Latest news with #KatharinePrice
Yahoo
10-03-2025
- Business
- Yahoo
PDS Biotechnology commences trial for head and neck squamous cell carcinoma
PDS Biotechnology has commenced the randomised, multi-centre Phase III clinical trial, VERSATILE-003, to assess the efficacy and safety of Versamune HPV plus pembrolizumab for head and neck squamous cell carcinoma (HNSCC). The combination therapy is intended for use as a first-line treatment of individuals with recurrent or metastatic HPV16-positive HNSCC. According to the company, the open-label, global and controlled trial is structured for enrolling nearly 350 subjects. They will be assigned to either the investigational arm or to a control arm, receiving only pembrolizumab at a 2:1 ratio. Overall survival is the primary endpoint, with secondary endpoints being progression-free survival, objective response rate, duration of response, and disease control rate. Mayo Clinic Comprehensive Cancer Center Oncology, Head and Neck Disease Group associate professor Katharine Price is set to oversee the trial as principal investigator. PDS Biotechnology CEO and president Frank Bedu-Addo said: 'We are thrilled to share that the first trial site has been initiated, and activation of additional clinical sites continues. 'Considering the strength and durability of the clinical responses in our VERSATILE-002 study, we are pleased to get this registrational trial underway. We are confident in the potential of our innovative combination therapy to improve patient outcomes and enhance the standard of care.' Versamune HPV is a subcutaneous immunotherapy that has demonstrated 'potential' in stimulating high levels of HPV16-specific cluster of differentiation 8 +(CD8+) and CD4+ T cells, activating several immune pathways. It received fast track designation from the US Food and Drug Administration (FDA). This status could result in a priority review for the biologics license application (BLA) when submitted. This decision by the US regulator is supported by data from the multicentre VERSATILE-002 Phase II trial. The company is advancing its lead programme in advanced HPV16-positive head and neck squamous cell cancers with the pivotal trial. PDS stated that Versamune HPV is being developed not only in conjunction with a standard-of-care immune checkpoint inhibitor, but also in a triple combo therapy that includes the Interleukin-12 (IL-12) IL-12 fused antibody-drug conjugate (ADC), PDS01ADC, and a standard-of-care immune checkpoint inhibitor. "PDS Biotechnology commences trial for head and neck squamous cell carcinoma" was originally created and published by Clinical Trials Arena, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site.
Web Release
14-02-2025
- Health
- Web Release
3 ways to prevent head and neck cancer
By Editor_wr Last updated Feb 13, 2025 Throat cancer is one of the fastest-growing cancers, and it is often linked to human papillomavirus (HPV). Oropharyngeal cancer, or throat cancer, is a type of head and neck cancer that can be divided into two subgroups: HPV-associated cancers and non-HPV-associated cancers. And depending on the type of subgroup, they are treated differently. Katharine Price, M.D., a medical oncologist with the Mayo Clinic Comprehensive Cancer Center in Rochester, says there are three ways to reduce your risks and help prevent head and neck cancer. Tobacco and alcohol use increase the risk of non-HPV tumors, while HPV is responsible for about 70% of head and neck cancers. 'What's important about that is they have different biology and are much more treatable, meaning they respond better to treatments and tend to have a higher cure rate. We're sort of treating those differently than how we treat some of the non-HPV cancers,' Dr. Price says. Surgery, radiation and chemotherapy are all treatment options, but Dr. Price says it is better to reduce the risks of infection. 'The big three: no smoking tobacco use, minimizing alcohol and then HPV vaccination,' she says. 'We know that smoking and alcohol are big risk factors for head and neck cancer if you do both. This increases your risk even more,' Dr. Price says. And she encourages eating a healthy diet. 'We really should be striving to have a good whole-food diet, trying to minimize eating processed foods and refined sugars,' Dr. Price says. 3 ways to prevent head and neck cancer Prev Post Newcop Opens its First Store in Dubai with Exclusive Kicks Comments are closed.
Zawya
13-02-2025
- Health
- Zawya
3 ways to prevent head and neck cancer
DUBAI, United Arab Emirates — Throat cancer is one of the fastest-growing cancers, and it is often linked to human papillomavirus (HPV). Oropharyngeal cancer, or throat cancer, is a type of head and neck cancer that can be divided into two subgroups: HPV-associated cancers and non-HPV-associated cancers. And depending on the type of subgroup, they are treated differently. Katharine Price, M.D., a medical oncologist with the Mayo Clinic Comprehensive Cancer Center in Rochester, says there are three ways to reduce your risks and help prevent head and neck cancer. Tobacco and alcohol use increase the risk of non-HPV tumors, while HPV is responsible for about 70% of head and neck cancers. "What's important about that is they have different biology and are much more treatable, meaning they respond better to treatments and tend to have a higher cure rate. We're sort of treating those differently than how we treat some of the non-HPV cancers," Dr. Price says. Surgery, radiation and chemotherapy are all treatment options, but Dr. Price says it is better to reduce the risks of infection. "The big three: no smoking tobacco use, minimizing alcohol and then HPV vaccination," she says. "We know that smoking and alcohol are big risk factors for head and neck cancer if you do both. This increases your risk even more," Dr. Price says. And she encourages eating a healthy diet. "We really should be striving to have a good whole-food diet, trying to minimize eating processed foods and refined sugars," Dr. Price says. About Mayo Clinic Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Visit the Mayo Clinic News Network for additional Mayo Clinic news.
