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New York Post
3 days ago
- Health
- New York Post
Promising cancer vaccine could prevent recurrence of pancreatic, colorectal tumors
An experimental cancer vaccine has shown promise in keeping certain cancers from coming back. In a phase 1 clinical trial led in part by the UCLA Health Jonsson Comprehensive Cancer Center, researchers tested the vaccine (ELI-002 2P) with 25 patients who had been treated for pancreatic and colorectal cancer. Advertisement The patients had all undergone surgery to remove tumors and showed 'signs of minimal residual disease' or traces of DNA, putting them at a high risk of recurrence, according to a UCLA press release. More than 80% of pancreatic cancer patients experience recurrence of the disease after surgery, research shows — and for 40% to 50%, this happens within the first year. For colorectal cancer, the recurrence rate is between 30% and 50% and is most likely to occur within the first two years after surgery. Mutations in the KRAS gene are responsible for half of colorectal cancers and more than 90% of pancreatic cancers. The vaccine, which targets those mutations, was given via a series of injections to activate an immune response in the lymph nodes. Advertisement 4 A phase 1 clinical trial indicates that a vaccine may prevent pancreatic and colorectal cancer from coming back. InsideCreativeHouse – A majority (21 out of 25) of the patients generated 'KRAS-specific T cells,' which indicates a stronger immune response. The ones with higher T-cell responses showed a longer relapse-free survival compared to those with lower responses, the researchers found. For three colorectal cancer patients and three pancreatic cancer patients, the vaccine appeared to remove all disease biomarkers. Among the patients who showed the strongest immune response, a majority were still cancer-free nearly 20 months after receiving the vaccine. Advertisement 4 The vaccine appeared to remove all disease biomarkers for three colorectal cancer patients out of the 25 pancreatic and colorectal cancer patients that were part of the trial. Jo Panuwat D – The findings were published in Nature Medicine. 'This is an exciting advance for patients with KRAS-driven cancers, particularly pancreatic cancer, where recurrence after standard treatment is almost a given and effective therapies are limited,' said first author of the study, Zev Wainberg, M.D., professor of medicine at the David Geffen School of Medicine at UCLA and researcher in the UCLA Health Jonsson Comprehensive Cancer Center, in the release. 'We observed that patients who developed strong immune responses to the vaccine remained disease-free and survived for much longer than expected.' Advertisement 4 'We observed that patients who developed strong immune responses to the vaccine remained disease-free and survived for much longer than expected,' Zev Wainberg, M.D., the first author of the study, said. manassanant – 'The new cancer vaccine from UCLA is very promising as a major tool against these cancers.' In another finding, 67% of the patients in the trial showed immune responses to 'additional tumor-associated mutations,' indicating that the vaccine could be used to suppress 'broader anti-tumor activity.' One of the benefits of ELI-002 2P, according to the researchers, is that it's considered 'off-the-shelf,' which means it's a mass-produced, standardized vaccine that doesn't have to be personalized for each individual patient. 'This study shows that the ELI-002 2P vaccine can safely and effectively train the immune system to recognize and fight cancer-driving mutations,' Wainberg said. 4 67% of the patients in the trial showed immune responses to 'additional tumor-associated mutations,' indicating that the vaccine could be used to suppress 'broader anti-tumor activity.' – 'It offers a promising approach to generating precise and durable immune responses without the complexity or cost of fully personalized vaccines.' The team has already finished enrolling participants for a phase 2 study that will test ELI-002 7P, the next iteration of the vaccine that will target a 'broader set' of KRAS mutations, the release stated. Advertisement The study was sponsored and funded by Elicio Therapeutics, the Massachusetts company that developed the vaccine. It was conducted in conjunction with the MD Anderson Cancer Center and the Memorial Sloan Kettering Cancer Center. Dr. Marc Siegel, Fox News senior medical analyst, was not involved in the study but commented that targeted therapies are becoming increasingly important tools in the fight against cancer. Advertisement 'Solid tumors, especially pancreatic, can be difficult to treat because they are not as mutagenic (capable of inducing or causing mutations) as hematological malignancies (blood cancers) or melanoma, for example, so they don't have as many ready targets for immunotherapy,' he told Fox News Digital. 'The new cancer vaccine from UCLA is very promising as a major tool against these cancers, as it 'programs' the immune system to target these mutations and has been shown in the NATURE study to elicit a strong clinical response.'
