Latest news with #JohnMarshall
Yahoo
17-07-2025
- Health
- Yahoo
Gastrointestinal cancers are rising dramatically in people under 50
Gastrointestinal cancers, which include colorectal, stomach and pancreatic cancer, are rising dramatically in younger adults, though doctors aren't fully sure why. Even some of the possible causes require more research, they say. According to a review published Thursday in JAMA, gastrointestinal cancers have become the fastest-growing type of cancers diagnosed in adults younger than 50 in the U.S. The review, one of the most comprehensive looks at gastrointestinal cancer trends, summarized the findings of major international and U.S. cancer databases, plus 115 papers on gastrointestinal cancers published from January 2014 to March 2025. The authors underscore the need for people to follow the screening guidelines for colorectal cancer, which suggest that people with an average risk start screening — usually a colonoscopy or stool test — at age 45. Since doctors don't routinely screen for pancreatic, stomach and esophageal cancers in the U.S., the authors also call for new ways to screen more people for these cancers. 'This really points to the importance of trying to improve screening and early detection,' said Dr. Kimmie Ng, the review's co-author and director of the Young-Onset Colorectal Cancer Center at Dana-Farber Cancer Institute. According to the review, colorectal cancer is by far the most common early-onset gastrointestinal cancer, with nearly 185,000 cases reported worldwide in 2022 and nearly 21,000 cases reported that same year in the U.S. Diagnoses in the U.S. have risen 2% annually in people younger than 50 since 2011, according to the American Cancer Society. 'It never used to happen in this age group, and now a very significant rise in 20-, 30- and 40-year-olds are getting colon cancer,' said Dr. John Marshall, chief medical consultant at the nonprofit Colorectal Cancer Alliance, who was not involved in the research. In one of the most high-profile examples, actor Chadwick Boseman was diagnosed with colon cancer in 2016 and died of the disease four years later at age 43. Early-onset cases of pancreatic, stomach and esophageal cancers are also rising, according to the new study. Previous research has shown a disproportionate share of those gastrointestinal cancer diagnoses were among Black and Hispanic people. Pancreatic cancer is among the deadliest forms of cancer, with just 13% of patients surviving five years after their diagnosis. Because colorectal cancer is the most common, doctors said they have a better grasp of what might be contributing to these early-onset cases compared with others. 'If we can understand what's going on in colorectal [cancer], I think it would really provide a lot of guidance to help us understand the other GI tract cancers,' said Dr. Scott Kopetz, a professor of gastrointestinal medical oncology at the University of Texas MD Anderson Cancer Center. Kopetz said there are likely multiple factors driving the increase in early-onset cases. 'The leading theory is that there is no single leading theory,' he said. Ng's new review in JAMA suggests that most gastrointestinal cancers in people under 50 are associated with lifestyle factors such as obesity, lack of exercise, poor diet, cigarette smoking or alcohol consumption. One study included in the review found that women who consumed more sugar-sweetened beverages during adolescence had a higher risk of developing early-onset colorectal cancer. 'It's really what people were doing or exposed to when they were infants, children, adolescents that is probably contributing to their risk of developing cancer as a young adult,' Ng said. Health Secretary Robert F. Kennedy Jr. has been vocal about the association between sugary beverages and health issues, including cancer. On Wednesday, President Donald Trump said Coca-Cola will start being made with cane sugar rather than corn syrup in the U.S., but the company did not commit to the change when asked about it by NBC News. Marshall said he suspects the rise in early-onset colorectal cancer could have something to do with changes in people's gut microbiomes — the bacteria that live in our gastrointestinal tracts. Diet, antibiotic use, microplastics and exposure to environmental chemicals likely all influence a person's gut bacteria, but scientists still don't have a clear understanding of what a healthy microbiome looks like nor how it affects our health. That is a booming area of research. Ng's review also found that 