Latest news with #LEGEND
Yahoo
2 days ago
- Business
- Yahoo
enGene Announces the Resignation of its Chief Medical Officer
BOSTON & MONTREAL, June 04, 2025--(BUSINESS WIRE)--enGene Holdings Inc. (Nasdaq: ENGN or "enGene" or the "Company"), a clinical-stage, non-viral genetic medicines company, announced today that Dr. Raj Pruthi resigned from his role as Chief Medical Officer on June 3, 2025. Dr. Pruthi's resignation as Chief Medical Officer will take effect on June 16, 2025. He will be supporting the organization to ensure an orderly transition of his responsibilities before he departs. The Company intends to reallocate Dr. Pruthi's responsibilities to the Company's other urology and clinical experts. The Company thanks Dr. Pruthi for his dedication and service and wishes him the best in his future endeavors. About enGene enGene is a clinical-stage biotechnology company mainstreaming genetic medicines through the delivery of therapeutics to mucosal tissues and other organs, with the goal of creating new ways to address diseases with high clinical needs. enGene's lead program is detalimogene voraplasmid (also known as detalimogene, and previously EG-70) for patients with Non-Muscle Invasive Bladder Cancer (NMIBC), a disease with a high clinical burden. Detalimogene is being evaluated in the ongoing multi-cohort LEGEND Phase 2 study, which includes a pivotal cohort studying detalimogene in Bacillus Calmette-Guérin (BCG)-unresponsive patients with carcinoma in situ (CIS). Detalimogene was developed using enGene's proprietary Dually Derivatized Oligochitosan (DDX) platform, which enables penetration of mucosal tissues and delivery of a wide range of sizes and types of cargo, including DNA and various forms of RNA. To learn more, please visit and follow us on LinkedIn, X and BlueSky. Forward-Looking Statements Certain statements contained in this press release may constitute "forward-looking statements" within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, and "forward-looking information" within the meaning of Canadian securities laws (collectively, "forward-looking statements"). enGene's forward-looking statements include, but are not limited to, statements regarding enGene's management teams' expectations, hopes, beliefs, intentions, goals, or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words "anticipate", "appear", "approximate", "believe", "continue", "could", "estimate", "expect", "foresee", "intends", "may", "might", "plan", "possible", "potential", "predict", "project", "seek", "should", "would", and similar expressions (or the negative version of such words or expressions) may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements may include, for example, statements about the transition of the responsibilities of the chief medical officer. Many factors, risks, uncertainties and assumptions could cause the Company's actual results, performance or achievements to differ materially from those expressed or implied by the forward-looking statements, including, without limitation, the Company's ability to recruit and retain qualified scientific and management personnel, establish clinical trial sites and enroll patients in its clinical trials, execute on the Company's clinical development plans and ability to secure regulatory approval on anticipated timelines, and other risks and uncertainties detailed in filings with Canadian securities regulators on SEDAR+ and with the U.S. Securities and Exchange Commission ("SEC") on EDGAR, including those described in the "Risk Factors" section of the Company's Annual Report on Form 10-K for the fiscal year ended October 31, 2024 (copies of which may be obtained at or You should not place undue reliance on any forward-looking statements, which speak only as of the date on which they are made. enGene anticipates that subsequent events and developments will cause enGene's assessments to change. While enGene may elect to update these forward-looking statements at some point in the future, enGene specifically disclaims any obligation to do so, unless required by applicable law. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. View source version on Contacts For media contact:media@ For investor contact:investors@ Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Business Wire
2 days ago
- Business
- Business Wire
enGene Announces the Resignation of its Chief Medical Officer