New York Post
07-08-2025
- Health
- New York Post
Young woman can't stop having orgasms — doctors stumped
Come again? Doctors in China say they're baffled over the case of a young woman who experiences uncontrollable organisms multiple times per day — leaving the terminally-titillated 20-year-old in a perpetual state of arousal. 'The sexual arousal symptoms are characterized by recurrent and spontaneous orgasmic experiences,' wrote Jing Yan and Dafang Ouyang of the Peking University Sixth Hospital in Beijing, in a study of the curious case published in AME Case Reports. Advertisement 3 'This case describes a 20-year-old woman who has experienced persistent genital arousal symptoms for approximately 5 years,' the authors wrote. íâ¢í²í³íµí½í¸í¹ í¨íµí¼íí°í¸í½ – For five years, the unnamed 20-year-old experienced this thunder down under — sans sexual stimulation, leading experts to deduce that she suffered from persistent genital arousal disorder (PGAD), PsyPost reported. While this affliction might sound like hours of fun, constant pleasure can be quite a pain, causing 'significant impairment in psychosocial well-being and daily functioning,' per the study. Advertisement This was certainly the case with the patient, who reportedly experienced immense distress and was unable to attend school or work, or maintain relationships. Unfortunately, getting diagnosed with PGAD was a long time coming. Her symptoms first reared their head when she was 14, initially manifesting as a 'electric' sensation in her abdomen accompanied by pelvic contractions resembling orgasms. 3 The cause of the condition is yet unclear, although possible triggers include everything from antidepressants to circulatory issues. Phushutter – Advertisement Somewhat confusingly, this was around the same time that the youngster also began displaying increased sensitivity — coupled with bizarre beliefs such as thinking others could read her thoughts, which led to her getting hospitalized a year later and treated for depressive and psychotic symptoms. Despite multiple remedies, including anti-epileptic and psychiatric medications, the patient's symptoms persisted, leading her to believe that her constant climaxes were caused by external stimuli. By the time she finally reported to the hospital, her condition snowballed to the point that she could barely explain her symptoms without getting interrupted by an orgasm. 3 Antipsychotics appeared to alleviate the patient's symptoms. InsideCreativeHouse – Advertisement Neurologists initially ruled out epilepsy through EEG monitoring and other tests, while physical examinations showed no structural abnormalities in her brain or reproductive organs that could've triggered her perennial pleasure responses. Doctors eventually diagnosed the patient with PGAD after a regimen of antipsychotic drugs appeared to mitigate both her big moments and delusions. After several weeks of treatment, the patient's condition improved to the point where she could go back to work and have a social life. But whenever she ceased treatments, her symptoms would come back with a vengeance. Unfortunately, PGAD still flies under the radar. First formally described in 2001, the malady affects a projected 1% of women in the US, but remains underdiagnosed, per the Cleveland Clinic. Possible causes include everything from nerves, blood flow, antidepressant medications such as selective serotonin reuptake inhibitors. Some have even linked the anomalous ailment to an imbalance of dopamine, a neurotransmitter involved in the brain's arousal and reward system. Advertisement Dosing the patient with the aforementioned antipsychotics likely curbed this dopamine response, thereby lessening her symptoms of arousal. Unfortunately, PGAD has no sure-fire cure as of yet.
New York Post
20-06-2025
- Business
- New York Post
Americans face vastly different retirement costs across states as Social Security cuts loom
Retirement remains top of mind for many Americans, whether they are approaching their so-called 'golden years' or have many years to go before leaving the workforce. How much money a person needs to have saved to retire without financial stress is an important consideration in the retirement preparation process, and that can vary depending on various factors, including where someone intends to live and their retirement income sources. Advertisement A study released this week by GOBankingRates calculated the amount of money that a 'comfortable' retirement would require without income from Social Security factored in and the associated yearly expenses a retiree would face in each U.S. state. The analysis comes as Social Security, a common source of retirement income, is looking at potential financing issues with its trust funds in the future. 