15% to 30% of people with early-onset gastrointestinal cancer carry hereditary genetic mutations that may have predisposed them to getting cancer at a young age. Because of that, she said, 'we do recommend that all young patients diagnosed under the age of 50 undergo testing for hereditary conditions.' Overall survival rates for gastrointestinal cancers have gotten better over time, due to improvements in treatment and screening. But Ng's review found that younger patients often have worse outcomes, despite typically receiving more treatments, including more surgery, radiation and aggressive combinations of chemotherapy, she said. One reason could be that primary care doctors may overlook symptoms such as abdominal pain, constipation, heartburn or reflux in younger patients, thereby delaying their diagnoses. 'My personal feeling is that it's because we're finding them at a more advanced stage, because people don't really think of colon or other GI cancers when they see a young person with these nonspecific complaints,' said Dr. Howard Hochster, director of gastrointestinal oncology at Rutgers Cancer Institute and RWJBarnabas Health in New Jersey. But Ng said that even after controlling for the stage at which patients are diagnosed, young people still seem to have worse survival rates. 'This makes us wonder as researchers whether that means that the cancers that develop in younger people may be biologically different and more aggressive, or maybe less responsive to treatment,' she said. This article was originally published on Solve the daily Crossword
NBC News
17-07-2025
- Health
- NBC News
Gastrointestinal cancers are rising dramatically in people under 50
Gastrointestinal cancers, which include colorectal, stomach and pancreatic cancer, are rising dramatically in younger adults, though doctors aren't fully sure why. Even some of the possible causes require more research, they say. According to a review published Thursday in JAMA, gastrointestinal cancers have become the fastest-growing type of cancers diagnosed in adults younger than 50 in the U.S. The review, one of the most comprehensive looks at gastrointestinal cancer trends, summarized the findings of major international and U.S. cancer databases, plus 115 papers on gastrointestinal cancers published from January 2014 to March 2025. The authors underscore the need for people to follow the screening guidelines for colorectal cancer, which suggest that people with an average risk start screening — usually a colonoscopy or stool test — at age 45. Since doctors don't routinely screen for pancreatic, stomach and esophageal cancers in the U.S., the authors also call for new ways to screen more people for these cancers. 'This really points to the importance of trying to improve screening and early detection,' said Dr. Kimmie Ng, the review's co-author and director of the Young-Onset Colorectal Cancer Center at Dana-Farber Cancer Institute. According to the review, colorectal cancer is by far the most common early-onset gastrointestinal cancer, with nearly 185,000 cases reported worldwide in 2022 and nearly 21,000 cases reported that same year in the U.S. Diagnoses in the U.S. have risen 2% annually in people younger than 50 since 2011, according to the American Cancer Society. 'It never used to happen in this age group, and now a very significant rise in 20-, 30- and 40-year-olds are getting colon cancer,' said Dr. John Marshall, chief medical consultant at the nonprofit Colorectal Cancer Alliance, who was not involved in the research. In one of the most high-profile examples, actor Chadwick Boseman was diagnosed with colon cancer in 2016 and died of the disease four years later at age 43. Early-onset cases of pancreatic, stomach and esophageal cancers are also rising, according to the new study. Previous research has shown a disproportionate share of those gastrointestinal cancer diagnoses were among Black and Hispanic people. Pancreatic cancer is among the deadliest forms of cancer, with just 13% of patients surviving five years after their diagnosis. Because colorectal cancer is the most common, doctors said they have a better grasp of what might be contributing to these early-onset cases compared with others. 'If we can understand what's going on in colorectal [cancer], I think it would really provide a lot of guidance to help us understand the other GI tract cancers,' said Dr. Scott Kopetz, a professor of gastrointestinal medical oncology at the University of Texas MD Anderson Cancer Center. Kopetz said there are likely multiple factors driving the increase in early-onset cases. 