Latest news with #HKU5-CoV-2
Scottish Sun
15 hours ago
- Health
- Scottish Sun
New coronavirus only ‘one small step from spilling over into humans' and sparking widespread outbreak, say scientists
Click to share on X/Twitter (Opens in new window) Click to share on Facebook (Opens in new window) A NEW coronavirus may only be "a small step away from spilling over into humans", scientists have warned - sparking fears of another pandemic. Scientists believe the variant, called HKU5-CoV-2, may infect a broader range of animals than Covid-19 and may have more potential for jumping between species. 1 Dr Michael Letko, a molecular virologist at WSU's College of Veterinary Medicine, lead the research into the concerning variant Credit: Ted S. Warren/College of Veterinary Medicine/WSU American scientists fear the virus - found in China - may be one small mutation away from also being able to infect humans, which could lead to a widespread outbreak. The new study, published in Nature Communications, looked at a lesser-known group of coronaviruses called merbecoviruses. It includes HKU5 and MERS-CoV, which is responsible for the deadly Middle East Respiratory Syndrome. First noted in 2012, the virus typically spreads from infected camels to humans causes severe respiratory disease, which can be fatal to 34 per cent of its victims. The research team, which included scientists at Washington State University (WSU), the California Institute of Technology and the University of North Carolina, sought to understand how merbecoviruses infiltrate the cells of their hosts. While most bugs in the group seemed to pose little threat to people, scientists said one subgroup, HKU5, has concerning traits. Michael Letko, a virologist at WSU's College of Veterinary Medicine, said: "Merbecoviruses – and HKU5 viruses in particular – really hadn't been looked at much, but our study shows how these viruses infect cells. "What we also found is HKU5 viruses may be only a small step away from being able to spill over into humans." Like other coronaviruses, merbecoviruses rely on a spike protein to bind to receptors and invade host cells. Dr Letko's team used virus-like particles containing the part of the spike protein responsible for binding to receptors and tested their ability to infect cells in their lab. World is not prepared for looming Disease X pandemic says Doctor Tedros Ghebreyesus While most merbecoviruses appeared unlikely to be able to infect humans, HKU5 viruses — which have been found across Asia, Europe, Africa and the Middle East — were shown to use a host receptor known as ACE2, the same used by the SARS-CoV-2 virus that causes Covid-19. But for now HKU5 viruses can only use the ACE2 gene in bats and can't deploy it on humans nearly as well. Examining HKU5 viruses found in Asia - where their host is the Japanese house bat - the researchers demonstrated some mutations in the spike protein that may allow the viruses to bind to ACE2 receptors in other species, including humans. 'These viruses are so closely related to MERS, so we have to be concerned if they ever infect humans,' Dr Letko said. 'While there's no evidence they've crossed into people yet, the potential is there — and that makes them worth watching.' Dr Letko said the study and its methods could be used for future research projects and to help the development of new vaccines and treatments. What is the new Covid variant confirmed in the UK? The new strain - called NB.1.8.1 - has been spotted in the parts of the UK, such as Ireland and Wales. It's also cropped up in Europe, the US and Australia, as well as Egypt, the Maldives, Thailand, China and Hong Kong. The World Health Organisation (WHO) recently issued a warning over NB.1.8.1, designating it as a "variant under monitoring" due to its global spread and key mutations. 'Despite a concurrent increase in cases and hospitalisations in some countries where NB.1.8.1 is widespread, current data do not indicate that this variant leads to more severe illness than other variants in circulation,' the WHO said. But while it may not be particularly severe, it may infect people more easily than previous variants, with some evidence suggesting that the variant binds more tightly to human cells. A recent study that has not yet been peer reviewed suggests that a person infected with NB.1.8.1 may be more likely to pass the virus on to someone else, compared to earlier variants. The WHO stressed that, based on available evidence, the variant's risk to public health was "low at the global level". "Currently approved Covid-19 vaccines are expected to remain effective to this variant against symptomatic and severe disease," it added. Symptoms include sore throat, fatigue, fever, mild cough, muscle aches and a blocked nose. Some people may also get gastrointestinal symptoms. It's not the first time concerns have been raised over HKU5. Earlier this year, Chinese scientists warned that HKU5-CoV-2 may be able to jump straight from bats to humans without another animal in between. This suggests a higher potential for zoonotic spillover - when a disease spreads from animal to human. If there is no 'intermediate 'middle animal', it becomes harder to predict and prevent spillover events through interactions such as wildlife trading or hunting. "There is the potential for this new virus to spillover to human, like previous coronaviruses including SARS-CoV-2," said Dr Gary R McLean, a research fellow at the Imperial College London, who was not involved in the study. But he noted that, so far, there is no "evidence" that HKU5-CoV-2 can infect people – the paper is based on tests in a laboratory, showing the bug's "potential". "Hopefully the Chinese authorities now have good surveillance systems in place and the laboratories work to rigid safety standards that minimise the risk of spillover occurring," he said. The WHO has previously listed MERS and Covid as two of several diseases - alongside the mysterious disease X - that could spark a pandemic, but for which there is no specific treatment or vaccine.
