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Qatar Tribune
3 days ago
- Health
- Qatar Tribune
WCM-Q study highlights potential of flavonoid-induced ferroptosis in treating cancer
Researchers at Weill Cornell Medicine-Qatar (WCM-Q) have explored preclinical evidence on the therapeutic potential of flavonoids that induce ferroptosis in gastrointestinal (GI) cancers in a new article published in the Journal of Advanced Research (ScienceDirect), a leading applied/natural sciences journal. Gastrointestinal cancers account for a quarter of all cancer cases and are the third leading cause of cancer-related deaths worldwide. In addition, the incidence of early-onset GI cancer in individuals under 50 has been rising at an alarming rate in recent years. Despite advances in cancer treatment, factors like rapid globalization, changes in the distribution and prevalence of key risk factors, and demographic trends contribute to epidemiological disparities and variations in the incidence and mortality of GI cancers worldwide. Of the GI cancers, colorectal cancer is considered the most predominant, followed by cancers of the stomach, liver, esophagus, and pancreas. While most GI cancers occur sporadically, only 10 percent are hereditary. Apart from the influence of genetic and environmental factors, lifestyle and dietary habits, and multi-causal combinations like obesity, smoking, and alcohol consumption, are all common risk factors associated with GI cancers. Current treatments for GI cancers include multidisciplinary strategies based on surgical intervention, chemotherapy, radiotherapy, immunotherapy, targeted therapy, and other therapeutic modalities. However, the efficacy of therapeutics is limited by the malignant characteristics of cancer cells, particularly their ability to resist treatment, metastasize, and promote angiogenesis. Emerging evidence suggests that ferroptosis, a novel iron-dependent form of cell death, may be a promising target for cancer therapy. Ferroptosis is a unique, regulated form of programmed cell death driven by the overaccumulation of lipid peroxides. Numerous preclinical studies have increasingly demonstrated the effectiveness of inducing ferroptosis using natural compounds such as flavonoids as an alternative strategy in cancer therapy. The article was authored by Ms Ruqaia Shoheeduzzaman, a graduate of the WCM-Q National Internship Program (June 2024), with co-corresponding authors from WCM-Q: Dr Dietrich Busselberg, professor of physiology and biophysics; Dr Samson Mathews Samuel, research associate in physiology and biophysics; and Ms Elizabeth Varghese, a senior research specialist. "The review highlights recent studies on the anticancer potential of flavonoids, mediated through ferroptosis, in gastrointestinal cancers, including data derived from in vitro cell culture and in vivo animal model tumor systems. It hypothesizes that flavonoid-mediated ferroptosis presents a strategic intervention in cancer therapy, serving as both anticancer agents and sensitizers to enhance the efficacy of current treatments," said Dr Busselberg. The article also suggests that the landscape of cancer therapy is continually evolving, and with the development of new, cutting-edge technologies, there is a greater scope to understand and implement natural compounds, such as flavonoids, in cancer therapy. This would facilitate the development of tailored ferroptosis-based therapeutic strategies and help bridge gaps where conventional therapies fall short, thereby further supporting the effective translation of these strategies to clinical use. The study was made possible through funding from the Biomedical Research Program at Weill Cornell Medicine-Qatar and NPRP-Standard (NPRP-S) 14th Cycle grant NPRP14S-0311-210033 from Qatar National Research Fund (a member of Qatar Foundation).
