Latest news with #MBRU
Dubai Eye
5 days ago
- Health
- Dubai Eye
Dubai scientists advance precision medicine with Arab pangenome study
In a groundbreaking development for healthcare and genetic research, scientists at Dubai's Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU) have published the first-ever Arab Pangenome Reference—a major leap forward in precision medicine for the region. The research, featured in the prestigious journal Nature Communications, provides a vital foundation for personalised healthcare tailored to Arab populations. Using advanced DNA sequencing from 53 individuals of diverse Arab heritage living in the UAE, researchers identified over 110 million new DNA base pairs, nearly nine million small genetic differences, and more than 235,000 larger structural variations unique to Arabs—many of which had never been documented before. The study supports the UAE's National Genome Strategy, launched in 2023 to push the frontiers of personalised and preventive medicine. One notable finding was a duplicated gene called TAF11L5, found in Arab individuals but absent in global genetic databases. Scientists believe this could offer new insights into disease risk and treatment response. Researchers say the Arab Pangenome will help close long-standing gaps in global genomic data and enable the development of more accurate diagnostic tools and therapies for the region. The project also developed 'PanScan', a bioinformatics tool to support more complex analysis of human pangenomes. Although not the central focus of the study, PanScan enables researchers to detect gene duplications, novel DNA changes, and complex DNA structures. Now publicly available on GitHub, a common resource used by scientists worldwide, the tool was created to support the Arab Pangenome Reference and similar efforts globally. Scientists at the Mohammed Bin Rashid University of Medicine and Health Sciences, the learning and discovery arm of Dubai Health, have published the first Arab Pangenome Reference, marking a major milestone in both regional and global genomic research. The study, released in… — Dubai Media Office (@DXBMediaOffice) July 24, 2025
Hi Dubai
5 days ago
- Health
- Hi Dubai
Dubai Health Scientists Publish First Arab Pangenome Reference, Advancing Precision Medicine in the Region
Scientists at the Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), the academic and research arm of Dubai Health, have published the first-ever Arab Pangenome Reference. The landmark study, featured in the peer-reviewed journal Nature Communications , sets a new benchmark for precision medicine and personalised healthcare in the region. The breakthrough aligns with the UAE's National Genome Strategy, a 10-year plan launched by the Emirates Genome Council in 2023 to enhance preventive and precision-based care using genomic science. The Arab Pangenome Reference is a foundational contribution to this vision. Built using high-quality DNA sequencing data from 53 individuals of diverse Arab descent residing in the UAE, the reference fills a critical gap in global genetic databases, which have long underrepresented Arab populations. The research uncovered over 110 million base pairs of novel DNA sequences and identified nearly 9 million small genetic variants, along with over 235,000 large structural differences unique to Arab genomes. These findings are significant not just for the region, but for the global scientific community, said Prof. Alawi Alsheikh-Ali, Director General of the Dubai Health Authority and co-author of the study. We are enabling more precise and equitable healthcare by building a genome reference that reflects our population. One of the study's key discoveries includes the identification of a duplicated gene, TAF11L5, which was found to be highly enriched in Arab individuals but absent in current global references. This gene may influence the activity of other genes, with potential implications for disease risk and treatment response. The research was conducted entirely in-house at MBRU's Center for Applied and Translational Genomics (CATG). This integration allowed us to control the full research pipeline—from sequencing to bioinformatics—ensuring top-tier quality, said Dr. Hanan Al Suwaidi, Acting Provost at MBRU and co-author of the study. As part of the initiative, the team also developed a new open-source bioinformatics tool called PanScan, which facilitates the detection of gene duplications and complex DNA structures. The tool is now publicly accessible on GitHub, enabling scientists worldwide to benefit from the work. Dr. Mohammed Uddin, Director of CATG and senior author of the study, noted: This pangenome reference is a major step in understanding Arab genetic diversity. It will be a critical asset for both research and clinical diagnostics. The study not only enhances the scientific understanding of Arab genomics but also reinforces Dubai Health's long-term commitment to world-class research and innovation in healthcare. MBRU's research strategy continues to contribute meaningful data to international scientific efforts, while ensuring local populations are represented in global health advancements. The full study can be accessed at Nature Communications. News Source: Dubai Media Office
TAG 91.1
5 days ago
- Health
- TAG 91.1
Dubai scientists advance precision medicine with Arab pangenome study
In a groundbreaking development for healthcare and genetic research, scientists at Dubai's Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU) have published the first-ever Arab Pangenome Reference—a major leap forward in precision medicine for the region. The research, featured in the prestigious journal Nature Communications, provides a vital foundation for personalised healthcare tailored to Arab populations. Using advanced DNA sequencing from 53 individuals of diverse Arab heritage living in the UAE, researchers identified over 110 million new DNA base pairs, nearly nine million small genetic differences, and more than 235,000 larger structural variations unique to Arabs—many of which had never been documented before. The study supports the UAE's National Genome Strategy, launched in 2023 to push the frontiers of personalised and preventive medicine. One notable finding was a duplicated gene called TAF11L5, found in Arab individuals but absent in global genetic databases. Scientists believe this could offer new insights into