Latest news with #Modena
Medscape
3 days ago
- Health
- Medscape
Gut Health in Rosacea: Diet, Probiotics, and the Microbiome
Growing evidence suggested that the skin and gut may be more closely linked than once thought — especially in chronic inflammatory conditions like rosacea. In a comprehensive review recently published in Biomolecules , Marco Manfredini, MD, from the Department of Dermatology at the University of Modena and Reggio Emilia, Modena, Italy, and colleagues explored the evolving science around how diet, gut microbiota, and probiotics may influence rosacea pathogenesis and symptom severity. While more clinical studies are needed, the review highlighted new pathways linking gastrointestinal dysbiosis to cutaneous inflammation. The authors proposed that specific dietary modifications and the use of probiotics could support traditional treatment approaches for certain patients. Pathogenesis of Rosacea: A Multifactorial Inflammatory Process Rosacea arises from a complex interplay of multiple contributing factors. 'The pathogenesis of rosacea continues to be a subject of investigation,' the authors wrote, involving 'dysregulation of the innate immune response and neuropeptide activity, microbial involvement, environmental factors, dietary triggers, and skin barrier dysfunction.' Central to these mechanisms is the innate immune system. In rosacea, elevated levels of kallikrein-5 trigger excessive processing of antimicrobial peptides into proinflammatory fragments such as LL-37. These fragments promote oxidative stress, cytokine release, and blood vessel changes, contributing to the inflammation and vascular symptoms seen in the disease, according to the authors. Neurovascular dysregulation is also a hallmark of the disease. The authors noted, 'activation of TRPV1 [Transient Receptor Potential Cation Channel Subfamily V Member 1] and related channels by environmental triggers like heat and UV [ultraviolet] radiation exacerbate flushing and erythema by promoting vasodilation and neurogenic inflammation.' These channels are hypersensitive in patients with rosacea, contributing to enhanced symptom severity. While the skin microbiome — particularly Demodex folliculorum and its associated Bacillus oleronius — has long been considered a contributing factor, recent attention has turned to the gut. 'Emerging evidence suggests that while microorganisms may not be central causative factors… alterations in the skin microbiome across multiple rosacea subtypes may act as trigger factors or potentiate inflammation,' the review authors wrote. 'Gastrointestinal dysbiosis, including conditions such as Helicobacter pylori infection and small intestinal bacterial overgrowth (SIBO),' they noted, 'has been hypothesized as a potential contributor to rosacea development.' Gut Dysbiosis and the Skin: The Available Evidence The concept of a gut–skin axis describes the bidirectional relationship between intestinal microbiota and skin inflammation. In rosacea, this relationship is supported by associations with conditions like SIBO, H pylori infection, and inflammatory bowel diseases, as highlighted in the Manfredini review. Asked to comment on this emerging topic, Rajani Katta, MD, clinical professor of dermatology at the McGovern Medical School, University of Texas, Houston, noted, 'We have strong evidence linking gut dysbiosis to rosacea, but it is important to note that this applies only to certain patients. In other words, only a subset of patients with rosacea seems to have gut dysbiosis, and in those patients, there appears to be a link.' Rajani Katta, MD Katta added that the most compelling mechanisms relate to inflammation. 'Patients with SIBO may have higher levels of inflammatory mediators, such as tumor necrosis factor alpha. In other studies, gut dysbiosis can lead to the activation of specific inflammatory pathways like the kallikrein-kinin pathway. Activation of these pathways has multiple downstream effects, which may ultimately increase neurogenic inflammation in the skin.' The review by Manfredini and colleagues supported these theories, citing studies that show improvement in rosacea symptoms following SIBO eradication, although the benefit of H pylori treatment is less clear. 'The association between Helicobacter pylori infection and rosacea remains complex and influenced by several confounding factors,' the authors wrote. 'The antibiotic treatment required for H pylori eradication represents an important confounding factor.' The authors caution that without large-scale prospective studies examining the gut microbiome before and after intervention, firm conclusions about causality remain elusive. Dietary Triggers: What the Evidence Supports Dietary factors may influence rosacea by promoting vasodilation, activating sensory receptors, or altering the gut microbiome. Yet, data on specific triggers remain mixed, according to the authors. Asked to comment on dietary triggers in rosacea, Lauren Kole, MD, associate professor of dermatology at the University of Alabama at Birmingham, said that 'the best data for dietary triggers for rosacea are for alcohol and hot beverages. Alcohol may induce peripheral vasodilation, promote inflammation, modulate the immune system, and may trigger histamine release. Hot beverages may cause direct vasodilation and trigger other pathways that lead to flushing, stinging, and sensitive skin.' Katta also noted that alcohol and hot beverages 'are common triggers, likely because they lead to vasodilation, which causes flushing.' She also highlighted spicy foods as a culprit. 'Foods that contain capsaicin may result in vasodilation and thus flare rosacea, so avoiding spicy foods may be helpful.' Another category included foods that contain cinnamaldehyde — a compound found in cinnamon, tomatoes, and citrus —which may trigger flushing in sensitive individuals, according to Katta. Katta recommended a practical approach for patients. 'For most patients, a 6-week trial of eliminating the most commonly reported food triggers in rosacea is a good first step… I tell patients that it can take 6 weeks of avoiding these foods to see if it will be helpful, and I recommend a food diary.' Interestingly, certain foods may offer benefits. Dairy products have been associated with reduced rosacea severity in some populations, potentially because of their anti-inflammatory effects. High-fiber diets may support gut microbial diversity and caffeine — despite its reputation — has been inversely associated with rosacea in large observational studies, cited in the Manfredini review. Probiotics: Potential but Preliminary Probiotics are another area of growing interest. These live microorganisms may influence rosacea by rebalancing the gut microbiome, reducing inflammatory cytokine production, and enhancing skin barrier function, according to the authors. 'Dietary probiotics may help normalize skin dysbiosis in rosacea and may limit substance P-induced skin inflammation,' said Kole. She referenced a study that found improved skin barrier function and reduced sensitivity with oral probiotic use alongside doxycycline therapy. Katta said that she has not used probiotics for rosacea in her practice. 'Preliminary results appear intriguing, but there are still many questions about the optimal strain of probiotics as well as dose and duration,' she told Medscape Medical News . She added that the current evidence is 'too preliminary to recommend specific strains or delivery routes, although some have shown benefit,' referencing studies on strains of Bifidobacterium , Lactobacillus , and Escherichia coli Nissle included in the Manfredini review. Topical formulations are also being explored with promising results, and a product containing Vitreoscilla filiformis has shown reductions in facial erythema and Demodex density while improving transepidermal water loss, according to the review's authors. However, mirroring Katta's sentiment, the authors concluded that 'despite promising results, the evidence supporting the use of probiotics in the treatment of rosacea remains relatively limited. Further clinical trials are necessary to evaluate and compare the effectiveness of various probiotic strains and different methods of delivery, such as oral ingestion and topical use.' Looking Ahead: Clinical Considerations and Research Needs While the current research is promising, more rigorous studies are needed. 'One of the research areas that I'd love to see more of,' Katta said, 'is measuring rates of gut dysbiosis in patients with rosacea, with prospective studies examining gut microbiome composition before and after treatment, and how that correlates to rosacea severity.' For now, clinicians may consider an individualized approach, she said, and asking about gastrointestinal symptoms, evaluating for common dietary triggers, and discussing a food elimination trial can be helpful strategies. Although formal probiotic guidelines for rosacea are lacking, some patients may benefit from a monitored trial of supplementation — particularly if they also have gut-related complaints, she added. 'There are many gaps in our understanding of the gut–skin axis,' Katta emphasized. 'But it's an exciting area of dermatologic research.'
