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Cision Canada
3 days ago
- Business
- Cision Canada
ImmunoGenesis to present IMGS-001 Phase 1a/1b Clinical Study Updates at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting
IMGS-001 is first dual-specific PD-L1/PD-L2 antibody with cytotoxic killing function and is designed to treat the many "immune-excluded" cancers that are resistant to existing immunotherapies HOUSTON, May 30, 2025 /CNW/ -- ImmunoGenesis, a clinical-stage biotech company developing innovative, science-driven immunotherapies, announced today that a Trial in Progress poster for its first-in-human, Phase 1a/1b clinical trial of IMGS-001 will be presented at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting being held in Chicago, Illinois from May 30 to June 3, 2025. This Phase 1a/1b first-in-human, open-label, multicenter study (NCT06014502) includes a dose escalation and an expansion portion to evaluate the safety, pharmacokinetics, and preliminary anti-tumor activity of IMGS-001 in adult patients with locally advanced or metastatic solid tumors refractory to standard-of-care treatment. The study will enroll approximately 25 patients in Phase 1a and up to 250 in Phase 1b. The first three of five planned dose cohorts have completed without any dose limiting toxicities (DLTs), with cohort 4 (10 mg/kg) now enrolling. "This clinical trial is an important first step to understand how IMGS-001 may potentially remove immunosuppressive cells while improving PD-1 pathway blockade to treat otherwise immunoresistant tumors that represent a significant unmet medical need," stated Charles Schweizer, PhD, Senior Vice President of Clinical Development at ImmunoGenesis. "We are pleased to discuss the study plan and progress at this important conference as we look ahead to sharing results." "We are encouraged by the early performance of IMGS-001 as we proceed with Phase 1 dose escalation in patients with a variety of advanced solid tumors," said James Barlow, President and CEO of ImmunoGenesis. "Initial low doses administered to date have been well-tolerated with no dose-limiting toxicities, and we are seeing promising early signs of anti-tumor activity in patients who have failed prior treatments. IMGS-001 has the potential to be a foundational therapy for immune-excluded tumors, addressing a major unmet need." ASCO Poster Presentation Title: A Phase 1a/1b study to evaluate the safety, tolerability, Pharmakokinetics, and anti-tumor activity of IMGS-001 in Patients with relapsed or refractory advanced solid tumors. Abstract: TS2686 | Poster Bd #: 324a Track: Developmental Therapeutics—Immunotherapy Location: Hall A -Posters and Exhibits | On Demand Time: June 2, 2025, 1:30 PM – 4:30 PM CDT About ImmunoGenesis ImmunoGenesis is a clinical-stage biotech company dedicated to transforming immuno-oncology by targeting key mechanisms of immune resistance. The company's lead product, IMGS-001, is a cytotoxic, dual-specific PD-L1/PD-L2 antibody currently in a Phase 1a/b clinical trial for the treatment of immune-excluded ("cold") tumors, which account for more than half of all cancers. In addition to its lead program, the company is developing a number of novel approaches to overcome immune resistance in cold tumors. ImmunoGenesis designs therapies to address the pathology of these tumors, overcoming immune exclusion to elicit a robust immune response. For more information, visit About IMGS-001, a PD-L1/PD-L2 Dual-Specific Inhibitor IMGS-001, the lead program at ImmunoGenesis, is a PD-L1/PD-L2 dual-specific monoclonal antibody with engineered cytotoxic effector function. IMGS-001 is the first molecule in clinical testing to target PD-L2 in addition to PD-L1, potentially improving blockade of the PD-1 pathway. The engineered effector function may enable IMGS-001 to eliminate immunosuppressive PD-L1- and/or PD-L2-expressing cells present in the tumor microenvironment, providing the potential to overcome immune resistance in immune-excluded tumors. Preclinical data showed that IMGS-001 drove higher response rates in head-to-head studies compared to currently available immunotherapies. IMGS-001 may provide a new foundational therapy with its innovative multitasking mechanism of superior blockade and cytotoxic effector function. IMGS-001 is being developed with support from the Cancer Prevention and Research Institute of Texas (CPRIT) DP200094 as well as an investment from the Cancer Focus Fund, LP. Contact ImmunoGenesis Investors: James Barlow President and CEO [email protected] SOURCE Immunogenesis Inc.