BOSTON & MONTREAL--(BUSINESS WIRE)--enGene Holdings Inc. (Nasdaq: ENGN or 'enGene' or the 'Company'), a clinical-stage, non-viral genetic medicines company, announced today that Dr. Raj Pruthi resigned from his role as Chief Medical Officer on June 3, 2025. Dr. Pruthi's resignation as Chief Medical Officer will take effect on June 16, 2025. He will be supporting the organization to ensure an orderly transition of his responsibilities before he departs. The Company intends to reallocate Dr. Pruthi's responsibilities to the Company's other urology and clinical experts. The Company thanks Dr. Pruthi for his dedication and service and wishes him the best in his future endeavors. About enGene enGene is a clinical-stage biotechnology company mainstreaming genetic medicines through the delivery of therapeutics to mucosal tissues and other organs, with the goal of creating new ways to address diseases with high clinical needs. enGene's lead program is detalimogene voraplasmid (also known as detalimogene, and previously EG-70) for patients with Non-Muscle Invasive Bladder Cancer (NMIBC), a disease with a high clinical burden. Detalimogene is being evaluated in the ongoing multi-cohort LEGEND Phase 2 study, which includes a pivotal cohort studying detalimogene in Bacillus Calmette-Guérin (BCG)-unresponsive patients with carcinoma in situ (CIS). Detalimogene was developed using enGene's proprietary Dually Derivatized Oligochitosan (DDX) platform, which enables penetration of mucosal tissues and delivery of a wide range of sizes and types of cargo, including DNA and various forms of RNA. To learn more, please visit and follow us on LinkedIn, X and BlueSky. Forward-Looking Statements Certain statements contained in this press release may constitute 'forward-looking statements' within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, and 'forward-looking information' within the meaning of Canadian securities laws (collectively, 'forward-looking statements'). enGene's forward-looking statements include, but are not limited to, statements regarding enGene's management teams' expectations, hopes, beliefs, intentions, goals, or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words 'anticipate', 'appear', 'approximate', 'believe', 'continue', 'could', 'estimate', 'expect', 'foresee', 'intends', 'may', 'might', 'plan', 'possible', 'potential', 'predict', 'project', 'seek', 'should', 'would', and similar expressions (or the negative version of such words or expressions) may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements may include, for example, statements about the transition of the responsibilities of the chief medical officer. Many factors, risks, uncertainties and assumptions could cause the Company's actual results, performance or achievements to differ materially from those expressed or implied by the forward-looking statements, including, without limitation, the Company's ability to recruit and retain qualified scientific and management personnel, establish clinical trial sites and enroll patients in its clinical trials, execute on the Company's clinical development plans and ability to secure regulatory approval on anticipated timelines, and other risks and uncertainties detailed in filings with Canadian securities regulators on SEDAR+ and with the U.S. Securities and Exchange Commission ('SEC') on EDGAR, including those described in the 'Risk Factors' section of the Company's Annual Report on Form 10-K for the fiscal year ended October 31, 2024 (copies of which may be obtained at or You should not place undue reliance on any forward-looking statements, which speak only as of the date on which they are made. enGene anticipates that subsequent events and developments will cause enGene's assessments to change. While enGene may elect to update these forward-looking statements at some point in the future, enGene specifically disclaims any obligation to do so, unless required by applicable law. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved.
Yahoo
13-05-2025
- Entertainment
- Yahoo
Blake Shelton, Kelly Clarkson, Alicia Keys set to return to ‘The Voice'
