Latest news with #PBC
Business Recorder
23-07-2025
- Politics
- Business Recorder
LHC reserves verdict on PBC-related plea
LAHORE: The Lahore High Court on Tuesday reserved its verdict on the maintainability of a petition challenging the proposed new eligibility criteria for candidates contesting the elections of Punjab Bar Council (PBC). The petitioner was filed by candidates in the PBC elections, Fahad Ikram Bhatti and Imran Fazal, against the proposed amendment to the Legal Practitioners and Bar Councils Act 1973. Earlier, the court noted that no formal amendment had yet been made to the law and the bill had not been approved by the parliament. The court asked the petitioners how the petition could be considered maintainable in the absence of an enacted amendment. The petitioners' counsel asked the court to at least seek a report from the government on the matter. The court reserved its verdict on the maintainability of the petition. A Senate Standing Committee on Law and Justice recently approved significant amendments to the Legal Practitioners and Bar Councils (Amendment) Bill, including a candidate's eligibility requirement of enrollment as a high court advocate from five to 10 years besides the condition of having handled at least 30 individual cases. Copyright Business Recorder, 2025
Business Recorder
22-07-2025
- Politics
- Business Recorder
PBC elections: Two Bar members move LHC against proposed amendment
LAHORE: Two Bar members have approached the Lahore High Court (LHC) against a proposed amendment regarding the eligibility criteria for candidates contesting the elections of Punjab Bar Council (PBC). The change includes a candidate's eligibility requirement of enrollment as a high court advocate from five to ten years besides the condition of having handled at least 30 individual cases. The petitioners candidates for the PBC elections Fahad Akram Bhatti and Imran Fazal contended that the bar council elections are scheduled to be held in November this year and candidates have already been running their election campaigns. They said that the government is introducing new eligibility requirements for contesting candidates, which is not appropriate at this stage. The petitioner asked the court to restrain the implementation of the new eligibility criteria for candidates in the upcoming bar council elections. Lahore High Court Bar Association (LHCBA) President Malik Asif Nissoana also rejected the amendments approved to the Legal Practitioners and Bar Council Election Rules. In a statement, he said the PBC chairman already issued a code of conduct for the upcoming elections. Therefore, he said, no amendments should be made to the rules. He demanded that any amendments to the law should be postponed until after the bar council's elections. Copyright Business Recorder, 2025
Yahoo
19-07-2025
- Sport
- Yahoo
Manny Pacquiao vs. Mario Barrios Livestream: How to Watch the Premier Boxing Champions Live Online
If you purchase an independently reviewed product or service through a link on our website, Variety may receive an affiliate commission. Vegas, baby! Premier Boxing Champions goes to 'The Gambling Capital of the World' tonight, where boxing icon Manny Pacquiao (62-8-2) takes on WBC Welterweight World Champion Mario Barrios (29-2-1) with his title up for grabs. More from Variety UFC 318 Livestream: How to Watch Holloway vs. Poirier 3 MMA Fight Live Online PFL Champions Series Cape Town 2025: How to Watch MMA Event Live Online How to Watch Oleksandr Usyk vs. Daniel Dubois 2 Live Online Pacquiao vs. Barrios takes place on Saturday, July 19 at MGM Grand Garden Arena in Las Vegas, Nevada with a start time of 8 p.m. ET/5 p.m. PT. The main event is set for 12 rounds starting around 11 p.m. ET/8 p.m. PT. watch Manny Pacquiao vs. Mario Barrios on Prime Video For How To Watch Manny Pacquiao vs. Mario Barrios Online Want to watch the PBC fight online? Manny Pacquiao vs. Mario Barrios livestream is available to watch for $79.95 on Prime Video. You don't have to be an Amazon Prime subscriber to watch the fight, but you do have to get purchase access for the pay-per-view livestream. If you're not an Amazon Prime member, you can sign up for a 30-day free trial to take advantage of all that the subscription service has to offer, including access to Prime Video, Prime Gaming and Amazon Photos; fast free shipping in less than two days with Prime Delivery; in-store discounts at Whole Foods Market; access to exclusive shopping events — such as Prime Day and Black Friday — and much more. Learn more about Amazon Prime and its benefits here. Manny Pacquiao vs. Mario Barrios Odds & Predictions For the main event, Barrios is the favorite to win against Pacquiao. Oddsmakers give Mario Barrios a -313 moneyline, while Manny Pacquiao received a line of +260, as the underdog. Want more odds? Check out the complete odds and wagers at online here. Visit If you're looking for last-minute tickets to the boxing event, they're still available on third-party resellers sites, such as StubHub, TicketNetwork and Vivid Seats. In fact, you can save $150 off when you spend $500 with promo code VARIETY150, or $300 off when you spend $1,000 with promo code VARIETY300 at TicketNetwork. Buy Pacquiao vs. Barrios Tickets at StubHub In addition, you can use Variety's exclusive promo code VAR30 for $20 off at Vivid Seats. Taking place on Saturday, July 19, Manny Pacquiao vs. Mario Barrios is available to stream on Prime Video starting at 8 p.m. ET/5 p.m. PT with coverage starting at 6 p.m. ET/3 p.m. PT. Fight Card, 8 p.m. ET/5 p.m. PT Welterweight: Manny Pacquiao vs. Mario Barrios (champion) — Main Event, WBC Title Fight Junior Middleweight: Tim Tszyu vs. Sebastian Fundora (champion) — Co-Main Event, WBC Title Fight Junior Welterweight: Isaac Cruz vs. Angel Fierro Featherweight: Brandon Figueroa vs. Joet Gonzalez Junior Featherweight: David Picasso vs. Kyonosuke Kameda Lightweight: Mark Magsayo vs. Jorge Mata Junior Lightweight: Gary Allen Russell Jr. vs. Hugo Castaneda watch Manny Pacquiao vs. Mario Barrios on Prime Video For Best of Variety New Movies Out Now in Theaters: What to See This Week 'Harry Potter' TV Show Cast Guide: Who's Who in Hogwarts? Final Emmy Predictions: Talk Series and Scripted Variety - New Blood Looks to Tackle Late Night Staples
Forbes
18-07-2025
- Sport
- Forbes
Manny Pacquiao Vs. Mario Barrios Fight Card Ring Walk Time
LAS VEGAS, NEVADA - JULY 18: (L-R) Trainers Buboy Fernandez and Freddie Roach, Manny Pacquiao, TGB ... More Promotions President Tom Brown, WBC welterweight champion Mario Barrios and his head coach Bob Santos pose during a ceremonial weigh-in at MGM Grand Garden Arena on July 18, 2025 in Las Vegas, Nevada. (Photo by) Manny Pacquiao's retirement ends on Saturday, July 19, when he faces WBC welterweight champion Mario Barrios in the main event of a PBC pay-per-view boxing card at the MGM Grand Garden Arena in Las Vegas. Pacquiao, the only boxer to win titles in eight weight divisions, walked away from the ring in 2021 following a decision loss to Yordenis Ugás. We look at when boxing fans can expect to see the ring walks for the Pacquiao vs. Pacquiao fight card. Manny Pacquiao Vs. Mario Barrios Main Event Mario Barrios (29-2-1) vs. Manny Pacquiao (62-8-2): For Barrios's WBC welterweight championship Manny Pacquiao Vs. Mario Barrios Undercard Sebastian Fundora (22-1-1-) vs. Tim Tszyu (25-2-0): For Fundora's WBC junior middleweight title Isaac Cruz (27-3-1) vs. Angel Fierro (23-3-2): Junior welterweight Brandon Figueroa (25-2-1) vs. Joet Gonzalez (27-4-0): Featherweight Gary Russell Jr. (31-2-0) vs. Hugo Castaneda (15-2-1): Lightweight David Picasso (31-0-1) vs. Kyonosuke Kamed (15-4-2): Junior featherweight Mark Magsayo (27-2) vs. Jorge Mata Cuellar (21-2-2): Junior lightweight Manny Pacquiao Vs. Mario Barrios Main Event Ring Walk Time The ring walk for the Pacquiao vs. Barrios fight is expected to occur at approximately 11 p.m. ET. Manny Pacquiao Vs. Mario Barrios Fight Card Date: Saturday, July 19, 2025 Manny Pacquiao Vs. Mario Barrios Fight Card Time: 5:30 p.m. ET Manny Pacquiao Vs. Mario Barrios Fight Card Location: MGM Grand Garden Arena in Las Vegas, NV Manny Pacquiao Vs. Mario Barrios Fight Card How to Watch Or Stream: Amazon Prime Video Manny Pacquiao Vs. Mario Barrios Fight Card Streaming Cost: $79.95 rios said of his opponent. 'It's hard to be like, 'Man, I'm about to square up with him for my title.' But I am going in there with bad intentions. I am trying to get him out of there.' Barrios (29-2-1, 18 KOs) is the No. 3 ranked 147-pounder according to ESPN. Filipino boxer Manny Pacquiao attends the press conference ahead of his July 19 WBC welterweight ... More title fight against Mexican-US boxer Mario Barrios at the NOVO at L.A. Live in Los Angeles on June 3, 2025. Manny Pacquiao on June 3 shrugged off concerns about his decision to return to boxing at the age of 46 as he prepares for next month's world welterweight title comeback against Mario Barrios. The charismatic Filipino boxing icon stunned the sports world last month after announcing he would take on World Boxing Council (WBC) champion Barrios on July 19 in Las Vegas, four years after his last fight ended in a disappointing defeat. (Photo by Patrick T. Fallon / AFP) (Photo by PATRICK T. FALLON/AFP via Getty Images) ESPN reported on Pacquiao coming out of retirement in early May. The former eight-division boxing champion confirmed his return on Instagram, writing, 'On July 19, I return to the ring to face WBC Welterweight Champion Mario Barrios at the MGM Grand in Las Vegas. Let's make history! #TeamPacquiao 🇵🇭' The 46-year-old Pacquiao last fought in August 2021 when he dropped a unanimous decision to Yordenis Ugas for the WBA welterweight championship. Not long after that setback, Pacquiao announced his retirement. "Even me, I'm amazed at what I have done," Pacquiao said in a video he posted on social media. "The only boxer to hold world titles in four different decades and became the oldest boxer to win a world welterweight title, an amazing accomplishment." "It is difficult for me to accept that my time as a boxer is over," he added. "Today, I am announcing my retirement. I never thought that this day would come. As I hang up my boxing gloves, I would like to thank the whole world, especially the Filipino people, for supporting Manny Pacquiao." Pacquiao (62-8-2, 39 KOs) was the No. 6 ranked welterweight, according to ESPN, when he retired. He is currently unranked. "Goodbye, boxing. Thank you for changing my life," Pacquiao added. "You gave me the chance to find a way out of poverty. Because of you, I was able to inspire people all over the world. Because of you, I have been given the courage to change more life. "I will never forget what I have done and accomplished in my life. I can't imagine that I have just heard the final bell." Manny Pacquiao Vs. Mario Barrios Breakdown Manny Pacquiao is 46. Couple that with his inactivity, and no one should expect to see the fighter they remember him being in his heyday when he steps into the ring on Saturday. The question facing Pacquiao is whether the athleticism that helped him in his younger days can still assist him in competition in 2025. Pacquiao's reflexes, speed, and natural abilities helped mask some of the gaps in his game when he was racking up titles in eight divisions. Pacquiao displayed remarkable speed in his punches and footwork, which allowed him to move in and out of range with ease, while also landing blows from odd angles as his foes looked to react to Pacquiao's movement. In his most recent fight, an August 2024 exhibition against kickboxer Rukiya Anpo, Pacquiao displayed slower movement and reflexes, which put him off balance and allowed his opponent to land while Pacquiao looked to recover his stance. At best, the slip in Pacquiao's athleticism will remain where it was during that three-round affair. Don't expect the best-case scenario on Saturday. Mario Barrios is 30 and in his prime. If Pacquiao has declined significantly in his athleticism, which should be apparent early in this matchup, then Barrios must exploit Pacquiao's pressure and tendency to push forward. If Barrios can pick up the timing of his aging opponent's attacks, he should be able to counter effectively and step back out of range before Pacquiao can regain his footing and respond. Barrios's height and reach advantages in this fight will also help him when it comes to countering Pacquiao's attacks. If Barrios can use his jab to keep Pacquiao and force him to work to get into range, that will also help Barrios when it comes to working effective counters. Sebastian Fundora Vs. Tim Tszyu 2 US boxer Sebastian Fundora speaks during the press conference ahead of his July 19 WBC super ... More welterweight title fight against Australian boxer Tim Tszyu at the NOVO at L.A. Live in Los Angeles on June 3, 2025. (Photo by Patrick T. Fallon / AFP) (Photo by PATRICK T. FALLON/AFP via Getty Images) Sebastian Fundora (22-1-1 with 14 knockouts) opened his boxing career on a 18-0-1 run before he got the opportunity to fight for a title. In April 2022, Fundora faced Erickson Lubin for the vacant WBC interim light middleweight belt. Fundora won that fight by stoppage in the ninth round. Fundora defended his belt in October 2022 with a unanimous decision win over Carlos Ocampo. His title run ended in April 2023 when Brian Mendoza knocked out Fundora in the early moments of the seventh round of their matchup. Fundora returned to the ring nearly a year later to face Tim Tszyu at T-Mobile Arena in Las Vegas in the main event of a PBC card. Tszyu's WBO junior middleweight title was on the line as well as the vacant WBC strap Fundora won that fight via split decision, scoring an upset split decision (112-116, 116-112, 115-113). Fundora defended his titles in March of this year, knocking out Chordale Booker in the fourth round at Michelob Ultra Arena in Las Vegas. The WBO stripped Fundora of his belt when he elected to face Tszyu in a rematch instead of WBO mandatory challenger Xander Zayas. ESPN has Fundora ranked as the No. 3 junior middleweight behind Terence Crawford and Vergil Ortiz Jr. LOS ANGELES, CALIFORNIA - JUNE 03: Tim Tszyu speaks prior to his WBC super welterweight rematch ... More fight versus Sebastian Fundora at The NOVO at L.A. Live on June 03, 2025 in Los Angeles, California. (Photo by) Tim Tszyu (25-2 with 18 KOs) moved to 22-0 in March 2023 when he knocked out Tony Harrison to become the interim WBO junior middleweight champion. He was elevated to full champ when Jermell Charlo faced Canelo Alvarez for the undisputed super middleweight title in September 2023. In his first title defense, Tszyu defeated Mendoza via unanimous decision in Australia in October 2023. Tszyu's next defense was his bloody bout against Fundora. When Tszyu returned to action in October 2024 it was against IBF junior middleweight champ Bakhram Murtazaliev, who knocked Tszyu down four times before Tszyu's corner threw in the towel. That loss had many wondering if Tszyu could get back to a title fight. However, an April 2025 TKO victory over Joseph Spencer put Tszyu back in the title fight conversation. ESPN has Tszyu ranked at No. 6 at 154 pounds. We will have more on the Manny Pacquiao Vs. Mario Barrios as fight night nears.
Yahoo
17-07-2025
- Health
- Yahoo
GSK's Linerixibat Poised to Address Substantial Unmet Need for the Treatment of Pruritus Associated with Primary Biliary Cholangitis, According to Spherix Global Insights
Despite new market entrants in the form of Gilead's Livdelzi and Ipsen's Iqirvo, US gastroenterologists report nearly half of PBC patients suffer from moderate to severe pruritus, underscoring an existing unmet need. EXTON, PA, July 17, 2025 (GLOBE NEWSWIRE) -- The treatment landscape for primary biliary cholangitis (PBC) has undergone a marked transformation over the past year, driven by the recent approvals of Gilead's Livdelzi (seladelpar) and Ipsen's Iqirvo (elafibranor). These additions to the therapeutic arsenal represent meaningful progress in disease management. However, new data from Spherix Global Insights' Market Dynamix™: Primary Biliary Cholangitis and Primary Sclerosing Cholangitis 2025 (US) reveal that pruritus—a persistent and often debilitating symptom—continues to pose a significant unmet need for many patients living with PBC. Among the 104 US gastroenterologists surveyed in the study, there was near-universal agreement on the importance of addressing pruritus—one of the most burdensome and distressing symptoms associated with PBC. Respondents estimated that approximately half of their PBC patients suffer from moderate to severe pruritus, a manifestation that significantly impacts quality of life and remains challenging to manage. As one specialist poignantly noted, 'Patients with cholestatic liver disease will go to the world's end to escape from pruritus and the insomnia it causes.' Most gastroenterologists surveyed also acknowledged a substantial unmet need for therapies specifically targeting PBC-associated pruritus. While Livdelzi has demonstrated a significant reduction in itch symptoms after six months of treatment, only about half of respondents reported that their patients on Livdelzi required no additional intervention for pruritus. The need for effective symptom control is even more pronounced among patients receiving Iqirvo, further highlighting the gap in adequate pruritus management and the continued demand for novel therapeutic approaches. In June, GSK announced that the FDA had accepted the New Drug Application (NDA) for its ileal bile acid transporter (IBAT) inhibitor, linerixibat, for the treatment of cholestatic pruritus in patients with PBC. The PDUFA target action date is set for March 24, 2026. Awareness of the IBAT class is already high among gastroenterologists, and most report they are likely to incorporate linerixibat into their treatment armamentarium if approved. As one specialist expressed, 'The results seem promising with a significant symptom reduction among moderate to severe pruritus. However, abdominal pain and diarrhea side effects are somewhat concerning and may limit real-world use.' Another echoed the sentiment, noting, 'It significantly improved symptoms of pruritus along with quality of life, which can be a challenging and quite debilitating symptom to treat.' If approved, linerixibat could represent a meaningful advancement for patients struggling with PBC-related pruritus—a symptom that continues to profoundly impair quality of life and remains inadequately addressed by current therapies. Spherix Global Insights will continue to closely track emerging developments across the PBC treatment landscape and pipeline through its Market Dynamix™: Primary Biliary Cholangitis and Primary Sclerosing Cholangitis service. Market Dynamix™ is an independent service providing analysis of markets anticipated to experience a paradigm shift within the next three to five years. Insights highlight market size, current treatment approaches, unmet needs, and expert opinions on the likely disruption introduced by pipeline agents. About Spherix Global Insights Spherix is a leading independent market intelligence and advisory firm that delivers commercial value to the global life sciences industry, across the brand lifecycle. The seasoned team of Spherix experts provides an unbiased and holistic view of the landscape within rapidly evolving specialty markets, including dermatology, gastroenterology, rheumatology, nephrology, neurology, ophthalmology, and hematology. Spherix clients stay ahead of the curve with the perspective of the extensive Spherix Physician Community. As a trusted advisor and industry thought leader, Spherix's unparalleled market insights and advisory services empower clients to make better decisions and unlock opportunities for growth. To learn more about Spherix Global Insights, visit or connect through LinkedIn. For more details on Spherix's primary market research reports and interactive dashboard offerings, visit or register here: NOTICE: All company, brand or product names in this press release are trademarks of their respective holders. The findings and analysis addressed within are based on Spherix Global Insight's analysis and do not imply a relationship with or endorsement of the companies or brands mentioned in this press release. CONTACT: Jim Hickey, Gastroenterology Franchise Head Spherix Global Insights 4848794284 in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
