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Time of India
16 hours ago
- Health
- Time of India
IIT-Roorkee researchers develop promising drug candidate to fight antibiotic resistance
Dehradun: In a significant step forward in the global fight against antibiotic resistance , IIT-Roorkee researchers have developed a new drug candidate, Compound 3b, that can restore the effectiveness of a potent antibiotic against deadly drug-resistant bacteria, an official release said. Led by Ranjana Pathania from the Department of Biosciences and Bioengineering, an IIT Roorkee team including Mangal Singh and Perwez Bakht, along with Norwegian collaborator Annette Bayer and her team from UiT Tromso, has designed a novel molecule that works alongside the antibiotic Meropenem to treat infections caused by KPC-2-producing Klebsiella pneumoniae , a superbug listed among the World Health Organization's top-priority threats, the release said. "This breakthrough offers a promising solution to one of the world's most urgent health challenges -- antimicrobial resistance. Our compound neutralises the resistance mechanism, showing strong therapeutic results in preclinical models," Pathania, the principal investigator of the study, said. The molecule belongs to a class of β-lactamase inhibitor drugs that prevents bacterial enzymes from breaking down life-saving antibiotics. Compound 3b is highly specific, safe to human cells, and works synergistically with Meropenem to kill resistant bacteria, the release said, adding that lab and animal tests significantly reduced bacterial infection in the lungs.
India Today
19 hours ago
- Health
- India Today
IIT Roorkee, Norway team develops potential cure for antibiotic resistance
IIT Roorkee researchers have developed a new drug candidate that could help restore the effectiveness of a widely used antibiotic against hard-to-treat bacterial infections. The compound, called 3b, works with the antibiotic Meropenem to target KPC-2-producing Klebsiella pneumoniae, a bacterium identified by the World Health Organisation as a top-priority pathogen due to its high resistance to ROORKEE, NORWAY TEAM DEVELOP COMPOUND TO COMBAT ANTIBIOTIC RESISTANCEThe study was led by Professor Ranjana Pathania from IIT Roorkee's Department of Biosciences and Bioengineering, with Dr. Mangal Singh and Perwez Bakht, in collaboration with Professor Annette Bayer and her team from UiT Troms¸ in found that Compound 3b blocks the enzyme that enables the bacteria to break down antibiotics. It is part of a class of drugs known as -lactamase inhibitors. Laboratory and animal model testing showed the compound to be safe for human cells and effective in combination with Meropenem in reducing bacterial load, including in lung infections.'This approach restores the antibiotic's activity, providing another option for treating resistant infections,' Professor Pathania KK Pant, Director of IIT Roorkee, said the project reflects the institute's focus on addressing public health concerns through research and work, published in the Journal of Medicinal Chemistry, could guide future development of treatments for drug-resistant infections. If successful in further testing, Compound 3b may be used alongside existing antibiotics to slow the spread of resistance is a growing concern globally, with experts warning that common infections may become harder to treat. Developments like this aim to extend the usefulness of current antibiotics while new drugs are in development.- Ends
Hindustan Times
2 days ago
- Health
- Hindustan Times
IIT Roorkee researchers develop novel drug candidate to restore strength of antibiotics against drug-resistant bacteria
The Indian Institute of Technology (IIT) Roorkee researchers have taken an innovative step towards the global fight against antibiotic resistance by developing a new drug candidate, Compound 3b, that has the potential to restore the effectiveness of a potent antibiotic against deadly drug-resistant bacteria. The newly discovered molecule belongs to a class of β-lactamase inhibitor drugs that prevent bacterial enzymes from breaking down life-saving antibiotics. The research team is led by Prof. Ranjana Pathania from the Department of Biosciences and Bioengineering, IIT Roorkee, and includes Dr. Mangal Singh and Perwez Bakht, as well as along with Norwegian collaborators Prof. Annette Bayer and her team from UiT Tromsø. Also read: IIT-KGP appoints dean to look after students' well-being following multiple suicides The team designed a novel molecule that works alongside the antibiotic Meropenem to treat infections caused by KPC-2-producing Klebsiella pneumoniae, a superbug listed among the World Health Organization's top-priority threats, IIT Roorkee said in a statement. It further added that the newly discovered molecule belongs to a class of β-lactamase inhibitor drugs that prevent bacterial enzymes from breaking down life-saving antibiotics. Speaking about the new discovery, Prof. Pathania said that the breakthrough offers a promising solution to one of the world's most urgent health challenges, antimicrobial resistance. 'Our compound neutralizes the resistance mechanism and shows strong therapeutic results in preclinical models,' she added. Also read: IIT Guwahati to establish Manekshaw centres for defence & national security research Prof. K. K. Pant, Director of IIT Roorkee, said that the innovation reflects IIT Roorkee's commitment to developing impactful scientific solutions for global challenges. 'In the face of rising antibiotic resistance, such research provides critical hope for effective and accessible treatments,' Prof. Pant added. It may be mentioned here that the research has been published in the prestigious Journal of Medicinal Chemistry, and is expected to contribute significantly to future drug development efforts targeting superbugs. Also read: Bright young minds should shape India's future: Prez Murmu at 45th convocation of IIT-ISM in Dhanbad IIT Roorkee stated that the discovery marks a significant advancement in safeguarding public health, particularly at a time when antibiotic resistance is threatening global healthcare systems.
