Latest news with #JasonWright
Medscape
05-08-2025
- Health
- Medscape
Uterine Cancers Outpace Clinical Tools to Curb Them
The incidence of uterine cancer among White and Black women is expected to increase exponentially over the next two decades, possibly a result of rising rates of obesity, lower rates of hysterectomy, and an aging population. The rates in Black women are expected to rise even more sharply, challenging clinicians to detect disease earlier in the absence of well-defined screening protocols. These trends point to a need to develop recommendations for screening of uterine cancer, and even developing screening tests, along with coming up with better prevention strategies, said Jason Wright, MD, a gynecologic oncologist at Columbia University College of Physicians and Surgeons in New York City and lead author of a recently published natural model study that projected uterine cancer incidence out to 2050. 'Over the last several years what we've seen is both the incidence and mortality of uterine cancer has risen,' Wright said in an interview. 'That's particularly true in Black women who are seeing a much higher increase in the incidence and mortality of uterine cancer.' The study included both endometrial and nonendometrial cancers of the uterus. The study also showed that disparities in the incidence of uterine cancer are widening, Wright said, and that mortality continues to increase 'despite the fact that for most cancers mortality is declining.' Disease Projections The study cited CDC data that showed the incidence and death rates from uterine cancer increased dramatically over the past 30 years, and a 2025 National Cancer Institute report that showed the average annual rate of uterine cancer increased by 0.8% from 2014 to 2019, but that mortality increased more than twice that: 1.9% annually from 2015 to 2019, the highest for any malignancy in women. Wright's natural model study has projected a number of disturbing trends in uterine cancer in the period from 2020 to 2050, using 2018 as the baseline year. Among them: In White women, the incidence is projected to increase from 57.7 cases per 100,000 to 74.2 cases, a 28% increase. In Black women, the rate is projected to increase from 56.8 cases to 86.9 cases per 100,000, a 53% increase. In White women, the incidence-based mortality will increase from 6.1 to 11.2 deaths per 100,000, an 83% increase. In Black women, the mortality rate will increase from 14.1 to 27.9 per 100,000, a 98% increase. The study noted that White women will have 'only a slight increase' in nonendometrioid tumors, but the incidence of these tumors will 'increase substantially' in Black women. The study projected the rate of nonendometrial cancer would increase from 21.4 to 36.3 cases per 100,000 in Black women from 2018 to 2050 and from 8.4 to 10.8 cases per 100,000 in White women — a rate almost four times higher in Black women. What's Driving the Increase The study identified two population trends that may be driving the increase in uterine cancers but did not define a causal relationship: the aging population and the increasing rate of overweight and obesity. But the study stated, these trends 'likely only explain a part of the changing trends in uterine cancer incidence and mortality.' Aging seems to be a major driver, Wright said. 'The median age of uterine cancer in most studies is typically in the early to mid-60s.' Another factor may be declining hysterectomy rates, he added. 'What we've seen in last several years is that the rate of hysterectomy is declining in the United States, and that's probably due to alternative treatments for other gynecologic disorders so that, overall, fewer women have their uteruses removed for benign or noncancerous conditions earlier in life,' Wright said. 'Almost by definition if you have a larger number of women that still have a uterus as they age, it does increase the absolute number of uterine cancer cases.' A systematic database search published in 2020 reported that hysterectomy rates peaked at 10.6 per 1000 women in 1975 and predicted that rates would fall to 3.9 per 1000 by 2035. Wright's natural model study acknowledged a 'substantial racial variation' in hysterectomy rates as a contributing factor for higher uterine cancer rates in Black women, the study stated. But even adjusting for declining hysterectomy rates, rising rates of obesity and aging, the numbers of uterine cancers are still rising, Kemi Doll, MD, director of the Gynecologic Research and Cancer Equity Canter at the University of Washington in Seattle, said, in an interview. 