Yahoo
05-04-2025
- Health
- Yahoo
Genuine Purity Liposomal NMN: Best NMN Supplement Brand by Leading Edge Health
Clinically-Backed Liposomal NMN from Leading Edge Health Sets New Standard in Anti-Aging and Longevity Support with Superior Bioavailability, Purity, and Trust Las Vegas, April 04, 2025 (GLOBE NEWSWIRE) -- In the world of anti-aging and cellular health, one NAD+ booster has risen above all others as the premier solution for longevity, energy, and age-defying wellness: GenuinePurity™ Liposomal NMN, developed and distributed by Leading Edge Health. With a strong emphasis on safety and trust, backed by two decades of formulation expertise and reinforced by clinical research, this supplement is quickly becoming recognized as the best NMN supplement brand available today. Why NAD+ and NMN Matter in the Fight Against Aging NAD+ (Nicotinamide Adenine Dinucleotide) is a critical molecule found in every living cell, playing a central role in cellular metabolism, mitochondrial function, DNA repair, and gene expression. As we age, NAD+ levels can decline by over 50% by midlife, leading to a host of degenerative changes: fatigue, cognitive decline, joint pain, poor skin quality, and slow metabolism. To counteract this biological decline, scientists have identified NMN (β-Nicotinamide Mononucleotide) as a highly efficient precursor to NAD+. When consumed, NMN is converted directly into NAD+ in cells, restoring youthful function from the inside out. The Science Behind GenuinePurity™ Liposomal NMN The formulation of GenuinePurity™ Liposomal NMN by Leading Edge Health is grounded in the latest advancements in longevity research. Each capsule contains: 250 mg of 96% pure NMN, verified by Certificate of Authenticity Liposomal encapsulation, a protective lipid layer that enhances absorption No fillers or synthetic additives, preserving molecular integrity What Sets GenuinePurity™ Liposomal NMN Apart? Most NMN supplements break down in the digestive system before being absorbed. The liposomal delivery system in GenuinePurity™ Liposomal NMN ensures NMN is safely transported through the stomach and delivered directly to cells, improving bioavailability by up to 3x compared to standard formulations. Boost your energy naturally—try GenuinePurity™ Liposomal NMN today. Clinical Studies That Validate NMN and NAD+ Supplementation Numerous peer-reviewed studies have highlighted the efficacy of NMN supplementation: Journal of Advanced Research (2022): NMN raised NAD+ levels and reversed age-related energy decline in mammals, extending their lifespans by up to 30%. Nature Communications (2019): Oral NMN improved insulin sensitivity and NAD+ biosynthesis in aging women. Cell Metabolism (2016): NMN supplementation reversed physiological aging symptoms in mice, improving muscle and brain function. Integrative Medicine (2020): Highlighted the role of NAD+ in cellular repair, mitochondrial rejuvenation, and inflammation control. 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Contact Information: Leading Edge Health Address: 6130 Elton Ave, Las Vegas, NV 89107 Email: support@ Toll-Free (North America): 1-866-968-6643 International: 1-778-770-2961 (6 am – 6 pm PST) Health Benefits of GenuinePurity™ Liposomal NMN Cellular and Mitochondrial Energy NMN supports mitochondrial function, which results in more consistent daily energy and stamina and reduced feelings of burnout or "brain fog." DNA Repair and Longevity By raising NAD+ levels, the supplement activates enzymes like sirtuins and PARPs, which repair DNA and extend lifespan potential. Cognitive Function and Neuroprotection Clinical trials suggest NMN may improve cognition and memory recall and protect against age-related neurodegeneration. Skin and Joint Health Users report visible anti-aging benefits in skin elasticity and radiance, along with relief from joint and muscular discomfort. 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How to Order To purchase GenuinePurity™ Liposomal NMN, please visit the official website: Website: For customer service or ordering assistance, contact the manufacturer: Leading Edge HealthAddress: 6130 Elton Ave Las Vegas, NV 89107Email: support@ (Toll-Free, North America): 1-866-968-6643International: +1-778-770-2961 (Available 6:00 AM – 6:00 PM PST) Frequently Asked Questions (FAQ) Is NMN safe to take long-term? Yes, NMN has demonstrated a high safety profile in both human and animal studies. Long-term use supports energy metabolism and cellular health without adverse effects. How is this product different from other NMN supplements? GenuinePurity™ Liposomal NMN uses liposomal technology for enhanced absorption and is manufactured with 96% purity by Leading Edge Health, a reputable wellness company. Can NMN help with weight loss or metabolism? Indirectly, yes. By improving mitochondrial function and increasing NAD+, NMN may enhance metabolic efficiency, helping with weight control. When will I see the results? Some users report improved energy and focus within 1–2 weeks. More significant anti-aging effects may become noticeable after 1–2 months of consistent use. Is this product vegan and allergen-free? Yes. It is vegan-friendly, gluten-free, and does not contain soy, dairy, or artificial additives. Feel the difference—order GenuinePurity™ Liposomal NMN today risk-free. Disclaimers and Legal Notices Medical Disclaimer: This content is provided for informational purposes only and is not intended to substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting any supplement or health regimen. Results Disclaimer: Results may vary. The Food and Drug Administration has not evaluated the statements regarding GenuinePurity™ Liposomal NMN. This product is not intended to diagnose, treat, cure, or prevent any disease. Affiliate Disclosure: Some links in this article may be affiliate links. If you make a purchase, the publisher may receive a commission at no extra cost to you. This does not affect the editorial integrity of the content. Third-Party Product Disclaimer: GenuinePurity™ Liposomal NMN is developed and distributed by Leading Edge Health. The publisher does not manufacture or fulfill the product and is not liable for any claims associated with product quality, delivery, or customer satisfaction. Jurisdictional Notice: This product is intended for consumers in regions where NMN supplements are legal and regulated. Customers are responsible for ensuring compliance with local regulations prior to purchase. CONTACT: Leading Edge Health Address: 6130 Elton Ave Las Vegas, NV 89107 Email: support@ Phone (Toll-Free, North America): 1-866-968-6643 International: +1-778-770-2961 (Available 6:00 AM – 6:00 PM PST)Sign in to access your portfolio
Forbes
29-03-2025
- Health
- Forbes
TikTokers Claim ‘Vabbing' Will Help Dating, Here Are The Issues
Various TikTokers have been pushing the practice of 'vabbing,' which is a portmanteau of the words ... More 'vagina" and 'dabbing.' It's when you get secretions from your vagina and then dab them on the so-called pulse points of your body like your wrists, neck and the inside the elbows. (Photo: Getty) When dating, you may be looking for more fluid interactions. But this may or may not necessarily be what you have in mind. Various TikTokers have been pushing the practice of 'vabbing,' which is a portmanteau of the words 'vagina" and 'dabbing.' It's when you get secretions from, guess where, your vagina and then dab them on the so-called pulse points of your body. These would be places where you can feel a pulse like your wrists, neck and the inside the elbows. And why would you do such a thing? Well, the claims are that such fluids contain pheromones and other natural attractants. After all, isn't the 'v' where many men want to be? But are such claims actually backed by that thing called science? Searching PubMed for 'vabbing' returns the following statement, 'Showing results for dabbing, Your search for vabbing retrieved no results' and a whole lot of scientific publications on cannabis. Apparently, there haven't been any rigorous clinical studies having women dab vaginal fluids, perfume and something else like motor oil versus nothing on their pulse points and comparing how men react to each. In fact, it's not completely clear whether vaginal fluid even has pheromones and how other humans may react to them. Pheromones are chemicals that many other animals secrete and use to communicate with each other in many different ways. This includes pheromones that serve as 'love chemicals' that help other animals attract each other so that can basically do the wild thing. But whether pheromones play any role in humans getting hot-and-heavy remains hotly debated. Currently, there isn't scientific consensus over whether humans even secrete any type of pheromones, as evidenced by the chapter in the book Neurobiology of Chemical Communication entitled 'Human Pheromones Do They Exist?' It's also not clear whether humans can even sense pheromones. A number of other mammals have structures inside their noses called the the vomeronasal organ (VNO) and main olfactory epithelium (MOE) designed to detect pheromones. However, the VNOs in humans are relatively smaller and may be too underdeveloped to process pheromones in the same way. A 2012 review article in the Journal of Advanced Research pointed out that although some studies do suggest that pheromones may play a role in human arousal, these studies are 'weak, because they were not controlled.' Don't confuse pheromones with hormones even though they kind of sound the same. Hormones are chemical messengers that work inside your body to regulate