'The leading theory is that there is no single leading theory,' he said. Ng's new review in JAMA suggests that most gastrointestinal cancers in people under 50 are associated with lifestyle factors such as obesity, lack of exercise, poor diet, cigarette smoking or alcohol consumption. One study included in the review found that women who consumed more sugar-sweetened beverages during adolescence had a higher risk of developing early-onset colorectal cancer. 'It's really what people were doing or exposed to when they were infants, children, adolescents that is probably contributing to their risk of developing cancer as a young adult,' Ng said. Health Secretary Robert F. Kennedy Jr. has been vocal about the association between sugary beverages and health issues, including cancer. On Wednesday, President Donald Trump said Coca-Cola will start being made with cane sugar rather than corn syrup in the U.S., but the company did not commit to the change when asked about it by NBC News. Marshall said he suspects the rise in early-onset colorectal cancer could have something to do with changes in people's gut microbiomes — the bacteria that live in our gastrointestinal tracts. Diet, antibiotic use, microplastics and exposure to environmental chemicals likely all influence a person's gut bacteria, but scientists still don't have a clear understanding of what a healthy microbiome looks like nor how it affects our health. That is a booming area of research. Ng's review also found that 15% to 30% of people with early-onset gastrointestinal cancer carry hereditary genetic mutations that may have predisposed them to getting cancer at a young age. Because of that, she said, 'we do recommend that all young patients diagnosed under the age of 50 undergo testing for hereditary conditions.' Overall survival rates for gastrointestinal cancers have gotten better over time, due to improvements in treatment and screening. But Ng's review found that younger patients often have worse outcomes, despite typically receiving more treatments, including more surgery, radiation and aggressive combinations of chemotherapy, she said. One reason could be that primary care doctors may overlook symptoms such as abdominal pain, constipation, heartburn or reflux in younger patients, thereby delaying their diagnoses. 'My personal feeling is that it's because we're finding them at a more advanced stage, because people don't really think of colon or other GI cancers when they see a young person with these nonspecific complaints,' said Dr. Howard Hochster, director of gastrointestinal oncology at Rutgers Cancer Institute and RWJBarnabas Health in New Jersey. But Ng said that even after controlling for the stage at which patients are diagnosed, young people still seem to have worse survival rates. 'This makes us wonder as researchers whether that means that the cancers that develop in younger people may be biologically different and more aggressive, or maybe less responsive to treatment,' she said.
NBC News
17-07-2025
- Health
- NBC News
Gastrointestinal cancers rising dramatically in people under 50
Gastrointestinal cancers, which include colorectal, stomach and pancreatic cancer, are rising dramatically in younger adults, though doctors aren't fully sure why. Even some of the possible causes require more research, they say. According to a review published Thursday in JAMA, gastrointestinal cancers have become the fastest-growing type of cancers diagnosed in adults younger than 50 in the U.S.. The review, one of the most comprehensive looks at gastrointestinal cancer trends, summarized the findings of major international and U.S. cancer databases, plus 115 papers on gastrointestinal cancers published from January 2014 to March 2025. The authors underscore the need for people to follow the screening guidelines for colorectal cancer, which suggest that people with an average risk start screening — usually a colonoscopy or stool test — at age 45. Since doctors don't routinely screen for pancreatic, stomach and esophageal cancers in the U.S., the authors also call for new ways to screen more people for these cancers. 'This really points to the importance of trying to improve screening and early detection,' said Dr. Kimmie Ng, the review's co-author and director of the Young-Onset Colorectal Cancer Center at Dana-Farber Cancer Institute. According to the review, colorectal cancer is by far the most common early-onset gastrointestinal cancer, with nearly 185,000 cases reported worldwide in 2022 and nearly 21,000 cases reported that same year in the U.S. Diagnoses in the U.S. have risen 2% annually in people younger than 50 since 2011, according to the American Cancer Society. 