Latest news with #Marea
Business Wire
04-08-2025
- Health
- Business Wire
Marea Therapeutics Enrolls First Patient in Phase 2b TYDAL-TIMI 78 Clinical Study Evaluating MAR001 in Adults at Risk of ASCVD
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Marea Therapeutics, Inc., a clinical-stage biotechnology company harnessing the latest advances in human genetics to develop first-in-class, next-generation medicines for cardioendocrine diseases, today announced that the first patient has been enrolled in Marea's Phase 2b TYDAL-TIMI 78 study evaluating MAR001 in adults with elevated levels of triglycerides (TG) and remnant cholesterol (RC) at increased risk of atherosclerotic cardiovascular disease (ASCVD). MAR001 is a monoclonal antibody delivered by subcutaneous injection that is designed to block the activity of ANGPTL4, a protein that is highly expressed in adipose tissue. MAR001 is being developed to address unmet risk in patients with ASCVD and persistently elevated levels of TG and RC. The Phase 2b TYDAL-TIMI 78 study aims to enroll approximately 216 patients who will be randomized in a 3:1 ratio to receive MAR001 or placebo every four weeks for 24 weeks. Patients in the MAR001 arms will be randomized to receive 300mg, 450mg or 900mg. The primary endpoints will evaluate the percent change from baseline at week 12 in fasting TGs and fasting RC as compared with placebo. Safety and tolerability will be assessed, and secondary endpoints include changes in fasting very low-density lipoprotein cholesterol (VLDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C). "Despite significant progress in managing cardiovascular risk, many patients continue to face elevated risk due to high levels of remnant cholesterol carried on triglyceride-rich lipoproteins. The TYDAL-TIMI 78 study offers an important opportunity to explore the therapeutic potential of MAR001, a genetically informed and promising approach to targeting ANGPTL4,' said Marc S. Sabatine, M.D., M.P.H., chairman of the thrombolysis in myocardial infarction (TIMI) study group and TYDAL study chair. 'By addressing a major unmet need with a novel mechanism, this trial could pave the way for a new class of therapies to reduce residual risk in patients with cardiometabolic disease. We're pleased to lead this important study and look forward to evaluating MAR001's impact on meaningful lipid parameters and overall cardiovascular health.' 'The initiation of the TYDAL study marks an important milestone for Marea and for patients at risk of atherosclerotic cardiovascular disease,' said Josh Lehrer, M.D., chief executive officer of Marea. 'MAR001 is a first-in-class, genetically validated investigational therapy with the potential to improve outcomes by reducing remnant cholesterol and triglycerides - two critical and under-addressed drivers of residual cardiovascular risk. We're advancing MAR001 into a Phase 2b trial and aim to generate data that could shift the treatment paradigm in cardiometabolic disease. MAR001 may offer precision therapy for patients with elevated residual risk despite control of traditional factors. We expect topline TYDAL results in mid-2026 and are energized to move this innovative therapy closer to the patient.' About MAR001 MAR001 is a monoclonal antibody designed to block the activity of ANGPTL4. MAR001 binds with high affinity to the N-terminal coiled-coil domain of ANGPTL4. Given the enrichment in expression of ANGPTL4 in adipose tissue, MAR001 leads to augmented hydrolysis of triglyceride (TG) rich lipoproteins and optimal storage of TGs, and both nonclinical and clinical studies have demonstrated significant reductions in TG and remnant cholesterol (RC), the cholesterol carried on TG-rich lipoproteins. Substantial reductions in TG and RC are predicted to reduce atherosclerotic cardiovascular disease (ASCVD) risk. About Marea Therapeutics Marea Therapeutics is a clinical-stage biotechnology company harnessing the latest advances in human genetics to develop first-in-class, next-generation medicines for cardioendocrine diseases. The company's lead therapy, MAR001, is in Phase 2 clinical development for adults with metabolic dysfunction and high risk for atherosclerotic cardiovascular disease. The company is also advancing MAR002 for the treatment of acromegaly. To learn more, please visit and follow us on LinkedIn and X.
Zawya
08-07-2025
- Business
- Zawya
Dar Global awards main works contract for Marea Costa Del Sol, Spain to ENE Construccion Amaz sl
Casares Costa, Spain – Dar Global, the London-listed luxury real estate developer, has awarded the main works contract for Marea (Block D), Costa Del Sol, Spain, to M/s ENE Construccion Amaz SL. This appointment marks a key milestone in the continued development of Marea – Interiors by Missoni, a refined residential project located on the sun-drenched coast of southern Spain. Drawing inspiration from Mediterranean living, Marea offers a seamless blend of elegance, natural beauty, and branded design. The interiors, inspired by the vibrant aesthetic of Missoni, infuse each space with a distinctive identity, translating the fashion house's iconic patterns and textures into a sophisticated architectural language. ENE Construccion Amaz SL was selected for its deep expertise in premium developments and its strong track record across the region. With main works now set to commence, Block D is anticipated to welcome residents in 2026. As one of Dar Global's flagship lifestyle projects in Spain, Marea reflects the company's ongoing commitment to creating world-class living environments that combine high design with exceptional investment value. About Dar Global DarGlobal PLC is an international real estate developer specializing in exclusive luxury developments across the world's most coveted cosmopolitan cities. Catering to global citizens seeking prime investments, second homes, and luxury living, DarGlobal transforms real estate into economic catalysts, unlocking opportunities for both investors and the countries it enters. DarGlobal has partnered with over 10 world-renowned luxury brands, including Trump Organization, Aston Martin, Automobili Lamborghini, Fendi, ELIE SAAB, Marriott Residences, Missoni, Mouawad, Pagani Automobili, and W Hotels. These collaborations offer unique investment opportunities in global cities, providing both wealth growth and protection. Listed on the London Stock Exchange, DarGlobal goes beyond property development, it drives economic transformation by attracting international clients and Foreign Direct Investment (FDI). By injecting capital, confidence, and industry expertise, DarGlobal enhances local infrastructure while elevating the global appeal of each destination. With a presence in 14 international cities across 9 countries, DarGlobal's portfolio spans the United Kingdom, Spain, Greece, Saudi Arabia, the UAE, Oman, and Qatar. The company is also expanding into world-class hospitality, developing luxury hotels in Dubai, the Maldives, and Oman. To support its international clientele, DarGlobal has sales and customer service offices in New York, London, Marbella, Athens, Dubai, Jeddah, Riyadh, Muscat, and Doha. For media enquiries, please contact: Reem AlTajer |Burson
Business Wire
01-07-2025
- Business
- Business Wire
Marea Therapeutics Appoints Shishir Gadam, Ph.D., as Chief Technical Officer
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Marea Therapeutics, Inc., a clinical-stage biotechnology company harnessing the latest advances in human genetics to develop first-in-class, next-generation medicines for cardioendocrine diseases, today announced the appointment of Shishir Gadam, Ph.D., as chief technical officer. Dr. Gadam has extensive experience in the biotechnology industry and brings deep expertise and leadership in biologics development and manufacturing to Marea Therapeutics. Dr. Gadam was most recently chief technical officer at Cargo Therapeutics and responsible for technical operations for the cell therapy portfolio. Prior to Cargo, he held the position of vice president and head of cell therapy global manufacturing sciences & technology at Juno therapeutics, a Celgene company and Bristol Myers Squibb where he was instrumental in launch of two cell therapy commercial CAR-T products. During his tenure at Genetech/Roche from 2006-2018, he held positions of increasing responsibility across technical development and manufacturing advancing multiple biologics programs. Dr. Gadam started his career at Merck & Company in developing bioprocesses for vaccines. He holds a Ph.D. in Biochemical Engineering from Rensselaer Polytechnic Institute, a M.S. in Chemical Engineering from West Virginia University and a B.S. in Chemical Engineering from the Institue of Chemical Technology, Mumbai, India. 'We are delighted to welcome Shishir to our senior leadership team,' said Josh Lehrer, M.D., FACC, chief executive officer of Marea Therapeutics. 'Shishir brings a remarkable track record of technical leadership across biologics, vaccines, and cell therapies, and his deep expertise in CMC and manufacturing operations will be instrumental as we advance our pipeline toward late-stage development. His proven ability to scale innovative therapies and build world-class technical capabilities will be invaluable as we prepare for Phase 3 readiness and continue to grow Marea into a leading cardioendocrine company.' 'I'm thrilled to join Marea at such an exciting moment in its growth,' said Dr. Gadam. 'The company's commitment to advancing first-in-class therapies for cardioendocrine diseases is both scientifically compelling and deeply meaningful. I look forward to working alongside this exceptional team to build and scale robust technical operations that will accelerate development and ultimately deliver transformative medicines to patients.' About Marea Therapeutics Marea Therapeutics is a clinical-stage biotechnology company harnessing the latest advances in human genetics to develop first-in-class, next-generation medicines for cardioendocrine diseases. The company's lead therapy, MAR001, is in Phase 2 clinical development for adults with metabolic dysfunction and high risk for cardiovascular disease. The company is also advancing MAR002 for the treatment of acromegaly. To learn more, please visit and follow us on LinkedIn and X.
New York Post
16-06-2025
- Business
- New York Post
Manhattan's power scene is back in full force at this luxe new Italian restaurant from Michael White: It's Marea 2.0
Midtown has its pre-pandemic swagger back — and People's Exhibit No. 1 is Santi (11 E. 53d St.), the buzzing new modern-Italian restaurant from celebrated chef Michael White. Its nexus of corporate power, great pasta and fun people-watching make it the area's hottest scene since White's Marea opened in prehistoric 2009. After splitting with the Altamarea group in 2021 due to disagreements over the company's direction, White has spent most of his time launching new venues in Florida. (A consulting gig at the Lambs Club on West 44th Street lasted only a few months in 2022.) 10 Michael White is back in NYC with Santi. EMMY PARK 10 The elegant midtown address was once home to White's Alto. EMMY PARK Santi, launched by his BBianco Hospitality Group with business partner Bruce Bronster, marks his triumphant, full-scale Big Apple return. Marea's still going strong and Midtown has other established, excellent Italian restaurants such as Il Gattopardo, Cellini and Fresco by Scotto. But others faded and the scene needed new blood. Santi delivers it for everyone — from shoppers and museum-goers to a Who's Who of Midtown glitterati. Once home to White's aughts-era hit Alto, the venue has overnight became a haunt where the city's prime movers wheel-and-deal over homemade gnocchi and tagliatelle, and cocktails such as the Fifty-Fifty, which features Taggiasca gin, made with prized Ligurian olives. Santi's pleasures unspool through several main areas designed by Michaelis Boyd, gorgeously lit by L'Observatoire International and festooned with luminous portraits from Bronster's private collection. Each section draws a different crowd. The front dining room, a few steps down from a horseshoe-shaped bar for the after-work, sip-and-flirt set, draws movers and shakers to its semicircular booths and banquettes. It's become a canteen for bankers at market-moving investment firm Jefferies Group and its CEO Rich Handler, who work upstairs. On any given afternoon or evening, you might spot Henry Kravis, Barry Diller or real estate mogul Bill Rudin, who's planning a new skyscraper a few blocks away. 10 Midtown power players are flocking to Santi. EMMY PARK 10 With dishes such a succulent veal chop, Santi's food is worthy of the five Michelin stars that White has earned at previous restaurants. . EMMY PARK Boldfaces such as Eva Longoria and Queen Rania of Jordan have popped in, too. Pop star Beck ordered a comfort dish from heaven — hand-folded tortellini ($36) filled with prosciutto, mortadella, pork and Parmigiano Reggiano, finished in a creamy sea of cheese and butter. A circular staircase leads to the slightly more intimate mezzanine, after passing a huge,1800s mirror that Bronster found buried under a Southampton barn. The upstairs area has attracted art and fashion luminaries such as designers Diane von Furstenberg and Michael Kors and painter Kehinde Wiley. The restaurant's noisiest section is the ground-floor atrium, where light globes suspended from the double-height ceiling suggest a galaxy in formation. On my visits, it drew canoodling couples in the corners and noisy groups of guys at middle tables. Fortunately, new wall fabrics and sound bafflers have begun to soften the din. 10 Amberjack crudo is one of many great seafood dishes. EMMY PARK 10 Gnocchi in tomato sauce is a standout pasta dish. EMMY PARK The menu, executed by the kitchen team of Jason Lin and Sol Han, is worthy of the five Michelin stars White earned at his other places. It boasts splendid seafood, both raw and cooked, like tasty, toothsome amberjack crudo ($32) and pleasingly moist halibut ($55) pan-seared on one side and then poached in extra-virgin olive oil. But the pastas — all original, none replicating White's previous plates — are the crowning glory. 'We've been deliberate about not copying expected dishes because that's not fun or challenging, and our guests deserve more than a rehash of old ideas,' White told me. The sautéed Italian breadcrumbs known as mollica, a White hallmark in the past, are mostly absent, letting the pasta and sauces speak for themselves. 10 Some notable guests, such as musician Beck, favor the booths in the front room. EMMY PARK 10 Beyond the front room is the elegant-but-noisy atrium. EMMY PARK Tagliatelle Ragu ($36), which Wiley has ordered more than once,gets my vote. The coarse-ground beef and pork are gently broken down to a velvety texture by a judicious infusion of milk. My favorite, though, was ricotta gnocchi ($28), lighter than the potato-filled variety and bathed in San Marzano tomato-and-basil sauce — a brave statement when too many chefs shy away from red sauce lest their dishes be mocked as Italian-American dinosaurs. 10 A sweeping staircase leads up to a mezzanine. EMMY PARK 10 The mezzanine dining area is slightly more intimate. EMMY PARK But I miss White's legendary fusilli with braised octopus and bone marrow, his heart-stopping, red-sauce masterpiece at Marea. Per Se's Thomas Keller once called his favorite dish in New York. Is there any chance we'll see it again at Santi? When asked, White smiled and said coyly, 'I'm talking to my chefs about it.'
Forbes
29-05-2025
- Lifestyle
- Forbes
New York Restaurants June 2025: Where To Go
Locanda Verde Edible enlightenment from our eatery experts and colleagues Monie Begley, Richard Nalley and Randall Lane, as well as brothers Bob, Kip and Tim. Santi; Photo by evan sung Chef Michael White, creator of Marea and Ai Fiori, has a new Midtown restaurant that's already a hit. The setting is multilevel and luxurious, but the pan-Italian fare is the draw. To start, try the delicious risotto—a creamy portion of acquarella rice and veal sausage mixed with chestnut and fontina; or the garganelli, tossed with parma prosciutto, English peas and truffle butter. Main courses are on par: The spigola—a delicately cooked black bass—is accompanied by squash blossom; the astice is a juicy Maine lobster served on a mound of white asparagus and morels; the vitello is a perfectly pink chop served with asparagus in a pancetta sauce. End your meal with the delizie al limone, a white chocolate ball filled with an airy sponge cake with limoncello. Locanda Verde It's a happy surprise to walk into a steel-and-glass skyscraper and find oneself in a richly paneled room with a gas fireplace. Steak tartare and lamb meatball sliders are a great opening act for a simply grilled Ligurian tuna antipasto salad or the tortelli di zucca, a squash-filled, slightly sweet ravioli. Three delectable desserts: the alpine honey cake, the olive oil panna cotta with wedges of grapefruit and kumquats and the grapefruit and Campari ice with shavings. BEA A good bet for a casual place for dinner before hitting a Broadway show. Highlights: manicotti stuffed with ground chicken, ricotta and mozzarella; miso salmon; and herb roasted chicken with toasted farro and mushroom crème sauce. As a vegetarian option, the eggplant and tofu is a great success. Skip the banana sundae and go for either the chocolate chip brownie à la mode or the panna cotta—both scrumptious. (Make a point of noting the start time of your show, as there can be long pauses between courses.) César Forgive the less than gracious welcome behind a locked entrance as well as the insistent waiter trying to upsell you on the already pricey prix fixe tasting menu, and a heavenly dinner will be your reward. Opt for the eight-course fish menu, as the succession of creatively conceived and exquisitely prepared dishes without a miss is astonishing. The bluefin tuna parfait and the foie gras flan with crab and wood ear mushroom are especially memorable. The fine Italian dining here is as expensive as you'd expect on the Upper East Side. The melon that accompanies the perfect prosciutto isn't quite ripe enough, but the Caesar salad is better than Grandma used to make. The Dover sole with lemon sauce and the duck à l'orange are first rate. The ricotta cheesecake and the tiramisu are excellent. Cozy atmosphere, with friendly and professional service. BG This quiet oasis on the seventh floor at Bergdorf 's is a civilized place for a Midtown lunch, with a classically decorated setting with views over Central Park. The mushroom tart is just the right size to leave room for the perfectly seared sea scallops. The clam chowder is tasty but has more corn than clams. Save room for a delightful strawberry shortcake or, if it's on the menu, key lime pie. METROPOLIS BY MARCUS SAMUELSSON; photo byLocated on the second floor inside the Perelman Performing Arts Center (a no-car zone), this is a sleek, modern place to have lunch or dinner if you're visiting the World Trade Center and environs. The limited menu is excellent: The salad with branzino is a particular success, and the French omelette is incomparable. The banana pudding is worth a visit all by itself. ly ly vietnamese cook house A joyful, jam-packed place serving authentic Vietnamese specialties. It employs a combination of fine Asian spices with an overlay of French finesse gained through nearly five decades of French rule. Visit with a group, as tasting all the colorful and delicious offerings is great fun. Begin with a round of salt-and-pepper squid, lightly fried with jalapeño, cherry tomatoes and crispy garlic. The bánh xèo is a crèpe with pork belly, shrimp, bean sprout, scallion and nuoc mam (traditional fish sauce and lime). The papaya salad is a must. The pho is a rich noodle soup of rice vermicelli cooked for 20 hours with cilantro, onions and scallions. It can be served with slow-cooked short ribs. There are a variety of spring rolls from which to choose. Other delectable dishes are the Saigon shaking beef, the lump crab noodles and the Saigon hawker rice—lemongrass pork chop, with a bit of steamed Vietnamese meatloaf and a fried egg.