and control various things whereas pheromones are supposed to work outside your body on other folks. So, when talking to your doctor, there would be a big difference between asking, 'What do you think about my hormone levels,' versus asking, 'What do you think about my pheromone levels?' Also, don't confuse things that smell nice with pheromones. Just because you associate certain smells with good feelings doesn't mean that they are acting as pheromones. The reaction to different smells can be a subjective, trained thing. Your personal history can determine what smells evoke positive feelings versus negative ones. Moreover, your perception of a smell can be very context and circumstance dependent. Say you love the smell of bacon and naturally gravitate towards any restaurant that emits such aromas. That doesn't necessarily mean that you will be writing on your dating profile, 'Potential partners must smell like bacon.' So, how then have TikTokers been supporting their claims that vabbing is effective in attracting men? Well, much of their evidence has consisted of personal anecdotes, you know, stories most often about themselves. They've been essentially telling you that it's worked like a charm for them so it should work the same for you. But whenever someone, especially a completely stranger, tells you anything about themselves, how do you know whether there's even a dab or a vab of truth? Here's a news flash: people can lie or come up with 'alternative facts.' Unless you know these TikTokers personally or follow them around constantly even when they are off video, which would be kind of creepy, it's difficult to verify how accurate such stories may be. I've written about other TikTok trends where it's not clear whether the TikTokers are doing what they are actually claiming that they are doing like eating dirt. This doesn't necessarily mean that all TikTokers touting vabbing are lying. But how can you tell whether they actually attracted all the men that they claimed they attracted? Even if these TikTokers have been relaying their successes and conquests quite honestly, you can't really tell what details are being left out from their stories consciously or unconsciously. For example, did they happen to do something else differently at the same time that may have been what attracted the attention of men like change their hairstyle, alter their outfit or not wear any pants? Furthermore, there's the whole placebo effect or in this case maybe the vacebo effect. Believing that something works can change your mentality, attitude, confidence and other things in positive ways that end up making you more attractive to others. After all, you can be pretty darn confident that confidence in itself can be considered attractive. So, perhaps thinking, 'Yeah, I've got vaginal fluid on me so the world is my oyster' will give you enough confidence to get the deal done. Finally, there's the selection bias issues. People are probably a whole lot more likely to post 'success stories' rather than failures on TikTok. You may not get the same amount of attention and number of likes if you were to post, 'Dabbed some vaginal fluids on me. Went to the club. No one really paid attention to me. Took an Uber home. Watched Netflix by myself.' Therefore, what you see on social media may not be an accurate representation of the true win-loss percentage for vabbing. Therefore, the jury is still out on whether vabbing even works to attract anyone. Another question is whether there is any harm in trying vabbing. Well, while it may not be as risky as following social media trends such as dropping heavy objects on your feet, it is not completely without any risks. Keep in mind that your vagina is not a perfume bottle. Or any kind of bottle for that matter. It's important to be careful about what you put in there in more ways than one. A finger that's not been thoroughly cleaned before insertion could bring in some harmful microbes, leading to various infections that you don't want to have. Also, if you've got harmful microbes in your vagina already such as with a sexually transmitted infection, dabbing vaginal fluids elsewhere could potentially spread such infections to other parts of your body or other people. That's the risk of body fluids, any type of body fluid. It's also one of the reasons why you wouldn't want to hear 'Oh, that's just someone else's body fluids on it' at a restaurant or costume rental shop. Finally, it's not clear how a given guy will react to vabbing or even the idea of vabbing. It could be a turn on for some and the opposite for others. Many might fall somewhere in between. Regardless, vabbing in and of itself is probably not the magic potion that will get guys to fall for you. What will matter ultimately is what's inside you in a different way.