Business Wire
15-05-2025
- Business
- Business Wire
BZI® Increases Hiring to Support More Construction Sites in Hesperia and Moreno Valley, and Extends Community Contributions in Its California Markets
KANARRAVILLE, Utah--(BUSINESS WIRE)--BZI®, a leading steel and construction company nationally known for transformative innovations in its industries, announced today that the company is increasing its hiring efforts to support work sites in Hesperia and Moreno Valley, and is extending its community contributions initiative into additional areas in California. The new construction projects will continue BZI's escalation of bringing employment and economic opportunities to California cities and surrounding regions where BZI operates. The company also stated that it will participate in the May 17, 2025 job fair focused on young adults, to be held at the Monterey Adult School in Seaside, California. BZI has many job openings to fill in positions such as welders, bolters, iron workers, deckers, safety reps, quality control inspectors, and estimators. For more information on career opportunities, visit Hesperia and Morena Valley will benefit from BZI's presence in the cities where its job sites are located. In addition to job opportunities for residents, the company will invest significantly in local housing, food, supportive materials, site resources and other categories to support their team and project needs. Many local restaurants, food trucks, suppliers, and other vendors who serve the construction job sites will also see a major uptick in their businesses. The Hesperia project involves the fabrication and erection of over 13,000 tons of steel for a 2.40-million-square-foot building. The Moreno Valley project will include the construction of a 1.01-million-square-foot building where BZI will be responsible for the steel erection. 'As BZI continues to attract more business from around the country, it is a critical and core value of ours to partner with and enhance the communities we are in, as well as increase opportunities for their residents,' said James Barlow, BZI CEO. 'Specialized skills and equipment training and career development for all of our new hires has ensured high-quality work, exceptional safety records and increased personal growth for each team member.' BZI's partnership with the one-of-a-kind SteelTech Academy™ provides training, certifications and continuing education to all its team members. An exclusive technical, safety, vocational, and leadership training center, the academy provides training in OSHA (10) and (30) certifications, equipment operations, fall protection, and industry-specific welding certifications. Since 2021, SteelTech Academy has issued thousands of certifications across these disciplines and consistently logs over 30,000 student contact hours annually. As part of this expansive training curriculum, the academy also offers a Department of Labor certified Apprenticeship Program, helping to shape relevant skills and advance careers for those wanting to pursue construction as a vocation. BZI launched its national Community Contributions Program ' BZI -- Lifting Steel as We Elevate People and Communities in Salinas, California,' last month, and is investigating community group partners in Hesperia, Moreno Valley and other cities where the company does business. BZI said it supports organizations that promote education and literacy, humanitarian causes, health and wellness, and vocational development in order to help contribute to the betterment of communities and residents. 'We encourage related groups interested in partnering with BZI to reach out to us,' said Megan Lamb, Manager of the BZI Community Contributions Program. BZI is now completing and executing major construction projects across the United States and is recognized as a leading provider of innovative construction solutions for companies worldwide, as well as highlighted for its positive influence on local communities. Exceptional client and operational performance by the company are attracting premier companies across the world and bringing these work sites and economic opportunities to California and other states across the U.S. Top BZI customer industries include retail, data centers, manufacturing facilities for batteries, aerospace, energy, microchips, electric vehicles, and food and beverage. About BZI Considered one of the top steel and construction organizations, the BZI® group of companies headquartered in Kanarraville, Utah, operates through three primary organizations: Building Zone Industries, LLC is responsible for steel erection, while BZI Steel, LLC specializes in steel fabrication. Innovatech®, LLC specializes in designing, engineering, and manufacturing innovative construction equipment and processes to enhance efficiency and safety on the job. The company continues to