'We need to think outside of the box to potential environmental exposures that may have affected the currently aging generation, and uterine cancer is a clue to find out what that is,' Doll said. The Disordered State of Screening 'One of the problems for uterine cancers is there are no real widespread recommendations for either screening or prevention for uterine cancer in a majority of the population,' Wright said. Indeed, the American College of Obstetricians and Gynecologists (ACOG) and the Society of Gynecologic Oncology, among other clinical organizations, concurred in 2015 guidance that no effective routine screening exists for endometrial cancer in women with no symptoms. The guidance suggests that abnormal postmenopausal bleeding is a trigger for immediate evaluation with biopsy, ultrasound or hysteroscopy-guided screening. Another risk factor is Lynch syndrome, previously known as hereditary nonpolyposis colorectal cancer. Women with the condition are at a 13%-26% increased risk for endometrial cancer, according to the National Comprehensive Cancer Network. For them, ACOG recommends annual endometrial sampling starting at age 30-35. Women who previously took tamoxifen for breast cancer may also have greater risk for endometrial cancer. Its use has long been associated with a heightened risk for endometrial cancer, with the risk increasing the longer a patient is on the drug. But, again, no routine screening is recommended for users with no symptoms, although ACOG has stated that pretreatment screening may have a role before starting tamoxifen therapy. The lack of effective screening tests for uterine cancers and detecting predictors of uterine cancer complicates the outlook, Wright said. 'Neither exist currently,' he said. Endometrial thickness > 4 mm, as measured on transvaginal ultrasound, is a biomarker for endometrial cancer. Despite this, Doll and her coauthors recently found that transvaginal ultrasound may not be reliable for evaluating endometrial thickness in Black women. ' This study underlines the importance of new strategies that do not rely on a patient to have a symptom or a provider to believe them,' Doll said. What Clinicians Can Do Despite the absence of routine screening protocols or preventive strategies for uterine cancers, clinicians must become more astute about warning signs and symptoms, Doll said. These include abnormal menstrual bleeding, which Wright said is a symptom most women diagnosed with uterine cancer have. 'Women that have abnormal bleeding should be evaluated in a timely manner and the clinician, the gynecologist, must recognize the importance of bleeding and rule out uterine cancer,' Wright said. Doll called for primary care providers to actively screen for abnormal and postmenopausal bleeding and provider education about 'the limits of ultrasound triage and the need for tissue biopsy with any concern for endometrial cancer.' 'We need to educate the public, especially those most at risk, about endometrial cancer symptoms and early detection,' she continued. Disproportionate Rise in Black Women Why uterine cancer rates in Black women are rising disproportionately compared with other groups is unclear, according to experts interviewed for this piece. 'Black women have been left behind in the world of uterine cancer research and it shows. Now that we have an increasing epidemic of nonendometrioid cancers — the histology that was always more common among Black women — we are faced with our major knowledge gaps in the etiology of these cancers and the fact our treatments are much less successful for them,' Doll said. Timothy Rebbeck, PhD, a researcher specializing in cancer prevention at Dana-Farber Cancer Institute in Boston, pointed to some potential explanations. Tumors in Black patients with prostate and colon cancers have unique molecular signatures compared with other ethnic groups, Rebbeck said. 'We think it's probably happening in uterine cancers as well.' Tumors in Black women may be more aggressive, he added. Reproductive history may also come into play. The lack of screening for uterine cancer may also mean that Black women are diagnosed later in the disease course than other groups. It's an area prime for more research, Rebbeck said. The natural model study was supported by the National Cancer Institute. Wright reported receiving grant funding from Merck. Doll and Rebbeck had no relevant disclosures.
