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Yahoo
01-05-2025
- Health
- Yahoo
Here's why belly fat is more common as we age, and 3 ways to prevent it
More people are focused on staying healthy and fit as they grow older — but it's true that it can become more challenging with age. New research has revealed that cellular changes during the aging process can cause belly fat — and that's exacerbated by stress and sleep issues that contribute to weight gain. "People often lose muscle and gain body fat as they age — even when their body weight remains the same," study author Qiong (Annabel) Wang, Ph.D., an assistant professor in the Department of Molecular & Cellular Endocrinology at City of Hope, said in a press release. 'Oatzempic' Diet Drink For Weight Loss: Does It Work And Is It Safe? Published in the journal Science, the preclinical research involved experiments on mice that were later confirmed with human cells. Researchers focused on a group of stem cells called adipocyte progenitor cells (APCs) within the fatty tissue responsible for age-related weight gain. Read On The Fox News App When they transplanted these cells from mice of various ages into another group of younger mice, they noticed the creation of large numbers of fat cells within the younger mice. Men Face Higher Cancer Risk With This Specific Body Fat Measurement However, when they transplanted a batch of cells from young mice into old mice, they did not see the same effect. The results confirmed that older stem cells are more likely to lead to new fat cells, regardless of the age of the host receiving them, the press release noted. "While most adult stem cells' capacity to grow wanes with age, the opposite holds true with APCs — aging unlocks these cells' power to evolve and spread," said Adolfo Garcia-Ocana, chair of the Department of Molecular & Cellular Endocrinology at City of Hope, in the press release. Aging also changes these APCs into yet another group of cells called committed preadipocytes, age-specific (CP-As), which actively churn out new fat cells. Fake Ozempic Drugs Found In Us Drug Supply, Fda Warns Humans have a "signaling pathway" — a chemical reaction that controls how the body makes cells — called the leukemia inhibitory factor receptor (LIFR), experts said. "Our research indicates that LIFR plays a crucial role in triggering CP-As to create new fat cells and expand belly fat in older mice," Wang said in the same release. Despite the effects of aging, there are steps people can take to prevent expanding waistlines, according to Dr. Sajad Zalzala, co-founder and chief medical officer of AgelessRx in Detroit, Michigan. "As we age, our ability to maintain lean muscle mass decreases, which contributes to metabolic slowdown and increased fat storage, particularly around the abdomen," Zalzala, who was not involved in the City of Hope study, told Fox News Digital. He recommends starting the day with 20 to 30 grams of protein, which can be found in foods like Greek yogurt, protein shakes and eggs. Eating protein at the beginning of the day keeps you full longer, stabilizes blood sugar and encourages muscle maintenance, according to the doctor. "Chronically high cortisol levels, which can be driven by poor sleep or stress, promote fat storage, especially around the waist," Zalzala noted. People should aim for seven to nine hours of quality sleep per night, according to experts. For more Health articles, visit Zalzala also recommends stress-reduction strategies like walking, mindfulness and breathwork, calling them "powerful tools for fat regulation and metabolic health." "The study reminds us that aging adipose tissue behaves differently — it's more inflammatory and prone to dysfunction," said Zalzala. Click Here To Sign Up For Our Health Newsletter "Minimizing added sugars and highly processed carbs (white bread, pastries, sugary drinks) reduces insulin resistance and fat accumulation, particularly visceral fat that sits deep in the belly."Original article source: Here's why belly fat is more common as we age, and 3 ways to prevent it
Fox News
01-05-2025
- Health
- Fox News
Here's why belly fat is more common as we age, and 3 ways to prevent it
More people are focused on staying healthy and fit as they grow older — but it's true that it can become more challenging with age. New research has revealed that cellular changes during the aging process can cause belly fat — and that's exacerbated by stress and sleep issues that contribute to weight gain. "People often lose muscle and gain body fat as they age — even when their body weight remains the same," study author Qiong (Annabel) Wang, Ph.D., an assistant professor in the Department of Molecular & Cellular Endocrinology at City of Hope, said in a press release. Published in the journal Science, the preclinical research involved experiments on mice that were later confirmed with human cells. Researchers focused on a group of stem cells called adipocyte progenitor cells (APCs) within the fatty tissue responsible for age-related weight gain. When they transplanted these cells from mice of various ages into another group of younger mice, they noticed the creation of large numbers of fat cells within the younger mice. However, when they transplanted a batch of cells from young mice into old mice, they did not see the same effect. The results confirmed that older stem cells are more likely to lead to new fat cells, regardless of the age of the host receiving them, the press release noted. "While most adult stem cells' capacity to grow wanes with age, the opposite holds true with APCs — aging unlocks these cells' power to evolve and spread," said Adolfo Garcia-Ocana, chair of the Department of Molecular & Cellular Endocrinology at City of Hope, in the press release. Aging also changes these APCs into yet another group of cells called committed preadipocytes, age-specific (CP-As), which actively churn out new fat cells. Humans have a "signaling pathway" — a chemical reaction that controls how the body makes cells — called the leukemia inhibitory factor receptor (LIFR), experts said. "Our research indicates that LIFR plays a crucial role in triggering CP-As to create new fat cells and expand belly fat in older mice," Wang said in the same release. Despite the effects of aging, there are steps people can take to prevent expanding waistlines, according to Dr. Sajad Zalzala, co-founder and chief medical officer of AgelessRx in Detroit, Michigan. "As we age, our ability to maintain lean muscle mass decreases, which contributes to metabolic slowdown and increased fat storage, particularly around the abdomen," Zalzala, who was not involved in the City of Hope study, told Fox News Digital. He recommends starting the day with 20 to 30 grams of protein, which can be found in foods like Greek yogurt, protein shakes and eggs. Eating protein at the beginning of the day keeps you full longer, stabilizes blood sugar and encourages muscle maintenance, according to the doctor. "Chronically high cortisol levels, which can be driven by poor sleep or stress, promote fat storage, especially around the waist," Zalzala noted. People should aim for seven to nine hours of quality sleep per night, according to experts. Zalzala also recommends stress-reduction strategies like walking, mindfulness and breathwork, calling them "powerful tools for fat regulation and metabolic health." "The study reminds us that aging adipose tissue behaves differently — it's more inflammatory and prone to dysfunction," said Zalzala. "Minimizing added sugars and highly processed carbs (white bread, pastries, sugary drinks) reduces insulin resistance and fat accumulation, particularly visceral fat that sits deep in the belly."
Yahoo
01-05-2025
- Health
- Yahoo
Aging Switches on Stem Cells That Drive Belly Fat Growth
Aging appears to unlock adult stem cells programmed to create more problematic belly fat cells, new research in mice and human tissues reveals. "This is the first evidence that our bellies expand with age due to the stem cell's high output of new fat cells," says City of Hope endocrinologist Adolfo Garcia-Ocana. These age-specific stem cells, called committed preadipocytes (CP-As), are found in white fat tissue, which is known to increase in humans during age-related weight gain. "People often lose muscle and gain body fat as they age – even when their body weight remains the same," explains endocrinologist Qiong (Annabel) Wang from the Arthur Riggs Diabetes and Metabolism Research Institute. "We discovered aging triggers the arrival of a new type of adult stem cell and enhances the body's massive production of new fat cells, especially around the belly." This can occur even without changes in diet and exercise. When researchers transplanted stem cells from the white fat tissue in younger male mice to older male mice, they didn't produce fat cells. This means that something during the aging process is responsible for the change in how these cells proliferate, rather than the environment they're currently in. "While most adult stem cells' capacity to grow wanes with age, the opposite holds true [here] – aging unlocks these cells' power to evolve and spread," says Garcia-Ocana. The team suggests this switch to greater fat production may be due to cell aging or immune dysregulation. More immune cells accumulate in white fat tissue with age. RNA analysis identified changes between the young and old mouse stem cells, including one of the specific signaling pathways (leukemia inhibitory factor receptor, or LIFR) involved in telling these specific stem cells to make more fat. This might be a useful target for developing interventions. Taking samples from five humans of different ages (with only one female donor), the team found the same stem cells were more active in older humans as well as in mice. A larger sample size with more female donors is required to confirm this trend is universal, the researchers caution. Meanwhile, the best way to keep on top of these age-related changes is to increase your movement. "Understanding the role of CP-As in metabolic disorders and how these cells emerge during aging could lead to new medical solutions for reducing belly fat and improving health and longevity," concludes Wang. This research was published in Science. Fasting-Style Diet Seems to Result in Dynamic Changes in Human Brains Which Arm Gets Vaccinated Could Play a Role in Your Immune Response Brisk Walking Could Lower Your Risk of Heart Rhythm Abnormalities
Gulf News
27-04-2025
- Health
- Gulf News
Scientists find cellular culprit behind age-related abdominal fat
New York: A team of US researchers has uncovered the cellular culprit behind age-related abdominal fat, providing new insights into why our midsections widen with middle age. "People often lose muscle and gain body fat as they age — even when their body weight remains the same,' said Qiong (Annabel) Wang, an associate professor of molecular and cellular endocrinology at City of Hope's Arthur Riggs Diabetes and Metabolism Research Institute. 'We discovered aging triggers the arrival of a new type of adult stem cell and enhances the body's massive production of new fat cells, especially around the belly,' Wang added. In collaboration with the UCLA laboratory co-corresponding author Xia Yang, the scientists conducted a series of mouse experiments later validated on human cells. Wang and her colleagues focused on white adipose tissue (WAT), the fatty tissue responsible for age-related weight gain. While it's well-known that fat cells grow larger with age, the scientists suspected that WAT also expanded by producing new fat cells, meaning it may have an unlimited potential to grow. To test their hypothesis, the researchers focused on adipocyte progenitor cells (APCs), a group of stem cells in WAT that evolve into fat cells. The team first transplanted APCs from young and older mice into a second group of young mice. The APCs from the older animals rapidly generated a colossal amount of fat cells. When the team transplanted APCs from young mice into the older mice, however, the stem cells did not manufacture many new fat cells. The results confirmed that older APCs are equipped to independently make new fat cells, regardless of their host's age. Using single-cell RNA sequencing, the scientists next compared APC gene activity in young and older mice. While barely active in young mice, APCs woke up with a vengeance in middle-aged mice and began pumping out new fat cells. A signalling pathway called leukemia inhibitory factor receptor (LIFR) proved critical for promoting these CP-A cells to multiply and evolve into fat cells. 'We discovered that the body's fat-making process is driven by LIFR. While young mice don't require this signal to make fat, older mice do,' explained Wang. 'Our research indicates that LIFR plays a crucial role in triggering CP-As to create new fat cells and expand belly fat in older mice.'