'It never used to happen in this age group, and now a very significant rise in 20, 30 and 40-year-olds are getting colon cancer,' said Dr. John Marshall, chief medical consultant at the nonprofit Colorectal Cancer Alliance, who was not involved in the research. In one of the most high-profile examples, actor Chadwick Boseman was diagnosed with colon cancer in 2016 and passed away of the disease four years later at age 43. Early-onset cases of pancreatic, stomach and esophageal cancers are also rising, according to the new study. Previous research has shown a disproportionate share of those gastrointestinal cancer diagnoses were among Black and Hispanic people. Pancreatic cancer is among the deadliest forms of cancer, with just 13% of patients surviving five years after their diagnosis. Because colorectal cancer is the most common, doctors said they have a better grasp of what might be contributing to these early-onset cases compared to others. 'If we can understand what's going on in colorectal [cancer], I think it would really provide a lot of guidance to help us understand the other GI tract cancers,' said Dr. Scott Kopetz, a professor of gastrointestinal medical oncology at the University of Texas MD Anderson Cancer Center. Kopetz said there are likely multiple factors driving the increase in early-onset cases. 'The leading theory is that there is no single leading theory,' he said. Ng's new review in JAMA suggests that most gastrointestinal cancers in people under 50 are associated with lifestyle factors such as obesity, lack of exercise, poor diet, cigarette smoking or alcohol consumption. One study included in the review found that women who consumed more sugar-sweetened beverages during adolescence had a higher risk of developing early onset colorectal cancer. 'It's really what people were doing or exposed to when they were infants, children, adolescents that is probably contributing to their risk of developing cancer as a young adult,' Ng said. Health and Human Services Secretary Robert F. Kennedy Jr. has been vocal about the association between sugary beverages and health issues, including cancer. On Wednesday, President Donald Trump said Coca-Cola will start being made with cane sugar rather than corn syrup in the U.S., but the company did not commit to the change when asked about it by NBC News. Marshall said he suspects the rise in early-onset colorectal cancer could have something to do with changes in people's gut microbiomes — the bacteria that live in our gastrointestinal tracts. Diet, antibiotic use, microplastics and exposure to environmental chemicals likely all influence a person's gut bacteria, but scientists still don't have a clear understanding of what a healthy microbiome looks like nor how it affects our health. That is a booming area of research. Ng's review also found that 15% to 30% of people with early-onset gastrointestinal cancer carry hereditary genetic mutations that may have predisposed them to getting cancer at a young age. Because of that, she said, 'we do recommend that all young patients diagnosed under the age of 50 undergo testing for hereditary conditions.' Overall survival rates for gastrointestinal cancers have gotten better over time, due to improvements in treatment and screening. But Ng's review found that younger patients often have worse outcomes, despite typically receiving more treatments, including more surgery, radiation and aggressive combinations of chemotherapy, she said. One reason could be that primary care doctors may overlook symptoms such as abdominal pain, constipation, heartburn or reflux in younger patients, thereby delaying their diagnoses. 'My personal feeling is that it's because we're finding them at a more advanced stage, because people don't really think of colon or other GI cancers when they see a young person with these non-specific complaints,' said Dr. Howard Hochster, director of gastrointestinal oncology at Rutgers Cancer Institute and RWJBarnabas Health in New Jersey. But Ng said that even after controlling for the stage at which patients are diagnosed, young people still seem to have worse survival rates. 'This makes us wonder as researchers whether that means that the cancers that develop in younger people may be biologically different and more aggressive, or maybe less responsive to treatment,' she said.