USA Today
12-07-2025
- Sport
- USA Today
Five years ago was a historic day for Washington's NFL franchise
Much has transpired in the last five years regarding the Commanders. July 12, 2021, Washington Football Team President Jason Wright, who was responsible for the business side of the NFL franchise, announced that the NFL team would not consider "Warriors" as its next permanent name. The previous July, the shocking news that the franchise was dropping the name "Redskins" floored many NFL fans across the nation. Most in the District, Maryland, and Virginia (DMV) were very upset with the decision, feeling betrayed by then-owner Daniel Snyder, who had once boldly proclaimed he would never change the name from "Redskins." The 2020 and 2021 seasons were played under the name of the "Washington Football Team." A team being named the team? Yes, it was redundant, and yes, initially it was laughed at and mocked by more than a few sports commentators. Wright disqualified the name "Warriors" and said the NFL team's new name would have "no ties to Native American imagery," following conversations with Native American leaders. How thorough were those conversations? Thinking people were left to ask, "If many Native Americans were not offended by 'Redskins,' why would they be offended by 'Warriors?' If that wasn't enough, remember the new Washington Football Team policy that was announced that summer of 2021? The owner and president were going to show everyone who was boss so they proclaimed they would no longer allow fans to wear "Native American inspired" dress inside their home stadium, including headdresses and face paint. Oh, that went over really well! After all "Redskins" fans easily pointed to how the Kansas City Chief fans could wear headdresses and face paint and even engage in mindless war chants associated with Native Americans, keep their team name "Chiefs" but Washington fans were going to face the wrath of the gatekeepers preventing anything to do with their "Redskins" past. What a summer it was five years ago for Washington fans. But for now, we again have a winning team with excellent leadership, which makes it much easier to deal with than the inferior branding that we enjoyed for decades.
Yahoo
03-07-2025
- Sport
- Yahoo
Which historic uniforms will Commanders wear in 2025?
The Commanders broke news Wednesday afternoon that new alternate uniforms are coming soon. That's right, on July 9, the Commanders will unveil their new alternate uniforms. The alternate uniforms themselves have been a controversial topic for the fan base, and rightly so. After all, the franchise colors are historically burgundy and gold, and yet, in 2022, Dan Snyder and Jason Wright determined that not only would the team's new name be "Commanders," but there would also be no longer be any historic throwback uniforms. Advertisement Wright actually broadcast that the fan base had expressed "Commanders" as one of their preferred choices on February 2 on the "Today Show," when he stated that the new name "broadly resonated with our fans." It did? Did they ever provide any actual proof of this? The former owner and former team president had determined that there would be no historic throwback uniforms. Instead, as a means of moving forward and attempting to dismiss the past, the "throwbacks" gave way to "alternates." No longer would there be burgundy and gold throwback uniforms from the days of Sammy Baugh or Sonny Jurgensen. No, the franchise was progressive, moving forward. They would wear black and gold uniforms instead. It was a new era, a new name, a new "alternate uniform." Advertisement The Josh Harris ownership group will reveal next Wednesday that they are going back to historic throwbacks, featuring actual burgundy and gold uniforms, you know, the team's original colors. Or are they? The actual release did not describe the uniforms as "throwbacks," but rather as "alternates." Which helmet will they use? Unfortunately, the Commanders' release on X (formerly Twitter) intentionally displays a "W" on the helmet. Is this their way of not getting our hopes up, so that we won't be too upset when the helmet is actually not a throwback? In a sense, perhaps the "W" in the current logo speaks to the uniforms being alternates rather than throwbacks? Advertisement On the other hand, there are NFL teams that use an entire throwback uniform, including the helmet. So, why not go ahead and embrace the past prior to the Dan Snyder years? If only a few games each season, enjoy a historic look, and have some fun with it. Whatever uniforms the Harris group chooses, they will at least include the team colors and franchise history. Most importantly, the team is winning again. So perhaps the "W" will cause fans to think more of Washington and winning. Here are some options that would be fun, dating back to helmets, which I recall from my first Redskins memories in the 1969 season. Will next week's reveal resemble any of these uniform combinations shown above? It sure sounds like it will. The Commanders have multiple options with the "throwback" or "alternate" helmet. This article originally appeared on Commanders Wire: There are four uniforms combinations the Commanders could choose