Top Gear
6 days ago
- Automotive
- Top Gear
Here's everything you need to know about the 2,137bhp Giamaro Automobili Katla
Like you, TG couldn't believe the claims of an unknown hypercar startup, so we went to the reveal event in search of answers Hopefully you've read the news about the 2,137bhhp Giamaro Automobili Katla by now. Heck, if that headline power figure didn't make you click on the initial story, we don't know what would have done. Of course, you'd be right to treat its claims with a healthy dose of skepticism given how regularly new companies pop up declaring that they're the next big thing in the world of hypercars. There are usually some renders of a car, outlandish performance figures and limited detail on who will actually build the thing or when deliveries to customers could feasibly begin. Yes, we're looking at you Dendrobium D-1, Devel Sixteen, Vencer Sarthe, TranStar Dagger GT etc. As a result, when an invitation landed in our inboxes to attend the launch of the latest 'thrilling new chapter in the annals of automotive excellence', we very nearly dismissed it without a second thought. Then we slapped ourselves on the wrists for not being giddy at 2,000bhp and jumped on the next plane to Italy. So yes, was there as Giamaro Automobili unveiled the Katla to the world. 'In Modena, at the heart of the Motor Valley,' said the invitation, which turned out to mean 'on a small industrial estate in Cavezzo, still in the province of Modena but roughly 40 minutes from the city's centre'. Still, the glitzy launch event was held in a genuine factory where the smell of fresh paint still lingered, and TG rubbed shoulders with local dignitaries (it wouldn't be an Italian event without the local police chief showing up), prospective customers and interested dealers. Given how little we knew about Giamaro from the initial press release, it was an enlightening evening. So, we're going to treat this like one of those Frequently Asked Questions sections that the internet seems to love. Here goes… Well, the claims are indeed wild, but the company's launch event did seem pretty legit. It turns out that Giamaro was actually born back in 2021 and is the work of father and son team Giacomo and Pierfrancesco Commendatore. Giacomo describes himself as an entrepreneur and seemingly made his money from a mattress company and through telesales in the 80s and 90s, but he was also one of the first investors in a little-known company called Pagani. Aha! 'This was a fantastic project,' he says. 'Horacio was an amazing man, but in the end, we had different ideas. He prefers aesthetics while I adore functionality.' Interesting. Commendatore Sr also tells TG that the reason we haven't heard of Giacomo until now, despite the company being four years old, is because 'we don't like to talk, we like to build cars'. And yes, he does have the perfect surname to be running a car company in Modena. Well, near Modena.
Yahoo
24-05-2025
- Automotive
- Yahoo
Italy's Newest Hypercar Will Have a Beastly 2,128 Horsepower Under the Hood
Italy is still the land from which ostentatious supercars grow on trees, despite the U.S., Japan, and the U.K. laying some claim to otherwise. Case in point: the Giamaro Katla, Itay's newest hypercar. True to its class, the Katla delivers a monstrous 2,128 horsepower from a quad-turbo 7.0-liter V-12 engine that powers two wheels. It also has a seven-speed manual transmission. It's the kind of Italian hypercar a teenager might build, or an old automaker indulging in nostalgia, or a new automaker trying to make some noise. Giamaro Automobili meets the last criterion. More from Robb Report Minnesota's Most Expensive Listing Is This Massive $55 Million Waterfront Estate NBA MVP Shai Gilgeous-Alexander Just Gifted His Teammates Rolexes Bruichladdich Just Dropped a Smoky New Single Malt Whisky Founded in Modena, which is also where an automaker called Ferrari was founded, Giamaro describes itself as nothing less than perfect. 'Each Giamaro vehicle is conceived as a unique creation that reflects a personal vision of perfection. More than machines, they are immersive experiences—created to forge a deep, instinctive connection between human and car, as a true extension of the senses,' the company, founded in 2021, says. This might sound a little fanciful because the Katla, which debuted this week, is not even in production. However, a reporter from Motor1 actually went to the Giamaro factory in Italy before the car's debut and found a company seriously engaged in the product of making a hypercar to compete with Bugatti, Pagani, and all the rest. 'We tried to give our car, our product, a specific identity, and create a deep connection between driver and machine, something that doesn't exist yet,' Giacomo Commendatore told the publication, as a yellow Katla for the debut event was being prepared. That V-12 engine is obviously the star of the show, though the car also has hypercar bits underneath to increase its cred, like a carbon-fiber monocoque and bespoke suspension. The car weighs less than 3,200 pounds. Giamaro has not given numbers like top speed or zero to 60 times, but they will probably be impressive given the mill. Price and delivery date are also seemingly up in the air, though you can likely expect a seven-figure cost, and a delivery date that amounts to whenever the car is ready, but hopefully not of Robb Report The 2024 Chevy C8 Corvette: Everything We Know About the Powerful Mid-Engine Beast The World's Best Superyacht Shipyards The ABCs of Chartering a Yacht Click here to read the full article.