8 Pompano Beach, Florida. Matthew Tighe – The trustees for Social Security and Medicare recently found that if Social Security's Old-Age and Survivors Insurance and Disability Insurance trust funds were combined, the trust funds would be able to pay 100% of scheduled benefits until 2034, one year earlier than reported last year. After that, the trust funds would be able to pay only 81% of scheduled benefits, meaning Social Security recipients would see a mandatory 19% cut automatically. Advertisement For the GOBankingRates study, the benchmark for a 'comfortable' retirement was a person holding twice the amount of money as the cost of living expenses. Hawaii tops the list of where the most savings would be necessary to retire 'comfortably' at 60 years old without Social Security, while West Virginia, nicknamed the Mountain State, required the least, it said. 8 For the GOBankingRates study, the benchmark for a 'comfortable' retirement was a person holding twice the amount of money as the cost of living expenses. InsideCreativeHouse – GOBankingRates found the nest egg that a person would need to accommodate a comfortable retirement at 60 years old sans Social Security in each state. Advertisement Alabama ($70,492 cost of living per year): $1,409,839 Alaska ($110,457 cost of living per year): $2,209,137 Arizona ($100,281 cost of living per year): $2,005,627 Arkansas ($67,502 cost of living per year): $1,350,045 Advertisement California ($155,117 cost of living per year): $3,102,333 Colorado ($114,744 cost of living per year): $2,294,882 Idaho ($101,912 cost of living per year): $2,038,236 8 Aerial view of Nantucket Island. Kevin – Illinois ($79,736 cost of living per year): $1,594,716 Indiana ($74,029 cost of living per year): $1,480,575 Iowa ($71,373 cost of living per year): $1,427,463 Kansas ($71,534 cost of living per year): $1,430,672 Advertisement Kentucky ($71,410 cost of living per year): $1,428,204 Louisiana ($67,482 cost of living per year): $1,349,639 Maryland ($101,991 cost of living per year): $2,039,812 8 Downtown Birmingham, Alabama, from Vulcan Park Robert Hainer – Advertisement Maine ($98,612 cost of living per year): $1,972,231 Massachusetts ($136,626 cost of living): $2,732,517 Michigan ($73,780 cost of living per year): $1,475,595 Minnesota ($88,321 cost of living per year): $1,766,414 Advertisement Mississippi ($65,523 cost of living per year): $1,310,451 Missouri ($73,667 cost of living per year): $1,473,335 Montana ($102,916 cost of living per year): $2,058,322 8 Waikiki Beach and Diamond Head, Oahu, Hawaii. tomas del amo – Advertisement Nebraska ($76,792 cost of living per year): $1,535,846 Nevada ($103,661 cost of living per year): $2,073,215 New Hampshire ($110,761 cost of living per year): $2,215,216 New Jersey ($118,338 cost of living per year): $2,366,765 New Mexico ($81,627 cost of living per year): $1,632,542 New York ($105,619 cost of living per year): $2,112,384 North Carolina ($86,857 cost of living per year): $1,737,146 8 The Brooklyn Bridge and the Manhattan skyline. jakartatravel – North Dakota ($78,734 cost of living per year): $1,574,682 Ohio ($73,120 cost of living per year): $1,462,391 Oklahoma ($69,161 cost of living per year): $1,383,214 Oregon ($111,541 cost of living per year): $2,230,814 Pennsylvania ($78,582 cost of living per year): $1,571,642 Rhode Island ($109,811 cost of living per year): $2,196,222 South Carolina ($81,586 cost of living per year): $1,631,721 South Dakota ($81,949 cost of living per year): $1,638,979 8 Teton Village homes at sunrise with fog in the valley. Nicole – Tennessee ($81,474 cost of living per year): $1,629,482 Texas ($81,985 cost of living per year): $1,639,693 Utah ($110,623 cost of living per year): $2,212,458 Vermont ($97,999 cost of living per year): $1,959,971 Virginia ($96,141 cost of living per year): $1,922,813 Washington ($126,952 cost of living per year): $2,539,048 West Virginia ($64,715 cost of living per year): $1,294,300 8 The analysis comes as Social Security, a common source of retirement income, is looking at potential financing issues with its trust funds in the future. lordn – Wisconsin ($84,485 cost of living per year): $1,689,700 Wyoming ($88,792 cost of living per year): $1,775,841 In early June, a Gallup survey found 50% of non-retired U.S. adults that own a retirement savings account felt they 'expect to have enough to live comfortably in retirement.' Confidence was lower among those that lacked a retirement savings account, with only 31% reporting they anticipated having sufficient funds for comfortable golden years.
