Latest news with #Nusinersen
Yahoo
a day ago
- Business
- Yahoo
Oligonucleotide Synthesis Market worth US$24.7 billion by 2030 with 10.8% CAGR
DELRAY BEACH, Fla., June 5, 2025 /PRNewswire/ -- The global Oligonucleotide Synthesis Market, valued at US$8.9 billion in 2024 stood at US$10.5 billion in 2025 and is projected to advance at a resilient CAGR of 18.6% from 2025 to 2030, culminating in a forecasted valuation of US$24.7 billion by the end of the period. The oligonucleotide synthesis market is experiencing significant growth, driven by the increasing applications of synthesized oligonucleotides in therapeutics & diagnostics. This growth is supported by technological advancements and rising investments in life sciences research and synthetic biology. Additionally, the growing emphasis on precision and personalized medicine contributes to this expansion, creating new opportunities as key players increase their research and development investments in emerging economies. Download PDF Brochure: Browse in-depth TOC on "Oligonucleotide Synthesis Market" 568 - Tables 77 - Figures 455 - Pages By product, the oligonucleotide-based drugs segment is categorized into antisense oligonucleotide-based drugs, siRNA oligonucleotide-based drugs, and other oligonucleotide-based drugs. In 2024, the ASOs or antisense oligonucleotide-based drugs segment accounted for the largest share of the market. ASOs are short, single-stranded nucleic acids that bind selectively to RNA targets. These have seen rapid clinical & commercial uptake owing to their versatility in modulating gene expression, treating rare genetic disorders, and addressing oncology targets. Regulatory approvals for landmark ASO therapies, such as Nusinersen for spinal muscular atrophy and Inotersen for hereditary ATTR amyloidosis, have driven both analyst & investor confidence, fueling expanded manufacturing capacity and robust R&D pipelines. The central importance of developing the oligonucleotide therapy scene is pronounced by high yields, reduced manufacturing complexity, and known delivery platforms, thus contributing to market uptake during the studied period. By end user, the oligonucleotide synthesis market includes hospitals, pharmaceutical & biotechnology companies, diagnostic laboratories, and CROs & CMOs. In 2024, the hospitals segment accounted for the largest share of the market. The growth of the hospitals segment is attributed to the rising demand for oligonucleotide-based drugs for rare & neurological diseases, primarily owing to the increasing target patient population. The significant share of this segment reflects the key role of hospitals in delivering these advanced treatments. The rising prevalence of infectious & chronic diseases is expected to fuel the need for precise therapeutics such as oligonucleotide drugs, which are also crucial for applying personalized medicine approaches in hospitals. By geography, in 2024, North America accounted for the largest share of the oligonucleotide synthesis market owing to its presence of strong regional players who have advanced manufacturing capabilities and robust supply-chain networks. These companies benefit from product approvals granted with supportive regulatory frameworks implemented by the USFDA and Health Canada. Product commercialization and innovation are the primary growth catalysts for the region's expanding pharmaceutical & biotechnology industry. Partnerships and investments with academic & research centers for upscaling production are also expected to be growth drivers for this regional segment. Request Sample Pages : Some of the leading players in the market include Danaher Corporation (US), Thermo Fisher Scientific Inc. (US), Merck KGaA (Germany), Eurofins Scientific (Luxembourg), LGC Limited (UK), Agilent Technologies, Inc. (US), Kaneka Corporation (Japan), Maravai LifeSciences (US), Azenta US Inc. (US), Twist Bioscience (US), and GenScript (US), among others. Danaher Corporation (US): One of the key players in the oligonucleotide synthesis market is Integrated DNA Technologies (IDT), a subsidiary of Danaher Corporation, along with its sister company, Cytiva. Together, they offer a variety of products, including pre-designed and custom oligonucleotide probes, primers, and therapeutic oligonucleotides, such as antisense oligonucleotides (ASOs). Additionally, the company supplies reagents, consumables, and equipment, including synthesizers for oligonucleotide synthesis. Geographically, the company operates in over 50 countries spanning North America, the Asia Pacific, Europe, the Middle East, and Africa. IDT and Cytiva have focused on organic growth strategies, emphasizing expansions and partnerships. For instance, in 2023, Integrated DNA Technologies opened a therapeutic oligonucleotide manufacturing facility in Coralville, Iowa. This state-of-the-art facility is designed to produce reagents for cGMP cell & gene therapy, including single-guide RNAs and HDR donor oligonucleotides. The facility includes eight ISO cleanrooms, purification suites, chemical distribution & storage areas, quality control laboratories, analytical spaces for product testing, and ancillary & office spaces. There are also shell spaces set aside for future expansion. Thermo Fisher Scientific (US) Thermo Fisher is one of the leading players in the oligonucleotide synthesis market in 2024. This significant share is due to a strong product portfolio, including custom & pre-designed primers, probes, DNA, RNA oligos, and reagents & consumables. The company undertakes various organic & inorganic strategies to strengthen its position in the market. For instance, in 2021, Thermo Fisher Scientific collaborated with the University of Sheffield to develop workflows to characterize and monitor complex oligonucleotide and mRNA products. The company also has a strong geographic presence and operates in over 50 countries across North America, Europe, the Asia Pacific, and Latin America. Biogen (US) Biogen is also a leading company in the oligonucleotide synthesis market. The recent FDA accelerated approval of QALSODY (Tofersen) for the treatment of amyotrophic lateral sclerosis (ALS) in adults, along with the growing adoption of Spinzara, a blockbuster oligonucleotide-based drug the company has offered since 2016, supports its leading position in the market. The company operates an oligonucleotide synthesis manufacturing (OSM) facility in North Carolina, which is used to produce antisense oligonucleotide drugs like Spinzara and other candidates currently in development. It employs various strategies to strengthen its market presence, including expansions and collaborations. For instance, in February 2025, Biogen and Stoke Therapeutics, Inc. collaborated to develop & commercialize Zorevunersen, an investigational antisense oligonucleotide (ASO) for treating Dravet syndrome. For more information, Inquire Now! Related Reports: Next Generation Sequencing Market Synthetic Biology Market Genomics Market Molecular Diagnostics Market Biomarkers Market Get access to the latest updates on Oligonucleotide Synthesis Companies and Oligonucleotide Synthesis Market Size About MarketsandMarkets™: MarketsandMarkets™ has been recognized as one of America's Best Management Consulting Firms by Forbes, as per their recent report. MarketsandMarkets™ is a blue ocean alternative in growth consulting and program management, leveraging a man-machine offering to drive supernormal growth for progressive organizations in the B2B space. With the widest lens on emerging technologies, we are proficient in co-creating supernormal growth for clients across the globe. Today, 80% of Fortune 2000 companies rely on MarketsandMarkets, and 90 of the top 100 companies in each sector trust us to accelerate their revenue growth. With a global clientele of over 13,000 organizations, we help businesses thrive in a disruptive ecosystem. The B2B economy is witnessing the emergence of $25 trillion in new revenue streams that are replacing existing ones within this decade. We work with clients on growth programs, helping them monetize this $25 trillion opportunity through our service lines – TAM Expansion, Go-to-Market (GTM) Strategy to Execution, Market Share Gain, Account Enablement, and Thought Leadership Marketing. Built on the 'GIVE Growth' principle, we collaborate with several Forbes Global 2000 B2B companies to keep them future-ready. Our insights and strategies are powered by industry experts, cutting-edge AI, and our Market Intelligence Cloud, KnowledgeStore™, which integrates research and provides ecosystem-wide visibility into revenue shifts. To find out more, visit or follow us on Twitter , LinkedIn and Facebook . Contact:Mr. Rohan SalgarkarMarketsandMarkets™ INC. 1615 South Congress Ave. Suite 103, Delray Beach, FL 33445 USA: +1-888-600-6441 Email: sales@ Visit Our Website: Logo: View original content: SOURCE MarketsandMarkets Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
