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Yahoo
3 hours ago
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- Yahoo
Global Antidote Market to Cross the USD 4 Billion Mark by 2032
The antidote market is witnessing substantial growth, largely propelled by the growing incidence of poisoning, drug overdoses, and snake or animal bites. This rising demand is supported by greater public health awareness, government efforts to combat drug overdoses, and continuous progress in product innovation. Moreover, strategic product launches and technological advancements by key industry players in the treatment of toxicities are further accelerating the market's upward momentum. New York, USA, June 05, 2025 (GLOBE NEWSWIRE) -- Global Antidote Market to Cross the USD 4 Billion Mark by 2032 | DelveInsight The antidote market is witnessing substantial growth, largely propelled by the growing incidence of poisoning, drug overdoses, and snake or animal bites. This rising demand is supported by greater public health awareness, government efforts to combat drug overdoses, and continuous progress in product innovation. Moreover, strategic product launches and technological advancements by key industry players in the treatment of toxicities are further accelerating the market's upward momentum. DelveInsight's Antidote Market Insights report provides the current and forecast market analysis, individual leading antidote companies' market shares, challenges, antidote market drivers, barriers, trends, and key market antidote companies in the market. Key Takeaways from the Antidote Market Report As per DelveInsight estimates, North America is anticipated to dominate the global antidote market during the forecast period. In the antidote type segment of the antidote market, the biological antidotes category accounted for the largest market share in 2024. Notable antidote companies such as Pfizer Inc., SERB Pharmaceuticals, McKesson Corporation, Amneal Pharmaceuticals LLC, EMERGENT, Novartis AG, Troikaa, Hope Pharmaceuticals, Rare Disease Therapeutics, Inc., BTG International Inc., Viatris Inc., Glentham® Life Sciences Limited, Kaleo, Inc., SGPharma Pvt. Ltd., American Regent, Inc., FFF Enterprises, Inc., Amphastar Pharmaceuticals, Inc., Purdue Pharma L.P., Indivior PLC, Harm Reduction Therapeutics, Inc., and several others are currently operating in the antidote market. In August 2024, Purdue Pharma L.P. received FDA approval for the New Drug Application (NDA) of Zurnai™ (nalmefene injection) auto-injector. In March 2024, Indivior PLC announced the results of a pharmacodynamic study showcasing that OPVEE® effectively and rapidly reverses opioid-induced respiratory depression, the primary cause of death in opioid overdoses. This breakthrough demonstrates the potential of OPVEE® as a critical intervention in emergency overdose situations, offering a swift response to prevent life-threatening complications associated with opioid toxicity. To read more about the latest highlights related to the antidote market, get a snapshot of the key highlights entailed in the Global Antidote Market Report Antidote Overview Antidote refers to a substance that counteracts the harmful effects of a poison or toxin. When an individual is exposed to a toxic substance, whether through ingestion, inhalation, injection, or skin contact, an antidote can help neutralize the toxin, reverse its effects, or support the body's natural elimination processes. Antidotes work through various mechanisms: some bind directly to the toxin, others block its biological effects, and some enhance the body's own detoxification systems. Common examples include activated charcoal for many oral poisons, naloxone for opioid overdoses, and atropine for certain nerve agent or pesticide exposures. The development and timely administration of antidotes are crucial in emergency medicine and toxicology. While some antidotes are broadly effective against a wide range of toxins, others are highly specific, targeting a single compound or class of poisons. Due to the diversity of toxic agents and the complexity of their effects on human biology, ongoing research in pharmacology and biochemistry continues to play a critical role in discovering new antidotes. In mass exposure events or cases of rare poisoning, the availability and distribution of appropriate antidotes can be a matter of life and death, underscoring their significance in public health preparedness and clinical Market Insights North America held a substantial share of the antidote market in 2024, fueled by several critical factors. The growing number of poisoning and drug overdose incidents across the region has significantly increased the need for effective antidote solutions. In particular, the opioid epidemic in the United States has driven demand for treatments like naloxone, which can reverse opioid overdoses. Public health campaigns and government-led efforts to curb and manage drug overdoses have further enhanced access to antidotes. Moreover, the market is witnessing a boost from ongoing pharmaceutical innovation and the introduction of new, targeted treatments. In response to this concerning trend, regional authorities have launched various initiatives to address drug overdoses and poisoning. For example, the U.S. Food and Drug Administration (FDA) implemented the Overdose Prevention Framework, which aims to reduce unnecessary opioid prescriptions, encourage harm-reduction strategies through education and innovation, and support the development of evidence-based therapies for substance use disorders and overdoses. Canada is also actively combating the overdose crisis. The Canadian government is investing in prevention programs, expanding access to treatment and harm-reduction services, and leveraging data-driven approaches to guide policy-making. These comprehensive efforts are fostering an environment conducive to the growth of the antidote market across North America. Additionally, pharmaceutical companies in the region are intensifying research and development efforts to bring advanced overdose treatments to market. For instance, in August 2024, Purdue Pharma L.P. received FDA approval for its New Drug Application (NDA) for Zurnai™ (nalmefene injection) auto-injector. This product is designed for emergency use in opioid overdoses caused by both natural and synthetic opioids in adults and adolescents aged 12 and above. The approval of Zurnai™ has expanded the arsenal of available opioid overdose antidotes, offering a fast-acting, user-friendly option to help tackle the ongoing opioid crisis. To know more about why North America is leading the market growth in the antidote market, get a snapshot of the Antidote Market Outlook Antidote Market Dynamics The antidote market is a crucial segment of the global pharmaceutical and toxicology landscape, driven by the increasing incidence of poisoning cases from pharmaceuticals, snake bites, chemical exposure, and overdoses. With growing awareness about drug misuse and rising environmental hazards, the demand for antidotes has surged in both developed and developing countries. Additionally, the rise in hospital admissions due to opioid overdoses, especially in North America and parts of Europe, has directly increased the need for effective and rapid-response antidotes like naloxone. One of the primary market dynamics shaping the antidote sector is the regulatory landscape. Antidotes, often falling under emergency-use drugs, receive fast-track approvals in certain jurisdictions due to their life-saving potential. Governments and healthcare bodies have also begun stockpiling critical antidotes as part of national preparedness programs, especially in regions vulnerable to snake bites or chemical attacks. Furthermore, innovations in biotechnology have allowed the development of more targeted and efficient antidotes, including monoclonal antibodies and small molecule inhibitors tailored for specific toxins or venoms. However, the market faces significant challenges. Many antidotes are expensive to develop and maintain, especially when the target population is small or geographically limited. For example, antivenoms for rare snake species may not be commercially viable due to high R&D costs and limited demand. This has led to a reliance on public-private partnerships and NGO involvement to ensure production and distribution in low-income areas. Moreover, the shelf-life and storage requirements of many antidotes add to supply chain complexity, often limiting their availability in remote or underdeveloped regions. Looking ahead, the antidote market is expected to benefit from increased global focus on public health preparedness and bioterrorism defense. The COVID-19 pandemic underscored the importance of rapid medical response capabilities, prompting governments to revisit their emergency drug inventories. Additionally, as pharmaceutical companies invest in advanced drug delivery systems and synthetic biology, novel antidotes with longer shelf lives and broader efficacy profiles are likely to emerge. The integration of digital health tools and AI in toxicology response systems could also streamline the identification and administration of antidotes, improving patient outcomes and operational efficiency in emergency care. Get a sneak peek at the antidote market dynamics @ Antidote Market Trends Report Metrics Details Coverage Global Study Period 2022–2032 Antidote Market CAGR ~7% Antidote Market Size by 2032 USD 4 Billion Key Antidote Companies Pfizer Inc., SERB Pharmaceuticals, McKesson Corporation, Amneal Pharmaceuticals LLC, EMERGENT, Novartis AG, Troikaa, Hope Pharmaceuticals, Rare Disease Therapeutics, Inc., BTG International Inc., Viatris Inc., Glentham® Life Sciences Limited, Kaleo, Inc., SGPharma Pvt. Ltd., American Regent, Inc., FFF Enterprises, Inc., Amphastar Pharmaceuticals, Inc., Purdue Pharma