receive numerous industry awards for its exceptional performance and contributions to its industries. The company has been the recipient of: Inc. Best in Business 2024 for Construction: BZI Innovation Park USA Today's Top Workplaces (Second year – Ranked #11 in the nation for midsize companies in 2025) Utah Business Fast 50 (#12 ranking) Top Workplaces Construction Industry Award Salt Lake City Tribune Top Workplaces for two years (#5 ranking in 2024) One Utah Summit "Rural Rockstar" Award presented by Utah Governor Cox Best Employer by Cedar City Chamber of Commerce CEO of the Year by Cedar City Chamber of Commerce CEO of the Year 2025 Award – Utah Business Trade Partner in Safety Excellence (Layton Construction) BZI is a proud member of and accredited by AISC, an organization that has recognized BZI with its top safety awards, the "Erector Award of Honor' and 'Safety Award of Merit.' CEO James Barlow serves on the Forbes Business Council and is a recipient of the prestigious Malcolm Baldrige Award. BZI's mission is to revolutionize the steel construction industry through innovation and team performance, while accelerating project delivery and setting new standards in safety and efficiency.
Business Wire
22-04-2025
- Business
- Business Wire
BZI Brings Construction Jobs, Training and Safety Programs to Salinas, California, and Introduces Its Community Contributions Initiative
KANARRAVILLE, Utah--(BUSINESS WIRE)--BZI®, a leading steel and construction company nationally known for transformative innovations in its industries, announced today that the company's three-million-square-foot, 21,000-ton steel construction project in Salinas, California, as well as its Bakersfield permanent office, are ramping up employment and economic opportunities for the two cities and surrounding regions. The company will participate in Salinas job fairs on April 23 and May 27, 2025, to fill many additional job openings, and launched its Community Contributions Program, which the company plans to roll out across its national markets, beginning in Salinas. New jobs have already been brought to the Salinas area through BZI's current building project there, and BZI is in search of additional workers in the area such as welders, bolters, iron workers, deckers, safety reps, quality control inspectors, estimators and many more. For more information on career opportunities, visit and visit the BZI booth at the Monterey County Works Job Fair, 344 Salinas Street, Salinas, CA. BZI is now completing and executing major construction projects across the United States and is recognized as a leading provider of innovative construction solutions for companies nationwide. It has been highlighted for its positive influence on the communities where it conducts business. Salinas will now be the recipient of many benefits brought by BZI's presence in the city. In addition to job opportunities for local citizens, the company is spending more than $400,000/month on employee housing related to the project. Many local restaurants, food trucks, suppliers, and other vendors, who serve the construction job site, are also seeing a major uptick in their businesses. 'BZI strives to make a positive impact in all communities where we live and operate. Our outstanding team members across the company maintain a responsible and uplifting culture wherever they work,' said James Barlow, BZI CEO. 'They not only bring quality to their job sites, but our team members' presence and economic infusions ripple positively across the areas where we do business. These types of contributions represent important company values and are byproducts of our core operations. We are committed to continuing these positive impacts throughout all of our markets across the country.' ' BZI -- Lifting Steel as We Elevate People and Communities.' In line with the BZI's values and mission, the company is embarking on a national Community Contributions Program and is rolling out the extensive initiative in Salinas this month. 'BZI's core values of Trust, Respect, and Integrity guide our daily operations and decision-making,' said Megan Lamb, Community Contributions Manager and one of the many local BZI Community Advocates to support the company's extensive community engagements. 