27-05-2025
Arkansas emergency medicine study at UAMS includes a Pennsylvania university
LITTLE ROCK, Ark. – The University of Arkansas for Medical Sciences is partnering with the University of Pittsburgh to study changes in the early treatment of emergency trauma patients.
UAMS officials said the study is to determine if early intervention in patients with traumatic injury with blood loss by using calcium and vasopressin can improve outcomes. They added that the study will include approximately 1,050 people aged 18 to 90 years old.
UAMS receives $1.9 million from Department of Justice to help Little Rock schools with emergency response
Metropolitan Emergency Medical Services (MEMS) will have participating emergency response crews applying the therapy. The therapy can also be applied after a patient arrives at UAMS.
Officials said the trials, labeled CAVALIER for CAlcium and VAsopressin following Injury Early Resuscitation, are a change from the standard procedure of blood transfusions & blood clotting medication and surgery to stop bleeding. UAMS officials said even with these treatments, up to 30% of patients suffering significant blood loss can die.
'We are committed at UAMS to helping improve survival rates of these severely injured patients,' trauma surgeon and the UAMS principal investigator on the study, Dr. Joseph Margolick, said. 'We think early treatment with calcium and vasopressin in trauma patients may improve outcomes.'
Officials said CAVALIER is an Exception from Informed Consent trial, meaning that the trial requires performing a potentially life-saving treatment on people who are too injured to give permission
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The study is supported by a Department of Defense contract and by the UAMS Translational Research Institute.
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