India.com
2 days ago
- Health
- India.com
US scientists issue chilling warning, say new virus found in China one step away from spreading in..., HKU5-CoV-2 virus is found in...
Covid-19: Active cases surge to 3207, 29 deaths, 60% of cases in Kerala and Maharashtra COVID-19 has once again dominated the news headlines. A new virus has been detected in China following the COVID-19 pandemic. According to the Independent report, Scientists suggest that the variant, known as HKU5-CoV-2, is likely to affect a wider range of animals than the original COVID-19 virus, which led to millions of deaths worldwide. It is to be noted that the new variant may pose a greater risk of spreading between species. American researchers have raised concerns that HKU5-CoV-2, detected in China in February, might also have the ability to infect humans, potentially triggering a large-scale outbreak. A new study published in Nature Communications studied a lesser-known group of coronaviruses referred to as merbecoviruses, which includes HKU5 and MERS-CoV — the virus that causes the deadly Middle East Respiratory Syndrome. Researchers from Washington State University studied how this new virus interacts with human cells. They discovered that a small alteration in the virus's spike protein would probably help it hook onto human ACE2 receptors located in the throat, mouth, and nose. HKU5-CoV-2 can infect and replicate within human cells in both the respiratory tract and the digestive tract. At present, the virus is found in bats, but with a small mutation, it could start spreading among people. This virus is similar to MERS (Middle East Respiratory Syndrome). The World Health Organization states that around 35% of those infected with Middle East Respiratory Syndrome (MERS) succumb to the disease. Since its emergence in 2012, approximately 27 countries have reported cases, resulting in 858 confirmed deaths. The infection is primarily transmitted from camels.
Yahoo
3 days ago
- Health
- Yahoo
New coronavirus discovered in China ‘only small step' from infecting humans
A new coronavirus discovered in China is only a small step from mutating and causing another global pandemic, experts have warned. Scientists believe the variant, called HKU5-CoV-2, may infect a broader range of animals than Covid-19 – which caused millions of deaths – and may have more potential for jumping between species. US researchers fear that HKU5-CoV-2, found in China, in February, could also infect humans, leading to a widespread outbreak. The new study, published in Nature Communications, looked at a lesser-known group of coronaviruses called merbecoviruses, which includes HKU5 and MERS-CoV, which is responsible for the deadly Middle East Respiratory Syndrome. The team from Washington State University looked at how the new pathogen interacts with human cells. They found that a small change in the virus's spike protein could allow it to attach to human ACE2 cells in people's throats, mouths and noses. HKU5-CoV-2 can infect and replicate inside human cells in both the airways and gut. According to the World Health Organisation, about 35 per cent of people infected with Middle East Respiratory Syndrome die. Since 2012, some 27 countries have reported cases, leading to 858 known deaths due to the infection, which spread from camels. But when HKU5 was discovered in February, scientists warned against exaggerating the risks because it does not enter human cells as readily as Sars-CoV-2, which caused Covid-19. HKU5 was first detected in bats by scientists from the Chinese laboratory where some say Covid originated in 2019. Prof Michael Letko, a virologist who co-led the study, said: 'HKU5 viruses in particular really hadn't been looked at much, but our study shows how these viruses infect cells. 'What we also found is HKU5 viruses may be only a small step away from being able to spill over into humans.' When Covid-19 emerged it was widely blamed on markets in China where different breeds of wild animal are kept caged and often slaughtered close to other animals. Meat is sold at the open-air stalls. Critics said the markets were the perfect breeding ground for new zoonotic diseases – those that spread to humans – to emerge. The scientists, whose experiments studied how the new pathogen interacts with human cells, believe the virus would have to carry certain mutations if it were to infect humans. 'These viruses are closely related to MERS, so we have to be concerned if they ever infect humans,' Prof Letko said. 'While there's no evidence they've crossed into people yet, the potential is there and that makes them worth watching.'
