Latest news with #InstituteofLiverandBiliarySciences
Hans India
5 days ago
- Health
- Hans India
Indian scientists develop new approach for treatment of liver cirrhosis
New Delhi: A team of Indian scientists has found a new way to treat liver cirrhosis, by targeting the lymphatic vessels in the liver and intestine that fail in case of cirrhosis. Chronic liver disease can progress from mild disease to fibrosis to cirrhosis (also known as scarring). Cirrhosis is accompanied by the distortion of both blood and lymphatic vessels in the liver and the intestine. Patients with advanced cirrhosis often develop complications like fluid accumulation in the abdomen. A team of scientists from the Institute of Liver and Biliary Sciences (ILBS), New Delhi, and National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, focussed on improving the drainage capacity of lymphatic vessels in the liver and intestine by using nanocarriers filled with a powerful protein called VEGF-C. 'Vascular endothelial growth factor-C (VEGF-C) is a key pro-lymphangiogenic factor that activates lymphangiogenesis or new lymphatic vessel growth. It does this through binding to a cell membrane tyrosine kinase receptor, vascular endothelial growth factor receptor-3 (VEGFR-3), the activation of which is essential for the growth and development of new lymphatic vessels,' said the researchers. The team probed the therapeutic efficacy of VEGF-C in ameliorating gut lymphatic dysfunction and improving lymph drainage. Owing to the hydrophilicity, short half-life, and systemic side effects of VEGF-C, the team led by Dr Subham Banerjee from NIPER Guwahati first focused on the development of VEGF-C encapsulated reverse micelle-based nanocarriers, which specifically bind to VEGFR-3 homodimers. Next, the ILBS team, led by Dr Savneet Kaur, tested the developed VEGF-C nanocarriers extensively in animal models of advanced cirrhosis and portal hypertension. The developed molecule was delivered via the oral route to ensure its gut lymphatic vessel uptake in the animal models. The team showed that VEGF-C nanocarriers significantly increased mesenteric lymph drainage, which reduced ascites. Importantly, the treatment also led to an attenuation of the portal pressures, improved cytotoxic T-cell immunity in mesenteric lymph nodes, and reduced local and systemic bacterial load. The research, published in the JHEP Reports journal, is the first to highlight that therapeutic lymphangiogenesis with VEGF-C is a promising treatment for reconstructing the fragmented lymphatic network and restoring lymphatic function and drainage in advanced cirrhosis.
India.com
02-08-2025
- Health
- India.com
Breakthrough In Liver Cirrhosis Treatment: Indian Scientists Develop New Approach
New Delhi: A team of Indian scientists has found a new way to treat liver cirrhosis, by targeting the lymphatic vessels in the liver and intestine that fail in case of cirrhosis. Chronic liver disease can progress from mild disease to fibrosis to cirrhosis (also known as scarring). Cirrhosis is accompanied by the distortion of both blood and lymphatic vessels in the liver and the intestine. Patients with advanced cirrhosis often develop complications like fluid accumulation in the abdomen. A team of scientists from the Institute of Liver and Biliary Sciences (ILBS), New Delhi, and National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, focussed on improving the drainage capacity of lymphatic vessels in the liver and intestine by using nanocarriers filled with a powerful protein called VEGF-C. Pic Credits: IANS 'Vascular endothelial growth factor-C (VEGF-C) is a key pro-lymphangiogenic factor that activates lymphangiogenesis or new lymphatic vessel growth. It does this through binding to a cell membrane tyrosine kinase receptor, vascular endothelial growth factor receptor-3 (VEGFR-3), the activation of which is essential for the growth and development of new lymphatic vessels,' said the researchers. The team probed the therapeutic efficacy of VEGF-C in ameliorating gut lymphatic dysfunction and improving lymph drainage. Owing to the hydrophilicity, short half-life, and systemic side effects of VEGF-C, the team led by Dr Subham Banerjee from NIPER Guwahati first focused on the development of VEGF-C encapsulated reverse micelle-based nanocarriers, which specifically bind to VEGFR-3 homodimers. Next, the ILBS team, led by Dr Savneet Kaur, tested the developed VEGF-C nanocarriers extensively in animal models of advanced cirrhosis and portal hypertension. The developed molecule was delivered via the oral route to ensure its gut lymphatic vessel uptake in the animal models. The team showed that VEGF-C nanocarriers significantly increased mesenteric lymph drainage, which reduced ascites. Importantly, the treatment also led to an attenuation of the portal pressures, improved cytotoxic T-cell immunity in mesenteric lymph nodes, and reduced local and systemic bacterial load. The research, published in the JHEP Reports journal, is the first to highlight that therapeutic lymphangiogenesis with VEGF-C is a promising treatment for reconstructing the fragmented lymphatic network and restoring lymphatic function and drainage in advanced cirrhosis.