Black America Web
30-04-2025
- Health
- Black America Web
Sun's Out, Still Down? Understanding Seasonal Depression In Spring And Summer
Black America Web Featured Video CLOSE Source: Inside Creative House / Getty It's finally feeling like spring is in the air! The weather is warming up, the pollen invasion is winding down, and summer is just around the corner. Time to shake off those winter blues, touch some grass, and engage in some much needed summer fun. But what if your mood is still feeling dark and cold despite the sunny weather? Or maybe even because of it? Seasonal Affective Disorder (SAD) typically impacts people during the winter months. However, studies show that seasonal depression isn't limited to just one time of the year. While it's less common, summertime seasonal depression is very real and thankfully, there are effective ways to ward off summertime SAD and look forward to brighter days ahead. RELATED: Here's How Social Connection Helps Combat Depression Source: Jacob Wackerhausen / Getty SAD affects about four to six percent of the population who typically experience an increase in depressive symptoms during the winter months, when days are shorter and colder and people are more isolated. However, about 10 percent of those with SAD experience their symptoms in the summer months. Researchers are still trying to definitively determine what causes SAD but many believe extreme weather to be one of the culprits. Winter weather limits the body's access to Vitamin D from sunlight which can cause a dip in serotonin levels leading to an unhappy mood. However, the excessive heat of the spring and summer months can be equally unbearable and depressing as the winter cold. Trying to beat the heat by staying indoors and remaining isolated can lead to depressive episodes. Symptoms of summer depression are consistent with typical SAD symptoms and include loss of appetite, trouble sleeping, changes in weight, depression and anxiety. Source: Drazen Zigic / Getty While for many people, summertime comes with fun in the sun, the warm days can also bring with them new stresses and triggers. Maintaining a routine is important for maintaining good mental health but the spring and summer months often come with multiple changes in personal schedules. Planned summer travel plus prolonged breaks from school for students or parents with children can disrupt sleep, meal times, and other self care habits which can lead to depression. Summer weather also puts body image issues on full display. Studies show that Black women experience higher rates of body dysmorphic disorders (BDD) and as temperatures rise, clothing becomes more revealing and insecurities can be on exposed. Feelings of embarrassment, inadequacy, or over exposure can cause anxiety, body dysmorphia, or isolation from outdoor social activities. Speaking of socializing, the spring and summer months are plentiful/abounding/have no shortage of outdoor activities to get involved in. But that can also create a sense of pressure in some people (or FOMO) to say yes to every plan, draining their bank accounts and their mental battery. If everyone else is having a good time having fun in the sun, why can't you? Experiencing SAD in the spring and summer months can lead to feelings of shame and guilt that only exacerbate depressive symptoms. There is help available for people who struggle with seasonal depression at any time of the year. If you're experiencing what you think may be depression symptoms, consult a physician or therapist right away. You can also preemptively combat summertime SAD by planning ahead for the warmer months. Eating a healthy diet to maintain balanced mood and energy levels, getting enough sleep, and staying as active as possible through exercise and socializing can also help you feel better. A doctor might also describe medication to help offset feelings of depression and anxiety. Most of all, don't get down on yourself if you're not feeling up to fun in the sun this spring and summertime. Everyone is different and enjoys different things. The most important thing you can do any time of year is to take care of yourself in the unique ways that you need. DON'T MISS… Prayer Garden: Why You Need One and How to Create It Let the Sunshine In: Surprising Health Benefits of Sunlight 7 Wellness Spas to Add to Your Bucket List Take the Plunge: Surprising Benefits of Cold Therapy for Your Body, Mind, and Skin SEE ALSO Sun's Out, Still Down? Understanding Seasonal Depression In Spring And Summer was originally published on
New York Post
25-04-2025
- Entertainment
- New York Post
Women will do this if they think you're hot — and they might not even realize it: dating coach
There's a body of proof that she's into you. Coquettish glances and flirtatious smiles — they're often good indicators that a lady is hot-to-trot for what a guy's got. But the cutesy cues are only the tip of the iceberg when it comes to telltale hints that a woman wants the man on the receiving end of her sensuous stare, so says a dating coach who's decoding the come-hither gestures of a gal on the prowl. 3 Dating coach Gracie Pleshcourt has virally shared the top five clues that woman drop when they're romantically interested in man. InsideCreativeHouse – 'Five body language signs women do when they find you attractive,' wrote Gracie Pleschourt, a romance pro with a knack for helping fellas find love, in the closed-captions of a clip with 2 million TikTok views. The relationship savant, from the Midwest, then revealed the most obviously subtle moves of a wannabe-sweetie. 'Play with her hair,' Pleschourt listed as the No. 1 demonstration of desire. 3 Hair twirling and head tilting are just two of the main moves that ladies often make when they want a date, according to Pleshcourt. Scott Griessel – 'Adjust their top,' she said of the second-most sultry signal. 'Plays with jewelry. Tilts her head and listens. Touches her lips,' all took the third, fourth and fifth spots on Pleschourt's risqué roster. But, if the body language isn't quite translating, folks can always fall back on their funny bones. 'Laughing or giggling at the other person's jokes is an effective flirtation tactic for both sexes,' Leif Edward Ottesen Kennair, a professor at NTNU's Department of Psychology, in a recent study. 3 Science has proven that joking and laughing are prime flirting tactics for both men and women. – Then, of course, there's the 'sticky eyes' method. 'You pick your target, stare at them until they look back at you,' Chelsea Anderson, a self-crowned 'professional life-hacker,' explained to her more than 6.8 million social media fans. 'Once you make eye contact, you look away like you've been caught.' 'The next time you look at them and they meet your eye again, don't look away,' she continued. 'Let them break first — you're going to have to hold [your stare] uncomfortably long.' 'And in about 45 seconds they will be in front of you as if they'd been summoned,' Anderson assured. 'It's one of my most powerful hacks.'