NZ Autocar
23-05-2025
- Automotive
- NZ Autocar
super range and superquick
On Xiaomi's 15th anniversary, CEO Lei Jun introduced the company's first electric SUV, the YU7. This follows the release of the SU7 sedan. It will launch in China officially in July this year when pricing will also be announced. What is it? The YU7 is a mid-to-large electric SUV built on the company's Modena platform. It is 5.0m in length, 2m in width, and 1608mm in height, with a 3m wheelbase. YU7 will be available in nine exterior colours, including a green shade inspired by Colombian emeralds. Weight varies between 2140 kg and 2460 kg depending on the model. Wheel choices include 19- and 20-inch sizes. Special features include inward-folding electric door handles with ambient lighting and Ultra Wideband support for smartphone-based keyless entry and trunk access. Inside, the 'zero gravity' front seats are Nappa leather lined, with massage function. Rear passengers benefit from electrically adjustable seats and a 6.68-inch touch control screen for climate, music, and navigation functions. Widescreen The dashboard has a 1.1m-wide 'HyperVision' set-up that consists of three Mini LED screens with high-level resolution. The system integrates driving data, media, blind-spot imaging, and customizable widgets. YU7 includes a 4-in-1 domain controller that integrates cabin, assisted driving, vehicle control, and communications systems. Underpinning it is a Snapdragon 8 Gen 3 chip set, ensuring fast boot-up in 1.35sec and over-the-air updates in 15 minutes. Three models YU7 RWD: This has a single 235kW rear motor offering 528Nm of torque and a sprint time to 100 of 5.9sec. YU7 Pro AWD: Dual motors produce system output of 365kW and 690Nm for a 0–100km/h time of 4.27sec. YU7 Max AWD: The top model makes with 508kW and 866Nm, for a claimed sprint time of 3.23sec. It uses a 220kW front motor and 295kW rear unit. All examples run on Xiaomi's 800V silicon carbide high-voltage platform. Under maximum charging speeds, the YU7 can add up to 620km of range in 15 minutes. Battery configurations RWD: 96.3kWh LFP battery, 835km of range Pro AWD: 96.3kWh LFP battery, 770km of range Max AWD: 101.7kWh NCM battery, 760km of range Safety first The vehicle structure includes a 2200 MPa ultra-high-strength steel integrated roll cage, an aluminium die-cast front frame, and a steel-aluminium hybrid body referred to as an 'armour cage.' The battery pack incorporates a reinforced shell with a 'bullet-resistant' coating. The mind boggles. Xiaomi says that over 50 passive safety tests have been conducted. The A- and B-pillars have also been structurally enhanced. YU7 uses Xiaomi's in-house developed end-to-end assisted driving system. Standard on all variants are Lidar sensors and Nvidia Drive AGX Thor (700 TOPS), paired with 4D mmWave radar and ALD-coated anti-glare cameras.
ABC News
22-05-2025
- Sport
- ABC News
Kaden Groves beaten by Olav Kooij in hectic Giro d'Italia sprint on stage 12
Dutchman Olav Kooij has come out on top in a sprint finish to win stage 12 of the Giro d'Italia, overtaking compatriot Casper van Uden before the line. Mexico's Isaac del Toro kept a firm grip on the overall lead on a day where the overall favourites only had to stay out of trouble. Kooij was led out by his Visma-Lease a Bike teammate Wout van Aert, but Van Uden, who beat Kooij into second place to win stage four, took the lead before Kooij battled to victory on Thursday local time. "It's really nice to see Olav finishing it off after a really good lead-out, I have to say," Van Aert said. "We used our horsepower and he has the kick." Briton Ben Turner (INEOS Grenadiers) came in third, ahead of one-time race leader Mads Pedersen, who won three of the opening five stages. Australian sprinter Kaden Groves (Alpecin-Deceuninck) was fifth. Del Toro (UAE Team Emirates) earned two seconds on the last intermediate sprint of the stage and has a 33-second lead over teammate Juan Ayuso of Spain with Italian Antonio Tiberi of Bahrain Victorious over one minute behind in third. Michael Storer (Tudor Pro) finished in the main bunch to remain the leading Australian in 14th place overall, 3:22 behind. The 172km ride from Modena to Viadana was expected to bring the sprinters back to the fore, and after an early breakaway of three riders was reeled in by the peloton, the final 25km was a tactical game as teams looked to set their sprinters up. Van Aert, who won stage nine, opted for an early lead-out before the final dangerous corner, with Kooij on his back wheel. Van Uden went past and Kooij had to wait to find room to attack but had the finish to overtake and take victory. "Only Wout can do such a long lead-out like today's," Kooij said. "I got an extraordinary support. I have to thank my teammates, also the rest of the team did a fantastic job." Friday's stage 13 will take the riders 180km from Rovigo to Vicenza. Reuters/ABC