Hypebeast
09-06-2025
- Business
- Hypebeast
NFL Explores Foreign Team Ownership, Says Ex-Commanders President
Summary TheNational Football League (NFL)is reportedly on the cusp of opening its doors to foreign investment in team ownership, according to Jason Wright, the former president of theWashington Commanders. Speaking on a sports business panel last week at Gabelli Funds' annual Media & Sports Symposium in New York, Wrightstatedthat his 'experience in NFL circles suggests the league is close to opening itself up to foreign investment.' While sovereign wealth funds from regions like Saudi Arabia, Qatar, and the United Arab Emirates have already taken significant stakes in global sports like soccer, golf, and auto racing, major U.S. leagues have historically resisted such direct foreign ownership. However, with the NFL's continued business surge and its ambition for international expansion, Wright sees the diversification of its money pool as an 'inevitability.' Wright explained that the NFL, being a 'slower mover,' will likely 'test the waters' initially through large-scale 'partnership deals with companies and brands that we know foreign governments are behind and supporting.' He suggested that once these significant sponsorships, such as naming rights deals at the team level or marquee league partnerships, start emerging, it will signal a direct investment from foreign entities is on the horizon. These discussions, he revealed, 'have been happening in the background.' Wright, who served as the first Black president of an NFL franchise from 2020 to 2024, emphasized that smaller leagues might see sovereign investment more directly first due to greater need, but the NFL's move is a matter of when, not if. This shift could significantly impact the financial landscape of the league, potentially unlocking new capital for team operations and further international growth.
Time of India
09-06-2025
- Business
- Time of India
NFL may soon open doors to foreign investors as team owners, claims former Washington Commanders president Jason Wright
NFL (via Getty Images) In a tremendous potential change for U.S. sports, former Washington Commanders president Jason Wright has disclosed that the National Football League (NFL) is reportedly on the verge of opening its doors to foreign investment in team ownership for the first time. League insiders think the NFL is 'close to opening itself up to foreign investment'—something that would dramatically shift the financial landscape of the United States' most successful sports league. NFL turns to global capital as league contemplates next step of financial growth The NFL's team president from 2020 to 2024, Jason Wright, seemed convinced that the league's growing international ambitions would make foreign investment unavoidable. According to Jason Wright, the NFL will start by 'testing the waters' in the guise of indirect investments such as wholesale commercial deals and corporate sponsorships linked to groups backed by foreigners. This transformation would move the NFL closer to global sporting patterns, where Saudi Arabian, Qatari, and United Arab Emirates sovereign wealth funds have taken huge stakes in sports such as golf (LIV Golf), Formula 1, and European football clubs. The NFL has shunned these types of ownership structures previously, however, due to regulatory, cultural, and political reasons. Foreign Ownership Looms Over NFL: Will Big Leagues Follow Soccer's Lead? The league has already welcomed regular-season games in London, Germany, and Mexico City, with even more exciting plans for future growth. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Keep Your Home Efficient with This Plug-In elecTrick - Save upto 80% on Power Bill Learn More Undo Leaning on sovereign wealth and international capital has the potential to unlock enormous funding for worldwide operations, infrastructure projects, and team-specific innovation. Wright indicated that other minor U.S. sports leagues, like Major League Soccer (MLS) or the WNBA, might be more nimble in embracing foreign investment first. Nevertheless, the NFL's eventual involvement, he added, is a question of "when, not if." Also read: NFL may be defeated by the IPL in per-match value if the latter gets a 12 to 16-week window period NFL at a financial crossroads If the NFL does eventually open the door to international capital, it would be a breathtaking development for the league. While risks—regulatory, cultural, and political—are unavoidable, the potential injection of billions of capital can turn teams' operations and expansion on their heads overseas. Jason Wright's perspective is an initial glance at what will ultimately be a defining challenge of the league's next era.