New Indian Express
04-07-2025
- Business
- New Indian Express
Delhi BJP chief accuses state-run liver hospital of misappropriating staff PF
NEW DELHI: Delhi BJP chief Virendra Sachdeva has lodged a complaint with Central Provident Fund Commissioner Ramesh Krishnamurti, alleging serious violations of labour laws and provident fund (PF) norms at the Institute of Liver and Biliary Sciences (ILBS), an autonomous body under the city government. In a letter dated May 15, Sachdeva alleged that the contributions made by the institute appear to be noncompliant with statutory norms. He claimed that the institute contributes only 8% of employees' salaries towards PF, instead of the mandatory 12%, and that an equivalent amount is being deducted from employees' pay. The complaint alleged that the salary amounts reported to the Employees' Provident Fund Organisation (EPFO) are understated and these irregularities have been going on for a few years now. The violations are apparently happening with the knowledge of senior officials, while employees, most of whom are contractual employees, refrain from complaining due to a fear of termination. 'This manipulation not only violates the Employees' Provident Fund and Miscellaneous Provisions Act, 1952, but also undermines the financial security of the employees. Moreover, it is alleged that these actions are taking place with the full knowledge and complicity of senior officials at the Institute,' the letter read.
Time of India
01-06-2025
- Health
- Time of India
Beware of common & silent non-alcoholic liver disease
Bhopal: Non-alcoholic fatty liver disease can be a silent disease that shows few or no symptoms but can escalate to serious liver damage. It is a common ailment as well, one that you should be beware of. A state-wide initiative for non-alcoholic fatty liver disease screening began from June 1, including in Bhopal, targeting citizens aged above 30 years. According to a press release, this initiative focuses on awareness, early detection, treatment and prevention of liver-related ailments. The govt of Madhya Pradesh has established a partnership with the Institute of Liver and Biliary Sciences, New Delhi through an MoU. Earlier on May 21, the governor and the chief minister officially inaugurated this campaign on May 21. The programme involves initial screening by Asha workers for suspected NAFLD cases. They will collect data on BMI exceeding 23, waist circumference surpassing 80 cm in women and 90 cm in men, and diabetes history. Suspected cases will be reported to community health officers and workers. Participants will receive guidance on consuming home-available nutritious food and avoiding alcohol and tobacco, with regular follow-ups. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Encontre voos low-cost Voos | Anúncios de Pesquisa Saiba Mais Undo Medical professionals will conduct platelet count, SGOT (AST), SGPT (ALT) tests based on FIB-4 score calculations, followed by FIBROSCAN when medically indicated. Chief medical and health officer (CMHO) Bhopal, Dr Prabhakar Tiwari, emphasised that regular check-ups for non-communicable diseases can reduce illness severity. The non-communicable disease control programme and viral hepatitis control programme offer free services for liver-related issues. Previously, the Nirogi Kaya Abhiyan campaign screened for various non-communicable diseases, including high blood pressure, diabetes, cancer and non-alcoholic fatty liver disease, reaching over 50,000 people. Field health workers received training about liver function, related issues, symptom identification, dietary advice, exercise recommendations, lifestyle guidance and BMI calculations. The liver performs crucial functions continuously, including blood purification, toxin removal, nutrient storage, energy regulation, blood clotting maintenance, and production of bile, proteins, vitamins and minerals. Common liver conditions include fatty liver, fibrosis, hepatitis, cirrhosis and liver cancer.
India Gazette
27-05-2025
- Health
- India Gazette
Selfless Love: Mother donates organ to son for second time
New Delhi [India], May 27 (ANI): In an extraordinary act of maternal love, a 60-year-old mother has given her son the gift of life for the second time at the Institute of Liver and Biliary Sciences (ILBS), New Delhi. The remarkable story began in 2015 when she donated a portion of her liver to her son, born in 1997, who was diagnosed with a life-threatening liver ailment. Nearly a decade later, her son developed kidney failure, and she selflessly offered to donate one of her kidneys. She was declared fit even after her earlier liver donation, and was cleared to donate one of her kidneys. The renal transplant team at the Institute of Liver and Biliary Sciences (ILBS) in New Delhi, led by Dr Abhiyutthan Singh Jadaon, performed a highly complex laparoscopic donor nephrectomy, overcoming challenges due to the mother's previous major surgery. The recipient's transplant was handled by a skilled team of nephrologists under the leadership of Dr RP Mathur, navigating critical immunological hurdles. The transplant was successful, and the son was discharged after a 10-day recovery period. This extraordinary act of love and sacrifice has given him a new lease on life, thanks to his mother's unwavering devotion. In a separate incident earlier this month on May 4, a 20-year-old driver's wife chose to donate his organs after he was declared brain dead following a tragic accident. Banoth Ramana, a resident of Warangal district in Telangana, got into an accident when a tractor suddenly collided with his two-wheeler on April 27 last month. His family rushed him to a private hospital in 9:05 PM on May 1, Ramana was declared brain dead. Ramana's wife, Kalyani, chose to donate his organs, which have given six patients a second chance at life. According to an official associated with Jeevandan, Telangana initiative, the donated organs include two kidneys, a liver, a heart, and two corneas. (ANI)
