Latest news with #NSAID
Business Upturn
3 days ago
- Business
- Business Upturn
Mangalore Refinery secures US patent for Iso-Butyl Benzene production technology
By Aman Shukla Published on May 30, 2025, 16:57 IST Mangalore Refinery and Petrochemicals Limited (MRPL) has been awarded a United States patent for its method of preparing iso-Butyl Benzene (i-BB), a key intermediate used in pharmaceutical manufacturing. The patented process, developed in-house, had previously received recognition through an Indian patent. The patented method centers on a side-chain alkylation process that converts a low-value captive stream into iso-Butyl Benzene using a specially engineered catalyst. This catalyst, developed at MRPL's Innovation Centre, is designed to achieve high conversion efficiency and selectivity toward the i-BB product. Iso-Butyl Benzene is an essential raw material in the synthesis of Brufen (ibuprofen), a commonly used non-steroidal anti-inflammatory drug (NSAID). By developing this production process domestically, MRPL aims to reduce dependence on imported intermediates and enhance self-reliance in pharmaceutical ingredient supply. As part of its scale-up efforts, MRPL is currently establishing a pilot plant for i-BB production. This facility will support the transition from laboratory development to commercial-scale manufacturing. The patent and ongoing pilot-scale activities reflect MRPL's focus on advancing technologies relevant to the pharmaceutical and chemical sectors, supporting India's broader goals in local manufacturing and process innovation. Aman Shukla is a post-graduate in mass communication . A media enthusiast who has a strong hold on communication ,content writing and copy writing. Aman is currently working as journalist at
Yahoo
7 days ago
- Health
- Yahoo
Dietary supplements containing drugs recalled due to serious health risks
Umary USA announced a voluntary recall of dietary supplements marketed nationwide for joint pain and arthritis relief as they contain drugs that pose serious health risks, according to the U.S. Food and Drug Administration. All lots and dates of the supplements, Unavy Ácido Hialurónico and Umovy Ácido Hialurónico caplets, are covered by the recall. Consumers who purchased the supplements should immediately stop taking them and consult their health care provider for safe discontinuation of use. The caplets contain the undeclared drugs diclofenac, dexamethasone and omeprazole, according to the FDA. Because they contain those drugs, they cannot be marketed as dietary supplements. Their safety and effectiveness have not been established, according to the FDA. 'Dexamethasone, a corticosteroid, can weaken the immune system, cause high blood sugar, muscle damage, psychiatric effects and cardiovascular problems,' the FDA press release states. 'Prolonged or high-dose use may suppress adrenal gland function and abrupt stopping can lead to withdrawal symptoms.' 'Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), may cause severe cardiovascular, gastrointestinal, kidney, and allergic reactions, especially in patients taking other NSAIDs or blood thinners or those with allergies or underlying health issues,' the statement reads. 'Omeprazole, a proton pump inhibitor used to treat stomach acid disorders, might mask serious gastric conditions such as ulcers or cancer if taken unknowingly,' the statement reads. Unavy Ácido Hialurónico comes in a white plastic bottle with a black label marked with white and yellow text. Umovy Ácido Hialurónico is packaged in a black plastic bottle with a black label featuring white and blue lettering. Both products come in 30-count, 850-mg caplets. The supplements were distributed nationwide by Umary USA, which is notifying distributors and customers by press release and email. The company is arranging for returns and refunds, according to the FDA. There have been no reported adverse reactions linked to using the two products. Consumers who are experiencing problems related to the caplets should contact their healthcare provider and report issues to the FDA's MedWatch program online. For questions about the recall, consumers can contact Umary USA at umaryusa2025@ available 24/7. For more information, visit the official FDA recall notice here. Multi-state salmonella outbreak linked to recalled cucumbers Public health alert: Listeria found in Big Y, Price Chopper ready-to-eat wrap Tattoo ink recalled due to contamination with infection-causing microorganisms Read the original article on MassLive.
Hans India
26-05-2025
- Health
- Hans India
Doctors treat 40-year-old woman's acute kidney allergy
Karimnagar: 'Timely diagnosis and treatment are important in case of kidney injury,' said Dr Arun Kumar Ponna, Consultant Nephrologist, Yashoda Hospitals, Somajiguda. Speaking at a press meet in Karimnagar on Sunday, he said that a 40-year-old woman from the district visited the hospital with weakness and vomiting two days after taking an NSAID injection (a commonly used painkiller). On routine evaluation, it her serum creatinine was found to be 6 mg/dL - a sign of significant kidney dysfunction - despite no major symptoms. However, in the next two days, her creatinine further deteriorated, a sign of impending kidney failure However, instead of going for dialysis, the doctors focused on a definitive diagnosis. A kidney biopsy was performed and the report guided necessary treatment. 'She was diagnosed with an allergic reaction to an NSAID injection,' said Dr Kumar. With proper management, her kidney function fully recovered without the need for dialysis. 'Now, she is doing well and has returned to a normal life,' he shared. The doctor guided that early detection is key as kidney injury is silent. 'Symptoms such as vomiting or weakness may seem mild but may mask serious damage,' he explained. 'Painkillers, especially NSAIDs, can be dangerous to the kidneys, especially if taken without proper guidance. Not all patients with high creatinine require dialysis. Understanding the cause is key,' he said. 'Early medical attention and timely nephrology referral saved this patient's life and kidneys,' Dr Kumar said. 'People and general practitioners should be alert to early signs, avoid using common painkillers, we want to see people not having to go on dialysis,' he added.
Mint
20-05-2025
- Health
- Mint
Fearing antimicrobial resistance in humans, India plans to ban 37 antibiotics for animal use
New Delhi: The Centre plans to ban the sale, manufacture, import, and distribution of 37 antimicrobial medicines used to boost animal growth and yield. The plan is to check the effect of antibiotic resistance in humans, which is transferred through the consumption of milk, meat, eggs, and other dairy products. Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi and parasites no longer respond to antimicrobial medicines. As a result, antibiotics and other antimicrobial medicines become ineffective and infections become difficult or impossible to treat; thereby increasing the risk of disease spread, severe illness, disability and even death. Also read: Is Covid-19 back in India? All we know amid recent surge in Hong Kong, Singapore The development assumes significance given that AMR has become a major global health issue, with around 6 lakh lives lost in India each year due to resistant infections, as per the data available with the ministry of chemical and fertilisers. 'These 37 antimicrobials have not been approved by the Central Drugs Standard Control Organisation (CDSCO) for veterinary use in the treatment of various diseases, but are still being used on animals. Using unapproved antibiotics may pose huge health risks not only to the animals but also to humans, as food produced by these animals may have elements of antibiotics which can be transferred to humans and cause antibiotic resistance," a government official said. Queries sent to the health ministry and the department of animal husbandry and dairying (DAHD) spokesperson remained unanswered. EU recommendations In 2022, the Commission Implementing Regulation (EU) recommended that 37 antibiotics be reserved for human use only for the treatment of certain life-threatening infections. Some of these drugs are ceftobiprole, ceftaroline, carbapenems, and the antiprotozoal drug nitazoxanide. Also read: 'Elder abuse! Criminal charges??' — Donald Trump's DOJ lawyer accuses Jill Biden of hiding Joe Biden's health problems 'Representatives of the animal husbandry department were also present at the meeting, which happened last month. After detailed deliberation, the apex drug panel board recommended prohibition of manufacture, import, sale, distribution and use of 34 antimicrobial medical products except three antimicrobials, i.e. carboxypenicillins, combinations of cephalosporins with beta-lactamase inhibitors and phosphonic acid derivatives only, for animal use," the official added. The health ministry has sought a report on these three antimicrobials from the department of animal husbandry and dairying to reach its conclusion. According to Crisil market intelligence and analytics, the market size of the anti-infective segment in India stood at about ₹251.3 billion for FY2024. These include antibiotics, antivirals, and antifungals. In December, the health ministry banned the manufacturing and sale of non-steroidal anti-inflammatory drug (NSAID) nimesulide and its formulation for animal use, citing a health risk to the animals. Also read: Mounjaro in India: The speed bumps impacting access to weight loss drugs Dr K.P. Singh from the Indian Veterinary Research Institute said, 'Basically, all veterinary institutes have qualified veterinarians, but the problem is that there is one population who are not qualified to provide treatment to animals. These people are using antibiotics irrationally. These three antibiotics—carboxypenicillins, combinations of cephalosporins with beta-lactamase inhibitors and phosphonic acid derivatives—are largely used to treat bacterial infections in the animals."
Los Angeles Times
02-05-2025
- Health
- Los Angeles Times
What You Need to Know About Esophagitis
Imagine swallowing food and feeling pain, like something is scraping your throat. That's what people with esophagitis experience. Esophagitis is the medical term for inflammation of the esophagus—the tube that moves food from your mouth to your stomach. This can be short-term or chronic, mild or severe and can be caused by acid reflux, infections, immune reactions, and even certain medications or chemicals [1]. At its core esophagitis is inflammation—meaning the esophageal lining is irritated or damaged. Infections that weaken the immune system and allergies, especially food allergies can cause esophagitis. This can make swallowing painful, uncomfortable or difficult. Various risk factors, lifestyle choices and health conditions can contribute to esophagitis. In some cases the inflammation can lead to ulcers, scarring or narrowing of the esophagus which can complicate eating and digestion. Symptoms of esophagitis can vary in severity from mild discomfort to severe pain. Different from something like Gastroparesis, The cause determines the type of esophagitis and getting the diagnosis right is key to choosing the right treatment [1]. Esophagitis isn't a one size fits all condition. There are several types, each with its own causes and characteristics. Each type has its own risk factors so certain groups are more prone to developing the condition. For example some types of esophagitis are linked to certain medications such as NSAID pain relievers, nitrates and beta blockers which can increase the risk of developing this condition. Also chronic vomiting medicines can cause esophagitis through irritation and inflammation of the esophagus potentially leading to serious health implications if left untreated. This is the most common type and is directly linked to a condition called gastroesophageal reflux disease (GERD)—a condition where stomach acid flows back into the esophagus regularly. That acid meant to break down food in the stomach can wreak havoc on the esophageal lining. The lower esophageal sphincter acts as a valve to prevent this acid reflux and its dysfunction is a common cause of GERD and reflux esophagitis. Over time this acid exposure can cause erosions, ulcers and even strictures (narrowing due to scar tissue). Doctors use the Los Angeles (LA) classification system to grade the severity based on what they see during an upper endoscopy [5], [10]. This is not acid related. EoE is driven by the immune system. EoE occurs when eosinophils—a type of white blood cell involved in allergic responses—build up in the esophagus often in response to allergens or food triggers [3]. Allergic reactions can cause this accumulation leading to inflammation. It's on the rise now affecting around 1 in 700 Americans [13]. People with EoE often have trouble swallowing and food getting stuck. Trouble swallowing also known as dysphagia is a common symptom of eosinophilic esophagitis. Long term inflammation can lead to strictures and about 28% of patients develop them mostly in the distal esophagus, or the lower third near the stomach [14]. Still a bit of a mystery lymphocytic esophagitis features an excess of lymphocytes, a type of white blood cell, in the esophageal tissue without signs of acid damage or typical allergic inflammation [2]. It's more common in older women and individuals with other immune related issues. While rare this condition may overlap with disorders like celiac disease or autoimmune conditions. An autoimmune disease such as scleroderma can increase the risk of esophagitis. When infection is the cause Candida albicans, herpes simplex virus, and cytomegalovirus are the usual culprits [6], [7]. These are more common in immunocompromised individuals such as those undergoing chemotherapy or living with HIV but are also being seen more frequently in healthy people with a weakened immune system. One subtype esophageal candidiasis occurs when Candida, a fungal organism that normally lives in the body, overgrows in the esophagus [15]. This often appears as white patches visible during an endoscopy. Radiation therapy infections can also cause esophagitis by causing irritation and inflammation in the esophagus. No matter the type esophagitis tends to show up with some common symptoms. The most common are: Severe esophagitis can lead to complications such as difficulty eating, risk of bleeding and narrowing of the esophagus. Symptoms may vary depending on the cause and some people especially with infectious or drug induced esophagitis may only notice symptoms when things become severe. Diagnosing esophagitis starts with a thorough review of symptoms and medical history. A physical exam by a healthcare provider, especially a gastroenterologist, is also necessary. To confirm the diagnosis esophagitis is diagnosed through various tests and procedures including an upper endoscopy where a flexible tube with a camera is passed down the throat to examine the esophagus directly. They may also take biopsies (small tissue samples) during the procedure especially if they suspect EoE or want to rule out infection or other immune related issues [3]. Fortunately esophagitis is treatable—especially when the cause is identified. Treatment depends on the type: Severe esophagitis is more than just a sore throat or heartburn—it's a condition that reflects the complexity of how our body's systems interact and can result in serious complications like bleeding. From acid reflux to immune responses and infections multiple pathways can lead to the same inflamed result. Untreated esophagitis can lead to Barrett's esophagus a condition that increases the risk of esophageal cancer. Though GERD is the most common type, the increasing awareness of EoE and other immune related types emphasizes the need for early diagnosis and accurate diagnosis. As research evolves new treatments and diagnostic tools will help patients with this uncomfortable condition. [1] Grossi, L., Ciccaglione, A. F., & Marzio, L. (2017). Esophagitis and its causes: Who is 'guilty' when acid is found 'not guilty'?. World journal of gastroenterology, 23(17), 3011–3016. [2] Pittman M. E. (2022). Lymphocytic Esophagitis: Current Understanding and Controversy. The American journal of surgical pathology, 46(1), e55–e63. [3] Dellon, E. S., Muir, A. B., Katzka, D. A., Shah, S. C., Sauer, B. G., Aceves, S. S., Furuta, G. T., Gonsalves, N., & Hirano, I. (2025). ACG Clinical Guideline: Diagnosis and Management of Eosinophilic Esophagitis. The American journal of gastroenterology, 120(1), 31–59. [4] Lisovsky M. (2020). Inflammatory conditions of the esophagus: an update. Annals of the New York Academy of Sciences, 1481(1), 5–10. [5] Nguyen, A. D., Spechler, S. J., Shuler, M. N., Souza, R. F., & Dunbar, K. B. (2019). Unique Clinical Features of Los Angeles Grade D Esophagitis Suggest That Factors Other Than Gastroesophageal Reflux Contribute to its Pathogenesis. Journal of clinical gastroenterology, 53(1), 9–14. [6] Patel, N. C., & Caicedo, R. A. (2015). Esophageal infections: an update. Current opinion in pediatrics, 27(5), 642–648. [7] Hoversten, P., Kamboj, A. K., & Katzka, D. A. (2018). Infections of the esophagus: an update on risk factors, diagnosis, and management. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 31(12), 10.1093/dote/doy094. [8] Goff J. S. (1988). Infectious causes of esophagitis. Annual review of medicine, 39, 163–169. [9] Reddy, C. A., McGowan, E., Yadlapati, R., & Peterson, K. (2024). AGA Clinical Practice Update on Esophageal Dysfunction Due to Disordered Immunity and Infection: Expert Review. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 22(12), 2378–2387. [10] Lottrup, C., Khan, A., Rangan, V., & Clarke, J. O. (2020). Esophageal physiology-an overview of esophageal disorders from a pathophysiological point of view. Annals of the New York Academy of Sciences, 1481(1), 182–197. [11] Guntipalli, P., Chason, R., Elliott, A., & Rockey, D. C. (2014). Upper gastrointestinal bleeding caused by severe esophagitis: a unique clinical syndrome. Digestive diseases and sciences, 59(12), 2997–3003. [12] Carmack, S. W., Vemulapalli, R., Spechler, S. J., & Genta, R. M. (2009). Esophagitis dissecans superficialis ('sloughing esophagitis'): a clinicopathologic study of 12 cases. The American journal of surgical pathology, 33(12), 1789–1794. [13] Thel, H. L., Anderson, C., Xue, A. Z., Jensen, E. T., & Dellon, E. S. (2025). Prevalence and Costs of Eosinophilic Esophagitis in the United States. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 23(2), 272–280.e8. [14] Eluri, S., Tappata, M., Huang, K. Z., Koutlas, N. T., Robey, B. S., Fan, C., Reed, C. C., Shaheen, N. J., & Dellon, E. S. (2020). Distal esophagus is the most commonly involved site for strictures in patients with eosinophilic esophagitis. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 33(2), doz088. [15] Mohamed, A. A., Lu, X. L., & Mounmin, F. A. (2019). Diagnosis and Treatment of Esophageal Candidiasis: Current Updates. Canadian journal of gastroenterology & hepatology, 2019, 3585136.
