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Time Business News
2 days ago
- Health
- Time Business News
Pregabalin 150mg for Post-Herpetic Neuralgia: Fast Relief?
Post-herpetic neuralgia (PHN) is one of the most common and challenging complications of shingles, affecting the nerves and causing persistent pain that can last for months or even years. Patients with PHN often struggle to find effective and sustainable relief. One medication that has gained attention in this domain is Pregabalin 150mg, known for its nerve-calming properties and effectiveness in chronic neuropathic pain. But how fast does it work? And is it truly a reliable solution? In this article, we explore the role of Pregabalin 150mg in managing post-herpetic neuralgia, its mechanism of action, how quickly it provides relief, and what patients can realistically expect. Understanding Post-Herpetic Neuralgia Post-herpetic neuralgia is nerve pain that persists after a shingles infection (herpes zoster) has healed. It typically affects older adults and results from nerve damage caused by the varicella-zoster virus. Symptoms include: Burning, stabbing, or aching pain in the area where shingles occurred Heightened skin sensitivity Pain lasting more than three months after the rash clears Sleep disturbances and emotional distress The intensity and duration of PHN pain can vary greatly between individuals, making personalized treatment crucial. What is Pregabalin 150mg? Pregabalin 150mg, sold under brand names like Lyrica, is an anticonvulsant and anxiolytic medication that is FDA-approved for treating neuropathic pain, including post-herpetic neuralgia. It belongs to a class of drugs known as gabapentinoids, which modulate nerve activity. The 150mg dose is considered a mid-range starting or maintenance dose in PHN treatment and can be adjusted based on response and tolerance. How Does Pregabalin Work for PHN? Pregabalin doesn't work by blocking pain signals directly like opioids or NSAIDs. Instead, it binds to the alpha-2-delta subunit of voltage-gated calcium channels in overexcited nerves. This reduces the release of neurotransmitters such as glutamate, norepinephrine, and substance P, all of which are associated with pain transmission and nerve sensitization. This calms the overactive nerves, reducing the abnormal firing that contributes to the burning and tingling sensations in PHN. How Fast Does Pregabalin 150mg Work for PHN? This is the key question for most patients suffering from PHN. The onset of relief depends on several factors, including the individual's pain intensity, how long they've had PHN, and their sensitivity to medications. Timeline of Effects: Initial Response : Some patients begin noticing relief within 3 to 5 days , especially improved sleep due to reduced nighttime pain. : Some patients begin noticing relief , especially improved sleep due to reduced nighttime pain. Peak Relief : Most patients experience significant improvement within 2 to 4 weeks at the 150mg dose. : Most patients experience at the 150mg dose. Full Effectiveness: It may take up to 6 to 8 weeks for the full benefits, especially in long-standing or severe PHN cases. If relief is insufficient, the dose may be increased to 300mg per day under medical supervision. Clinical Evidence Supporting Pregabalin for PHN Multiple clinical studies have confirmed Pregabalin's effectiveness in reducing PHN pain: A randomized controlled trial published in Neurology found that patients on Pregabalin 150–600mg/day had significantly lower pain scores and better sleep quality compared to placebo. found that had significantly lower pain scores and better sleep quality compared to placebo. In another meta-analysis of over 1000 patients, Pregabalin showed substantial relief within 2 weeks, particularly in patients with moderate to severe pain. These findings reinforce its role as a first-line treatment in neuropathic pain management. Advantages of Pregabalin 150mg for PHN ✅ Targeted Nerve Pain Relief Pregabalin targets nerve-related pain specifically, which is crucial for conditions like PHN where traditional painkillers may not work. ✅ Improved Sleep Quality PHN pain often flares up at night. Pregabalin helps improve sleep by calming nerve activity and reducing nighttime pain. ✅ Better Quality of Life Reduction in pain leads to better mood, fewer depressive symptoms, and improved physical activity levels. ✅ Fewer Gastrointestinal Side Effects Compared to NSAIDs and opioids, Pregabalin does not cause stomach ulcers or constipation. Potential Side Effects of Pregabalin 150mg While effective, Pregabalin is not without side effects, particularly in elderly patients. Common side effects include: Dizziness or drowsiness Blurred vision Weight gain Dry mouth Swelling in hands or feet Serious but rare effects: Suicidal thoughts Severe allergic reactions Mood changes Starting with a low dose and gradually increasing to 150mg can minimize side effects. Who Should Not Take Pregabalin? Not everyone is an ideal candidate for Pregabalin. Caution is advised in: Elderly patients with balance issues (due to risk of falls) with balance issues (due to risk of falls) Patients with kidney disease (Pregabalin is renally excreted) (Pregabalin is renally excreted) People with a history of substance misuse Those who drive or operate machinery until they know how it affects them Always consult a healthcare provider before starting Pregabalin. Pregabalin 150mg: Dosage & Administration for PHN Starting Dose : Often 75mg twice daily or 150mg once at night : Often 75mg twice daily or 150mg once at night Maintenance : 150–300mg/day in divided doses : 150–300mg/day in divided doses Maximum Dose: 600mg/day (usually reserved for severe or unresponsive cases) Food doesn't affect its absorption, so it can be taken with or without meals. Patient Tips for Best Results Take consistently at the same time daily at the same time daily Do not stop suddenly – taper down gradually to avoid withdrawal – taper down gradually to avoid withdrawal Track pain levels – use a journal to monitor response – use a journal to monitor response Report side effects – dizziness and swelling should be noted – dizziness and swelling should be noted Combine with lifestyle support – gentle exercise, meditation, and physical therapy can boost recovery What to Expect After Starting Pregabalin 150mg Week Expected Outcome Week 1 Mild pain reduction, better sleep, possible dizziness Week 2 Noticeable drop in burning/stabbing sensations Maximum effect, pain is significantly more manageable Steady relief, improved daytime function Week 6+ Maximum effect, pain significantly more manageable Note: If no benefit is seen by Week 4, dosage adjustment or medication change may be necessary. Is Pregabalin 150mg a Long-Term Solution? For many patients, yes. Some continue taking it for months or even years under medical supervision if PHN is persistent. Others taper off as the nerve heals. However, long-term use requires regular monitoring, especially in elderly patients, to prevent dependence or tolerance. Conclusion: Is Pregabalin 150mg the Answer for PHN? When used under proper medical guidance and combined with supportive therapies, Pregabalin 150mg can significantly improve the lives of those suffering from PHN. It might not cure the condition, but for many, it restores comfort, mobility, and peace of mind. FAQs Q: Is Pregabalin 150mg addictive? A: While not highly addictive, it can cause dependence if misused or taken long-term without supervision. Q: Can I take Pregabalin with other medications for PHN? A: Yes, but always check for interactions. Tricyclic antidepressants and topical lidocaine are sometimes used together with Pregabalin. Q: Can Pregabalin cure PHN? A: No, it manages symptoms. The goal is to reduce pain while the nerve heals naturally over time. Q: What if 150mg doesn't work? A: Your doctor may increase the dose or combine it with another therapy. TIME BUSINESS NEWS
Arab Times
18-07-2025
- Arab Times
Kuwait Cracks Down Hard: 31 Arrested in Drug Raids
KUWAIT CITY, July 18: In a major blow to drug traffickers, the General Department for Combating Narcotics, operating under the Criminal Security Sector, has intensified its security campaigns across various regions in the country, leading to the arrest of 31 individuals. The detainees include Kuwaiti citizens, residents from Arab and Asian communities, and stateless individuals. During the raids, authorities confiscated a substantial quantity of illegal drugs and weapons, including: Approximately 7.1 kilograms of hashish Around 5.35 kilograms of shabu (methamphetamine) Nearly 3.8 kilograms of marijuana About 2.1 kilograms of heroin 570 grams of chemical substances 273 grams of cocaine 250 grams of Lyrica powder 500 ml of cannabinoid oil 25,000 Lyrica capsules 2,000 psychotropic pills 17 electronic scales and empty pouches 8 firearms and ammunition All suspects and seized materials have been referred to the competent Drugs and Alcohol Prosecution for necessary legal action. The Ministry of Interior, through the General Department for Drug Control, reaffirmed its commitment to combating drug-related crimes. It emphasized the continuation of security campaigns aimed at protecting the country and its people from the destructive impact of narcotics.
Arab Times
02-06-2025
- Arab Times
Ten Arrested in Kuwait, Large Quantities of Narcotics Seized in Security Raid
KUWAIT CITY, June 2: The Ministry of Interior announced on Monday the detention of ten persons on charges of dealing with narcotics and psychotropic drugs in a chain of well-planned raids. The MoI security information department said in a statement that the suspects were apprehended during security operations in Al-Gurain, Wafra, Andalos, Saad Al-Abdullah City, Khairan, and Sabah Al-Salem districts. The engaged personnel found and confiscated six kilograms of shabu (methamphetamine) materials, three kilograms of hashish, 7000 Lyrica capsules, guns of various calibers, ammunition, and suspicious funds. It has affirmed the determination to pursue the security campaigns against 'dealers in these contaminating substances,' warning that the security forces will act firmly against such dangerous activities. It called on the citizens and residents to cooperate with the security personnel and report any suspicious activities for the sake of safeguarding society
Arab Times
02-06-2025
- Arab Times
Kuwaiti security raids net drugs, firearms, and 10 suspects
KUWAIT CITY, June 2: Kuwaiti authorities arrested 10 suspects in connection with drug trafficking and illegal possession of firearms following a series of coordinated security raids, the Ministry of Interior said on Monday. The ministry's General Department of Security Relations and Media said in a statement that the arrests took place across several locations, including Al-Qurain, Al-Wafra, Andalus, Saad Al-Abdullah City, Al-Khiran, and Sabah Al-Salem. During the operations, security forces seized six kilograms of shabu (methamphetamine), three kilograms of hashish, around 7,000 capsules of the psychotropic drug Lyrica, nine firearms, a quantity of live ammunition, and cash believed to be proceeds from drug trafficking. The ministry reaffirmed its commitment to combating the distribution of narcotics and other illegal substances, pledging continued security campaigns to target drug traffickers and illegal arms possession. Authorities urged the public to support law enforcement efforts by reporting any suspicious activity to help maintain safety and security across the country.
Gulf Insider
23-05-2025
- Gulf Insider
Kuwait Sentences Police Officers To 10 Years For Drug Smuggling
A Kuwaiti court has sentenced two policemen and a customs inspector to 10 years in prison each for attempting to smuggle drugs. The country's Court of Appeals has upheld the conviction of the three, including a firefighting officer, on attempting to smuggle 1 million banned Lyrica pills at Kuwait Airport. The defendants had been arrested by the Kuwaiti anti-drug police after receiving information that they were smuggling the substance in seven suitcases, Al Qabas newspaper reported without specifying the date of the arrests. Several countries ban dealing in Lyrica pills because of potential abuse and addiction. In recent months, Kuwaiti authorities have announced foiling several bids to smuggle drugs into the country. Earlier this month, a shipment arriving at Kuwait's Shuwaikh Port was found out to have contained 110kg of hashish that had been secretly hidden inside marble slabs. Two suspects — a Syrian national and an illegal resident with Eritrean citizenship— were arrested in connection with the bid, the Kuwaiti Interior Ministry said. They attempted to smuggle the shipment in collaboration with a person outside Kuwait identified as a Gulf national. In addition to the drugs, 6,000 Captagon pills, 5 grams of the intoxicating shabu substance, and a digital scale used in preparing and distributing narcotics were found at one suspect' house. The origin country of the illicit cargo was not revealed.
