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Yahoo
an hour ago
- Business
- Yahoo
InnoCare Announces Approval of Clinical Trial of BCL2 Inhibitor Mesutoclax for Myelodysplastic Syndromes in China
BEIJING, May 29, 2025--(BUSINESS WIRE)--InnoCare Pharma (HKEX: 09969; SSE: 688428), a leading biopharmaceutical company focusing on the treatment of cancer and autoimmune diseases, announced today the approval of the Investigational New Drug (IND) by the Center for Drug Evaluation (CDE) of the China National Medical Products Administration (NMPA) to conduct the clinical trial of B-cell lymphoma-2 (BCL2) inhibitor mesutoclax (ICP-248) in combination with azacitidine for the treatment of myeloid malignancies, including but not limited to myelodysplastic syndromes (MDS). Mesutoclax is a novel, orally bioavailable BCL2 selective inhibitor. BCL2 is an important regulatory protein in the apoptosis pathway, and its abnormal expression is associated with the development of various hematologic malignancies. Mesutoclax exerts anti-tumor activity by selectively inhibiting BCL2 and restoring the normal apoptosis process in cancer cells. Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal myeloid diseases characterized by the abnormal proliferation of hematopoietic stem cells, recurrent genetic abnormalities, myelodysplasia, ineffective hematopoiesis, peripheral-blood cytopenia, and a high risk of progression to acute myeloid leukemia (AML). The annual incidence of myelodysplastic syndromes is about 4 cases/100,000 people/year (reaching 40–50/100,000 in patients aged ≥ 70 years). Mesutoclax has been granted Breakthrough Therapy Designation (BTD) by the CDE for the treatment of BTKi-treated relapsed or refractory mantle cell lymphoma (R/R MCL). This marks the first BCL2 inhibitor to receive BTD recognition in China. The Company is accelerating patient enrollment of a Phase III registrational trial of mesutoclax in combination with orelabrutinib as a first line therapy for the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), as well as a clinical trial of mesutoclax for the treatment of AML. Dr. Jasmine Cui, the Co-founder, Chairwoman, and CEO of InnoCare, said, "Mesutoclax is an important global asset of our company in the field of hematology. We are delighted to receive approval to initiate the clinical trial for the fourth indication of our BCL2 inhibitor. We will accelerate the clinical development of mesutoclax across multiple indications in China and globally to bring benefits to patients as early as possible." About InnoCare InnoCare is a commercial stage biopharmaceutical company committed to discovering, developing, and commercializing first-in-class and/or best-in-class drugs for the treatment of cancers and autoimmune diseases with unmet medical needs in China and worldwide. InnoCare has branches in Beijing, Nanjing, Shanghai, Guangzhou, Hong Kong, and the United States. InnoCare Forward-looking Statements This report contains the disclosure of some forward-looking statements. Except for statements of facts, all other statements can be regarded as forward-looking statements, that is, about our or our management's intentions, plans, beliefs, or expectations that will or may occur in the future. Such statements are assumptions and estimates made by our management based on its experience and knowledge of historical trends, current conditions, expected future development and other related factors. This forward-looking statement does not guarantee future performance, and actual results, development and business decisions may not match the expectations of the forward-looking statement. Our forward-looking statements are also subject to a large number of risks and uncertainties, which may affect our short-term and long-term performance. View source version on Contacts Media Chunhua Investors 86-10-66609999ir@ Error while retrieving data Sign in to access your portfolio Error while retrieving data Error while retrieving data Error while retrieving data Error while retrieving data
The Province
3 hours ago
- Entertainment
- The Province
Top ballet dancers in Vancouver to celebrate dance company's 20th anniversary
B.C. dancer and choreographer Joshua Beamish created MOVETHECOMPANY 20 years ago and now some of North America's top dancers are in the city for a celebration gala As part of their 20th anniversary gala on May 29 and 30 at Vancouver Playhouse, Joshua Beamish and MOVETHECOMPANY perform Lollapalooza. The 2018 piece was Beamish's first work for The National Ballet of Canada. Photo by Paulo-Garcia Reviews and recommendations are unbiased and products are independently selected. Postmedia may earn an affiliate commission from purchases made through links on this page. This advertisement has not loaded yet, but your article continues below. THIS CONTENT IS RESERVED FOR SUBSCRIBERS ONLY Subscribe now to read the latest news in your city and across Canada. Exclusive articles by top sports columnists Patrick Johnston, Ben Kuzma, J.J. Abrams and others. Plus, Canucks Report, Sports and Headline News newsletters and events. Unlimited online access to The Province and 15 news sites with one account. The Province ePaper, an electronic replica of the print edition to view on any device, share and comment on. Daily puzzles and comics, including the New York Times Crossword. Support local journalism. SUBSCRIBE TO UNLOCK MORE ARTICLES Subscribe now to read the latest news in your city and across Canada. Exclusive articles by top sports columnists Patrick Johnston, Ben Kuzma, J.J. Abrams and others. Plus, Canucks Report, Sports and Headline News newsletters and events. Unlimited online access to The Province and 15 news sites with one account. The Province ePaper, an electronic replica of the print edition to view on any device, share and comment on. Daily puzzles and comics, including the New York Times Crossword. Support local journalism. REGISTER / SIGN IN TO UNLOCK MORE ARTICLES Create an account or sign in to continue with your reading experience. Access articles from across Canada with one account. Share your thoughts and join the conversation in the comments. Enjoy additional articles per month. Get email updates from your favourite authors. THIS ARTICLE IS FREE TO READ REGISTER TO UNLOCK. Create an account or sign in to continue with your reading experience. Access articles from across Canada with one account Share your thoughts and join the conversation in the comments Enjoy additional articles per month Get email updates from your favourite authors When: May 29 & 30, 2025 at 7:30 p.m. Where: Vancouver Playhouse, 600 Hamilton St., Vancouver Tickets: From $44-$99 at Some of North America's best ballet dancers are congregating in Vancouver to celebrate the work of Joshua Beamish and MOVETHECOMPANY, the company that the B.C. dancer and choreographer created 20 years ago. The five pieces in the program include one remount and four Vancouver premieres and feature dancers from San Francisco Ballet, The National Ballet of Canada, American Ballet Theatre, Ballet Edmonton and Royal Winnipeg Ballet, as well as local dancers and former artists from Ballet B.C. We talked to Beamish about the retrospective: Q: We're talking a day before the performances. Are you wondering why you decided to mount such an ambitious project? Essential reading for hockey fans who eat, sleep, Canucks, repeat. By signing up you consent to receive the above newsletter from Postmedia Network Inc. Please try again This advertisement has not loaded yet, but your article continues below. A: If you had asked me that a few days ago, I would have said no. But today, now that we're in the thick of it, one could say 'possibly.' Except that the cast is absolutely phenomenal and the dancers have been working so hard. And we're incredibly fortunate as a community to have them here and to be able to see them perform. Q: The program is focused on ballet. Why ballet instead of contemporary dance? A: As a company, our identity is always kind of shifted between more balletic programming with work on point, and then contemporary and theatre work. And our ballet @giselle that we did in 2019 was a big success. We don't often see a lot of classical ballet here, outside of The Nutcracker. And because our last two productions, Source Amnesia and Salt, were more contemporary dance, it felt like the right time for a ballet-focused program. This advertisement has not loaded yet, but your article continues below. B.C. dancer/choreographer Joshua Beamish celebrates 20 years of being on point with a retrospective at Vancouver Playhouse May 29 and 30. Photo by Alex Brinson Photography Q: The earliest piece, Trap Door Party, is from 2007 and features original cast member Amber Barton. What's it like working with a dancer again after all these years? Did she remember the moves? A: I think her experience, as she related it to me, was that she had so many memories of being back in the studio when we were making it. Her movements came back quite readily, and then it was all about approaching the movement with her body as it is now, 18 years later. We're in completely different places in our dancing, in our relationship to dance, and how our bodies approach movement. In my opinion, she looks better now than she did when we made it in our 20s. It's quite extraordinary how the knowledge we gain through a sustained career can allow us to approach virtuosity with a greater efficiency and therefore more freedom. And I've loved being able to reconnect with her, especially in the Dance Center building, where I held the first rehearsals of my career. This advertisement has not loaded yet, but your article continues below. Joshua Beamish and MOVETHECOMPANY's Endless Summer is set to several Beach Boys songs. Photo by Jake Tupper Q: What can you tell us about Endless Summer, the most recent piece in the program, which is choreographed to music by the Beach Boys? A: I always wanted to make a ballet to pop, because I'm really interested in the rhythm of vocalization. And the Beach Boys are incredibly rhythmic in their approach to the way that they use their voices. Something I love about a lot of their songs is that they sound easy breezy on the surface, but the lyrics are kind of melancholy, there's a lot of hidden depth. That references the era and how it felt like things were free and groovy but at the same time while there was a lot of turmoil politically. The ballet is really about what's under the surface or the untold stories of that era, and also a celebration of being together. Q: Will we hear Kokomo? A: No. But you'll get Good Vibrations. Read More
The Province
4 hours ago
- Business
- The Province
B.C. premier prepares to jet off to Asia in effort to diversify exports
David Eby and B.C.'s agriculture minister will make stops in Japan, South Korea and Malaysia in effort to support trade diversification. Martin Turenne, the CEO of FPX Nickel Corp., is hoping to discuss a project that could generate upwards of $45 billion of GDP in B.C. over the next 30 years. Premier David Eby's 10-day visit to Asia starting June 1 is 'extremely important' as B.C.'s relationship with its biggest trading partner, the United States, has faltered and the province is hoping to to diversify its economic relationships, experts say. This advertisement has not loaded yet, but your article continues below. THIS CONTENT IS RESERVED FOR SUBSCRIBERS ONLY Subscribe now to read the latest news in your city and across Canada. Exclusive articles by top sports columnists Patrick Johnston, Ben Kuzma, J.J. Abrams and others. Plus, Canucks Report, Sports and Headline News newsletters and events. Unlimited online access to The Province and 15 news sites with one account. The Province ePaper, an electronic replica of the print edition to view on any device, share and comment on. Daily puzzles and comics, including the New York Times Crossword. Support local journalism. SUBSCRIBE TO UNLOCK MORE ARTICLES Subscribe now to read the latest news in your city and across Canada. Exclusive articles by top sports columnists Patrick Johnston, Ben Kuzma, J.J. Abrams and others. Plus, Canucks Report, Sports and Headline News newsletters and events. Unlimited online access to The Province and 15 news sites with one account. The Province ePaper, an electronic replica of the print edition to view on any device, share and comment on. Daily puzzles and comics, including the New York Times Crossword. Support local journalism. REGISTER / SIGN IN TO UNLOCK MORE ARTICLES Create an account or sign in to continue with your reading experience. Access articles from across Canada with one account. Share your thoughts and join the conversation in the comments. Enjoy additional articles per month. Get email updates from your favourite authors. THIS ARTICLE IS FREE TO READ REGISTER TO UNLOCK. Create an account or sign in to continue with your reading experience. Access articles from across Canada with one account Share your thoughts and join the conversation in the comments Enjoy additional articles per month Get email updates from your favourite authors Kristen Hopewell, a professor and director of the Liu Institute for Global Issues at the University of B.C., said the province has historically been playing catch-up in the Asia-Pacific region with competitors such as Australia having a deeper presence there. 'We're fighting geography. It's been much easier for companies in B.C. and in Canada to trade with the U.S., given our geographic proximity, given our linguistic similarity and so forth, than to try to reach out to target these Asian markets,' said Hopewell. 'About 50 per cent of our trade goes to the U.S. That's an extremely high degree of trade vulnerability.' Eby will be visiting Japan, South Korea and Malaysia during the trade mission, which coincides with the end of the spring legislative session. He will be joined by Agriculture Minister Lana Popham and Paul Choi, parliamentary secretary for Asia-Pacific trade, as well as a number of companies hoping to add to investments already made in B.C. by companies such as Mitsubishi and Samsung. Stay on top of the latest real estate news and home design trends. By signing up you consent to receive the above newsletter from Postmedia Network Inc. Please try again This advertisement has not loaded yet, but your article continues below. Eby said the government has two goals for the trip. 'One is to meet with our existing customers and investors overseas (at) a time of global instability and uncertainty to remind them that British Columbia is a stable jurisdiction, a strong partner, and we value the relationship we have with them,' he explained. 'The other is to identify opportunities to expand markets.' It follows a 2023 trade mission to Japan, South Korea, Singapore and Vietnam that aimed to promote the province's LNG and forestry industries as well as provide an opportunity to speak with officials about their efforts at providing affordable housing. The premier's office said some of the concrete outcomes of that trip included the signing of two memorandums of understanding with Japan that outline cooperation on supply chains for batteries and science and technology. This advertisement has not loaded yet, but your article continues below. Jagrup Brar, secretary of state for trade, also officially opened the government's trade office in Vietnam. Currently, Japan is B.C.'s third-largest trading partner with $5.6 billion worth of trade between the two jurisdictions in 2024. South Korea was just behind Japan in fourth with $3.6 billion in trade with B.C. in the same year. Malaysia is farther back in 16th with only $162 million of goods and services moving back and forth. Popham said one of the sectors with the greatest potential for an increase in trade is seafood. She said the trip will feature attendance at a halal trade show in Malaysia as well as visits to Costco Japan and Costco Korea to view the B.C. seafood sold there. 'We'll be talking to some fish brokers, vegetable brokers. We'll also be looking at some of the technologies that they use down there, especially in South Korea, to produce food,' explained Popham. This advertisement has not loaded yet, but your article continues below. For some of the companies travelling on the trip, the opportunities will be in meeting with partners on projects already underway. Martin Turenne, the CEO of FPX Nickel Corp., said he plans to speak to executives from Nippon Steel and Sumitomo Metal Corp., one of its largest shareholders, as well as executives from the Japan Organization for Metals and Energy Security. Both have partnered with FPX on the Baptiste Nickel Project, a proposed mine in central B.C. that is currently undergoing a feasibility study. Turenne said he hopes to get the feasibility study done and the environmental assessment process underway in the next couple of years. 'It's a project that could generate upwards of $45 billion of GDP through the province over its 30-year lifespan,' he said. This advertisement has not loaded yet, but your article continues below. 'Japan obviously is a large player in batteries and in electric vehicles, looking for sources of nickel for that purpose for the next many decades.' Jock Finlayson, an economist with the Independent Contractors and Businesses Association, said that while B.C. is less exposed than other provinces to the U.S., it has become less diversified since 2011 with its share of exports to Canada's southern neighbour increasing from 43 per cent to 52.4 per cent. The share of U.S. trade had previously dropped from 65.8 per cent in 2000 to 43 per cent in 2011, according to Finlayson. He said the key for this trip is to try to reverse that trend, which has also seen trade to Japan decline by one-fifth and South Korea by 11 per cent. 'Having political leaders from our various levels of government show up, especially if they're part of larger business delegations, can be helpful in making connections and laying the groundwork for subsequent business transactions and business deals,' said Finlayson. 'The competitive environment here, business environment for a lot of the industries that supply our exports hasn't been very good. So a lot of companies are choosing not to invest and expand in B.C. for a mix of different reasons.' alazenby@ Read More
Time of India
6 hours ago
- Health
- Time of India
Social media campaign urges India to view menstruation as a sign of health
1 2 3 Pune: On World Menstrual Hygiene Day (May 28), a new social media campaign is challenging India's entrenched narrative around menstruation. Launched by Tata Trusts, the initiative asks a provocative question: "What if we delink menstruation from fertility, and instead see it simply as a symbol of health?" The campaign spotlights four influential figures in a woman's menstrual journey, including mothers, mothers-in-law, ASHA workers, and men. Through a series of short films and a catchy jingle, 'Maheena Aa Gaya', the campaign aims to normalise conversations about periods and dismantle long-standing taboos. Medical experts support this reframing. Dr Sunita Tandulwadkar, president of the Federation of Obstetric and Gynaecological Societies of India and head of obstetrics and gynaecology at Ruby Hall Clinic, Pune, stated, "The regulation of periods goes much beyond highlighting the fertility of a woman. It represents her health condition. Monitoring periods is even more important in today's world where lifestyles have changed. Long working hours, high stress, irregular sleep, fast food, and rising obesity all play a role, not just in fertility but also overall health. " Dr Manisha Kulkarni, senior consultant in the obstetrics and gynaecology department at Sahyadri Hospitals, Hadapsar, said, "Many women experience heavy or painful periods, which can lead to anaemia due to blood loss. Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like The Killer New Toyota 4Runner Is Utter Perfection (Take A Look) MorninJoy Undo Some also face premenstrual syndrome (PMS), a real condition marked by mood swings, sadness, or irritability before periods. In cases of severe pain or heavy bleeding, conditions like endometriosis — where tissue similar to the uterus lining grows outside it — may be diagnosed. These issues can lead to fatigue, weight gain, or even hypothyroidism. However, irregular periods don't always mean infertility. With minimal treatment, many women with irregular cycles can still conceive. Common myths persist such as painful periods are not normal and should be checked; you can and should bathe and exercise during periods; periods don't need to last a full week to be 'cleaning' the body; and healthy cycles can vary. PMS is real—many women experience emotional and physical changes days before their period." Kulkarni emphasises getting medical help early is key. The campaign also highlights several issues that women continue to face as the topic is not often talked about freely in Indian households. "The lack of reliable access to water and private spaces, whether to bathe, change, or dispose of pads, makes it difficult for girls to manage their periods with safety and dignity," said Divyang Waghela, head of Water, Sanitation and Hygiene (WASH) at Tata Trusts. "Lack of infrastructure and agency compound this problem. We strive to tackle barriers around infrastructure, belief systems, and environments perpetuating them. Through this, girls can view periods as a normal part of health, not something to be hidden away," Waghela said. Creative director Keigan Pinto emphasised the campaign's relatable approach. "We're not asking people to radically shift their thinking. We simply want them to understand that a period is just a 'lakshan'—a symptom, like hair loss. Capturing this, we created a simple, light film that we shot in people's homes, with a powerful, memorable song with a hook rooted in Indian pop culture, offering an important reminder: 'Maheene ko sirf sehat se jodo' (link that time of the month only to health)."
Toronto Sun
8 hours ago
- Toronto Sun
Abandoned boat and 11 bodies found on eastern Caribbean island with Mali passports
Published May 28, 2025 • 1 minute read Two sea huts in the bay at Canouan in the Grenadines. Photo by Getty Images SAN JUAN, Puerto Rico (AP) — Authorities in the Caribbean country of St. Vincent and the Grenadines say they have discovered an abandoned boat and the remains of 11 people along with passports from the west African country of Mali. This advertisement has not loaded yet, but your article continues below. THIS CONTENT IS RESERVED FOR SUBSCRIBERS ONLY Subscribe now to read the latest news in your city and across Canada. Unlimited online access to articles from across Canada with one account. Get exclusive access to the Toronto Sun ePaper, an electronic replica of the print edition that you can share, download and comment on. Enjoy insights and behind-the-scenes analysis from our award-winning journalists. Support local journalists and the next generation of journalists. Daily puzzles including the New York Times Crossword. SUBSCRIBE TO UNLOCK MORE ARTICLES Subscribe now to read the latest news in your city and across Canada. Unlimited online access to articles from across Canada with one account. Get exclusive access to the Toronto Sun ePaper, an electronic replica of the print edition that you can share, download and comment on. Enjoy insights and behind-the-scenes analysis from our award-winning journalists. Support local journalists and the next generation of journalists. Daily puzzles including the New York Times Crossword. REGISTER / SIGN IN TO UNLOCK MORE ARTICLES Create an account or sign in to continue with your reading experience. Access articles from across Canada with one account. Share your thoughts and join the conversation in the comments. Enjoy additional articles per month. Get email updates from your favourite authors. THIS ARTICLE IS FREE TO READ REGISTER TO UNLOCK. Create an account or sign in to continue with your reading experience. Access articles from across Canada with one account Share your thoughts and join the conversation in the comments Enjoy additional articles per month Get email updates from your favourite authors Don't have an account? Create Account The boat was found on the shores of Canouan island in the eastern Caribbean, police said in a statement Tuesday. Authorities said they are working with regional and international partners to identify the victims and the origin of the boat, which was discovered on Monday. 'This incident is deeply concerning,' police said. 'We are committed to pursuing every lead.' In January, officials in the eastern Caribbean island of St. Kitts and Nevis said they found a boat with the bodies of 19 people, some with identifications from Mali. Meanwhile, in May 2021, the bodies of more than a dozen men were found on a boat drifting near the twin-island Caribbean nation of Trinidad and Tobago. An Associated Press investigation found that they were part of a group of 43 people believed to have left Mauritania for Spain's Canary Islands but instead were swept away by the Atlantic Ocean. Toronto & GTA Canada Canada Tennis Music