L.P., Indivior PLC, Harm Reduction Therapeutics, Inc., among others Antidote Market Assessment Antidote Market Segmentation Antidote Market Segmentation By Type: Chemical Antidotes and Biological Antidotes Antidote Market Segmentation By Route of Administration: Oral and Parenteral Antidote Market Segmentation By Distribution Channel: Hospital and Retail Pharmacies Antidote Market Segmentation By Geography: North America, Europe, Asia-Pacific, and Rest of World Porter's Five Forces Analysis, Product Profiles, Case Studies, KOL's Views, Analyst's View Which MedTech key players in the antidote market are set to emerge as the trendsetter explore @ Antidote Companies Table of Contents 1 Antidote Market Report Introduction 2 Antidote Market Executive Summary 3 Competitive Landscape 4 Regulatory Analysis 5 Antidote Market Key Factors Analysis 6 Antidote Market Porter's Five Forces Analysis 7 Antidote Market Layout 8 Antidote Market Company and Product Profiles 9 KOL Views 10 Project Approach 11 About DelveInsight 12 Disclaimer & Contact Us Interested in knowing the antidote market by 2032? Click to get a snapshot of the Antidote Market Analysis Related Reports Heavy Metal Poisoning Market Heavy Metal Poisoning Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key heavy metal poisoning companies, including EmeraMed, Magellan Diagnostics, Bezoloven Inc., among others. Substance Use Disorder Market Substance Use Disorder Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key SUD companies including BioXcel Therapeutics, NFL Biosciences, STALICLA, Embera NeuroTherapeutics, PleoPharma, Kinnov Therapeutics, Imbrium Therapeutics, Atai Life Sciences, Beckley Psytech, among others. 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These services are tailored to the specific needs of each client and are delivered through a combination of reports, dashboards, and interactive presentations, enabling clients to make informed decisions, mitigate risks, and identify opportunities for growth and expansion. Other Business Pharmaceutical Consulting Services Healthcare Conference Coverage Pipeline Assessment Healthcare Licensing Services Discover how a mid-pharma client gained a level of confidence in their soon-to-be partner for manufacturing their therapeutics by downloading our Due Diligence Case Study About DelveInsight DelveInsight is a leading Business Consultant, and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. CONTACT: Contact Us Shruti Thakur info@ +14699457679Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Business Standard
2 days ago
- Business
- Business Standard
Gland Pharma receives USFDA approval for Angiotensin II Acetate Injection 2.5 mg/mL
Gland Pharma has received approval from the United States Food and Drug Administration (USFDA) for its Abbreviated New Drug Application for Angiotensin II Acetate Injection 2.5 mg/mL. The Product is bioequivalent and therapeutically equivalent to the reference listed drug (RLD), GIAPREZA of La Jolla Pharma LLC. This Product is indicated for increasing the blood pressure in adults with septic or other distributive shock. Gland Pharma is the exclusive First-to-File and is eligible for 180 days of generic drug exclusivity. According to IQVIA, the product had US sales of approximately USD 58 million for the twelve months ending March 2025.
Associated Press
2 days ago
- Business
- Associated Press
Affinia Therapeutics and DCM Foundation Announce Partnership to Increase Awareness About BAG3 Dilated Cardiomyopathy and Critical Need for Genetic Testing to Help Save Lives
WALTHAM, Mass. & DUBLIN, Ohio--(BUSINESS WIRE)--Jun 3, 2025-- Affinia Therapeutics ('Affinia'), an innovative gene therapy company with a pipeline of first-in-class and/or best-in-class adeno-associated virus (AAV) gene therapies for devastating cardiovascular and neurological diseases, and the DCM Foundation together with the Genetic Cardiomyopathy Awareness Consortium (GCAC), today announced they have joined forces to raise awareness about BAG3 dilated cardiomyopathy (DCM), with the goal of promoting early diagnosis and the critical need for genetic testing. BAG3 DCM is a devastating monogenic heart disease affecting more than 70,000 patients in the U.S., Europe, and U.K. regions alone. The BAG3 gene, or Bcl2-associated athanogene 3, encodes for a protein that is critical to the normal structure and function of heart cells. Patients with BAG3 DCM have a mutation in the BAG3 gene and a deficiency in functional BAG3 protein, resulting in early onset heart failure that progresses rapidly. Despite current standard of care, almost 25% of patients require a heart transplant. According to a study published in Circulation, the journal of the American Heart Association, close to 50% of cardiomyopathy has some type of genetic basis, such as BAG3 DCM, yet only a fraction of diagnosed cardiomyopathy patients get genetic testing. This new-found partnership between Affinia and the DCM Foundation and GCAC aims to educate about BAG3 DCM and the critical need for genetic testing, and champions the needs and voices of people living with this devastating heart disease through initiatives including: 'The DCM Foundation and GCAC are very grateful for this partnership with Affinia,' said Greg Ruf, Founder and Executive Director, the DCM Foundation. 'By getting more cardiomyopathy patients tested, we can potentially save and improve lives and help advance cardiomyopathy research and therapies. Through this collaboration, we will collectively unite our strengths and work together in the hope of making a real difference for those living with this devastating disease.' Hideo Makimura, M.D., Ph.D., Chief Medical Officer of Affinia, commented, 'BAG3 DCM is a devastating heart disease with a known genetic cause. Unfortunately, only a fraction of patients affected with BAG3 DCM and other genetic cardiomyopathies are tested, which is putting lives at risk. We are committed to working together with the DCM Foundation and GCAC to increase disease awareness and the role genetics plays in cardiomyopathy, which we believe will ultimately lead to better outcomes for people living with BAG3 DCM.' 'Our partnership with the DCM Foundation and GCAC is an exciting milestone as we advance our lead program, AFTX-201 for BAG3 DCM, toward an Investigational New Drug submission and clinical trial initiation which are aligned with Affinia's purpose to make a lasting positive impact in the lives of people affected by devastating rare and prevalent diseases where the genetic cause is understood,' said Rick Modi, Affinia's Chief Executive Officer. About Affinia Therapeutics Affinia Therapeutics is pioneering a shift to a new class of rationally designed gene therapies that treat rare and prevalent diseases. Affinia Therapeutics' pipeline of first-in-class or best-in-class product candidates in cardiovascular and neurological diseases leverages its proprietary next-generation capsids, payloads, or manufacturing approaches and have shown efficacy, safety, and differentiation in relevant animal models. For more information, visit About DCM Foundation Founded in 2018, the DCM Foundation's mission is to provide hope and support to DCM patients and families with dilated cardiomyopathy through education, research and advocacy. Our mission is being executed through three foundational pillars: information and education, patient and family support, and understanding the need for genetic testing. In 2023, DCMF created the Genetic Cardiomyopathy Awareness Consortium, comprised of 11 patient group members, to address the extreme lack of knowledge about genetics and genetic testing in the cardiomyopathy patient and medical community. For more information, visit and View source version on CONTACT: Media contacts:For Affinia Kathy Vincent [email protected] 310-403-8951For DCM Foundation Buddy Butler [email protected] 304-615-9884 KEYWORD: MASSACHUSETTS OHIO UNITED STATES NORTH AMERICA INDUSTRY KEYWORD: RESEARCH NEUROLOGY GENETICS CARDIOLOGY PHILANTHROPY BIOTECHNOLOGY PHARMACEUTICAL HEALTH FOUNDATION SCIENCE SOURCE: Affinia Therapeutics Copyright Business Wire 2025. PUB: 06/03/2025 07:45 AM/DISC: 06/03/2025 07:44 AM
Yahoo
6 days ago
- Business
- Yahoo
CirCode Biomed Announces FDA Clearance for IND Application of HM2002, the world's first circular RNA drug being administrated in patients
SHANGHAI, May 30, 2025 /PRNewswire/ -- Shanghai CirCode Biomed Co. Ltd. (CirCode), an innovative biotech company pioneering circular RNA therapies, recently announced that its leading pipeline HM2002 received Investigational New Drug (IND) clearance from the US Food and Drug Administration (FDA) for ischemic heart disease on May 30, 2025. With the first patient administrated on September of 2024 in an investigator initiated trial (IIT), HM2002 is the world's first circular RNA drug ever being used in patients. It received IND approval from the National Medical Products Administration (NMPA) of China on January 10th, 2025. HM2002 is currently the first circular RNA therapy to receive IND clearance in both China and the United States, and is also the only circular RNA drug globally approved for clinical study on patients with ischemic heart disease. With the global aging population, ischemic heart disease shows a steadily rising incidence, and has been the leading cause of death globally for the past decades. The current standard of care shows limited effects in promoting myocardial microcirculation reconstruction and angiogenesis, leading to suboptimal efficacy and limited benefit in 10-year survival. There is an urgent unmet medical need for next generation therapies to improve patients' prognosis and quality of life. With the advantages of improved stability and low immunogenicity from circular RNAs, HM2002 can safely and continuously express vascular endothelial growth factor (VGEF) in the myocardium, which