Music superstars Blake Shelton, Kelly Clarkson, and Alicia Keys are returning to The Voice. No, the iconic trio of coaches aren't taking back their big red chairs (at least yet), but they will appear on the Season 27 finale on May 20 (9 p.m. ET/PT). More from GoldDerby 'The Masked Singer' is skipping the fall season 'to regroup' 'The Voice' sets Season 28 coaches as it shifts to a truncated schedule in the fall Breanna Nix is the last woman standing on 'American Idol' after the eliminations of Gabby Samone, Mattie Pruitt Shelton, Clarkson, and Keys are among the all-star lineup of performers scheduled to take the stage, including former coach Chance The Rapper and Season 22 champ Bryce Leatherwood. See the complete list below. Alicia Keys featuring Amanda Reid from Broadway's Hell's Kitchen: Television debut performance of 'The River/'Empire State of Mind' Blake Shelton, returning for the first time since his final season in Spring 2023: 'Texas,' from new album For Recreational Use Only, which marks his 30th career No. 1 country radio single Chance the Rapper: 'Space and Time,' the latest song from the Grammy Award-winning artist's project, 'Star Line' Foreigner: A medley of their greatest hits 'Feels Like the First Time,' 'Juke Box Hero' and 'I Want to Know What Love Is' James Bay featuring Sheryl Crow: Debut television performance of 'You and Me Time,' the first collaboration between the multiplatinum singer, songwriter and guitarist and the nine-time Grammy Award-winning icon Joe Jonas: New single 'Heart by Heart' from the global superstar's forthcoming solo album, Music for People Who Believe in Love, arriving May 23. Kelly Clarkson: New song 'Where Have You Been' Season 22 winner Bryce Leatherwood: 'God Made' from his self-titled, debut album set for release on May 16 Current coaches Kelsea Ballerini, Michael Bublé, John Legend, and Adam Levine will also perform special duets with their final artists before host Carson Daly announces the Season 27 winner. Season 27 live shows kick off May 12, airing Mondays (8 p.m. ET/PT) and Tuesdays (9 p.m. ET/PT). The updated teams are: TEAM LEGEND — Bryson Battle, Renzo TEAM BUBLÉ — Adam David, Jadyn Cree TEAM KELSEA — Alanna Lynise, Iris Herrera TEAM ADAM — Kolby Cordell, Lucia Flores-Wiseman In addition to these eight, each coach is allowed to bring back one previously eliminated contestant to complete the Top 12. SIGN UP for Gold Derby's free newsletter with latest predictions Best of GoldDerby 'The Masked Singer' spoilers: Who is Boogie Woogie? 'RuPaul's Drag Race' winners list: Every season, plus 'All Stars' Vote for 'Survivor 50': The 3 new questions center around design, survival, and strategy Click here to read the full article.
Yahoo
06-05-2025
- Automotive
- Yahoo
NASCAR Texas results: Joey Logano is winner, plus full leaderboard
The checkered flag is out for the NASCAR Cup Series Texas race. Joey Logano won the WURTH 400 on May 4 at Texas Motor Speedway after starting 27th following his disqualification penalty in the last race at Talladega. This is the 37th win of Logano's NASCAR Cup Series career. Advertisement Austin Cindric won the opening stage of the race for his first career stage win at Texas. Kyle Larson won the second stage. The race had 12 cautions and 20 lead changes. Here are the results from the NASCAR Texas race. LEGEND OF L.W. WRIGHT PART 2: The long Talladega con: Could L.W. Wright drive as fast as he could talk? L.W. WRIGHT PART 1: The long Talladega con: How L.W. Wright talked his way onto NASCAR's fastest track Who won NASCAR Texas race? Winner, race results for WURTH 400 Cup Series race The unofficial full running order, results from NASCAR Cup Series WURTH 400 at Texas Motor Speedway. Advertisement Joey Logano, No. 22 Team Penske Ford Ross Chastain, No. 1 Trackhouse Racing Chevrolet Ryan Blaney, No. 12 Team Penske Ford Kyle Larson, No. 5 Hendrick Motorsports Chevrolet Erik Jones, No. 43 Legacy Motor Club Toyota Ricky Stenhouse Jr., No. 47 HYAK Motorsports Chevrolet Austin Dillon, No. 3 Richard Childress Racing Chevrolet John Hunter Nemechek, No. 42 Legacy Motor Club Toyota Christopher Bell, No. 20 Joe Gibbs Racing Toyota Daniel Suarez, No. 99 Trackhouse Racing Chevrolet Todd Gilliland, No. 34 Front Row Motorsports Ford Ty Dillon, No. 10 Kaulig Racing Chevrolet William Byron, No. 24 Hendrick Motorsports Chevrolet Riley Herbst, No. 35 23XI Racing Toyota Justin Haley, No. 7 Spire Motorsports Chevrolet Chase Elliott, No. 9 Hendrick Motorsports Chevrolet Zane Smith, No. 38 Front Row Motorsports Ford Chris Buescher, No. 17 RFK Racing Ford Cole Custer, No. 41 Haas Factory Team Ford Kyle Busch, No. 8 Richard Childress Racing Chevrolet Tyler Reddick, No. 45 23XI Racing Ford Shane van Gisbergen, No. 88 Trackhouse Racing Chevrolet Ty Gibbs, No. 54 Joe Gibbs Racing Toyota Carson Hocevar, No. 77 Spire Motorsports Chevrolet Austin Cindric, No. 2 Team Penske Ford Michael McDowell, No. 71 Front Row Motorsports Ford Chase Briscoe, No. 19 Joe Gibbs Racing Toyota Brad Keselowski, No. 6 RFK Racing Ford Ryan Preece, No. 60 RFK Racing Ford Cody Ware, No. 51 Rick Ware Racing Ford Jesse Love, No. 62 Beard Motorsports Chevrolet Josh Berry, No. 21 Wood Brothers Racing Ford Bubba Wallace, No. 23 23XI Racing Toyota Noah Gragson, No. 4 Front Row Motorsports Ford Alex Bowman, No. 48 Hendrick Motorsports Chevrolet AJ Allmendinger, No. 16 Kaulig Racing Chevrolet Chad Finchum, No. 66 Garage 66 Ford Denny Hamlin, No. 11 Joe Gibbs Racing Toyota This article originally appeared on Nashville Tennessean: NASCAR Texas results: Joey Logano is winner Sunday
The Guardian
05-05-2025
- Politics
- The Guardian
Ex-French interior minister apologises to Liverpool fans for using them as a ‘scapegoat'
The former French interior minister has apologised to Liverpool fans for using them as a 'scapegoat' for the chaos surrounding the 2022 Champions League final in Paris, where supporters of the club, including children, were teargassed by police amid false claims they had caused a riot. Gérald Darmanin, who is now France's justice minister, called the night 'the biggest failure' of his career. On 28 May 2022, Liverpool supporters said they feared for their lives as they were forced to enter Stade de France via a narrow subway and boxed-in lanes that could not accommodate the thousands of people that had arrived. This led to severe overcrowding which a French senate report later said posed 'a risk of crushing'. Security and ticket checks were abandoned. This led to people without tickets, including some local young men who attacked Liverpool fans, to gain entry into the stadium. Shortly before kick-off, the turnstiles were closed, leaving many fans with tickets unable to get inside the stadium. As more people arrived, police used pepper spray and teargas on the crowd. After the match, Liverpool supporters complained of being robbed by local gangs and said police had offered no protection. The French government, police and Uefa placed the blame on Liverpool supporters, claiming that the chaos was caused by thousands seeking entry with fake tickets. Darmanin apologised to Liverpool fans for the first time on Monday. Speaking to the LEGEND YouTube channel, he said: 'It was a failure because I had not foreseen. That was a mistake on my part. I was led astray by my preconceptions. 'The scapegoat was easy to find, and I apologise now to Liverpool supporters. They were quite right to be hurt. It was a mistake and a failure.' After the match, Darmanin made a statement saying the chaos had been caused by '30,000-40,000 Liverpool fans' with forged or no tickets and alleged there had been an 'industrial scale' ticket fraud. Ian Byrne, the MP for Liverpool West Derby, told the Guardian: 'Darmanin's conduct after Paris was unforgivable and I questioned his fitness in being a minister responsible for justice at the time. 'He repeated all the lies about hooliganism, fake tickets to frame the blame on the Liverpool supporters who were once again victims of a state cover-up. It was only because of the collective fightback of Liverpool supporters and fine journalism that prevented the narrative Darmanin was spinning gaining traction. 'The partial apology will be noted by Liverpool supporters but Darmanin's actions will not be forgiven or forgotten.' A month after the game, Darmanin, apologised to 'everyone who suffered from bad management' but stopped short of saying sorry to the Liverpool fans. 'Should the Stade de France have been better managed? The answer is yes,' he told the French radio station RTL at the time. 'Am I partly responsible? The answer is yes. Of course, I readily apologise towards everyone who suffered from this bad management of the event.' A Guardian investigation in the aftermath of the game detailed the near disaster Liverpool fans faced, including reporting that children were among those pepper sprayed unprovoked by police. In March, a judge ruled that Liverpool fans affected by the game had the right to have their personal injury claims heard in the UK after an attempt by European football's governing body to block it.