The Independent
3 days ago
- Health
- The Independent
New coronavirus discovered in China ‘only small step' from infecting humans
A new coronavirus discovered in China is only a small step from mutating and causing another global pandemic, experts have warned. Scientists believe the variant, called HKU5-CoV-2, may infect a broader range of animals than Covid-19 – which caused millions of deaths – and may have more potential for jumping between species. US researchers fear that HKU5-CoV-2, found in China, in February, could also infect humans, leading to a widespread outbreak. The new study, published in Nature Communications, looked at a lesser-known group of coronaviruses called merbecoviruses, which includes HKU5 and MERS-CoV, which is responsible for the deadly Middle East Respiratory Syndrome. The team from Washington State University looked at how the new pathogen interacts with human cells. They found that a small change in the virus's spike protein could allow it to attach to human ACE2 cells in people's throats, mouths and noses. HKU5-CoV-2 can infect and replicate inside human cells in both the airways and gut. According to the World Health Organisation, about 35 per cent of people infected with Middle East Respiratory Syndrome die. Since 2012, some 27 countries have reported cases, leading to 858 known deaths due to the infection, which spread from camels. But when HKU5 was discovered in February, scientists warned against exaggerating the risks because it does not enter human cells as readily as Sars-CoV-2, which caused Covid-19. HKU5 was first detected in bats by scientists from the Chinese laboratory where some say Covid originated in 2019. Prof Michael Letko, a virologist who co-led the study, said: 'HKU5 viruses in particular really hadn't been looked at much, but our study shows how these viruses infect cells. 'What we also found is HKU5 viruses may be only a small step away from being able to spill over into humans.' When Covid-19 emerged it was widely blamed on markets in China where different breeds of wild animal are kept caged and often slaughtered close to other animals. Meat is sold at the open-air stalls. Critics said the markets were the perfect breeding ground for new zoonotic diseases – those that spread to humans – to emerge. The scientists, whose experiments studied how the new pathogen interacts with human cells, believe the virus would have to carry certain mutations if it were to infect humans. 'These viruses are closely related to MERS, so we have to be concerned if they ever infect humans,' Prof Letko said. 'While there's no evidence they've crossed into people yet, the potential is there and that makes them worth watching.'
India Today
4 days ago
- Health
- India Today
New coronavirus in China shows pandemic-like threat, scientists warn
A group of mysterious bat viruses might be just one tiny mutation away from becoming a serious problem for humans, warn US researchers in a new study published in the peer-reviewed journal Nature viruses belong to the same family as MERS-CoV, a dangerous coronavirus that emerged in 2012 and causes severe respiratory a death rate of around 34%, MERS-CoV has already shown the world what these viruses are capable Now, scientists from Washington State University, Caltech, and the University of North Carolina have turned their focus to a lesser-known subgroup called these, one subgroup in particular, called the HKU5 viruses, is raising red flags."HKU5 viruses haven't been studied much, but our research shows they have the machinery to infect cells. In fact, they might be only a single step away from being able to infect humans,' said Dr. Michael Letko, a virologist and lead author of the IS THIS WORRYING?Like the SARS-CoV-2 virus that causes Covid-19, these bat viruses use a spike protein to latch onto cells and infect them. With a death rate of around 34%, MERS-CoV has already shown the world what these viruses are capable of. () advertisementThis study showed that HKU5 viruses can bind to a receptor called ACE2, the same one used by Covid-19, but currently only in bats, not that line is thinner than it just a small genetic tweak, these viruses could potentially start binding to human cells. In fact, some versions have already been spotted infecting minks in China, a sign that they can jump across if that mutation happens in just the right way, the next big spillover could be on the horizon."These viruses are very close relatives of MERS. That alone should make us pay attention," Letko said in a take the research a step further, scientists also used AI, specifically a tool called AlphaFold 3, to simulate how the spike protein would interact with ACE2 receptors. This study showed that HKU5 viruses can bind to a receptor called ACE2, the same one used by Covid-19, but currently only in bats, not humans.() This software predicted virus behaviour in minutes, a process that would usually take months of lab work. The AI's findings closely matched results from traditional lab researchers had earlier shared findings of the new bat coronavirus, HKU5-CoV-2 in study led by virologist Shi Zhengli, who is also known as the 'batwoman".Zhengli found that in lab experiments, HKU5-CoV-2 infected human cells with high ACE2 levels in test tubes and in models of human intestines and researchers also identified monoclonal antibodies and antiviral drugs that target the bat DOES THIS STUDY MATTER?The study's findings matter because, as we've learned from Covid-19, viruses don't need a passport to go global. If we ignore the warning signs, we risk another pandemic blindsiding an eye on viruses like HKU5 gives scientists a head start in developing vaccines, treatments, and public health strategies, before it's too Dr. Letko put it, there's no need to panic, but there is every reason to prepare.