disease risk and treatment response. Researchers say the Arab Pangenome will help close long-standing gaps in global genomic data and enable the development of more accurate diagnostic tools and therapies for the region. The project also developed 'PanScan', a bioinformatics tool to support more complex analysis of human pangenomes. Although not the central focus of the study, PanScan enables researchers to detect gene duplications, novel DNA changes, and complex DNA structures. Now publicly available on GitHub, a common resource used by scientists worldwide, the tool was created to support the Arab Pangenome Reference and similar efforts globally. Scientists at the Mohammed Bin Rashid University of Medicine and Health Sciences, the learning and discovery arm of Dubai Health, have published the first Arab Pangenome Reference, marking a major milestone in both regional and global genomic research. The study, released in… — Dubai Media Office (@DXBMediaOffice) July 24, 2025
Economy ME
5 days ago
- Health
- Economy ME
MBRU scientists publish first Arab Pangenome Reference in major genomic breakthrough
Scientists at the Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), the academic and research arm of Dubai Health , have achieved a major milestone in global genomic science with the publication of the first Arab Pangenome Reference. Featured in Nature Communications , a leading peer-reviewed journal, the study marks a pivotal advancement in precision medicine and personalized healthcare for Arab populations. The landmark achievement supports the UAE's National Genome Strategy, a 10-year initiative launched in 2023 by the Emirates Genome Council. The strategy aims to transform healthcare in the UAE through cutting-edge genomic research focused on personalized, preventive, and precision medicine. The Arab Pangenome Reference was created using high-quality DNA sequencing from 53 individuals of diverse Arab heritage residing in the UAE. Conducted at MBRU's state-of-the-art Center for Applied and Translational Genomics (CATG), the research identified more than 110 million base pairs of novel DNA sequences. Additionally, it uncovered nearly 9 million small genetic variations and over 235,000 large structural differences unique to Arab populations — none of which had been previously reported in global DNA references. Read: Sheikh Hamdan awards golden visas to nurses with 15+ years of service at Dubai Health Leadership insights Professor Alawi Alsheikh-Ali , director general, Dubai Health Authority (DHA), and co-author of the study, said: 'This achievement strengthens the UAE's position in genomic science. By building a reference that reflects the genetic diversity of Arab populations, we are enabling more precise and equitable healthcare. It's a foundational step towards realising the goals of our National Genome Strategy and ensuring that future medical innovations are shaped by data from our own communities.' Dr. Hanan Al Suwaidi, acting Provost of MBRU, and co-author of the study said: 'The capabilities of the CATG lab were central to the success of this project. From genetic sequencing to advanced bioinformatics, every stage of the research was completed in-house. This level of integration gave us full control over quality and timelines, reflecting Dubai Health's commitment to building world-class infrastructure and fostering national scientific leaders.' Dr. Mohammed Uddin, director of CATG and associate professor of Genetics at MBRU, and senior author of the study, said: 'This pangenome reference marks a major advancement in our understanding of Arab genomic diversity. It serves as a critical resource for both research discovery and clinical genome diagnostics, with lasting impact for future generations across the region.' Professor Alawi Alsheikh-Ali, director general, Dubai Health Authority (DHA) Addressing gaps in global genomic databases Historically, global genomic databases have significantly underrepresented Arab populations, limiting the accuracy of genetic risk assessment and treatment strategies for these communities. The Arab Pangenome Reference fills a critical gap by introducing high-resolution genomic data from a population long absent in international references. One particularly notable finding from the study was the discovery of the duplicated gene TAF11L5, which is highly enriched among Arab individuals but missing in existing global genomic references. Researchers believe this gene could influence the regulation of other genes and may hold important insights into disease risk and variations in treatment response. Enabling precision healthcare in the Arab World The Arab Pangenome Reference provides a foundational tool for national and regional precision medicine initiatives. It enables the development of population-specific biomarkers, disease risk models, and targeted therapies — advancing the region's ability to deliver more accurate, personalized healthcare solutions. Alongside the genomic map, the research team also introduced a new bioinformatics tool called PanScan. Designed to support more complex analysis of human pangenomes, PanScan helps researchers detect gene duplications, novel DNA variants, and complex genomic structures. Though not the main focus of the study, the tool has been made freely available on GitHub, offering global researchers access to further investigate human genomic diversity. The strategy aims to transform healthcare in the UAE through cutting-edge genomic research focused on personalized, preventive, and precision medicine A strategic step toward global representation Genomic research has progressed rapidly in recent decades, but much of the foundational data has come from a limited range of populations, creating blind spots in medical understanding. The Arab Pangenome Reference contributes to a growing international effort to correct this imbalance and promote global inclusivity in genomic science. The initiative also reflects Dubai Health's long-term commitment to research and innovation through MBRU. By investing in foundational studies such as this, Dubai Health is ensuring that Arab populations are actively represented in the future of genomics and precision healthcare. This groundbreaking research not only elevates the UAE's position in global genomic science but also lays the groundwork for more equitable, effective, and personalized healthcare systems across the Arab World.
Emirates 24/7
6 days ago
- Health
- Emirates 24/7
Dubai Health scientists publish first Arab Pangenome Reference, marking a milestone for precision medicine
Scientists at the Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), the learning and discovery arm of Dubai Health, have published the first Arab Pangenome Reference, marking a major milestone in both regional and global genomic research. The study, released in Nature Communications, a leading scientific journal, provides a crucial foundation for advancing precision medicine and personalised healthcare for Arab populations, while also supporting the UAE's National Genome Strategy, a 10-year initiative launched in 2023 by the Emirates Genome Council to advance personalised, preventive, and precision healthcare through cutting-edge genomic science. The reference was built using high-quality DNA sequencing from 53 people of diverse Arab backgrounds in the UAE. The work, conducted in MBRU's state-of-the-art Center for Applied and Translational Genomics (CATG), uncovered over 110 million base pairs of novel DNA sequences and identified nearly nine million small differences and more than 235,000 larger structural differences specific to Arab populations that have not been reported before. These findings are significant, as global DNA references have historically underrepresented Arab populations — a gap this research helps to close. The Arab Pangenome Reference supports national and regional precision medicine initiatives by enabling the development of population-specific biomarkers, risk models, and therapeutic targets. One notable discovery was the duplicated gene TAF11L5, found highly enriched in Arab individuals studied but absent from global references. This gene may play a role in regulating other genes and could have implications for understanding disease risk and individual variation in treatment response. Professor Alawi Alsheikh-Ali, Director General, Dubai Health Authority, and co-author of the study, said: 'This achievement strengthens the UAE's position in genomic science. By building a reference that reflects the genetic diversity of Arab populations, we are enabling more precise and equitable healthcare. It's a foundational step towards realising the goals of our National Genome Strategy and ensuring that future medical innovations are shaped by data from our own communities.' Dr. Hanan Al Suwaidi, Acting Provost of MBRU, and co-author of the study said: 'The capabilities of the CATG lab were central to the success of this project. From genetic sequencing to advanced bioinformatics, every stage of the research was completed in-house. This level of integration gave us full control over quality and timelines, reflecting Dubai Health's commitment to building world-class infrastructure and fostering national scientific leaders." While genomic research has advanced rapidly over the past two decades, much of the foundational data has come from a narrow subset of global populations. This has created blind spots in how genetic risk is understood and addressed across different communities. The Arab Pangenome Reference contributes to a growing international effort to correct this imbalance by introducing high-quality data from a historically underrepresented population. Dr. Mohammed Uddin, Director of CATG and Associate Professor of Genetics at MBRU, and senior author of the study, said: 'This pangenome reference marks a major advancement in our understanding of Arab genomic diversity. It serves as a critical resource for both research discovery and clinical genome diagnostics, with lasting impact for future generations across the region.' The project also developed 'PanScan', a bioinformatics tool to support more complex analysis of human pangenomes. Although not the central focus of the study, PanScan enables researchers to detect gene duplications, novel DNA changes, and complex DNA structures. Now publicly available on GitHub, a common resource used by scientists worldwide, the tool was created to support the Arab Pangenome Reference and similar efforts globally. Dr. Nasna Nassir, lead author of the study and Assistant Professor at MBRU, said: 'To support the Arab Pangenome Reference study, we developed PanScan, a tool designed to identify novel variants, gene duplications, and complex haplotype patterns specific to Arab populations. PanScan was key to uncovering unique genomic insights in our study and is now publicly available to support similar research globally.' The research reflects Dubai Health's commitment to advancing learning and discovery through MBRU. The university's research strategy is focused on contributing to global scientific progress. By investing in foundational genomic research, Dubai Health is helping to ensure that Arab populations are represented in the future of precision healthcare. The full study is available at:
