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News18
25-07-2025
- Health
- News18
The Crucial Role Of Genetic Testing And Genetic Counselling In IVF
Last Updated: As IVF becomes increasingly intertwined with genomics, the need for ethical, empathetic, and informed genetic counselling becomes ever more critical Advancements in reproductive healthcare have helped many couples realize their dream of parenthood. Among these innovations, in vitro fertilization (IVF) has become a widely used approach. IVF is an assisted reproductive technology where an egg and sperm are fertilized outside the body. As our understanding of reproductive science has evolved, so has our knowledge of the genetic factors that can influence fertility outcomes. This growing insight has made genetic testing and counselling an increasingly important part of the IVF journey, helping couples make informed choices at every step. This World IVF Day, as we understand the life-changing potential of IVF, Dr GK Madhavilatha, Principal Genetic Counsellor, MedGenome helps us explore the crucial role of genetic testing and counselling in the IVF journey. Why Genetic Testing is important in IVF Incorporating genetic testing in the IVF journey not only significantly improves the chances of a healthy pregnancy but also makes pregnancy care more personalised. However, it is essential to remember that genetic testing is not a tool to engineer or design babies. It is about reproductive efficiency, not perfection. • Reduce the Risk of Miscarriage Chromosomal abnormalities are a leading cause of miscarriage. In case of such anomalies, using preimplantation genetic testing for aneuploidies (PGT-A) in the IVF process can help select embryos with the correct number of chromosomes, improving implantation rates and reducing miscarriage risk, particularly for women over 35 or couples with recurrent pregnancy loss, thus enhancing the chances of a successful pregnancy. • Diagnose Structural Rearrangements Couples with known structural chromosome rearrangements face a high risk of miscarriage or affected offspring. In such cases, preimplantation genetic testing for structural rearrangement (PGT-SR) helps identify embryos with numerical and structural aberrations. • Informed Decisions and Personalized Treatment With clear genetic information, couples can make informed choices about embryo transfer, prenatal testing, or alternative reproductive options. Understanding their genetic risks allows for more tailored IVF protocols and postnatal care. Role of Genetic Counselling: Beyond the Test Genetic tests are only as meaningful as the interpretation they receive. This is where genetic counselling becomes crucial. Genetic counsellors offer couples expert guidance about the implications of genetic testing, help couples understand their results, and explain the available reproductive options. Beyond medical understanding, they also provide support to couples coping with the emotional aspects of uncertain or difficult results and the complexities associated with reproductive decisions. Genetic counsellors serve as neutral facilitators and not decision-makers. Their role is to support autonomy, not steer choices. The Power of Genetic Information A couple in Delhi had lost three pregnancies. Antenatal scans showed that each baby had abnormal kidneys, but the exact cause was unknown. MedGenome's carrier screening test identified a disease-causing variation in a specific gene that both partners carried, causing a lethal kidney disease in the foetuses. This gene mutation was identified as a founder mutation originating from a specific community. Following the diagnosis, the couple received genetic counselling, where they were explained about the condition and guided on the reproductive options available for them. They then opted for ART-IVF, during which embryo biopsies were sent for genetic testing, helping select the embryos free of the condition for implantation. Today, the couple has a healthy baby. This case illustrates the deep and meaningful impact that genetic testing and counselling have on the lives of people. When should a couple consider Genetic Testing and Counselling in IVF? Couples should opt for genetic testing at different times in their pregnancy planning journey. When combined with genetic counselling, this helps them understand risks and plan better. Here's when genetic testing and counselling are typically recommended: • Before starting IVF for preconception carrier screening • Couples with a known personal history or family history of genetic disorders • Couples who have a history of recurrent miscarriages or failed IVF cycles • When a couple is considering PGT-A or PGT-M • Couples in a consanguineous (related by blood) marriage Looking Ahead: Genetics with Compassion As IVF becomes increasingly intertwined with genomics, the need for ethical, empathetic, and informed genetic counselling becomes ever more critical. Genetic information is powerful, but without guidance, it can be confusing or even distressing. Couples deserve support that honours both the science and the deeply human nature of reproductive choices. Genetic counselling is about empowering people with knowledge, choice, and support in one of the most personal journeys of their lives. If you're a couple navigating IVF, consider speaking with a certified genetic counsellor early in your journey. The insight may not only enhance your outcomes; it may bring peace of mind in an otherwise complex process. About the Author Swati Chaturvedi Swati Chaturvedi, a seasoned media and journalism aficionado with over 10 years of expertise, is not just a storyteller; she's a weaver of wit and wisdom in the digital landscape. As a key figure in News18 More The News18 Lifestyle section brings you the latest on health, fashion, travel, food, and culture — with wellness tips, celebrity style, travel inspiration, and recipes. Also Download the News18 App to stay updated! view comments Location : New Delhi, India, India First Published: July 25, 2025, 10:07 IST News lifestyle » health-and-fitness The Crucial Role Of Genetic Testing And Genetic Counselling In IVF Disclaimer: Comments reflect users' views, not News18's. Please keep discussions respectful and constructive. Abusive, defamatory, or illegal comments will be removed. News18 may disable any comment at its discretion. By posting, you agree to our Terms of Use and Privacy Policy.