'BZI believes that supporting projects which promote education and literacy, humanitarian causes, health and wellness, and vocational development, contribute to the betterment of our communities and residents. We encourage related organizations interested in partnering with BZI to reach out to us.' The BZI team will work in the Food Bank for Monterey County at the end of this month and will make additional announcements about its national Community Contributions Program and community partners in Salinas in the coming weeks and months. BZI's work culture has received numerous national awards applauding its approach to its overall environment, growth opportunities, training innovations and safety standards. In addition to benefits packages that exceed industry norms, BZI partners with the one-of-a-kind SteelTech Academy™ to provide training, certifications and continuing education to all its team members. An exclusive technical, safety, vocational, and leadership training center, the academy provides training in OSHA (10) and (30) certifications, equipment operations, fall protection, and industry-specific welding certifications. Since 2021, SteelTech Academy has issued thousands of certifications across these disciplines and consistently logs over 10,000 student contact hours annually. As part of this expansive training curriculum, the academy also offers a Department-of-Labor-certified apprenticeship program, helping to shape relevant skills and advance careers for those wanting to pursue construction as a vocation. Tim Gardiner, SteelTech Academy instructor and the director of its apprenticeship program, is illustrative of BZI's commitment to its teams and people, providing opportunities to grow, prosper and excel personally and professionally. According to Gardiner, BZI provides a rich and supportive environment for team members to develop and succeed along with the growth and success of the company. 'Every one of our new hires starts with a one-to-two-week training and will receive numerous forms of resources, continuing education, mentorship and networking opportunities to make their experience at BZI what they want to make of it,' said Gardiner. 'I am humbled to participate in a program that is bringing high-value opportunities and improving lives. We prepare team members for their overall vocational path, bringing skills training and guidance to last throughout their career. It's an honor to walk with our team members throughout their journey of professional development and growth, and to witness their ongoing transformations.' Construction is one of the most dangerous professions. Safe work sites are a key focus for BZI, and their track record shows it. The company has received awards from national construction organizations such as AISC and partners for its safety approach. Through its differentiated safety methodologies, processes, equipment and skills training, as well as ongoing monitoring and team reinforcement, the company safety numbers are beating industry standards with their TRIR number at 2.37 and EMR rating at 0.48. As the company's Chief Safety Officer, Jesus Cadena, who began as a decker at BZI, has created policies and procedures that minimize risk and ensure the safety of the company's team members. He is responsible for enforcing policies and procedures, overseeing all safety protocols and developing improved safety training. 'One of the biggest and most valuable benefits we provide our team members, and their families, is a safe work environment,' said Cadena. 'The highest level of safety is something our teams count on and work together to achieve. It's not just a goal. It's a culture.' For more information about BZI and its Community Contributions Program, visit email office@ or call 888.509.2280. About BZI Considered one of the top steel and construction organizations, the BZI® group of companies headquartered in Kanarraville, Utah, operates through three primary organizations: Building Zone Industries, LLC is responsible for steel erection, while BZI Steel, LLC specializes in steel fabrication. Innovatech®, LLC specializes in designing, engineering, and manufacturing innovative construction equipment and processes to enhance efficiency and safety on the job. The company continues to receive numerous industry awards for its exceptional performance and contributions to its industries. Just in 2024, the company was bestowed with: Inc. Best in Business 2024 for Construction: BZI Innovation Park USA Today's Top Workplaces (Second year – Ranked #11 in the nation for midsize companies in 2025) Utah Business Fast 50 (#12 ranking) Top Workplaces Construction Industry Award Salt Lake City Tribune Top Workplaces for two years (#5 ranking in 2024) One Utah Summit "Rural Rockstar" Award presented by Utah Governor Cox Best Employer by Cedar City Chamber of Commerce CEO of the Year by Cedar City Chamber of Commerce CEO of the Year 2025 Award - Utah Business Trade Partner in Safety Excellence (Layton Construction) BZI is a proud member of and accredited by AISC, an organization that has recognized BZI with its top safety award, the "Erector Award of Honor'. CEO James Barlow serves on the Forbes Business Council and is a recipient of the prestigious Malcolm Baldrige Award. BZI's mission is to revolutionize the steel construction industry through innovation and team performance, while accelerating project delivery and setting new standards in safety and efficiency.
Yahoo
02-04-2025
- Business
- Yahoo
BZI®'s James Barlow Named Among Top CEOs of the Year 2025 by Utah Business and CEO of the Year by Cedar City Chamber of Commerce
KANARRAVILLE, Utah, April 02, 2025--(BUSINESS WIRE)--BZI® CEO, James Barlow, has recently been recognized for his outstanding leadership with multiple awards. BZI ( a leading steel and construction company nationally known for transformative innovations in its industries, celebrated with other top CEOs from across Utah on March 27, when Barlow was among executives who received a "CEO of the Year 2025" award. The event was sponsored and award presented by Utah Business. Barlow was also named CEO of the Year by Cedar City Chamber of Commerce, who honored his leadership at a 75th annual Best of Cedar City awards event hosted by the organization last week. As cited in the article featured in the Utah Business March 2025 issue: "James Barlow has transformed BZI into a national leader in steel erection and fabrication since becoming CEO in 2016. Under his team-centered leadership, the company reached $1 billion in accumulated revenue in 2024, grew from 80 to over 800 employees and erected 139.7 million square feet of steel. "His innovative vision established Innovatech, which developed revolutionary construction equipment like WallMaster200™ and MezzMaster™. BZI expanded into new industries including battery plants and microchip manufacturing while launching the 820-acre BZI Innovation Park and RailSync transportation hub. The company's SteelTech Academy has delivered over 100,000 training hours, supporting BZI's recognition as a top workplace in America and recipient of numerous industry awards." "It is an honor to serve and lead the team members at BZI, a hardworking, committed group that makes me proud every day," said James Barlow, CEO of BZI. "These CEO awards are a reflection of our entire organization. I am pleased to accept them on behalf of the collective accomplishments that represent our values of Teamwork, Innovation and Action." For more information about BZI, visit email office@ or call 888.509.2280. About BZI Considered one of the top steel and construction organizations, the BZI® group of companies headquartered in Kanarraville, Utah, operates through three primary organizations: Building Zone Industries, LLC is responsible for steel erection, while BZI Steel, LLC specializes in steel fabrication. Innovatech®, LLC specializes in designing, engineering, and manufacturing innovative construction equipment and processes to enhance efficiency and safety on the job. To support its workforce and maintain high safety and quality standards, BZI partners with SteelTech Academy™, an exclusive technical, safety, vocational, and leadership training center offered to all team members. The academy provides training in OSHA (10) and (30) certifications, equipment operations, fall protection, and industry-specific welding certifications. Since 2021, SteelTech Academy has issued thousands of certifications across these disciplines and consistently logs over 10,000 student contact hours annually. The company continues to receive numerous industry awards for its exceptional performance and contributions to its industries. Just in 2024, the company was bestowed with: Inc. Best in Business 2024 for Construction: BZI Innovation Park USA Today's Top Workplaces (Second year – Ranked #11 in the nation for midsize companies in 2025) Utah Business Fast 50 (#12 ranking) Top Workplaces Construction Industry Award Salt Lake City Tribune Top Workplaces for two years (#5 ranking in 2024) One Utah Summit "Rural Rockstar" Award presented by Utah Governor Cox Best Employer by Cedar City Chamber of Commerce Best CEO by Cedar City Chamber of Commerce Trade Partner in Safety Excellence (Layton Construction) BZI is a proud member of and accredited by AISC, an organization that has recognized BZI with its top safety award, the "Erector Award of Honor". CEO James Barlow serves on the Forbes Business Council and is a recipient of the prestigious Malcolm Baldrige Award. BZI is now completing and executing major construction projects across the United States and is recognized as a leading provider of innovative construction solutions for companies worldwide. View source version on Contacts For more information: kayla@ Teresa@ Sign in to access your portfolio
Associated Press
25-03-2025
- Business
- Associated Press
BZI®'s Innovatech® To Showcase Equipment Innovations and Advancements for the Steel and Construction Industries at The Steel Conference (NASCC), Booth #1071, April 2-4, 2025 in Louisville, Kentucky
BZI® ( a leading steel and construction company nationally recognized for transformative innovations in its industries, announced today that Innovatech ®, its equipment engineering, design and manufacturing group, will showcase breakthrough construction products and proprietary processes at the AISC national steel conference (NASCC), booth #1071, April 2-4, 2025 at the Kentucky International Convention Center in Louisville, Kentucky. This press release features multimedia. View the full release here: Innovatech will feature Beam Champ ® 30, the industry first beam rotator, among other industry advancements at the show. BZI leadership and more than 50 team members will attend the event to support industry collaboration, learning and contributions. 'The NASCC show represents our community and provides an excellent opportunity for all companies across the construction and steel ecosystems to share, collaborate and work together to advance our industries,' said James Barlow, CEO of BZI. 'We look forward to sharing our insights on enhanced systems and explore new ways of addressing safety and innovation for the betterment of our industry and its customers. We also expect to uncover and forge exciting new opportunities and relationships for our company.' BZI and Innovatech team members will be directly addressing the current and future needs of architects, engineers, fabricators and other steel erectors while attending NASCC. BZI's top customer industries include data centers, e-commerce distribution/warehouse, EV auto and battery plants, microchip manufacturing, and food and beverage. To schedule an appointment at NASCC email [email protected], or call 888.509.2280. BZI is a proud member of and accredited by AISC, who has recognized BZI with its top safety award, the 'Erector Award of Honor' in past years. More on Beam Champ® 30 Innovatech designed Beam Champ to facilitate faster and safer beam loading and access for welding teams. This groundbreaking system sets a new standard in the steel industry, optimizing weld positioning and reducing risks associated with beam handling. Customers report experiencing a 20% gain in productivity since utilizing Beam Champ in their operations. Accessing all sides of a heavy steel beam for welding can be time-consuming and dangerous. While various rotator solutions have emerged, they have not addressed several practical needs, such as beam placement, removal, and secure positioning. Innovatech's proprietary Beam Champ 30 beam-rotating system presents a new approach to solving these challenges. This patented system allows welding teams to access all sides of a beam more safely and efficiently. The Beam Champ 30 cradles the beam on a chain and rotates it within two or more Beam Champ units. This system offers several advantages over previous rotators, including a larger opening for beam placement and removal. Additionally, its Vertical Jaw Arm enables effortless insertion and removal, while the Support Arm holds the beam securely in place during welding or configuration. About BZI ( Considered one of the top steel and construction organizations, the BZI® group of companies headquartered in Kanarraville, Utah, operates through three primary organizations: Building Zone Industries, LLC is responsible for steel erection, while BZI Steel, LLC specializes in steel fabrication. Innovatech®, LLC specializes in designing, engineering, and manufacturing innovative construction equipment and processes to enhance efficiency and safety on the job. To support its workforce and maintain high safety and quality standards, BZI partners with SteelTech Academy™, an exclusive technical, safety, vocational, and leadership training center offered to all team members. The academy provides training in OSHA (10) and (30) certifications, equipment operations, fall protection, and industry-specific welding certifications. Since 2021, SteelTech Academy has issued thousands of certifications across these disciplines and consistently logs over 10,000 student contact hours annually. The company continues to receive numerous industry awards for its exceptional performance and contributions to its industries. Just in 2024, the company was bestowed with: CEO James Barlow serves on the Forbes Business Council and is a recipient of the prestigious Malcolm Baldrige Award. BZI is completing and executing major construction projects across the United States and is recognized as a leading provider of innovative construction solutions for companies worldwide. View source version on SOURCE: BZI Copyright Business Wire 2025. PUB: 03/25/2025 11:00 AM/DISC: 03/25/2025 11:03 AM