a day ago
- Business
- Yahoo
Oligonucleotide Synthesis Market worth US$24.7 billion by 2030 with 10.8% CAGR
DELRAY BEACH, Fla., June 5, 2025 /PRNewswire/ -- The global Oligonucleotide Synthesis Market, valued at US$8.9 billion in 2024 stood at US$10.5 billion in 2025 and is projected to advance at a resilient CAGR of 18.6% from 2025 to 2030, culminating in a forecasted valuation of US$24.7 billion by the end of the period. The oligonucleotide synthesis market is experiencing significant growth, driven by the increasing applications of synthesized oligonucleotides in therapeutics & diagnostics. This growth is supported by technological advancements and rising investments in life sciences research and synthetic biology. Additionally, the growing emphasis on precision and personalized medicine contributes to this expansion, creating new opportunities as key players increase their research and development investments in emerging economies. Download PDF Brochure: Browse in-depth TOC on "Oligonucleotide Synthesis Market" 568 - Tables 77 - Figures 455 - Pages By product, the oligonucleotide-based drugs segment is categorized into antisense oligonucleotide-based drugs, siRNA oligonucleotide-based drugs, and other oligonucleotide-based drugs. In 2024, the ASOs or antisense oligonucleotide-based drugs segment accounted for the largest share of the market. ASOs are short, single-stranded nucleic acids that bind selectively to RNA targets. These have seen rapid clinical & commercial uptake owing to their versatility in modulating gene expression, treating rare genetic disorders, and addressing oncology targets. Regulatory approvals for landmark ASO therapies, such as Nusinersen for spinal muscular atrophy and Inotersen for hereditary ATTR amyloidosis, have driven both analyst & investor confidence, fueling expanded manufacturing capacity and robust R&D pipelines. The central importance of developing the oligonucleotide therapy scene is pronounced by high yields, reduced manufacturing complexity, and known delivery platforms, thus contributing to market uptake during the studied period. By end user, the oligonucleotide synthesis market includes hospitals, pharmaceutical & biotechnology companies, diagnostic laboratories, and CROs & CMOs. In 2024, the hospitals segment accounted for the largest share of the market. The growth of the hospitals segment is attributed to the rising demand for oligonucleotide-based drugs for rare & neurological diseases, primarily owing to the increasing target patient population. The significant share of this segment reflects the key role of hospitals in delivering these advanced treatments. The rising prevalence of infectious & chronic diseases is expected to fuel the need for precise therapeutics such as oligonucleotide drugs, which are also crucial for applying personalized medicine approaches in hospitals. By geography, in 2024, North America accounted for the largest share of the oligonucleotide synthesis market owing to its presence of strong regional players who have advanced manufacturing capabilities and robust supply-chain networks. These companies benefit from product approvals granted with supportive regulatory frameworks implemented by the USFDA and Health Canada. Product commercialization and innovation are the primary growth catalysts for the region's expanding pharmaceutical & biotechnology industry. Partnerships and investments with academic & research centers for upscaling production are also expected to be growth drivers for this regional segment. Request Sample Pages : Some of the leading players in the market include Danaher Corporation (US), Thermo Fisher Scientific Inc. (US), Merck KGaA (Germany), Eurofins Scientific (Luxembourg), LGC Limited (UK), Agilent Technologies, Inc. (US), Kaneka Corporation (Japan), Maravai LifeSciences (US), Azenta US Inc. (US), Twist Bioscience (US), and GenScript (US), among others. Danaher Corporation (US): One of the key players in the oligonucleotide synthesis market is Integrated DNA Technologies (IDT), a subsidiary of Danaher Corporation, along with its sister company, Cytiva. Together, they offer a variety of products, including pre-designed and custom oligonucleotide probes, primers, and therapeutic oligonucleotides, such as antisense oligonucleotides (ASOs). Additionally, the company supplies reagents, consumables, and equipment, including synthesizers for oligonucleotide synthesis. Geographically, the company operates in over 50 countries spanning North America, the Asia Pacific, Europe, the Middle East, and Africa. IDT and Cytiva have focused on organic growth strategies, emphasizing expansions and partnerships. For instance, in 2023, Integrated DNA Technologies opened a therapeutic oligonucleotide manufacturing facility in Coralville, Iowa. This state-of-the-art facility is designed to produce reagents for cGMP cell & gene therapy, including single-guide RNAs and HDR donor oligonucleotides. The facility includes eight ISO cleanrooms, purification suites, chemical distribution & storage areas, quality control laboratories, analytical spaces for product testing, and ancillary & office spaces. There are also shell spaces set aside for future expansion. Thermo Fisher Scientific (US) Thermo Fisher is one of the leading players in the oligonucleotide synthesis market in 2024. This significant share is due to a strong product portfolio, including custom & pre-designed primers, probes, DNA, RNA oligos, and reagents & consumables. The company undertakes various organic & inorganic strategies to strengthen its position in the market. For instance, in 2021, Thermo Fisher Scientific collaborated with the University of Sheffield to develop workflows to characterize and monitor complex oligonucleotide and mRNA products. The company also has a strong geographic presence and operates in over 50 countries across North America, Europe, the Asia Pacific, and Latin America. Biogen (US) Biogen is also a leading company in the oligonucleotide synthesis market. The recent FDA accelerated approval of QALSODY (Tofersen) for the treatment of amyotrophic lateral sclerosis (ALS) in adults, along with the growing adoption of Spinzara, a blockbuster oligonucleotide-based drug the company has offered since 2016, supports its leading position in the market. The company operates an oligonucleotide synthesis manufacturing (OSM) facility in North Carolina, which is used to produce antisense oligonucleotide drugs like Spinzara and other candidates currently in development. It employs various strategies to strengthen its market presence, including expansions and collaborations. For instance, in February 2025, Biogen and Stoke Therapeutics, Inc. collaborated to develop & commercialize Zorevunersen, an investigational antisense oligonucleotide (ASO) for treating Dravet syndrome. For more information, Inquire Now! Related Reports: Next Generation Sequencing Market Synthetic Biology Market Genomics Market Molecular Diagnostics Market Biomarkers Market Get access to the latest updates on Oligonucleotide Synthesis Companies and Oligonucleotide Synthesis Market Size About MarketsandMarkets™: MarketsandMarkets™ has been recognized as one of America's Best Management Consulting Firms by Forbes, as per their recent report. MarketsandMarkets™ is a blue ocean alternative in growth consulting and program management, leveraging a man-machine offering to drive supernormal growth for progressive organizations in the B2B space. With the widest lens on emerging technologies, we are proficient in co-creating supernormal growth for clients across the globe. Today, 80% of Fortune 2000 companies rely on MarketsandMarkets, and 90 of the top 100 companies in each sector trust us to accelerate their revenue growth. With a global clientele of over 13,000 organizations, we help businesses thrive in a disruptive ecosystem. The B2B economy is witnessing the emergence of $25 trillion in new revenue streams that are replacing existing ones within this decade. We work with clients on growth programs, helping them monetize this $25 trillion opportunity through our service lines – TAM Expansion, Go-to-Market (GTM) Strategy to Execution, Market Share Gain, Account Enablement, and Thought Leadership Marketing. Built on the 'GIVE Growth' principle, we collaborate with several Forbes Global 2000 B2B companies to keep them future-ready. Our insights and strategies are powered by industry experts, cutting-edge AI, and our Market Intelligence Cloud, KnowledgeStore™, which integrates research and provides ecosystem-wide visibility into revenue shifts. To find out more, visit or follow us on Twitter , LinkedIn and Facebook . Contact:Mr. Rohan SalgarkarMarketsandMarkets™ INC. 1615 South Congress Ave. Suite 103, Delray Beach, FL 33445 USA: +1-888-600-6441 Email: sales@ Visit Our Website: Logo: View original content: SOURCE MarketsandMarkets Sign in to access your portfolio
Daily Record
22-05-2025
- Entertainment
- Daily Record
Scots schoolboy told he wouldn't live past first birthday granted sweet Spider-Man wish
A Scots schoolboy who was told he wouldn't live to see his first birthday but continued to overcome the odds has received a Disney Wish to met his superhero idol Spider-Man. Max Farmer, from Perth, was born healthy but then diagnosed with spinal muscular atrophy (SMA) type 1 – a rare and genetic condition that causes progressive muscle wasting - when he was just nine weeks old. Doctors told his heartbroken parents he wouldn't live beyond 12 months. However, Max soon became the first child in Scotland to receive a groundbreaking new treatment. Last week, the now eight-year-old's dream came true when he had a private meet-and-greet with Spider-Man at a special Make-A-Wish UK event in partnership with Disney. Mum Elaine Donoghue, 48, told the Record: "It was absolutely magical and Max was so captivated by the characters he saw. It was such an inspirational and magical experience for our whole family. "We had no idea he'd get to meet Spider-Man one-on-one. He showed him his Spidey moves and even introduced him to Strictly's Amy Dowden, it was unbelievable." The event at Hoar Cross Hall Hotel in Burton-on-Trent was a specially designed experience for children with life-limiting conditions. It was made possible through a referral from CHAS (Children's Hospices Across Scotland), where Max receives respite care through Rachel House in Kinross. At nine weeks old Max stopped moving which led to the diagnosis of the condition that not only affects muscles in the arms and legs but also those needed for breathing and swallowing. It was then Max was offered a place on a new drug trial just weeks later, becoming the first child in Scotland to get the Nusinersen (Spinraza) treatment through an expanded access programme. Elaine said: "We were told he wouldn't make it to his first birthday. It was heartbreaking. "He went through 21 lumbar punctures in five years, but it gave him a chance at life." Now, Max is on a daily oral drug called Risdiplam, which means he no longer needs hospital stays or general anaesthetic to receive treatment. Despite needing 24/7 care, Max is full of life. He goes to school every day, uses a power chair, and receives constant support from mum Elaine, dad Stewart, 47, and big sister Beth, 17. Elaine said: "His day starts at 6.30am with medication and feeding, but he never complains. He's got a huge team around him, and he just takes it all in his stride. "There are no words to describe what the experience done for us as a family. We wouldn't even be able to take him to Euro Disney in Paris, due to the equipment and meds, it would be unachievable. 'But this event was fully accessible. There were profiling beds, hoists, proper changing places – everything we needed. They covered everything. "It was a dream come true for him to meet Spider-Man and we made memories which will last a lifetime." Max, who is under the care of nearly every major hospital in Scotland, continues to defy expectations. "He's just incredible. He's happy, he's funny, he loves school - and he's living his best life, in the way he can. We are exceptionally lucky to be able to call ourselves his parents." Join the Daily Record WhatsApp community! Get the latest news sent straight to your messages by joining our WhatsApp community today. You'll receive daily updates on breaking news as well as the top headlines across Scotland. No one will be able to see who is signed up and no one can send messages except the Daily Record team. All you have to do is click here if you're on mobile, select 'Join Community' and you're in! If you're on a desktop, simply scan the QR code above with your phone and click 'Join Community'. We also treat our community members to special offers, promotions, and adverts from us and our partners. If you don't like our community, you can check out any time you like. To leave our community click on the name at the top of your screen and choose 'exit group'.