News18
21-07-2025
- Business
- News18
MedGenome raises USD 47.5 mn in Series E funding round
New Delhi, Jul 21 (PTI) Genomic diagnostics and research services company MedGenome on Monday said it has raised USD 47.5 million (over Rs 409 crore) in Series E funding round from private equity firm Maj Invest and existing investor Novo Holdings. The round also saw participation from Sofina, an existing shareholder in the company, the Bengaluru-based firm said in a statement. The funding will enable the company to broaden access to its genomics and integrated diagnostics solutions across India and other emerging markets, it added. 'This fundraise also reflects the growing adoption of genomics in personalised and preventive healthcare in India as well as other emerging economies," MedGenome CEO Vedam Ramprasad said. MedGenome offers over 1,300 high-end genetic tests across major disease categories – oncology, inherited diseases, reproductive diseases, infectious diseases, and preventive wellness. PTI MSS MSS SHW Disclaimer: Comments reflect users' views, not News18's. Please keep discussions respectful and constructive. Abusive, defamatory, or illegal comments will be removed. News18 may disable any comment at its discretion. By posting, you agree to our Terms of Use and Privacy Policy.
News18
14-06-2025
- Health
- News18
Metabolic Syndrome In Men: Why Is This A Growing Health Crisis In India?
Last Updated: Metabolic disorders are becoming increasingly common among Indian men across both urban and rural settings. This calls for a need to understand and manage this health concern. Indian lifestyle has undergone significant changes over the past few decades that have led to several health implications, unintentionally paving the path for a silent epidemic – metabolic disorders. For Indian men in particular, these lifestyle changes have translated into a rising burden of chronic health conditions, such as type 2 diabetes, obesity, hypertension, and cardiovascular disease. Recent estimates suggest that nearly 26% of Indian men may be living with metabolic syndrome or related lifestyle disorders, which are conditions that significantly increase the risk of long-term complications and early mortality. With these lifestyle disorders becoming increasingly common, affecting men at younger ages and across both urban and rural settings, there is an urgent need to understand and manage this growing health concern. As we observe Men's Health Week, it is an important moment to spotlight these silent but escalating threats. Dr Ramesh Menon, Associate Director of Personal Genomics and Genomic Medicine, MedGenome, Bengaluru talks about the risks, the need for making early lifestyle changes, and undergoing regular health check-ups. Uncovering the New Drivers of Men's Health Risks While not always life-threatening, metabolic disorders serve as subtle precursors to more serious cardiovascular events such as coronary artery disease (CAD) and stroke, posing a considerable health hazard. Dr Menon says, 'With an often disproportionately higher incidence in men, these disorders have traditionally been associated with smoking, excess alcohol, and sedentary lifestyles, which drive metabolic dysfunction. However, today the reasons go beyond these evident causes." Dr Menon adds, 'Chronic stress and sleep deprivation, for example, are now acknowledged as major non-traditional contributors to metabolic disorders. Apart from its psychological effects, stress also triggers hormonal changes, including higher cortisol levels, which can directly lead to insulin resistance, weight gain, and hypertension, all of which give rise to metabolic imbalance." This complex interplay of factors culminates in a set of conditions collectively known as metabolic disorders, such as hypertension (high blood pressure), obesity, type 2 diabetes, sleep disturbances, and fatty liver disease. They increase the risk of life-threatening conditions like heart attacks and strokes, as they frequently advance without any symptoms until serious harm has been done. Dr Menon says, 'A landmark report published in 2023 by the Indian Council of Medical Research (ICMR) found a much greater prevalence of metabolic non-communicable diseases (NCDs) than was previously estimated, indicating the urgency of addressing metabolic disorders in the country. The study also highlighted a higher urban than rural prevalence for most metabolic NCDs, signifying the impact of urbanisation and changing lifestyles." Other studies have found growing and higher prevalence of these diseases in men as compared to women. Dr Menon continued, 'The National Family Health Survey 2019–2021 stated that hypertension prevalence was 30.3% among men and 28.6% among women, and diabetes prevalence was 19.7% among men and 17.4% among women. Though there is no consolidated report, across regions in the country, fatty liver disease also has a predominance among men, with a prevalence ranging between 24.6–76.6%, while it's between 13.6–35.13% among women." Dr Menon also revealed how the National Academy of Medical Sciences (India) reported that NCDs, which are typically present in individuals aged 55 years or older in many developed countries, have their onset in India a decade earlier (≥45 years of age). This accelerated progression underscores a unique and pressing public health challenge. The Risk Beyond Lifestyle Besides these lifestyle and environmental factors, genetic makeup also predisposes individuals to metabolic disorders. One of the most effective tools for early intervention is knowing one's genetic risk. Genetic screening can identify inherited predispositions such as type 2 diabetes or hypertension, enabling individuals to make informed lifestyle choices. Dr Menon shares some lifestyle changes that can help you take care of your health. Cultivate an active lifestyle: Consistent exercise, regardless of intensity, can have a profound impact on insulin sensitivity, weight management, and blood pressure. The current standard is to achieve 150 minutes of moderate intensity exercise, supplemented with daily movement. Manage stress effectively: Incorporate practices like yoga, meditation, mindfulness, and spending time with nature in your daily routine to reduce and manage stress. Ensure adequate sleep: Sleep is important for hormones and metabolic regulation. Try to get between seven and nine hours of uninterrupted sleep every night. Regular Health Check-ups: The key is early detection. Frequent checks for weight, cholesterol, blood pressure, and blood sugar allow any problems to be identified and managed in time. Know Your Family History and Genetic Risk: Talk to your doctor about your family's health risks and consider undertaking genetic testing and discussing options with your doctor as part of your personalised prevention efforts. By recognising the contributing risk factors, acknowledging the influence of genetics, and embracing proactive lifestyle changes, meaningful steps can be taken toward preventing metabolic disorders. The News18 Lifestyle section brings you the latest on health, fashion, travel, food, and culture — with wellness tips, celebrity style, travel inspiration, and recipes. Also Download the News18 App to stay updated! First Published:
