to access your portfolio
Yahoo
11-02-2025
- Entertainment
- Yahoo
Ten Essential Local Artists Inspired by the City of Angels
February's two huge annual art events — Frieze Los Angeles and the LA Art Show — promote the local art market on a global scale, exponentially elevating its influence and impact. With collectors, creatives, celebrities and art aficionados of all kinds coming together to showcase, enjoy, buy and sell, Los Angeles' art scene has finally gained not only commercial viability but the respect it richly in the wake of last month's Southern California wildfire damage and loss, celebrating our city's creative spirit is about more than prestige or commerce. It's an opportunity for healing and unity — to advocate for our fellow Angelenos, and to express our ideas, emotions, hopes and pop art painters to eclectic photographers, street artists to fine artists, portraitists to muralists, multimedia forms of expression in L.A. have the spotlight right now — and rightfully so. But the truth is, art flourishes every day, year-round, in times of joy and times of sorrow, bringing diverse communities together and inspiring us all. We need art now more than we spotlight 10 essential L.A. artists who've put their vision into practice this year, reflecting the shared experiences of living and creating in the City of Angels. The local Latino artist, who grew up in Boyle Heights and blew up in Downtown L.A., took his career to new heights last year. Vargas completed two huge murals — of the Los Angeles Dodgers' Shohei Ohtani and Fernando Valenzuela — both promoting his ethos of community representation. With a square named after him in his old neighborhood and his own designated City of Los Angeles day (Sept. 8), he's one of the most popular and active artists in town. After creating one of Los Angeles magazine's three special covers this month honoring the city's first responders, he'll be live-painting a massive mural called 'HEROES' (a tribute to the L.A. firefighters), at the LA Art Show later this Next: His 14-story 'Angelus' mural at Pershing Square, currently in progress, is set to break the world record this July as the largest freehand mural by a single artist. @therobertvargas Featured in LACMA's current Imagining Black Diasporas: 21st-Century Art and Poetics exhibition, Cullors' meld of art and activism continues to evolve and thrive. Known for her work with Black Lives Matter and the Center for Art and Abolition, her multimedia creative commentary incorporates cultural artifacts, textiles and metalwork that manifest 'a sanctuary of reflection and empowerment.' An artist-in-residence for the Los Angeles County Department of Arts and Culture's Homeless Initiative, Cullors also served as executive producer on the HBO docuseries Eyes on the Prize, about the civil rights movement. What's Next: In March, Cullors' West Hollywood billboard project 'Black Women Rest' will debut, and she'll perform her Sacred Resistance piece at UC A native Angeleno who's paid homage to the soulful resilience of his hometown for over three decades (including one of Los Angeles special February print edition covers), Swing lives up to his 'Mr. L.A.' moniker. With a background in street, fine and pop art, his abstract expressionist work can be found at major L.A. restaurants and hotels, and at galleries and public spaces around the U.S. Swing's amalgamation of classic iconography and proud street vibes will be a highlight at this month's LA Art Show — and it's just the beginning for Next: Swing will be a part of Burning Bright - The Strength, Struggle, and Survival of LA Artists at Art Share L.A. and the AAF spring N.Y. fair, both in March. He'll also partake in the AMP San Francisco Art Fair in April, the Ampersand Show in May, the Hamptons Fine Art Fair in July and additional group shows in New York City and Miami. A figurative painter blending reality with fantasy in a fresh and defiantly feminine way, Fabia's work uses saturated color palettes and bold lines to arrest the viewer. Her oil-painted nudes and portraits convey magical moments in time and many local figures in her hometown of L.A. With a photographic yet surrealist approach that also evokes the punk rock energy of her homelife as a wife (to Bad Religion's Jay Bentley) and a mother, she's also commissioned for projects and has a line of fine art Next: In addition to teaching painting classes at her O.C. studio and recently releasing a line of paint brushes, Fabia is working on an upcoming solo show in Los Angeles and will be administering a two-week painting workshop in Rome this summer. With notable works at Watts Towers Arts Center, 18th Street Arts Center, Barnsdall Art Park and LACMA over the years, Grant's oeuvre gives rise to conversations about identity and love. She examines language and written texts through the mediums of painting, neon sculpture, video and books. The latter comes via the X Artists' Books imprint — launched with her partner, actor Keanu Reeves — publishing art books with a philanthropic component that's central to her Next: After a solo exhibition in Berlin at Carlier|Gebauer, Grant will partake in a group show at The Pit in Glendale. She's the honorary chair of Project Angel Food's Angel Art Transformation benefit on Feb. 27 and her just-launched LOVE Wine, featuring labels designed by her favorite artists, will release its second drop this summer. The French-born, L.A.-based street artist known as Mr. Brainwash incorporates a dizzying aggregation of ideas, mediums and references in his work, but his main inspiration is joy. His mantra, 'Life is Beautiful,' is imparted through all he does, from his whimsical Beverly Hills museum to his latest exhibit at the Petersen Automotive Museum — which celebrates the beauty and significance of cars through his signature collision of pop culture and fine art. In December, he set a Guinness World Record for the largest dual-sided mosaic made with Rubik's Cubes. He also created one of Los Angeles magazine's three February print covers and did a mural of the piece for everyone to enjoy at 1255 S. La Brea Ave. in Next: Guetta's work will next be seen at the Bob Marley Museum in Jamaica (on the reggae great's birthday) and in a new installation on Rodeo Drive, which includes over 18 sculptures and immersive photo backdrops inspired by famous artworks. Known for incorporating L.A. cityscapes into his edgy work, the native Angeleno's heightened reflections are both cinematic and thought-provoking. The city after dark conjures a special kind of energy and Israel — who's collaborated with everyone from Bret Easton Ellis to Louis Vuitton — captures it with animated realism and moodiness. Shamrock Social Club tattoo shop, Trashy Lingerie and the Troubadour are just a few of the landmarks included in his latest Gagosian exhibit, Noir. Paused during the fires, it reopened on Feb. 6 and spotlights nostalgic odes to his hometown Next: His next solo show, Heaven, in partnership with Aspen One, opens at the Aspen Art Museum this month. Through a lift ticket, an exhibition and on-mountain signage, he integrates pop culture, celebrity and entertainment. @alexisrael Movement and physical communication are revelatory art forms, and the L.A.-based, Japanese-born interdisciplinary performer incorporates both in dynamic ways. Specializing in Butoh dance, Kuramochi weaves live painting, video and tangible installations into her work, making for a uniquely visceral and theatrical kind of entertainment. Her immersive cultural commentary also explores history and rituals via a posthuman feminist perspective. What's Next: This month, Kuramochi is in a group show called Raze the Whitebox Presents a Butoh Opera at the Philosophical Research Society in Los Feliz, and Moon & Stars in the Desert at Palm Desert's Walter N. Marks Center for the Arts. In June, she'll present a new solo show at the Japan Foundation, Los Ilse Valfré's enchanting female-driven universe has built an avid fan base through her brand, which includes apparel, home decor, day planners and artwork. The Mexican contemporary illustrator, who splits her time between L.A. and Nayarit, is known for evoking cosmic, character-driven aesthetics and dreamy narratives with a pop culture flair — as seen on her big mural outside the Spotlight nightclub at Cahuenga and Selma in Hollywood. She also just released a new book of her most popular pieces and launched a collaboration with Golden Goose Next: Exhibiting at international art fairs — in Hong Kong, Taiwan, Madrid and Tokyo — is in the pipeline. Valfré is also working on an upcoming solo show in L.A. and setting up her own space in Mexico City, called Casa Valfré. His iconic street art brand Obey Giant might own the most recognizable L.A. graphic designs ever, but Fairey has never rested on his laurels. From his powerful 2008 "Hope" portrait of Barack Obama to his "We the People" series during the 2017 Women's March and his Echo Park Gallery Subliminal Projects, Fairey's output has redefined how social commentary-driven street art makes people think, feel and see the Next: 'Warning Signs' opening Feb. 7 in New Orleans, features painted and printed works from his repertoire centered around combating injustice. 'The Golden Compass' opening Feb. 27 in collaboration with Over The Influence in Bankok, explores the human struggle to find balance and manage rage and grief. His gallery also a full schedule of events this month, during Frieze and the LA Art Show. After so many local artists and creators lost their residences, studios and livelihoods, or were otherwise been impacted by the L.A. fires, local arts organizations and philanthropists joined forces to create the LA Arts Community Fire Relief Fund, an emergency relief effort to help them. Led by the J. Paul Getty Trust ( the coalition's many partners include the Mohn Art Collective (Hammer Museum, LACMA and MOCA); philanthropists like Sheikha Al Mayassa bint Hamad bin Khalifa Al Thani of Qatar; and foundations like Steven Spielberg's The Hearthland and the Andy Warhol Foundation for the Visual Arts. The fund launched with $12 million and applicants can apply through the Center for Cultural Innovation at .