CNBC
12-07-2025
- Business
- CNBC
Goldman's top trades for this upcoming earnings season
The first full week of earnings kicks off Monday, and several stocks stand to move higher on the strength of their quarterly results, according to Goldman Sachs. To be exact, 35 S & P 500 companies and six in the Dow Jones Industrial Average are set to report next week, including two of the largest banks in the country, JPMorgan and Citigroup , both of which report before the market opens on Tuesday. Other standard bearers, like PepsiCo and Netflix , are scheduled to release their latest financials on Thursday. "We expect investors to reward fundamental beats this quarter as positioning appears neither crowded nor fearful," Goldman analysts led by John Marshall wrote in a report on Thursday. The options market is anticipating average earnings-day moves of plus or minus 4.7%, the lowest in two years, and far below the 7.1% that was priced in last quarter, suggesting investors are "much less fearful" in July than they were in April, the Goldman analysts said. "We expect a return to elevated single stock earnings-day volatility driven by thematic trades (AI, Tariffs, policy) this quarter," Marshall said. Heading into second-quarter earnings, Goldman analysts screened for 25 of the most "out-of-consensus" stock opportunities and found 19 opportunities where upward earnings revisions might lead individual stocks to outperform. Below are some of the names that floated to the top of the Goldman screen. Oil and natural gas company Permian Resources could see gains ahead. The stock has already soared more than 28% in the past three months, through Friday, outpacing the S & P 500 gain of nearly 17% in the same period. PR 3M mountain Permian Resources over three months. Goldman energy analyst Neil Mehta rates Permian a buy and sees roughly 13% upside ahead, believing that it can outperform its peers due to "continued efforts to reduce well costs, optimize the cost structure of the business, Midland headquarters and increased scale through small to larger scale M & A." Permian Resources is scheduled to release earnings August 6, Goldman said. Financial services provider State Street Corp., which has also outperformed the market in the past three months by climbing about 38%, may continue to rally. Asset managers and capital markets analyst Alexander Blostein, who rates State Street a buy, calls its risk-reward profile the "most attractive" among trust banks in his coverage. STT 3M mountain STT, 3-month State Street is expected to report second-quarter results Tuesday before the market opens, and Blostein believes analysts will raise their estimates afterward, spurred by "stronger fees, stable [net interest income]/deposit outlooks and continued focus on expenses." GE HealthCare is additionally expected to exceed earnings expectations this next season due to stability in end markets, Goldman said. Medical technology analyst David Roman rates GE HealthCare a buy and believes its 2% guidance for 2Q and 3Q growth underestimates a strong U.S. imaging market, the pace of recovery in China and the launch of its radioactive diagnostic drug, Flyrcardo . GEHC 3M mountain GE HealthCare over the past three months. Shares have risen more than 19% over the past three months through Friday. The $35 billion, Chicago-based medical equipment maker is expected to release second-quarter financials before the market's opening bell on July 30.
CNBC
11-07-2025
- Business
- CNBC
Goldman's winning options strategy for the upcoming earnings season
The second-quarter earnings season will kick into high gear next week, bringing with it an opportunity for options traders to make a profit, according to Goldman Sachs. John Marshall, head of derivatives research at Goldman, said in a note to clients Wednesday that his team thinks investors can find success by betting on outsized moves for stocks around the time that they report their latest earnings. "One of our preferred options strategies ahead of earnings is buying straddles on names where options implied moves are inexpensive relative to their typical earnings-day move," Marshall said. "When applied strategically across a portfolio, we find this overlay can provide a hedge or amplify upside exposure should the market make a correlated up or down move." Straddles are a type of options strategy where a trader buys both put and call options on the same stock, with the same strike price and expiration date. The goal is to profit from volatility, regardless of whether or not the underlying stock moves up or down. A straddle trade makes money when the move of the stock is greater than the premium paid to create the options position. Marshall's team identified several stocks with earnings dates this month where the implied move in the options market is low relative to history. Netflix One of the biggest names on the Goldman list is Netflix , which is set to report its results on July 17. The leading streaming platform has a history of big post-earnings moves, including a jump of more than 9% after its quarterly report in January. The stock enters this earnings season already up 40% year to date, through Thursday. However, shares of Netflix are off their highs made in late June, when the stock reached a record $1339, making that a level to watch if results are better than expected. NFLX YTD mountain Shares of Netflix are outperforming the broader market in 2025. Two other companies on Goldman's list set to report next week are Fastenal on July 14 and 3M on July 18. Those stocks are both up about 21% year to date. This week, 3M shares hit their highest level since 2021, while Fastenal reached an all-time record high dating back to its public debut in 1987. Industrial plays Later in July, there are other industrial stocks highlighted by Goldman. Defense contractor RTX is one, and it has also been a big winner in 2025. Shares of RTX are up more than 26% on the year, in part because of increased military spending plans in the United States and Europe. RTX is set to report on July 22. Honeywell , on the other hand, may need a post-earnings bounce to play catch-up. The stock has gained 5% this year through Thursday, less than the S & P 500. Honeywell reports earnings on July 24.