promotes angiogenesis, improves myocardial perfusion, and facilitates cardiac function recovery. It has demonstrated excellent safety and efficacy in the preclinical studies. In the first-in-human IIT at Ruijin Hospital initiated last year, all subjects showed significant cardiac function improvement without any drug-related adverse events. "To promote angiogenesis and relief ischemia through VEGF overexpression is a well-tested solution, but there is a tremendous challenge to achieve an efficient, persistent, and controllable expression of VEGF in vivo. We find an excellent match between the need and the properties of circular RNA. A single dose of HM2002 can express VEGF protein for a perfect time window in vivo: long enough for efficient angiogenesis, short enough for any safety concerns. Once the microcirculation reformed, it brings long-lasting benefits to patients without the presence of HM2002 or VEGF protein," said Dr. Chenxiang Tang, CEO of CirCode. "The IND clearances from both NMPA and FDA for HM2002 is a strong recognition for our innovation and competitiveness in the circular RNA therapeutic industry. Dr. Yun Yang, co-founder, chairman, and chief technology officer of CirCode, stated that, "CirCode's robust, proprietary circular RNA platform laid the foundation for the fast IND approval of HM2002. With the help of our AI tools, we were able to leap from a concept to IND approval of HM2002 in less than 2 years. We now have built a strong pipeline portfolio in various fields such as therapeutic proteins, vaccines, and in vivo CAR-T, covering multiple therapeutic areas such as cardiovascular diseases, infectious diseases, autoimmune diseases, and oncology. These pipelines have showed a favorable risk benefit profile with great efficacy and safety data in preclinical settings, many of which will enter the clinical stage within the next year. We are so excited to keep pushing the frontier of circular RNA therapy forward and providing more innovative therapies for patients." About CirCode CirCode is a clinical-stage biotechnology company specializing in circular RNA therapeutics. Leveraging strong science and deep know-how, the company has built a fully integrated and proprietary platform, protected by a comprehensive global patent network, paving the way for the development of circular RNA therapeutics. Focusing on unmet medical needs, CirCode has built a robust pipeline targeting vaccines, cardiovascular diseases, autoimmune disorders, and oncology. CirCode is backed by top-tier investors and has received strong recognitions from leading pharmaceutical companies. Circode is committed to promoting the transformation of scientific and technological achievements and realizing the benefit of science and technology for mankind. More information please visit Or contact info@ for business cooperation. View original content to download multimedia: SOURCE Shanghai CirCode Biomed Co. Ltd. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
20-05-2025
- Business
- Yahoo
Pfizer in deal with China's 3SBio to license cancer drug candidate, take equity stake
(Reuters) -U.S. drugmaker Pfizer said it would license an experimental cancer treatment from China's 3SBio Inc, paying $1.25 billion upfront and up to another $4.8 billion if developmental milestones are met. Pfizer also plans to make a $100 million equity investment in the Chinese biotechnolgoy company after the transaction closes, which is expected to happen in the third quarter. Shares in 3SBio surged 35% in Hong Kong trade on Tuesday, valuing the Chinese biopharmaceutical company at nearly $6 billion. The deal underscores solid demand for Chinese assets from global pharmaceutical firms looking to replenish their drug pipelines and boost their presence in the China market, even as the trade war between Beijing and Washington and potential U.S. tariffs on pharmaceuticals pose risks to the sector. The licensed drug candidate, SSGJ-707, is being evaluated for non-small cell lung cancer, metastatic colorectal cancer and gynaecological tumors. It is undergoing multiple clinical trials in China and 3SBio plans to initiate the first Phase III trial in China this year. The agreement covers the development, manufacturing and commercialisation of the drug. Pfizer has been granted a global license, excluding China, as well as the option to obtain commercialisation rights in China. 3SBio said separately that the drug has received clearance from the U.S. Food and Drug Administration for its Investigational New Drug application. Pfizer plans to manufacture the drug substance for SSGJ-707 in Sanford, North Carolina, and the drug product in McPherson, Kansas. 3SBio has facilities in China and Italy and its products were sold in 20 countries in 2024, according to its latest annual report. Core products include a treatment for thrombocytopenia, TPIAO, and small molecule drug Mandi. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