New Indian Express
19-07-2025
- New Indian Express
Sextortion gang busted in Delhi: Kingpin, 3 others held for blackmailing with obscene videos
NEW DELHI: Four members of a sextortion syndicate, including its kingpin, were arrested for extorting people after blackmailing them with obscene videos. Based on the complainant's statement a case was registered, who alleged that the accused contacted him initially on an internet application, then via WhatsApp video call, and played a pre-recorded obscene video featuring a woman. The complainant said that he was manipulated and later received the obscene video of himself recorded by the fraudster. In lieu of deleting it, the fraudster demanded money for not circulating it on social media, police said. The complainant was scared and transferred Rs 35,000 to the fraudster. When the fraudster demanded more money, he lodged the complaint. Analysing the money trail, police tracked the suspects in Mewat region, of Rajasthan. The first raid was conducted in Delhi, where two accused -- Mangal Singh and Shyam Singh -- were arrested. The kingpin Armaan Khan was arrested too from Mewat Rajasthan. Khan said that he received the payment scanner of Mangal through his associate Aasid Khan, who was arrested too.
Time of India
18-07-2025
- Time of India
Delhi Police arrests four for sextortion and blackmail in Shahdara
New Delhi: Delhi Police has arrested four individuals allegedly involved in a sextortion racket that targeted a resident of Shahdara's Bhagwanpur Khera area. According to police, a complaint was received through the NCRP portal on June 12, alleging that the victim was contacted via a dating app. A senior police officer said, "He was later video-called, during which a pre-recorded obscene video was played. The complainant alleged that he was manipulated into getting nude, and the call was recorded. The accused then allegedly used the video to blackmail him, extorting Rs 35,000." An FIR was registered at Cyber Police Station, Shahdara, under Sections 318 (cheating), 308 (extortion), and 351 (criminal intimidation) of the Bharatiya Nyaya Sanhita (BNS). A dedicated police team was formed to investigate the case. You Can Also Check: Delhi AQI | Weather in Delhi | Bank Holidays in Delhi | Public Holidays in Delhi DCP (Shahdara) Prashant Gautam said, "Through technical surveillance and analysis of the money trail, the suspects were traced to the Mewat region in Rajasthan. The first raid was conducted in Delhi, where two suspects — Mangal Singh (31), the alleged holder of the bank account where the extorted money was transferred, and his associate Shyam Singh (21) — were arrested." Further investigation led to the arrest of the alleged mastermind, Armaan Khan (21), from Mewat. "He confessed to orchestrating the blackmailing scheme using obscene video calls to extort money. Armaan revealed that he received a UPI scanner from his associate Aasid Khan (37), also a resident of Mewat, who was subsequently arrested," said DCP Gautam. Police said the accused would contact victims using fake or misleading profiles on dating apps, lure them into explicit conversations, and record compromising videos for extortion. A total of seven mobile phones and six SIM cards have been recovered from the accused.
